C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B722_LEIMU

TriTrypDb:

LmxM.34.4950

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B722

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B722

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.422
CLV_C14_Caspase3-7	2	6	PF00656	0.614
CLV_MEL_PAP_1	773	779	PF00089	0.554
CLV_NRD_NRD_1	520	522	PF00675	0.722
CLV_NRD_NRD_1	66	68	PF00675	0.496
CLV_NRD_NRD_1	844	846	PF00675	0.729
CLV_NRD_NRD_1	865	867	PF00675	0.741
CLV_NRD_NRD_1	987	989	PF00675	0.772
CLV_NRD_NRD_1	992	994	PF00675	0.682
CLV_PCSK_KEX2_1	520	522	PF00082	0.722
CLV_PCSK_KEX2_1	865	867	PF00082	0.817
CLV_PCSK_KEX2_1	935	937	PF00082	0.732
CLV_PCSK_KEX2_1	987	989	PF00082	0.733
CLV_PCSK_KEX2_1	992	994	PF00082	0.675
CLV_PCSK_KEX2_1	996	998	PF00082	0.635
CLV_PCSK_PC1ET2_1	935	937	PF00082	0.732
CLV_PCSK_PC1ET2_1	996	998	PF00082	0.722
CLV_PCSK_PC7_1	988	994	PF00082	0.725
CLV_PCSK_SKI1_1	161	165	PF00082	0.477
CLV_PCSK_SKI1_1	293	297	PF00082	0.719
CLV_PCSK_SKI1_1	472	476	PF00082	0.671
CLV_PCSK_SKI1_1	636	640	PF00082	0.660
CLV_PCSK_SKI1_1	738	742	PF00082	0.725
CLV_PCSK_SKI1_1	769	773	PF00082	0.555
CLV_PCSK_SKI1_1	795	799	PF00082	0.587
CLV_PCSK_SKI1_1	820	824	PF00082	0.607
CLV_PCSK_SKI1_1	846	850	PF00082	0.666
DEG_COP1_1	397	405	PF00400	0.621
DEG_SCF_FBW7_1	957	964	PF00400	0.710
DEG_SPOP_SBC_1	370	374	PF00917	0.552
DEG_SPOP_SBC_1	413	417	PF00917	0.672
DEG_SPOP_SBC_1	556	560	PF00917	0.642
DEG_SPOP_SBC_1	675	679	PF00917	0.674
DOC_CKS1_1	30	35	PF01111	0.578
DOC_CKS1_1	476	481	PF01111	0.656
DOC_CYCLIN_yCln2_LP_2	388	391	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	500	506	PF00134	0.557
DOC_MAPK_DCC_7	508	518	PF00069	0.725
DOC_MAPK_gen_1	804	814	PF00069	0.602
DOC_MAPK_MEF2A_6	805	814	PF00069	0.604
DOC_PP1_RVXF_1	109	116	PF00149	0.480
DOC_PP1_RVXF_1	796	803	PF00149	0.571
DOC_PP2B_LxvP_1	388	391	PF13499	0.705
DOC_PP2B_LxvP_1	405	408	PF13499	0.564
DOC_PP2B_LxvP_1	474	477	PF13499	0.707
DOC_PP2B_PxIxI_1	463	469	PF00149	0.561
DOC_PP4_FxxP_1	610	613	PF00568	0.596
DOC_USP7_MATH_1	200	204	PF00917	0.590
DOC_USP7_MATH_1	233	237	PF00917	0.602
DOC_USP7_MATH_1	246	250	PF00917	0.698
DOC_USP7_MATH_1	369	373	PF00917	0.620
DOC_USP7_MATH_1	395	399	PF00917	0.668
DOC_USP7_MATH_1	408	412	PF00917	0.576
DOC_USP7_MATH_1	444	448	PF00917	0.713
DOC_USP7_MATH_1	545	549	PF00917	0.734
