LeishMANIAdb
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PAP2_C domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PAP2_C domain-containing protein
Gene product:
sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional
Species:
Leishmania mexicana
UniProt:
E9B725_LEIMU
TriTrypDb:
LmxM.34.4990
Length:
383

Annotations

LeishMANIAdb annotations

Publication identifier(s): 20457606
Bidirectional lipid inositolphosphotransferase (experimentally validated). Homologous to animal phosphatidylcholine:ceramide cholinephosphotransferases. Expanded on the Trypanosoma lineage.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005768 endosome 7 1
GO:0005794 Golgi apparatus 5 1
GO:0005886 plasma membrane 3 1
GO:0020016 ciliary pocket 2 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

E9B725
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B725

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 16
GO:0006643 membrane lipid metabolic process 4 16
GO:0006665 sphingolipid metabolic process 4 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0044255 cellular lipid metabolic process 3 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0006066 alcohol metabolic process 3 1
GO:0006576 biogenic amine metabolic process 5 1
GO:0006580 ethanolamine metabolic process 5 1
GO:0006672 ceramide metabolic process 4 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009308 amine metabolic process 4 1
GO:0009309 amine biosynthetic process 5 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0034308 primary alcohol metabolic process 4 1
GO:0034309 primary alcohol biosynthetic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0042401 biogenic amine biosynthetic process 6 1
GO:0042439 ethanolamine-containing compound metabolic process 4 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046335 ethanolamine biosynthetic process 6 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046513 ceramide biosynthetic process 5 1
GO:1901160 primary amino compound metabolic process 4 1
GO:1901162 primary amino compound biosynthetic process 5 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 16
GO:0033188 sphingomyelin synthase activity 5 5
GO:0047493 ceramide cholinephosphotransferase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 327 331 PF00656 0.722
CLV_NRD_NRD_1 142 144 PF00675 0.390
CLV_PCSK_KEX2_1 142 144 PF00082 0.383
CLV_PCSK_SKI1_1 103 107 PF00082 0.331
CLV_PCSK_SKI1_1 132 136 PF00082 0.299
CLV_PCSK_SKI1_1 148 152 PF00082 0.154
CLV_PCSK_SKI1_1 157 161 PF00082 0.292
DOC_CDC14_PxL_1 35 43 PF14671 0.286
DOC_CKS1_1 321 326 PF01111 0.732
DOC_MAPK_MEF2A_6 244 253 PF00069 0.334
DOC_MAPK_MEF2A_6 36 45 PF00069 0.281
DOC_MAPK_MEF2A_6 66 73 PF00069 0.288
DOC_PP1_RVXF_1 130 136 PF00149 0.590
DOC_PP4_FxxP_1 237 240 PF00568 0.524
DOC_USP7_MATH_1 260 264 PF00917 0.281
DOC_WW_Pin1_4 232 237 PF00397 0.424
DOC_WW_Pin1_4 320 325 PF00397 0.733
DOC_WW_Pin1_4 342 347 PF00397 0.658
DOC_WW_Pin1_4 364 369 PF00397 0.716
LIG_14-3-3_CanoR_1 157 163 PF00244 0.288
LIG_14-3-3_CanoR_1 244 250 PF00244 0.299
LIG_14-3-3_CanoR_1 262 271 PF00244 0.158
LIG_BRCT_BRCA1_1 115 119 PF00533 0.596
LIG_BRCT_BRCA1_1 224 228 PF00533 0.339
LIG_eIF4E_1 265 271 PF01652 0.233
LIG_FHA_1 16 22 PF00498 0.617
LIG_FHA_1 219 225 PF00498 0.291
LIG_FHA_1 264 270 PF00498 0.226
LIG_FHA_1 277 283 PF00498 0.272
LIG_FHA_1 29 35 PF00498 0.422
LIG_FHA_1 343 349 PF00498 0.730
LIG_FHA_1 84 90 PF00498 0.356
LIG_FHA_1 95 101 PF00498 0.390
LIG_FHA_2 306 312 PF00498 0.621
LIG_FHA_2 321 327 PF00498 0.679
LIG_FHA_2 4 10 PF00498 0.664
LIG_FHA_2 78 84 PF00498 0.389
LIG_IRF3_LxIS_1 249 254 PF10401 0.320
LIG_LIR_Apic_2 235 240 PF02991 0.535
LIG_LIR_Gen_1 116 124 PF02991 0.528
LIG_LIR_Gen_1 160 170 PF02991 0.371
LIG_LIR_Gen_1 254 260 PF02991 0.281
LIG_LIR_Nem_3 116 120 PF02991 0.536
LIG_LIR_Nem_3 160 165 PF02991 0.395
LIG_LIR_Nem_3 233 237 PF02991 0.503
LIG_LIR_Nem_3 254 259 PF02991 0.311
LIG_LIR_Nem_3 279 283 PF02991 0.276
LIG_LIR_Nem_3 44 50 PF02991 0.343
LIG_MYND_1 236 240 PF01753 0.535
LIG_PCNA_yPIPBox_3 125 138 PF02747 0.508
LIG_Pex14_2 228 232 PF04695 0.395
LIG_Pex14_2 237 241 PF04695 0.514
LIG_SH2_CRK 162 166 PF00017 0.292
LIG_SH2_CRK 24 28 PF00017 0.572
LIG_SH2_CRK 256 260 PF00017 0.292
LIG_SH2_PTP2 274 277 PF00017 0.409
LIG_SH2_STAP1 162 166 PF00017 0.292
LIG_SH2_STAP1 265 269 PF00017 0.226
LIG_SH2_STAT5 256 259 PF00017 0.286
LIG_SH2_STAT5 265 268 PF00017 0.228
LIG_SH2_STAT5 274 277 PF00017 0.305
LIG_SH3_1 343 349 PF00018 0.552
LIG_SH3_3 246 252 PF00018 0.304
LIG_SH3_3 318 324 PF00018 0.736
LIG_SH3_3 343 349 PF00018 0.675
LIG_SUMO_SIM_anti_2 315 323 PF11976 0.720
LIG_SUMO_SIM_par_1 198 204 PF11976 0.287
LIG_SUMO_SIM_par_1 315 323 PF11976 0.723
LIG_TRAF2_1 308 311 PF00917 0.545
LIG_TRAF2_1 314 317 PF00917 0.580
LIG_TYR_ITIM 253 258 PF00017 0.339
LIG_TYR_ITSM 158 165 PF00017 0.395
LIG_WRC_WIRS_1 114 119 PF05994 0.608
LIG_WRC_WIRS_1 126 131 PF05994 0.602
MOD_CK1_1 152 158 PF00069 0.511
MOD_CK1_1 218 224 PF00069 0.272
MOD_CK1_1 263 269 PF00069 0.270
MOD_CK1_1 3 9 PF00069 0.665
MOD_CK2_1 305 311 PF00069 0.490
MOD_CK2_1 320 326 PF00069 0.677
MOD_CK2_1 77 83 PF00069 0.281
MOD_CMANNOS 300 303 PF00535 0.417
MOD_Cter_Amidation 140 143 PF01082 0.396
MOD_GlcNHglycan 139 142 PF01048 0.380
MOD_GlcNHglycan 206 209 PF01048 0.569
MOD_GlcNHglycan 217 220 PF01048 0.272
MOD_GlcNHglycan 330 334 PF01048 0.546
MOD_GlcNHglycan 356 359 PF01048 0.527
MOD_GlcNHglycan 83 86 PF01048 0.496
MOD_GSK3_1 174 181 PF00069 0.319
MOD_GSK3_1 218 225 PF00069 0.258
MOD_GSK3_1 322 329 PF00069 0.741
MOD_GSK3_1 338 345 PF00069 0.675
MOD_GSK3_1 349 356 PF00069 0.751
MOD_GSK3_1 77 84 PF00069 0.207
MOD_N-GLC_1 93 98 PF02516 0.389
MOD_N-GLC_2 183 185 PF02516 0.560
MOD_NEK2_1 158 163 PF00069 0.273
MOD_NEK2_1 174 179 PF00069 0.281
MOD_NEK2_1 215 220 PF00069 0.273
MOD_NEK2_1 222 227 PF00069 0.339
MOD_NEK2_1 276 281 PF00069 0.377
MOD_NEK2_1 41 46 PF00069 0.340
MOD_NEK2_1 81 86 PF00069 0.356
MOD_NEK2_1 93 98 PF00069 0.409
MOD_PIKK_1 29 35 PF00454 0.459
MOD_PK_1 338 344 PF00069 0.557
MOD_PKA_2 377 383 PF00069 0.636
MOD_Plk_1 329 335 PF00069 0.561
MOD_Plk_1 338 344 PF00069 0.549
MOD_Plk_1 93 99 PF00069 0.424
MOD_Plk_4 125 131 PF00069 0.517
MOD_Plk_4 198 204 PF00069 0.293
MOD_Plk_4 218 224 PF00069 0.292
MOD_Plk_4 245 251 PF00069 0.254
MOD_Plk_4 41 47 PF00069 0.297
MOD_Plk_4 77 83 PF00069 0.360
MOD_Plk_4 94 100 PF00069 0.254
MOD_ProDKin_1 232 238 PF00069 0.424
MOD_ProDKin_1 320 326 PF00069 0.734
MOD_ProDKin_1 342 348 PF00069 0.658
MOD_ProDKin_1 364 370 PF00069 0.718
TRG_DiLeu_BaEn_3 315 321 PF01217 0.535
TRG_ENDOCYTIC_2 162 165 PF00928 0.272
TRG_ENDOCYTIC_2 234 237 PF00928 0.433
TRG_ENDOCYTIC_2 255 258 PF00928 0.281
TRG_ENDOCYTIC_2 274 277 PF00928 0.198
TRG_ENDOCYTIC_2 280 283 PF00928 0.281
TRG_ER_diArg_1 142 144 PF00400 0.588
TRG_Pf-PMV_PEXEL_1 66 70 PF00026 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRL7 Leptomonas seymouri 72% 100%
A0A0S4J1W3 Bodo saltans 46% 100%
A0A1X0P4U9 Trypanosomatidae 50% 100%
A0A3S7XA07 Leishmania donovani 85% 99%
A0A422NCN9 Trypanosoma rangeli 43% 100%
A4HNG1 Leishmania braziliensis 67% 100%
A4IC70 Leishmania infantum 86% 99%
B3A0L9 Trypanosoma brucei brucei 42% 100%
B3A0M0 Trypanosoma brucei brucei 43% 100%
B3A0M1 Trypanosoma brucei brucei 43% 100%
B3A0M2 Trypanosoma brucei brucei 42% 100%
C9ZYF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZYF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZYF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZYF9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZYG0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZYG2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AFX2 Leishmania major 87% 100%
Q20696 Caenorhabditis elegans 21% 79%
Q38E53 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 43% 100%
Q38E54 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 44% 100%
Q38E55 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 44% 100%
Q38E56 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 43% 100%
Q4E4I4 Trypanosoma cruzi (strain CL Brener) 52% 100%
Q4JM44 Rattus norvegicus 24% 100%
Q4R763 Macaca fascicularis 23% 100%
Q7T3T4 Gallus gallus 24% 92%
Q8NHU3 Homo sapiens 23% 100%
Q96LT4 Homo sapiens 24% 92%
Q9D4B1 Mus musculus 23% 100%
Q9DA37 Mus musculus 25% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS