Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B712_LEIMU

TriTrypDb:

LmxM.34.4840

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B712

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B712

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.442
CLV_NRD_NRD_1	124	126	PF00675	0.428
CLV_NRD_NRD_1	139	141	PF00675	0.409
CLV_PCSK_KEX2_1	117	119	PF00082	0.442
CLV_PCSK_SKI1_1	117	121	PF00082	0.439
CLV_PCSK_SKI1_1	126	130	PF00082	0.422
CLV_PCSK_SKI1_1	17	21	PF00082	0.311
CLV_PCSK_SKI1_1	183	187	PF00082	0.529
CLV_PCSK_SKI1_1	77	81	PF00082	0.413
DEG_APCC_DBOX_1	182	190	PF00400	0.519
DEG_Nend_Nbox_1	1	3	PF02207	0.428
DOC_ANK_TNKS_1	66	73	PF00023	0.631
DOC_CDC14_PxL_1	129	137	PF14671	0.630
DOC_CDC14_PxL_1	145	153	PF14671	0.560
DOC_CYCLIN_RxL_1	114	123	PF00134	0.638
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.649
DOC_MAPK_gen_1	117	124	PF00069	0.637
DOC_MAPK_gen_1	140	147	PF00069	0.608
DOC_MAPK_MEF2A_6	36	44	PF00069	0.626
DOC_PP2B_LxvP_1	185	188	PF13499	0.675
DOC_PP4_FxxP_1	124	127	PF00568	0.629
DOC_PP4_FxxP_1	130	133	PF00568	0.628
DOC_PP4_FxxP_1	143	146	PF00568	0.584
DOC_PP4_FxxP_1	321	324	PF00568	0.473
DOC_PP4_FxxP_1	328	331	PF00568	0.453
DOC_PP4_FxxP_1	53	56	PF00568	0.643
DOC_USP7_MATH_1	9	13	PF00917	0.299
DOC_USP7_UBL2_3	233	237	PF12436	0.552
DOC_USP7_UBL2_3	83	87	PF12436	0.622
DOC_WW_Pin1_4	103	108	PF00397	0.653
DOC_WW_Pin1_4	190	195	PF00397	0.680
DOC_WW_Pin1_4	338	343	PF00397	0.518
DOC_WW_Pin1_4	42	47	PF00397	0.629
DOC_WW_Pin1_4	91	96	PF00397	0.699
LIG_14-3-3_CanoR_1	140	146	PF00244	0.612
LIG_14-3-3_CanoR_1	51	56	PF00244	0.674
LIG_14-3-3_CanoR_1	77	86	PF00244	0.616
LIG_14-3-3_CterR_2	347	350	PF00244	0.466
LIG_BRCT_BRCA1_1	120	124	PF00533	0.699
LIG_BRCT_BRCA1_1	192	196	PF00533	0.398
LIG_BRCT_BRCA1_1	26	30	PF00533	0.586
LIG_BRCT_BRCA1_1	340	344	PF00533	0.524
LIG_BRCT_BRCA1_1	44	48	PF00533	0.612
LIG_BRCT_BRCA1_1	6	10	PF00533	0.276
LIG_BRCT_BRCA1_2	120	126	PF00533	0.634
LIG_CtBP_PxDLS_1	109	113	PF00389	0.636
LIG_EH_1	325	329	PF12763	0.504
LIG_FHA_1	160	166	PF00498	0.325
LIG_FHA_1	172	178	PF00498	0.381
LIG_FHA_1	233	239	PF00498	0.469
LIG_FHA_1	289	295	PF00498	0.497
LIG_FHA_1	334	340	PF00498	0.514
LIG_FHA_1	35	41	PF00498	0.622
LIG_FHA_1	9	15	PF00498	0.276
LIG_FHA_2	277	283	PF00498	0.473
LIG_LIR_Apic_2	121	127	PF02991	0.655
LIG_LIR_Apic_2	142	146	PF02991	0.606
LIG_LIR_Apic_2	319	324	PF02991	0.491
LIG_LIR_Gen_1	157	166	PF02991	0.301
LIG_LIR_Gen_1	173	182	PF02991	0.376
LIG_LIR_Gen_1	193	204	PF02991	0.357
LIG_LIR_Gen_1	256	267	PF02991	0.410
LIG_LIR_Gen_1	27	38	PF02991	0.597
LIG_LIR_Gen_1	7	18	PF02991	0.282
LIG_LIR_LC3C_4	37	42	PF02991	0.622
LIG_LIR_Nem_3	157	161	PF02991	0.301
LIG_LIR_Nem_3	173	179	PF02991	0.376
LIG_LIR_Nem_3	193	199	PF02991	0.357
LIG_LIR_Nem_3	256	262	PF02991	0.415
LIG_LIR_Nem_3	27	33	PF02991	0.587
LIG_LIR_Nem_3	278	283	PF02991	0.481
LIG_LIR_Nem_3	37	41	PF02991	0.612