DOC_USP7_MATH_1	550	554	PF00917	0.677
DOC_USP7_MATH_1	556	560	PF00917	0.616
DOC_USP7_MATH_1	630	634	PF00917	0.582
DOC_USP7_MATH_1	659	663	PF00917	0.653
DOC_USP7_MATH_1	676	680	PF00917	0.553
DOC_USP7_MATH_1	775	779	PF00917	0.547
DOC_USP7_MATH_1	828	832	PF00917	0.692
DOC_USP7_MATH_1	840	844	PF00917	0.576
DOC_USP7_MATH_1	877	881	PF00917	0.788
DOC_USP7_MATH_1	922	926	PF00917	0.729
DOC_USP7_MATH_1	965	969	PF00917	0.727
DOC_USP7_MATH_1	978	982	PF00917	0.577
DOC_USP7_UBL2_3	931	935	PF12436	0.735
DOC_WW_Pin1_4	18	23	PF00397	0.625
DOC_WW_Pin1_4	231	236	PF00397	0.682
DOC_WW_Pin1_4	29	34	PF00397	0.679
DOC_WW_Pin1_4	391	396	PF00397	0.721
DOC_WW_Pin1_4	46	51	PF00397	0.524
DOC_WW_Pin1_4	472	477	PF00397	0.684
DOC_WW_Pin1_4	626	631	PF00397	0.618
DOC_WW_Pin1_4	644	649	PF00397	0.600
DOC_WW_Pin1_4	660	665	PF00397	0.577
DOC_WW_Pin1_4	666	671	PF00397	0.677
DOC_WW_Pin1_4	873	878	PF00397	0.720
DOC_WW_Pin1_4	881	886	PF00397	0.581
DOC_WW_Pin1_4	917	922	PF00397	0.716
DOC_WW_Pin1_4	925	930	PF00397	0.649
DOC_WW_Pin1_4	941	946	PF00397	0.568
DOC_WW_Pin1_4	951	956	PF00397	0.644
DOC_WW_Pin1_4	957	962	PF00397	0.588
DOC_WW_Pin1_4	967	972	PF00397	0.572
LIG_14-3-3_CanoR_1	227	232	PF00244	0.716
LIG_14-3-3_CanoR_1	293	298	PF00244	0.721
LIG_14-3-3_CanoR_1	347	353	PF00244	0.665
LIG_14-3-3_CanoR_1	570	575	PF00244	0.668
LIG_14-3-3_CanoR_1	586	592	PF00244	0.616
LIG_14-3-3_CanoR_1	738	745	PF00244	0.715
LIG_14-3-3_CanoR_1	776	784	PF00244	0.545
LIG_14-3-3_CanoR_1	820	829	PF00244	0.521
LIG_14-3-3_CanoR_1	845	852	PF00244	0.721
LIG_Actin_WH2_2	782	800	PF00022	0.562
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	130	134	PF00533	0.502
LIG_EH1_1	139	147	PF00400	0.473
LIG_EH1_1	697	705	PF00400	0.708
LIG_FHA_1	125	131	PF00498	0.478
LIG_FHA_1	136	142	PF00498	0.386
LIG_FHA_1	269	275	PF00498	0.676
LIG_FHA_1	296	302	PF00498	0.674
LIG_FHA_1	507	513	PF00498	0.679
LIG_FHA_1	616	622	PF00498	0.714
LIG_FHA_1	637	643	PF00498	0.548
LIG_FHA_1	772	778	PF00498	0.549
LIG_FHA_1	781	787	PF00498	0.448
LIG_FHA_1	839	845	PF00498	0.735
LIG_FHA_1	847	853	PF00498	0.790
LIG_FHA_1	951	957	PF00498	0.648
LIG_FHA_2	147	153	PF00498	0.481
LIG_FHA_2	332	338	PF00498	0.556
LIG_FHA_2	739	745	PF00498	0.712
LIG_FHA_2	971	977	PF00498	0.731
LIG_Integrin_isoDGR_2	758	760	PF01839	0.689
LIG_LIR_Gen_1	152	163	PF02991	0.462
LIG_LIR_Gen_1	93	103	PF02991	0.469
LIG_LIR_Nem_3	152	158	PF02991	0.452
