Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B728_LEIMU

TriTrypDb:

LmxM.34.5020

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B728

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B728

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.637
CLV_C14_Caspase3-7	155	159	PF00656	0.516
CLV_C14_Caspase3-7	201	205	PF00656	0.451
CLV_C14_Caspase3-7	292	296	PF00656	0.573
CLV_C14_Caspase3-7	574	578	PF00656	0.457
CLV_NRD_NRD_1	369	371	PF00675	0.590
CLV_NRD_NRD_1	384	386	PF00675	0.334
CLV_NRD_NRD_1	69	71	PF00675	0.461
CLV_NRD_NRD_1	75	77	PF00675	0.407
CLV_NRD_NRD_1	797	799	PF00675	0.599
CLV_PCSK_FUR_1	382	386	PF00082	0.504
CLV_PCSK_FUR_1	73	77	PF00082	0.427
CLV_PCSK_KEX2_1	369	371	PF00082	0.590
CLV_PCSK_KEX2_1	384	386	PF00082	0.441
CLV_PCSK_KEX2_1	73	75	PF00082	0.430
CLV_PCSK_KEX2_1	797	799	PF00082	0.599
CLV_PCSK_PC7_1	70	76	PF00082	0.435
CLV_PCSK_SKI1_1	335	339	PF00082	0.490
CLV_PCSK_SKI1_1	362	366	PF00082	0.634
CLV_PCSK_SKI1_1	369	373	PF00082	0.464
CLV_PCSK_SKI1_1	377	381	PF00082	0.322
CLV_PCSK_SKI1_1	384	388	PF00082	0.332
CLV_PCSK_SKI1_1	480	484	PF00082	0.559
CLV_PCSK_SKI1_1	580	584	PF00082	0.404
CLV_PCSK_SKI1_1	694	698	PF00082	0.500
CLV_PCSK_SKI1_1	798	802	PF00082	0.572
CLV_PCSK_SKI1_1	865	869	PF00082	0.349
CLV_PCSK_SKI1_1	89	93	PF00082	0.526
CLV_Separin_Metazoa	832	836	PF03568	0.280
DEG_SPOP_SBC_1	238	242	PF00917	0.607
DOC_CDC14_PxL_1	254	262	PF14671	0.514
DOC_CKS1_1	757	762	PF01111	0.539
DOC_CKS1_1	850	855	PF01111	0.417
DOC_CYCLIN_RxL_1	381	391	PF00134	0.446
DOC_CYCLIN_RxL_1	691	700	PF00134	0.498
DOC_CYCLIN_RxL_1	794	804	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	757	763	PF00134	0.517
DOC_MAPK_gen_1	262	269	PF00069	0.486
DOC_MAPK_gen_1	692	699	PF00069	0.508
DOC_MAPK_gen_1	70	81	PF00069	0.415
DOC_MAPK_MEF2A_6	558	567	PF00069	0.456
DOC_MAPK_MEF2A_6	692	699	PF00069	0.558
DOC_MAPK_NFAT4_5	692	700	PF00069	0.558
DOC_PP1_RVXF_1	87	94	PF00149	0.433
DOC_USP7_MATH_1	105	109	PF00917	0.772
DOC_USP7_MATH_1	121	125	PF00917	0.703
DOC_USP7_MATH_1	181	185	PF00917	0.417
DOC_USP7_MATH_1	230	234	PF00917	0.617
DOC_USP7_MATH_1	238	242	PF00917	0.619
DOC_USP7_MATH_1	246	250	PF00917	0.398
DOC_USP7_MATH_1	708	712	PF00917	0.600
DOC_USP7_MATH_1	753	757	PF00917	0.582
DOC_USP7_MATH_1	839	843	PF00917	0.455
DOC_USP7_MATH_1	99	103	PF00917	0.502
DOC_WW_Pin1_4	160	165	PF00397	0.400
DOC_WW_Pin1_4	643	648	PF00397	0.557
DOC_WW_Pin1_4	697	702	PF00397	0.611
DOC_WW_Pin1_4	710	715	PF00397	0.711
DOC_WW_Pin1_4	756	761	PF00397	0.505
DOC_WW_Pin1_4	849	854	PF00397	0.707
DOC_WW_Pin1_4	883	888	PF00397	0.355
LIG_14-3-3_CanoR_1	209	214	PF00244	0.440
LIG_14-3-3_CanoR_1	362	372	PF00244	0.613
LIG_14-3-3_CanoR_1	439	448	PF00244	0.440
LIG_14-3-3_CanoR_1	580	589	PF00244	0.445
LIG_14-3-3_CanoR_1	632	637	PF00244	0.478
LIG_14-3-3_CanoR_1	752	758	PF00244	0.538
LIG_14-3-3_CanoR_1	779	788	PF00244	0.559
LIG_14-3-3_CanoR_1	823	828	PF00244	0.493
LIG_14-3-3_CanoR_1	888	898	PF00244	0.489
LIG_Actin_WH2_2	420	438	PF00022	0.517
LIG_BRCT_BRCA1_1	224	228	PF00533	0.432
LIG_BRCT_BRCA1_1	403	407	PF00533	0.313
LIG_CtBP_PxDLS_1	164	168	PF00389	0.524
LIG_deltaCOP1_diTrp_1	287	291	PF00928	0.267
LIG_DLG_GKlike_1	209	216	PF00625	0.485
LIG_DLG_GKlike_1	632	639	PF00625	0.266
LIG_FHA_1	143	149	PF00498	0.356
LIG_FHA_1	374	380	PF00498	0.552
LIG_FHA_1	492	498	PF00498	0.457
LIG_FHA_1	524	530	PF00498	0.530
LIG_FHA_1	581	587	PF00498	0.452
LIG_FHA_1	757	763	PF00498	0.486
LIG_FHA_1	787	793	PF00498	0.396
LIG_FHA_1	850	856	PF00498	0.626
LIG_FHA_1	872	878	PF00498	0.417
LIG_FHA_2	136	142	PF00498	0.516
LIG_FHA_2	487	493	PF00498	0.448
LIG_FHA_2	572	578	PF00498	0.541
LIG_FHA_2	615	621	PF00498	0.539
LIG_FHA_2	688	694	PF00498	0.551
LIG_Integrin_RGD_1	199	201	PF01839	0.528
LIG_LIR_Gen_1	208	218	PF02991	0.439
LIG_LIR_Gen_1	404	414	PF02991	0.319
LIG_LIR_Gen_1	41	50	PF02991	0.460
LIG_LIR_Gen_1	514	523	PF02991	0.421
LIG_LIR_Gen_1	53	63	PF02991	0.574
LIG_LIR_Gen_1	631	640	PF02991	0.486
LIG_LIR_Gen_1	64	69	PF02991	0.441
LIG_LIR_Nem_3	160	165	PF02991	0.469
LIG_LIR_Nem_3	208	213	PF02991	0.437
LIG_LIR_Nem_3	404	410	PF02991	0.344
LIG_LIR_Nem_3	514	519	PF02991	0.456
LIG_LIR_Nem_3	53	59	PF02991	0.577
LIG_LIR_Nem_3	555	560	PF02991	0.461
LIG_LIR_Nem_3	631	636	PF02991	0.455
LIG_LIR_Nem_3	64	68	PF02991	0.427
LIG_LIR_Nem_3	778	784	PF02991	0.510
LIG_NRBOX	329	335	PF00104	0.439
LIG_Pex14_1	780	784	PF04695	0.507
LIG_SH2_CRK	437	441	PF00017	0.557
LIG_SH2_CRK	663	667	PF00017	0.385
LIG_SH2_SRC	413	416	PF00017	0.551
LIG_SH2_SRC	552	555	PF00017	0.356
LIG_SH2_SRC	85	88	PF00017	0.551
LIG_SH2_STAP1	516	520	PF00017	0.575
LIG_SH2_STAP1	633	637	PF00017	0.548
LIG_SH2_STAP1	663	667	PF00017	0.385
LIG_SH2_STAT5	336	339	PF00017	0.328
LIG_SH2_STAT5	42	45	PF00017	0.402
LIG_SH2_STAT5	787	790	PF00017	0.511
LIG_SH2_STAT5	879	882	PF00017	0.438
LIG_SH3_3	123	129	PF00018	0.670
LIG_SH3_3	531	537	PF00018	0.579
LIG_SH3_3	585	591	PF00018	0.553
LIG_SH3_3	698	704	PF00018	0.678
LIG_SH3_3	733	739	PF00018	0.516
LIG_SUMO_SIM_anti_2	620	626	PF11976	0.480
LIG_SUMO_SIM_par_1	539	545	PF11976	0.392
LIG_SxIP_EBH_1	250	264	PF03271	0.545
LIG_TRAF2_1	721	724	PF00917	0.504
LIG_TYR_ITIM	435	440	PF00017	0.561
LIG_TYR_ITIM	661	666	PF00017	0.496
LIG_UBA3_1	473	480	PF00899	0.342
LIG_UBA3_1	499	506	PF00899	0.457
LIG_WRC_WIRS_1	633	638	PF05994	0.511
LIG_WRC_WIRS_1	855	860	PF05994	0.620
MOD_CDK_SPK_2	883	888	PF00069	0.355
MOD_CK1_1	10	16	PF00069	0.376
MOD_CK1_1	157	163	PF00069	0.520
MOD_CK1_1	231	237	PF00069	0.648
MOD_CK1_1	314	320	PF00069	0.568
MOD_CK1_1	442	448	PF00069	0.504
MOD_CK1_1	486	492	PF00069	0.497
MOD_CK1_1	614	620	PF00069	0.566
MOD_CK1_1	631	637	PF00069	0.500
MOD_CK1_1	756	762	PF00069	0.457
MOD_CK1_1	892	898	PF00069	0.686
MOD_CK2_1	135	141	PF00069	0.449
MOD_CK2_1	355	361	PF00069	0.634
MOD_CK2_1	450	456	PF00069	0.459
MOD_CK2_1	511	517	PF00069	0.510
MOD_CK2_1	687	693	PF00069	0.550
MOD_CK2_1	762	768	PF00069	0.458
MOD_Cter_Amidation	367	370	PF01082	0.605
MOD_GlcNHglycan	241	244	PF01048	0.615
MOD_GlcNHglycan	282	285	PF01048	0.539
MOD_GlcNHglycan	398	401	PF01048	0.603
MOD_GlcNHglycan	456	459	PF01048	0.514
MOD_GlcNHglycan	46	50	PF01048	0.534
MOD_GlcNHglycan	706	709	PF01048	0.667
MOD_GlcNHglycan	781	784	PF01048	0.546
MOD_GlcNHglycan	841	844	PF01048	0.463
MOD_GlcNHglycan	894	897	PF01048	0.667
MOD_GlcNHglycan	9	12	PF01048	0.407
MOD_GSK3_1	105	112	PF00069	0.763
MOD_GSK3_1	153	160	PF00069	0.560
MOD_GSK3_1	182	189	PF00069	0.533
MOD_GSK3_1	228	235	PF00069	0.541
MOD_GSK3_1	351	358	PF00069	0.580
MOD_GSK3_1	439	446	PF00069	0.565
MOD_GSK3_1	450	457	PF00069	0.429
MOD_GSK3_1	50	57	PF00069	0.590
MOD_GSK3_1	518	525	PF00069	0.499
MOD_GSK3_1	628	635	PF00069	0.499
MOD_GSK3_1	674	681	PF00069	0.659
MOD_GSK3_1	699	706	PF00069	0.681
MOD_GSK3_1	775	782	PF00069	0.485
MOD_GSK3_1	819	826	PF00069	0.554
MOD_GSK3_1	883	890	PF00069	0.438
MOD_N-GLC_1	165	170	PF02516	0.322
MOD_N-GLC_1	592	597	PF02516	0.479
MOD_N-GLC_1	650	655	PF02516	0.353
MOD_NEK2_1	44	49	PF00069	0.443
MOD_NEK2_1	440	445	PF00069	0.459
MOD_NEK2_1	483	488	PF00069	0.541
MOD_NEK2_1	50	55	PF00069	0.478
MOD_NEK2_1	519	524	PF00069	0.506
MOD_NEK2_1	628	633	PF00069	0.492
MOD_NEK2_1	649	654	PF00069	0.597
MOD_NEK2_1	686	691	PF00069	0.417
MOD_NEK2_1	762	767	PF00069	0.441
