CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B721_LEIMU

TriTrypDb:

LmxM.34.4940

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B721

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B721

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.362
CLV_NRD_NRD_1	174	176	PF00675	0.409
CLV_NRD_NRD_1	38	40	PF00675	0.544
CLV_NRD_NRD_1	95	97	PF00675	0.410
CLV_PCSK_FUR_1	93	97	PF00082	0.491
CLV_PCSK_KEX2_1	95	97	PF00082	0.461
CLV_PCSK_SKI1_1	178	182	PF00082	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.361
DOC_MAPK_gen_1	163	169	PF00069	0.598
DOC_MAPK_gen_1	178	188	PF00069	0.564
DOC_USP7_MATH_1	109	113	PF00917	0.756
DOC_USP7_UBL2_3	116	120	PF12436	0.662
DOC_USP7_UBL2_3	40	44	PF12436	0.705
DOC_WW_Pin1_4	126	131	PF00397	0.640
LIG_14-3-3_CanoR_1	114	124	PF00244	0.745
LIG_14-3-3_CanoR_1	163	168	PF00244	0.701
LIG_BRCT_BRCA1_1	165	169	PF00533	0.638
LIG_FHA_1	175	181	PF00498	0.770
LIG_FHA_1	60	66	PF00498	0.606
LIG_FHA_2	154	160	PF00498	0.650
LIG_LIR_Apic_2	3	7	PF02991	0.340
LIG_LIR_Nem_3	121	127	PF02991	0.621
LIG_MLH1_MIPbox_1	165	169	PF16413	0.652
LIG_Pex14_2	16	20	PF04695	0.281
LIG_REV1ctd_RIR_1	166	174	PF16727	0.639
LIG_SH2_SRC	4	7	PF00017	0.404
LIG_SH2_STAT5	4	7	PF00017	0.307
LIG_SH3_3	124	130	PF00018	0.735
LIG_SH3_4	40	47	PF00018	0.736
LIG_SUMO_SIM_par_1	55	63	PF11976	0.642
LIG_TRAF2_1	157	160	PF00917	0.588
LIG_TRAF2_1	182	185	PF00917	0.671
LIG_TRAF2_1	98	101	PF00917	0.707
LIG_UBA3_1	21	27	PF00899	0.458
MOD_CDK_SPK_2	126	131	PF00069	0.640
MOD_CK1_1	171	177	PF00069	0.708
MOD_CK1_1	43	49	PF00069	0.737
MOD_CK2_1	153	159	PF00069	0.629
MOD_CK2_1	23	29	PF00069	0.646
MOD_GlcNHglycan	117	120	PF01048	0.528
MOD_GlcNHglycan	74	77	PF01048	0.455
MOD_GSK3_1	149	156	PF00069	0.759
MOD_GSK3_1	170	177	PF00069	0.599
MOD_GSK3_1	201	208	PF00069	0.634
MOD_GSK3_1	21	28	PF00069	0.504
MOD_GSK3_1	43	50	PF00069	0.741
MOD_GSK3_1	72	79	PF00069	0.652
MOD_NEK2_1	168	173	PF00069	0.630
MOD_PIKK_1	43	49	PF00454	0.678
MOD_PIKK_1	99	105	PF00454	0.647
MOD_PKA_1	163	169	PF00069	0.651
MOD_PKA_2	149	155	PF00069	0.661
MOD_PKA_2	174	180	PF00069	0.598
MOD_PKA_2	47	53	PF00069	0.683
MOD_Plk_4	163	169	PF00069	0.664
MOD_ProDKin_1	126	132	PF00069	0.644
MOD_SUMO_for_1	182	185	PF00179	0.733
MOD_SUMO_rev_2	157	166	PF00179	0.570
MOD_SUMO_rev_2	173	182	PF00179	0.607
MOD_SUMO_rev_2	75	84	PF00179	0.702
TRG_ER_diArg_1	92	95	PF00400	0.651
TRG_ER_diLys_1	205	209	PF00400	0.649
TRG_NLS_MonoCore_2	38	43	PF00514	0.738
TRG_NLS_MonoExtN_4	37	43	PF00514	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICF1	Leptomonas seymouri	57%	95%
A0A0S4J7Q9	Bodo saltans	29%	100%
A0A1X0P5X3	Trypanosomatidae	38%	100%
A0A3Q8IN24	Leishmania donovani	90%	100%
A0A3R7KQ70	Trypanosoma rangeli	39%	100%
A4HNF7	Leishmania braziliensis	75%	98%
A4IC29	Leishmania infantum	91%	100%
C9ZYH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
E9AFW8	Leishmania major	93%	100%