LIG_LIR_Nem_3	7	13	PF02991	0.276
LIG_MLH1_MIPbox_1	26	30	PF16413	0.605
LIG_NRBOX	181	187	PF00104	0.505
LIG_Pex14_2	120	124	PF04695	0.634
LIG_Pex14_2	201	205	PF04695	0.391
LIG_Pex14_2	49	53	PF04695	0.642
LIG_PTB_Apo_2	315	322	PF02174	0.509
LIG_REV1ctd_RIR_1	27	36	PF16727	0.610
LIG_SH2_PTP2	259	262	PF00017	0.398
LIG_SH2_PTP2	38	41	PF00017	0.625
LIG_SH2_SRC	213	216	PF00017	0.371
LIG_SH2_STAP1	213	217	PF00017	0.462
LIG_SH2_STAT5	154	157	PF00017	0.398
LIG_SH2_STAT5	259	262	PF00017	0.485
LIG_SH2_STAT5	38	41	PF00017	0.625
LIG_SH3_3	104	110	PF00018	0.679
LIG_SH3_3	143	149	PF00018	0.679
LIG_SH3_3	185	191	PF00018	0.756
LIG_SH3_3	321	327	PF00018	0.483
LIG_SH3_3	44	50	PF00018	0.632
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.276
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.276
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.624
LIG_SUMO_SIM_par_1	37	43	PF11976	0.624
LIG_TRAF2_1	239	242	PF00917	0.566
LIG_TRFH_1	130	134	PF08558	0.631
LIG_TYR_ITIM	257	262	PF00017	0.400
LIG_UBA3_1	119	126	PF00899	0.635
MOD_CK1_1	232	238	PF00069	0.552
MOD_CK1_1	24	30	PF00069	0.471
MOD_CK2_1	236	242	PF00069	0.665
MOD_CK2_1	250	256	PF00069	0.485
MOD_CK2_1	275	281	PF00069	0.489
MOD_CK2_1	91	97	PF00069	0.636
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.555
MOD_GlcNHglycan	113	116	PF01048	0.471
MOD_GlcNHglycan	241	245	PF01048	0.724
MOD_GlcNHglycan	53	56	PF01048	0.443
MOD_GlcNHglycan	6	9	PF01048	0.299
MOD_GlcNHglycan	88	91	PF01048	0.424
MOD_GSK3_1	135	142	PF00069	0.648
MOD_GSK3_1	232	239	PF00069	0.552
MOD_GSK3_1	240	247	PF00069	0.504
MOD_GSK3_1	288	295	PF00069	0.493
MOD_GSK3_1	333	340	PF00069	0.559
MOD_GSK3_1	342	349	PF00069	0.603
MOD_GSK3_1	4	11	PF00069	0.269
MOD_N-GLC_2	96	98	PF02516	0.443
MOD_NEK2_1	120	125	PF00069	0.747
MOD_NEK2_1	135	140	PF00069	0.752
MOD_NEK2_1	161	166	PF00069	0.427
MOD_NEK2_1	171	176	PF00069	0.374
MOD_NEK2_1	229	234	PF00069	0.540
MOD_NEK2_1	286	291	PF00069	0.473
MOD_NEK2_1	4	9	PF00069	0.283
MOD_NEK2_2	21	26	PF00069	0.311
MOD_PIKK_1	269	275	PF00454	0.433
MOD_PIKK_1	77	83	PF00454	0.614
MOD_PK_1	118	124	PF00069	0.635
MOD_PKA_1	250	256	PF00069	0.467
MOD_PKA_2	139	145	PF00069	0.616
MOD_Plk_4	161	167	PF00069	0.398
MOD_Plk_4	171	177	PF00069	0.323
MOD_Plk_4	9	15	PF00069	0.276
MOD_ProDKin_1	103	109	PF00069	0.647
MOD_ProDKin_1	190	196	PF00069	0.680
MOD_ProDKin_1	338	344	PF00069	0.520
MOD_ProDKin_1	42	48	PF00069	0.630
MOD_ProDKin_1	91	97	PF00069	0.699
MOD_SUMO_rev_2	243	253	PF00179	0.558
MOD_SUMO_rev_2	94	101	PF00179	0.644
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.639
TRG_ENDOCYTIC_2	259	262	PF00928	0.523
TRG_ENDOCYTIC_2	283	286	PF00928	0.570
TRG_ENDOCYTIC_2	38	41	PF00928	0.625
TRG_ER_diArg_1	117	119	PF00400	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJX6	Leishmania donovani	83%	100%
A4IC20	Leishmania infantum	83%	100%
E9AFV9	Leishmania major	84%	100%