LIG_LIR_Nem_3	93	98	PF02991	0.458
LIG_LIR_Nem_3	99	105	PF02991	0.417
LIG_PCNA_yPIPBox_3	83	95	PF02747	0.484
LIG_SH2_CRK	214	218	PF00017	0.668
LIG_SH2_CRK	95	99	PF00017	0.455
LIG_SH2_PTP2	102	105	PF00017	0.468
LIG_SH2_STAP1	170	174	PF00017	0.477
LIG_SH2_STAT3	184	187	PF00017	0.660
LIG_SH2_STAT5	102	105	PF00017	0.468
LIG_SH2_STAT5	140	143	PF00017	0.470
LIG_SH2_STAT5	148	151	PF00017	0.394
LIG_SH2_STAT5	784	787	PF00017	0.637
LIG_SH2_STAT5	799	802	PF00017	0.489
LIG_SH3_2	243	248	PF14604	0.678
LIG_SH3_2	503	508	PF14604	0.610
LIG_SH3_2	861	866	PF14604	0.603
LIG_SH3_3	240	246	PF00018	0.659
LIG_SH3_3	285	291	PF00018	0.556
LIG_SH3_3	359	365	PF00018	0.532
LIG_SH3_3	397	403	PF00018	0.716
LIG_SH3_3	473	479	PF00018	0.658
LIG_SH3_3	500	506	PF00018	0.609
LIG_SH3_3	579	585	PF00018	0.707
LIG_SH3_3	608	614	PF00018	0.687
LIG_SH3_3	664	670	PF00018	0.614
LIG_SH3_3	69	75	PF00018	0.468
LIG_SH3_3	858	864	PF00018	0.699
LIG_SH3_3	871	877	PF00018	0.609
LIG_SH3_3	888	894	PF00018	0.840
LIG_SH3_3	915	921	PF00018	0.669
LIG_SH3_3	949	955	PF00018	0.721
LIG_SUMO_SIM_par_1	638	645	PF11976	0.549
LIG_SUMO_SIM_par_1	810	815	PF11976	0.616
LIG_TRAF2_1	632	635	PF00917	0.666
LIG_TRAF2_1	854	857	PF00917	0.727
LIG_TRAF2_1	981	984	PF00917	0.803
LIG_UBA3_1	154	161	PF00899	0.450
LIG_WW_3	389	393	PF00397	0.663
MOD_CDC14_SPxK_1	928	931	PF00782	0.720
MOD_CDK_SPxK_1	925	931	PF00069	0.727
MOD_CDK_SPxxK_3	881	888	PF00069	0.666
MOD_CDK_SPxxK_3	967	974	PF00069	0.730
MOD_CK1_1	157	163	PF00069	0.466
MOD_CK1_1	173	179	PF00069	0.367
MOD_CK1_1	21	27	PF00069	0.712
MOD_CK1_1	229	235	PF00069	0.545
MOD_CK1_1	289	295	PF00069	0.546
MOD_CK1_1	29	35	PF00069	0.618
MOD_CK1_1	354	360	PF00069	0.643
MOD_CK1_1	394	400	PF00069	0.719
MOD_CK1_1	411	417	PF00069	0.561
MOD_CK1_1	418	424	PF00069	0.620
MOD_CK1_1	641	647	PF00069	0.713
MOD_CK1_1	660	666	PF00069	0.551
MOD_CK1_1	780	786	PF00069	0.535
MOD_CK1_1	839	845	PF00069	0.698
MOD_CK1_1	876	882	PF00069	0.718
MOD_CK1_1	884	890	PF00069	0.641
MOD_CK1_1	916	922	PF00069	0.643
MOD_CK1_1	925	931	PF00069	0.715
MOD_CK1_1	944	950	PF00069	0.539
MOD_CK1_1	964	970	PF00069	0.609
MOD_CK2_1	273	279	PF00069	0.673
MOD_CK2_1	322	328	PF00069	0.669
MOD_CK2_1	331	337	PF00069	0.608
MOD_CK2_1	370	376	PF00069	0.671
MOD_CK2_1	924	930	PF00069	0.835
MOD_CK2_1	970	976	PF00069	0.728
MOD_CK2_1	978	984	PF00069	0.629
MOD_Cter_Amidation	990	993	PF01082	0.722
MOD_Cter_Amidation	994	997	PF01082	0.684
MOD_GlcNHglycan	1	4	PF01048	0.682
MOD_GlcNHglycan	175	178	PF01048	0.522
MOD_GlcNHglycan	187	190	PF01048	0.559
MOD_GlcNHglycan	249	252	PF01048	0.726
MOD_GlcNHglycan	304	307	PF01048	0.602
MOD_GlcNHglycan	310	313	PF01048	0.664
MOD_GlcNHglycan	316	319	PF01048	0.672
MOD_GlcNHglycan	339	342	PF01048	0.727
MOD_GlcNHglycan	380	383	PF01048	0.625
MOD_GlcNHglycan	446	449	PF01048	0.710
MOD_GlcNHglycan	459	462	PF01048	0.597
MOD_GlcNHglycan	480	483	PF01048	0.695
MOD_GlcNHglycan	547	550	PF01048	0.728
MOD_GlcNHglycan	553	556	PF01048	0.667
MOD_GlcNHglycan	559	562	PF01048	0.610
MOD_GlcNHglycan	572	575	PF01048	0.555
MOD_GlcNHglycan	578	581	PF01048	0.536
MOD_GlcNHglycan	624	627	PF01048	0.720
MOD_GlcNHglycan	659	662	PF01048	0.628
MOD_GlcNHglycan	678	681	PF01048	0.550
MOD_GlcNHglycan	710	713	PF01048	0.657
MOD_GlcNHglycan	779	782	PF01048	0.533
MOD_GlcNHglycan	83	86	PF01048	0.484
MOD_GlcNHglycan	837	841	PF01048	0.574
MOD_GlcNHglycan	915	918	PF01048	0.675
MOD_GlcNHglycan	948	951	PF01048	0.671
MOD_GSK3_1	124	131	PF00069	0.479
MOD_GSK3_1	146	153	PF00069	0.478
MOD_GSK3_1	166	173	PF00069	0.283
MOD_GSK3_1	227	234	PF00069	0.718
MOD_GSK3_1	289	296	PF00069	0.548
MOD_GSK3_1	327	334	PF00069	0.713
MOD_GSK3_1	391	398	PF00069	0.670
MOD_GSK3_1	408	415	PF00069	0.584
MOD_GSK3_1	444	451	PF00069	0.713
MOD_GSK3_1	551	558	PF00069	0.723
MOD_GSK3_1	566	573	PF00069	0.565
MOD_GSK3_1	622	629	PF00069	0.662
MOD_GSK3_1	638	645	PF00069	0.614
MOD_GSK3_1	666	673	PF00069	0.661
MOD_GSK3_1	771	778	PF00069	0.549
MOD_GSK3_1	780	787	PF00069	0.452
MOD_GSK3_1	836	843	PF00069	0.778
MOD_GSK3_1	869	876	PF00069	0.730
MOD_GSK3_1	877	884	PF00069	0.533
MOD_GSK3_1	913	920	PF00069	0.778
MOD_GSK3_1	937	944	PF00069	0.725
MOD_GSK3_1	946	953	PF00069	0.625
MOD_GSK3_1	957	964	PF00069	0.594
MOD_GSK3_1	965	972	PF00069	0.564
MOD_N-GLC_1	1005	1010	PF02516	0.425
MOD_N-GLC_1	219	224	PF02516	0.716
MOD_N-GLC_1	455	460	PF02516	0.589
MOD_N-GLC_1	545	550	PF02516	0.729
MOD_N-GLC_1	551	556	PF02516	0.670
MOD_N-GLC_1	87	92	PF02516	0.497
MOD_N-GLC_1	96	101	PF02516	0.383
MOD_N-GLC_1	965	970	PF02516	0.726
MOD_NEK2_1	1005	1010	PF00069	0.541
MOD_NEK2_1	141	146	PF00069	0.451
MOD_NEK2_1	154	159	PF00069	0.312
MOD_NEK2_1	226	231	PF00069	0.661
MOD_NEK2_1	335	340	PF00069	0.676
MOD_NEK2_1	353	358	PF00069	0.596
MOD_NEK2_1	576	581	PF00069	0.617
MOD_NEK2_1	624	629	PF00069	0.553
MOD_NEK2_1	771	776	PF00069	0.558
MOD_NEK2_1	87	92	PF00069	0.497
MOD_NEK2_2	150	155	PF00069	0.465
MOD_NEK2_2	840	845	PF00069	0.556
MOD_PIKK_1	124	130	PF00454	0.476
MOD_PIKK_1	205	211	PF00454	0.520
MOD_PIKK_1	26	32	PF00454	0.542
MOD_PIKK_1	273	279	PF00454	0.673
MOD_PIKK_1	395	401	PF00454	0.668
MOD_PIKK_1	489	495	PF00454	0.673
MOD_PIKK_1	828	834	PF00454	0.720
MOD_PIKK_1	905	911	PF00454	0.675
MOD_PK_1	227	233	PF00069	0.716
MOD_PKA_2	194	200	PF00069	0.655
MOD_PKA_2	205	211	PF00069	0.558
MOD_PKA_2	226	232	PF00069	0.663
MOD_PKA_2	247	253	PF00069	0.719
MOD_PKA_2	262	268	PF00069	0.578
MOD_PKA_2	346	352	PF00069	0.623
MOD_PKA_2	519	525	PF00069	0.721
MOD_PKA_2	775	781	PF00069	0.545
MOD_PKA_2	844	850	PF00069	0.734
MOD_Plk_1	1005	1011	PF00069	0.407
MOD_Plk_1	116	122	PF00069	0.467
MOD_Plk_1	327	333	PF00069	0.725
MOD_Plk_1	87	93	PF00069	0.496
MOD_Plk_1	922	928	PF00069	0.729
MOD_Plk_1	965	971	PF00069	0.722
MOD_Plk_2-3	262	268	PF00069	0.723
MOD_Plk_4	141	147	PF00069	0.459
MOD_Plk_4	150	156	PF00069	0.376
MOD_Plk_4	159	165	PF00069	0.296
MOD_Plk_4	170	176	PF00069	0.287
MOD_Plk_4	200	206	PF00069	0.705
MOD_Plk_4	587	593	PF00069	0.558
MOD_Plk_4	87	93	PF00069	0.496
MOD_ProDKin_1	18	24	PF00069	0.627
MOD_ProDKin_1	231	237	PF00069	0.682
MOD_ProDKin_1	29	35	PF00069	0.674
MOD_ProDKin_1	391	397	PF00069	0.721
MOD_ProDKin_1	46	52	PF00069	0.523
MOD_ProDKin_1	472	478	PF00069	0.686
MOD_ProDKin_1	626	632	PF00069	0.616
MOD_ProDKin_1	644	650	PF00069	0.597
MOD_ProDKin_1	660	666	PF00069	0.572
MOD_ProDKin_1	873	879	PF00069	0.719
MOD_ProDKin_1	881	887	PF00069	0.581
MOD_ProDKin_1	917	923	PF00069	0.719
MOD_ProDKin_1	925	931	PF00069	0.649
MOD_ProDKin_1	941	947	PF00069	0.568
MOD_ProDKin_1	951	957	PF00069	0.641
MOD_ProDKin_1	961	967	PF00069	0.548
MOD_SUMO_rev_2	801	806	PF00179	0.552
TRG_DiLeu_BaEn_3	766	772	PF01217	0.564
TRG_DiLeu_BaEn_4	792	798	PF01217	0.578
TRG_ENDOCYTIC_2	102	105	PF00928	0.400
TRG_ENDOCYTIC_2	214	217	PF00928	0.672
TRG_ENDOCYTIC_2	799	802	PF00928	0.564
TRG_ENDOCYTIC_2	95	98	PF00928	0.455
TRG_ER_diArg_1	816	819	PF00400	0.599
TRG_ER_diArg_1	864	866	PF00400	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIU2	Leishmania donovani	91%	100%
A4HNF8	Leishmania braziliensis	75%	97%
E9AFW9	Leishmania major	89%	100%
E9AHX0	Leishmania infantum	91%	100%