LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B724_LEIMU
TriTrypDb:
LmxM.34.4970
Length:
348

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific signal-anchored protein. Might be part of a bigger complex.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

E9B724
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B724

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 150 154 PF00656 0.593
CLV_NRD_NRD_1 217 219 PF00675 0.631
CLV_NRD_NRD_1 275 277 PF00675 0.637
CLV_NRD_NRD_1 292 294 PF00675 0.568
CLV_NRD_NRD_1 335 337 PF00675 0.677
CLV_PCSK_KEX2_1 217 219 PF00082 0.631
CLV_PCSK_KEX2_1 275 277 PF00082 0.642
CLV_PCSK_PC7_1 213 219 PF00082 0.544
CLV_PCSK_SKI1_1 337 341 PF00082 0.507
CLV_PCSK_SKI1_1 6 10 PF00082 0.427
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P2I6 Leptomonas seymouri 61% 99%
A0A0S4J6X6 Bodo saltans 34% 100%
A0A0S4J7W0 Bodo saltans 32% 100%
A0A1X0P4T2 Trypanosomatidae 38% 100%
A0A3R7MCD3 Trypanosoma rangeli 41% 100%
A0A3S7XA27 Leishmania donovani 92% 100%
A4HNG0 Leishmania braziliensis 78% 100%
A4IC71 Leishmania infantum 92% 100%
C9ZYG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AFX1 Leishmania major 91% 100%
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Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS