FAM184 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B715_LEIMU

TriTrypDb:

LmxM.34.4870

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B715

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B715

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.537
CLV_C14_Caspase3-7	362	366	PF00656	0.466
CLV_C14_Caspase3-7	467	471	PF00656	0.521
CLV_C14_Caspase3-7	486	490	PF00656	0.530
CLV_C14_Caspase3-7	696	700	PF00656	0.636
CLV_C14_Caspase3-7	813	817	PF00656	0.339
CLV_NRD_NRD_1	263	265	PF00675	0.631
CLV_NRD_NRD_1	428	430	PF00675	0.697
CLV_NRD_NRD_1	616	618	PF00675	0.622
CLV_NRD_NRD_1	702	704	PF00675	0.682
CLV_NRD_NRD_1	853	855	PF00675	0.662
CLV_NRD_NRD_1	891	893	PF00675	0.659
CLV_PCSK_FUR_1	261	265	PF00082	0.411
CLV_PCSK_KEX2_1	145	147	PF00082	0.593
CLV_PCSK_KEX2_1	185	187	PF00082	0.577
CLV_PCSK_KEX2_1	263	265	PF00082	0.663
CLV_PCSK_KEX2_1	286	288	PF00082	0.621
CLV_PCSK_KEX2_1	436	438	PF00082	0.632
CLV_PCSK_KEX2_1	616	618	PF00082	0.600
CLV_PCSK_KEX2_1	702	704	PF00082	0.682
CLV_PCSK_KEX2_1	840	842	PF00082	0.591
CLV_PCSK_KEX2_1	853	855	PF00082	0.609
CLV_PCSK_KEX2_1	891	893	PF00082	0.659
CLV_PCSK_KEX2_1	982	984	PF00082	0.781
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.593
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.577
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.571
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.681
CLV_PCSK_PC1ET2_1	840	842	PF00082	0.660
CLV_PCSK_PC1ET2_1	982	984	PF00082	0.693
CLV_PCSK_SKI1_1	135	139	PF00082	0.452
CLV_PCSK_SKI1_1	167	171	PF00082	0.482
CLV_PCSK_SKI1_1	177	181	PF00082	0.571
CLV_PCSK_SKI1_1	223	227	PF00082	0.685
CLV_PCSK_SKI1_1	287	291	PF00082	0.623
CLV_PCSK_SKI1_1	329	333	PF00082	0.632
CLV_PCSK_SKI1_1	384	388	PF00082	0.733
CLV_PCSK_SKI1_1	466	470	PF00082	0.579
CLV_PCSK_SKI1_1	649	653	PF00082	0.618
CLV_PCSK_SKI1_1	784	788	PF00082	0.678
CLV_PCSK_SKI1_1	867	871	PF00082	0.631
CLV_Separin_Metazoa	258	262	PF03568	0.404
CLV_Separin_Metazoa	442	446	PF03568	0.613
DEG_APCC_DBOX_1	241	249	PF00400	0.432
DOC_MAPK_gen_1	145	155	PF00069	0.655
DOC_MAPK_gen_1	807	814	PF00069	0.484
DOC_MAPK_gen_1	915	924	PF00069	0.593
DOC_MIT_MIM_1	275	283	PF04212	0.587
DOC_USP7_MATH_1	202	206	PF00917	0.618
DOC_USP7_MATH_1	366	370	PF00917	0.571
DOC_USP7_MATH_1	409	413	PF00917	0.675
DOC_USP7_MATH_1	496	500	PF00917	0.671
DOC_USP7_MATH_1	519	523	PF00917	0.528
DOC_USP7_MATH_1	792	796	PF00917	0.379
DOC_USP7_UBL2_3	16	20	PF12436	0.613
DOC_USP7_UBL2_3	23	27	PF12436	0.495
LIG_14-3-3_CanoR_1	117	125	PF00244	0.437
LIG_14-3-3_CanoR_1	223	228	PF00244	0.759
LIG_14-3-3_CanoR_1	279	284	PF00244	0.573
LIG_14-3-3_CanoR_1	410	414	PF00244	0.684
LIG_14-3-3_CanoR_1	445	453	PF00244	0.616
LIG_14-3-3_CanoR_1	457	461	PF00244	0.481
LIG_14-3-3_CanoR_1	983	988	PF00244	0.706
LIG_14-3-3_CterR_2	994	999	PF00244	0.726
LIG_Actin_WH2_2	420	438	PF00022	0.427
LIG_Actin_WH2_2	542	560	PF00022	0.405
LIG_Actin_WH2_2	633	651	PF00022	0.684
LIG_Actin_WH2_2	85	103	PF00022	0.356
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BIR_III_4	799	803	PF00653	0.360
LIG_CaM_IQ_9	71	87	PF13499	0.558
LIG_Clathr_ClatBox_1	280	284	PF01394	0.462
LIG_Clathr_ClatBox_1	503	507	PF01394	0.384
LIG_eIF4E_1	125	131	PF01652	0.363
LIG_FHA_1	126	132	PF00498	0.566
LIG_FHA_1	142	148	PF00498	0.629
LIG_FHA_1	30	36	PF00498	0.544
LIG_FHA_1	439	445	PF00498	0.402
LIG_FHA_1	47	53	PF00498	0.544
LIG_FHA_1	653	659	PF00498	0.642
LIG_FHA_2	117	123	PF00498	0.394
LIG_FHA_2	253	259	PF00498	0.631
LIG_FHA_2	272	278	PF00498	0.455
LIG_FHA_2	325	331	PF00498	0.676
LIG_FHA_2	457	463	PF00498	0.584
LIG_FHA_2	465	471	PF00498	0.658
LIG_FHA_2	873	879	PF00498	0.553
LIG_FHA_2	902	908	PF00498	0.622
LIG_GBD_Chelix_1	332	340	PF00786	0.384
LIG_LIR_Gen_1	940	951	PF02991	0.637
LIG_LIR_Gen_1	957	968	PF02991	0.511
LIG_LIR_Gen_1	972	980	PF02991	0.657
LIG_LIR_Nem_3	957	963	PF02991	0.612
LIG_LIR_Nem_3	972	976	PF02991	0.705
LIG_NRBOX	821	827	PF00104	0.648
LIG_SH2_CRK	960	964	PF00017	0.654
LIG_SH2_CRK	973	977	PF00017	0.710
LIG_SH2_NCK_1	960	964	PF00017	0.654
LIG_SH2_NCK_1	973	977	PF00017	0.710
LIG_SH2_STAP1	125	129	PF00017	0.582
LIG_SH2_STAP1	619	623	PF00017	0.678
LIG_SH2_STAP1	67	71	PF00017	0.557
LIG_SH2_STAP1	724	728	PF00017	0.611
LIG_SH2_STAP1	973	977	PF00017	0.704
LIG_SH2_STAT3	67	70	PF00017	0.385
LIG_SH2_STAT5	36	39	PF00017	0.566
LIG_SUMO_SIM_anti_2	671	677	PF11976	0.642
LIG_SUMO_SIM_anti_2	810	817	PF11976	0.346
LIG_SUMO_SIM_anti_2	920	926	PF11976	0.592
LIG_SUMO_SIM_par_1	126	132	PF11976	0.361
LIG_SUMO_SIM_par_1	279	285	PF11976	0.465
LIG_SUMO_SIM_par_1	810	817	PF11976	0.346
LIG_TRAF2_1	102	105	PF00917	0.646
LIG_TRAF2_1	119	122	PF00917	0.366
LIG_TRAF2_1	255	258	PF00917	0.584
LIG_TRAF2_1	459	462	PF00917	0.613
LIG_TRAF2_1	817	820	PF00917	0.622
LIG_TRAF2_1	904	907	PF00917	0.633
LIG_UBA3_1	811	818	PF00899	0.636
LIG_UBA3_1	924	933	PF00899	0.592
MOD_CK1_1	234	240	PF00069	0.753
MOD_CK1_1	282	288	PF00069	0.622
MOD_CK1_1	324	330	PF00069	0.611
MOD_CK1_1	369	375	PF00069	0.643
MOD_CK1_1	412	418	PF00069	0.577
MOD_CK1_1	937	943	PF00069	0.372
MOD_CK2_1	116	122	PF00069	0.655
MOD_CK2_1	234	240	PF00069	0.753
MOD_CK2_1	252	258	PF00069	0.540
MOD_CK2_1	271	277	PF00069	0.545
MOD_CK2_1	324	330	PF00069	0.615
MOD_CK2_1	414	420	PF00069	0.590
MOD_CK2_1	456	462	PF00069	0.495
MOD_CK2_1	491	497	PF00069	0.661
MOD_CK2_1	66	72	PF00069	0.638
MOD_CK2_1	814	820	PF00069	0.562
MOD_CK2_1	872	878	PF00069	0.555
MOD_CK2_1	900	906	PF00069	0.591
MOD_CK2_1	914	920	PF00069	0.444
MOD_CK2_1	92	98	PF00069	0.550
MOD_Cter_Amidation	980	983	PF01082	0.708
MOD_GlcNHglycan	1	4	PF01048	0.770
MOD_GlcNHglycan	204	207	PF01048	0.598
MOD_GlcNHglycan	232	236	PF01048	0.769
MOD_GlcNHglycan	497	501	PF01048	0.678
MOD_GlcNHglycan	561	566	PF01048	0.667
MOD_GlcNHglycan	586	589	PF01048	0.646
MOD_GlcNHglycan	59	62	PF01048	0.611
MOD_GlcNHglycan	936	939	PF01048	0.378
MOD_GlcNHglycan	972	976	PF01048	0.619
MOD_GSK3_1	112	119	PF00069	0.626
MOD_GSK3_1	120	127	PF00069	0.548
MOD_GSK3_1	194	201	PF00069	0.382
MOD_GSK3_1	240	247	PF00069	0.643
MOD_GSK3_1	321	328	PF00069	0.613
MOD_GSK3_1	369	376	PF00069	0.636
MOD_GSK3_1	412	419	PF00069	0.577
MOD_GSK3_1	452	459	PF00069	0.472
MOD_GSK3_1	460	467	PF00069	0.496
MOD_GSK3_1	810	817	PF00069	0.570
MOD_GSK3_1	990	997	PF00069	0.738
MOD_N-GLC_1	415	420	PF02516	0.735
MOD_N-GLC_2	40	42	PF02516	0.629
MOD_NEK2_1	217	222	PF00069	0.591
MOD_NEK2_1	336	341	PF00069	0.644
MOD_NEK2_1	343	348	PF00069	0.669
MOD_NEK2_1	460	465	PF00069	0.655
MOD_NEK2_1	491	496	PF00069	0.670
MOD_NEK2_1	52	57	PF00069	0.453
MOD_NEK2_1	652	657	PF00069	0.698
MOD_NEK2_1	658	663	PF00069	0.689
MOD_NEK2_1	691	696	PF00069	0.740
MOD_NEK2_1	709	714	PF00069	0.386
MOD_NEK2_1	753	758	PF00069	0.660
MOD_NEK2_1	872	877	PF00069	0.607
MOD_NEK2_1	92	97	PF00069	0.660
MOD_NEK2_2	464	469	PF00069	0.409
MOD_PIKK_1	240	246	PF00454	0.644
MOD_PIKK_1	373	379	PF00454	0.723
MOD_PIKK_1	396	402	PF00454	0.714
MOD_PIKK_1	607	613	PF00454	0.502
MOD_PIKK_1	66	72	PF00454	0.339
MOD_PIKK_1	792	798	PF00454	0.528
MOD_PIKK_1	92	98	PF00454	0.583
MOD_PKA_1	429	435	PF00069	0.637
MOD_PKA_1	982	988	PF00069	0.708
MOD_PKA_2	116	122	PF00069	0.436
MOD_PKA_2	147	153	PF00069	0.479
MOD_PKA_2	396	402	PF00069	0.786
MOD_PKA_2	409	415	PF00069	0.527
MOD_PKA_2	456	462	PF00069	0.459
MOD_PKA_2	901	907	PF00069	0.585
MOD_PKA_2	914	920	PF00069	0.453
MOD_PKA_2	982	988	PF00069	0.708
MOD_PKB_1	264	272	PF00069	0.609
MOD_PKB_1	721	729	PF00069	0.394
MOD_PKB_1	782	790	PF00069	0.593
MOD_Plk_1	125	131	PF00069	0.545
MOD_Plk_1	792	798	PF00069	0.415
MOD_Plk_1	971	977	PF00069	0.697
MOD_Plk_2-3	116	122	PF00069	0.570
MOD_Plk_2-3	271	277	PF00069	0.653
MOD_Plk_2-3	456	462	PF00069	0.416
MOD_Plk_2-3	810	816	PF00069	0.350
MOD_Plk_4	125	131	PF00069	0.517
MOD_Plk_4	366	372	PF00069	0.650
MOD_Plk_4	636	642	PF00069	0.610
MOD_SUMO_for_1	184	187	PF00179	0.652
MOD_SUMO_for_1	272	275	PF00179	0.593
MOD_SUMO_for_1	401	404	PF00179	0.724
MOD_SUMO_rev_2	105	109	PF00179	0.563
MOD_SUMO_rev_2	139	147	PF00179	0.590
MOD_SUMO_rev_2	175	184	PF00179	0.451
MOD_SUMO_rev_2	269	274	PF00179	0.586
MOD_SUMO_rev_2	559	565	PF00179	0.597
MOD_SUMO_rev_2	799	808	PF00179	0.568
MOD_SUMO_rev_2	813	822	PF00179	0.442
MOD_SUMO_rev_2	864	872	PF00179	0.587
TRG_DiLeu_BaEn_1	154	159	PF01217	0.517
TRG_DiLeu_BaEn_1	420	425	PF01217	0.669
TRG_DiLeu_BaEn_1	487	492	PF01217	0.688
TRG_DiLeu_BaEn_1	671	676	PF01217	0.437
TRG_DiLeu_BaEn_1	810	815	PF01217	0.352
TRG_DiLeu_BaEn_1	920	925	PF01217	0.592
TRG_DiLeu_BaEn_4	671	677	PF01217	0.439
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.630
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.570
TRG_ENDOCYTIC_2	166	169	PF00928	0.521
TRG_ENDOCYTIC_2	943	946	PF00928	0.526
TRG_ENDOCYTIC_2	960	963	PF00928	0.598
TRG_ENDOCYTIC_2	973	976	PF00928	0.709
TRG_ER_diArg_1	263	266	PF00400	0.658
TRG_ER_diArg_1	615	617	PF00400	0.604
TRG_ER_diArg_1	721	724	PF00400	0.606
TRG_ER_diArg_1	781	784	PF00400	0.622
TRG_NES_CRM1_1	767	780	PF08389	0.471
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	824	828	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I973	Leptomonas seymouri	45%	98%
A0A0S4JCQ5	Bodo saltans	27%	93%
A0A3S7XA02	Leishmania donovani	89%	100%
A4HNF1	Leishmania braziliensis	68%	99%
A4IC23	Leishmania infantum	89%	100%
E9AFW2	Leishmania major	88%	100%