MOD_PIKK_1	274	280	PF00454	0.472
MOD_PIKK_1	592	598	PF00454	0.457
MOD_PK_1	823	829	PF00069	0.568
MOD_PKA_2	289	295	PF00069	0.526
MOD_PKA_2	628	634	PF00069	0.502
MOD_PKA_2	655	661	PF00069	0.324
MOD_PKA_2	69	75	PF00069	0.575
MOD_PKA_2	887	893	PF00069	0.513
MOD_Plk_2-3	135	141	PF00069	0.496
MOD_Plk_2-3	355	361	PF00069	0.420
MOD_Plk_2-3	409	415	PF00069	0.516
MOD_Plk_4	135	141	PF00069	0.496
MOD_Plk_4	182	188	PF00069	0.546
MOD_Plk_4	311	317	PF00069	0.506
MOD_Plk_4	393	399	PF00069	0.610
MOD_Plk_4	50	56	PF00069	0.583
MOD_Plk_4	635	641	PF00069	0.439
MOD_Plk_4	823	829	PF00069	0.513
MOD_ProDKin_1	160	166	PF00069	0.404
MOD_ProDKin_1	643	649	PF00069	0.555
MOD_ProDKin_1	697	703	PF00069	0.622
MOD_ProDKin_1	710	716	PF00069	0.703
MOD_ProDKin_1	756	762	PF00069	0.502
MOD_ProDKin_1	849	855	PF00069	0.707
MOD_ProDKin_1	883	889	PF00069	0.367
MOD_SUMO_rev_2	64	72	PF00179	0.566
MOD_SUMO_rev_2	86	91	PF00179	0.491
TRG_DiLeu_BaEn_1	329	334	PF01217	0.461
TRG_DiLeu_BaEn_1	682	687	PF01217	0.408
TRG_DiLeu_BaEn_2	402	408	PF01217	0.533
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.504
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.419
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.387
TRG_DiLeu_BaLyEn_6	796	801	PF01217	0.616
TRG_DiLeu_BaLyEn_6	872	877	PF01217	0.557
TRG_ENDOCYTIC_2	42	45	PF00928	0.402
TRG_ENDOCYTIC_2	437	440	PF00928	0.556
TRG_ENDOCYTIC_2	516	519	PF00928	0.601
TRG_ENDOCYTIC_2	557	560	PF00928	0.502
TRG_ENDOCYTIC_2	56	59	PF00928	0.470
TRG_ENDOCYTIC_2	633	636	PF00928	0.409
TRG_ENDOCYTIC_2	65	68	PF00928	0.540
TRG_ENDOCYTIC_2	663	666	PF00928	0.386
TRG_ENDOCYTIC_2	85	88	PF00928	0.222
TRG_ER_diArg_1	369	371	PF00400	0.590
TRG_ER_diArg_1	382	385	PF00400	0.347
TRG_ER_diArg_1	73	76	PF00400	0.439
TRG_ER_diArg_1	797	799	PF00400	0.599
TRG_ER_diArg_1	81	84	PF00400	0.429
TRG_NES_CRM1_1	265	278	PF08389	0.252
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	798	802	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	810	815	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	861	866	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ19	Leptomonas seymouri	52%	86%
A0A1X0P5W4	Trypanosomatidae	33%	90%
A0A3Q8IJL5	Leishmania donovani	89%	100%
A0A3R7KBK5	Trypanosoma rangeli	35%	97%
A4HNG4	Leishmania braziliensis	75%	100%
A4IC55	Leishmania infantum	89%	100%
C9ZYE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	93%
E9AFX5	Leishmania major	88%	100%