PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9B726_LEIMU

TriTrypDb:

LmxM.34.5000

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B726

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B726

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.493
CLV_NRD_NRD_1	154	156	PF00675	0.379
CLV_NRD_NRD_1	166	168	PF00675	0.315
CLV_NRD_NRD_1	218	220	PF00675	0.365
CLV_NRD_NRD_1	253	255	PF00675	0.603
CLV_NRD_NRD_1	257	259	PF00675	0.592
CLV_PCSK_KEX2_1	154	156	PF00082	0.379
CLV_PCSK_KEX2_1	16	18	PF00082	0.601
CLV_PCSK_KEX2_1	166	168	PF00082	0.356
CLV_PCSK_KEX2_1	218	220	PF00082	0.318
CLV_PCSK_KEX2_1	253	255	PF00082	0.603
CLV_PCSK_KEX2_1	257	259	PF00082	0.583
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.682
CLV_PCSK_PC7_1	253	259	PF00082	0.710
CLV_PCSK_SKI1_1	148	152	PF00082	0.410
CLV_PCSK_SKI1_1	154	158	PF00082	0.288
CLV_PCSK_SKI1_1	167	171	PF00082	0.243
CLV_PCSK_SKI1_1	201	205	PF00082	0.301
CLV_PCSK_SKI1_1	222	226	PF00082	0.310
CLV_PCSK_SKI1_1	268	272	PF00082	0.526
CLV_PCSK_SKI1_1	47	51	PF00082	0.415
CLV_PCSK_SKI1_1	63	67	PF00082	0.712
DEG_SPOP_SBC_1	83	87	PF00917	0.421
DOC_CKS1_1	30	35	PF01111	0.635
DOC_CYCLIN_RxL_1	218	226	PF00134	0.424
DOC_CYCLIN_RxL_1	60	67	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.655
DOC_MAPK_gen_1	201	207	PF00069	0.301
DOC_MAPK_gen_1	209	217	PF00069	0.309
DOC_PP1_RVXF_1	229	235	PF00149	0.413
DOC_USP7_MATH_1	4	8	PF00917	0.679
DOC_USP7_MATH_1	52	56	PF00917	0.573
DOC_USP7_MATH_1	61	65	PF00917	0.562
DOC_USP7_MATH_1	69	73	PF00917	0.659
DOC_USP7_MATH_1	77	81	PF00917	0.577
DOC_USP7_MATH_1	83	87	PF00917	0.679
DOC_USP7_UBL2_3	106	110	PF12436	0.383
DOC_WW_Pin1_4	140	145	PF00397	0.555
DOC_WW_Pin1_4	29	34	PF00397	0.559
DOC_WW_Pin1_4	48	53	PF00397	0.678
DOC_WW_Pin1_4	57	62	PF00397	0.557
LIG_14-3-3_CanoR_1	166	170	PF00244	0.398
LIG_14-3-3_CanoR_1	179	188	PF00244	0.330
LIG_14-3-3_CanoR_1	209	215	PF00244	0.320
LIG_14-3-3_CanoR_1	257	267	PF00244	0.566
LIG_Actin_WH2_2	237	255	PF00022	0.478
LIG_BRCT_BRCA1_1	210	214	PF00533	0.440
LIG_FHA_1	140	146	PF00498	0.517
LIG_FHA_1	202	208	PF00498	0.294
LIG_FHA_1	247	253	PF00498	0.666
LIG_FHA_2	155	161	PF00498	0.307
LIG_FHA_2	166	172	PF00498	0.307
LIG_FHA_2	187	193	PF00498	0.270
LIG_LIR_Gen_1	211	220	PF02991	0.307
LIG_LIR_Gen_1	99	107	PF02991	0.453
LIG_LIR_Nem_3	211	217	PF02991	0.316
LIG_LIR_Nem_3	264	270	PF02991	0.421
LIG_LIR_Nem_3	99	105	PF02991	0.422
LIG_PALB2_WD40_1	229	237	PF16756	0.377
LIG_PCNA_yPIPBox_3	110	124	PF02747	0.325
LIG_PCNA_yPIPBox_3	218	228	PF02747	0.424
LIG_Pex14_2	112	116	PF04695	0.362
LIG_SH2_CRK	267	271	PF00017	0.420
LIG_SH2_STAP1	26	30	PF00017	0.543
LIG_SH2_STAT5	236	239	PF00017	0.363
LIG_SH3_3	182	188	PF00018	0.318
LIG_SH3_3	245	251	PF00018	0.695
LIG_SH3_3	30	36	PF00018	0.520
LIG_SH3_3	68	74	PF00018	0.650
LIG_SH3_3	86	92	PF00018	0.466
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.303
LIG_SUMO_SIM_par_1	122	127	PF11976	0.431
LIG_SUMO_SIM_par_1	203	208	PF11976	0.413
LIG_UBA3_1	195	202	PF00899	0.379
MOD_CDC14_SPxK_1	60	63	PF00782	0.679
MOD_CDK_SPxK_1	57	63	PF00069	0.625
MOD_CK1_1	180	186	PF00069	0.407
MOD_CK1_1	208	214	PF00069	0.359
MOD_CK1_1	272	278	PF00069	0.504
MOD_CK1_1	29	35	PF00069	0.622
MOD_CK1_1	3	9	PF00069	0.631
MOD_CK1_1	48	54	PF00069	0.565
MOD_CK1_1	55	61	PF00069	0.607
MOD_CK1_1	72	78	PF00069	0.447
MOD_CK2_1	165	171	PF00069	0.366
MOD_CK2_1	186	192	PF00069	0.270
MOD_CK2_1	258	264	PF00069	0.696
MOD_CK2_1	32	38	PF00069	0.486
MOD_CK2_1	61	67	PF00069	0.553
MOD_Cter_Amidation	107	110	PF01082	0.479
MOD_GlcNHglycan	2	5	PF01048	0.679
MOD_GlcNHglycan	86	89	PF01048	0.484
MOD_GSK3_1	154	161	PF00069	0.419
MOD_GSK3_1	197	204	PF00069	0.270
MOD_GSK3_1	242	249	PF00069	0.544
MOD_GSK3_1	270	277	PF00069	0.515
MOD_GSK3_1	3	10	PF00069	0.598
MOD_GSK3_1	48	55	PF00069	0.537
MOD_GSK3_1	57	64	PF00069	0.628
MOD_NEK2_1	2	7	PF00069	0.642
MOD_NEK2_1	271	276	PF00069	0.431
MOD_NEK2_1	9	14	PF00069	0.613
MOD_NEK2_2	174	179	PF00069	0.431
MOD_PIKK_1	159	165	PF00454	0.368
MOD_PIKK_1	180	186	PF00454	0.241
MOD_PIKK_1	4	10	PF00454	0.523
MOD_PKA_1	154	160	PF00069	0.424
MOD_PKA_1	201	207	PF00069	0.321
MOD_PKA_2	154	160	PF00069	0.424
MOD_PKA_2	165	171	PF00069	0.424
MOD_PKA_2	208	214	PF00069	0.322
MOD_Plk_4	26	32	PF00069	0.531
MOD_ProDKin_1	140	146	PF00069	0.558
MOD_ProDKin_1	29	35	PF00069	0.557
MOD_ProDKin_1	48	54	PF00069	0.680
MOD_ProDKin_1	57	63	PF00069	0.559
MOD_SUMO_rev_2	193	203	PF00179	0.363
TRG_DiLeu_BaEn_1	147	152	PF01217	0.302
TRG_ENDOCYTIC_2	267	270	PF00928	0.421
TRG_ER_diArg_1	153	155	PF00400	0.381
TRG_ER_diArg_1	17	20	PF00400	0.458
TRG_ER_diArg_1	217	219	PF00400	0.357
TRG_ER_diArg_1	228	231	PF00400	0.144
TRG_ER_diArg_1	252	254	PF00400	0.663
TRG_NLS_MonoExtC_3	14	19	PF00514	0.497
TRG_NLS_MonoExtN_4	15	20	PF00514	0.498
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	28%	73%
A0A0N1PC14	Leptomonas seymouri	64%	97%
A0A0S4J5L8	Bodo saltans	30%	95%
A0A0S4KL40	Bodo saltans	27%	100%
A0A1X0NLP9	Trypanosomatidae	29%	100%
A0A1X0P536	Trypanosomatidae	44%	100%
A0A3Q8IJZ1	Leishmania donovani	91%	100%
A0A3R7NIU7	Trypanosoma rangeli	41%	100%
A4HGI7	Leishmania braziliensis	32%	100%
A4HMC6	Leishmania braziliensis	25%	68%
A4HNG2	Leishmania braziliensis	82%	100%
A4IC69	Leishmania infantum	91%	100%
C9ZYF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AES0	Leishmania major	26%	68%
E9AFX3	Leishmania major	92%	100%
V5DA19	Trypanosoma cruzi	30%	71%