LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B724_LEIMU
TriTrypDb:
LmxM.34.4970
Length:
348

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific signal-anchored protein. Might be part of a bigger complex.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9B724
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B724

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.593
CLV_NRD_NRD_1 217 219 PF00675 0.631
CLV_NRD_NRD_1 275 277 PF00675 0.637
CLV_NRD_NRD_1 292 294 PF00675 0.568
CLV_NRD_NRD_1 335 337 PF00675 0.677
CLV_PCSK_KEX2_1 217 219 PF00082 0.631
CLV_PCSK_KEX2_1 275 277 PF00082 0.642
CLV_PCSK_PC7_1 213 219 PF00082 0.544
CLV_PCSK_SKI1_1 337 341 PF00082 0.507
CLV_PCSK_SKI1_1 6 10 PF00082 0.427
CLV_Separin_Metazoa 97 101 PF03568 0.440
DEG_SCF_FBW7_1 307 312 PF00400 0.453
DEG_SPOP_SBC_1 154 158 PF00917 0.569
DOC_CYCLIN_yClb5_NLxxxL_5 43 52 PF00134 0.378
DOC_MAPK_DCC_7 10 19 PF00069 0.520
DOC_MAPK_DCC_7 275 283 PF00069 0.370
DOC_MAPK_gen_1 275 283 PF00069 0.370
DOC_MAPK_gen_1 72 79 PF00069 0.399
DOC_MAPK_MEF2A_6 10 19 PF00069 0.522
DOC_MAPK_MEF2A_6 275 283 PF00069 0.370
DOC_MAPK_RevD_3 260 276 PF00069 0.273
DOC_USP7_MATH_1 154 158 PF00917 0.583
DOC_USP7_MATH_1 160 164 PF00917 0.544
DOC_USP7_MATH_1 177 181 PF00917 0.319
DOC_USP7_MATH_1 342 346 PF00917 0.392
DOC_USP7_UBL2_3 6 10 PF12436 0.629
DOC_WW_Pin1_4 143 148 PF00397 0.537
DOC_WW_Pin1_4 164 169 PF00397 0.522
DOC_WW_Pin1_4 221 226 PF00397 0.401
DOC_WW_Pin1_4 250 255 PF00397 0.452
DOC_WW_Pin1_4 305 310 PF00397 0.448
LIG_14-3-3_CanoR_1 221 225 PF00244 0.400
LIG_14-3-3_CanoR_1 293 300 PF00244 0.407
LIG_14-3-3_CanoR_1 336 342 PF00244 0.303
LIG_14-3-3_CanoR_1 92 96 PF00244 0.390
LIG_Actin_WH2_2 318 333 PF00022 0.418
LIG_BIR_II_1 1 5 PF00653 0.639
LIG_deltaCOP1_diTrp_1 298 304 PF00928 0.408
LIG_FHA_1 156 162 PF00498 0.524
LIG_FHA_1 306 312 PF00498 0.415
LIG_FHA_1 316 322 PF00498 0.355
LIG_FHA_1 338 344 PF00498 0.425
LIG_FHA_1 52 58 PF00498 0.431
LIG_FHA_2 148 154 PF00498 0.591
LIG_FHA_2 25 31 PF00498 0.450
LIG_FHA_2 92 98 PF00498 0.473
LIG_LIR_Apic_2 64 69 PF02991 0.424
LIG_LIR_Gen_1 130 139 PF02991 0.310
LIG_LIR_Gen_1 185 196 PF02991 0.397
LIG_LIR_Gen_1 94 103 PF02991 0.368
LIG_LIR_Nem_3 118 124 PF02991 0.351
LIG_LIR_Nem_3 130 134 PF02991 0.290
LIG_LIR_Nem_3 230 235 PF02991 0.371
LIG_LIR_Nem_3 94 98 PF02991 0.372
LIG_PCNA_yPIPBox_3 133 141 PF02747 0.432
LIG_Pex14_1 300 304 PF04695 0.379
LIG_Pex14_2 19 23 PF04695 0.337
LIG_Rb_LxCxE_1 328 348 PF01857 0.477
LIG_REV1ctd_RIR_1 261 270 PF16727 0.377
LIG_REV1ctd_RIR_1 6 14 PF16727 0.632
LIG_RPA_C_Fungi 208 220 PF08784 0.406
LIG_SH2_STAP1 232 236 PF00017 0.416
LIG_SH2_STAP1 53 57 PF00017 0.587
LIG_SH2_STAT5 110 113 PF00017 0.438
LIG_SH2_STAT5 121 124 PF00017 0.368
LIG_SH2_STAT5 53 56 PF00017 0.565
LIG_SH3_1 141 147 PF00018 0.625
LIG_SH3_3 137 143 PF00018 0.577
LIG_SH3_3 248 254 PF00018 0.643
LIG_SH3_3 280 286 PF00018 0.509
LIG_SH3_3 336 342 PF00018 0.368
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.558
LIG_SUMO_SIM_par_1 75 81 PF11976 0.558
LIG_TRAF2_1 115 118 PF00917 0.567
LIG_TRAF2_1 253 256 PF00917 0.445
LIG_TYR_ITIM 119 124 PF00017 0.438
LIG_UBA3_1 76 82 PF00899 0.568
LIG_WRC_WIRS_1 136 141 PF05994 0.539
MOD_CDC14_SPxK_1 224 227 PF00782 0.541
MOD_CDK_SPxK_1 221 227 PF00069 0.555
MOD_CK1_1 163 169 PF00069 0.690
MOD_CK1_1 296 302 PF00069 0.380
MOD_CK2_1 143 149 PF00069 0.690
MOD_CK2_1 183 189 PF00069 0.423
MOD_CK2_1 220 226 PF00069 0.559
MOD_CK2_1 24 30 PF00069 0.391
MOD_CK2_1 250 256 PF00069 0.538
MOD_CK2_1 58 64 PF00069 0.525
MOD_CK2_1 72 78 PF00069 0.449
MOD_CK2_1 91 97 PF00069 0.618
MOD_GlcNHglycan 1 4 PF01048 0.637
MOD_GlcNHglycan 158 161 PF01048 0.768
MOD_GlcNHglycan 162 165 PF01048 0.752
MOD_GSK3_1 143 150 PF00069 0.684
MOD_GSK3_1 152 159 PF00069 0.698
MOD_GSK3_1 160 167 PF00069 0.710
MOD_GSK3_1 305 312 PF00069 0.528
MOD_N-GLC_1 305 310 PF02516 0.530
MOD_N-GLC_1 84 89 PF02516 0.636
MOD_NEK2_1 183 188 PF00069 0.511
MOD_NEK2_1 191 196 PF00069 0.525
MOD_NEK2_1 198 203 PF00069 0.416
MOD_PIKK_1 51 57 PF00454 0.577
MOD_PK_1 72 78 PF00069 0.500
MOD_PKA_1 293 299 PF00069 0.273
MOD_PKA_2 220 226 PF00069 0.553
MOD_PKA_2 91 97 PF00069 0.518
MOD_Plk_1 198 204 PF00069 0.397
MOD_Plk_2-3 91 97 PF00069 0.520
MOD_Plk_4 135 141 PF00069 0.522
MOD_Plk_4 183 189 PF00069 0.506
MOD_Plk_4 191 197 PF00069 0.551
MOD_Plk_4 258 264 PF00069 0.468
MOD_Plk_4 58 64 PF00069 0.566
MOD_ProDKin_1 143 149 PF00069 0.704
MOD_ProDKin_1 164 170 PF00069 0.656
MOD_ProDKin_1 221 227 PF00069 0.503
MOD_ProDKin_1 250 256 PF00069 0.565
MOD_ProDKin_1 305 311 PF00069 0.564
TRG_DiLeu_BaEn_1 30 35 PF01217 0.490
TRG_DiLeu_BaLyEn_6 276 281 PF01217 0.649
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.392
TRG_ENDOCYTIC_2 121 124 PF00928 0.429
TRG_ER_diArg_1 217 219 PF00400 0.547
TRG_ER_diArg_1 275 277 PF00400 0.555
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2I6 Leptomonas seymouri 61% 99%
A0A0S4J6X6 Bodo saltans 34% 100%
A0A0S4J7W0 Bodo saltans 32% 100%
A0A1X0P4T2 Trypanosomatidae 38% 100%
A0A3R7MCD3 Trypanosoma rangeli 41% 100%
A0A3S7XA27 Leishmania donovani 92% 100%
A4HNG0 Leishmania braziliensis 78% 100%
A4IC71 Leishmania infantum 92% 100%
C9ZYG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AFX1 Leishmania major 91% 100%
V5B4K6 Trypanosoma cruzi 40% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS