Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B711_LEIMU

TriTrypDb:

LmxM.34.4830

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B711

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B711

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.428
CLV_NRD_NRD_1	365	367	PF00675	0.668
CLV_NRD_NRD_1	384	386	PF00675	0.427
CLV_NRD_NRD_1	40	42	PF00675	0.460
CLV_PCSK_KEX2_1	365	367	PF00082	0.668
CLV_PCSK_KEX2_1	40	42	PF00082	0.434
CLV_PCSK_SKI1_1	185	189	PF00082	0.554
CLV_PCSK_SKI1_1	275	279	PF00082	0.491
CLV_PCSK_SKI1_1	317	321	PF00082	0.583
CLV_Separin_Metazoa	156	160	PF03568	0.268
DOC_CKS1_1	131	136	PF01111	0.508
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.518
DOC_MAPK_gen_1	188	196	PF00069	0.520
DOC_MAPK_MEF2A_6	188	196	PF00069	0.533
DOC_MAPK_MEF2A_6	74	81	PF00069	0.571
DOC_PP1_RVXF_1	2	8	PF00149	0.598
DOC_PP2B_LxvP_1	169	172	PF13499	0.491
DOC_PP2B_PxIxI_1	191	197	PF00149	0.535
DOC_PP4_FxxP_1	312	315	PF00568	0.587
DOC_PP4_FxxP_1	7	10	PF00568	0.510
DOC_SPAK_OSR1_1	214	218	PF12202	0.425
DOC_USP7_MATH_1	267	271	PF00917	0.449
DOC_USP7_MATH_1	330	334	PF00917	0.683
DOC_WW_Pin1_4	130	135	PF00397	0.501
DOC_WW_Pin1_4	188	193	PF00397	0.489
LIG_14-3-3_CanoR_1	365	369	PF00244	0.695
LIG_14-3-3_CanoR_1	4	8	PF00244	0.391
LIG_Actin_WH2_2	350	367	PF00022	0.699
LIG_APCC_ABBA_1	170	175	PF00400	0.433
LIG_BIR_III_4	59	63	PF00653	0.554
LIG_Clathr_ClatBox_1	86	90	PF01394	0.373
LIG_EH1_1	226	234	PF00400	0.463
LIG_FHA_1	189	195	PF00498	0.470
LIG_FHA_1	26	32	PF00498	0.525
LIG_FHA_1	359	365	PF00498	0.713
LIG_FHA_1	66	72	PF00498	0.490
LIG_FHA_1	94	100	PF00498	0.440
LIG_FHA_2	108	114	PF00498	0.419
LIG_FHA_2	131	137	PF00498	0.582
LIG_FHA_2	145	151	PF00498	0.447
LIG_FHA_2	353	359	PF00498	0.680
LIG_LIR_Apic_2	101	105	PF02991	0.438
LIG_LIR_Apic_2	282	287	PF02991	0.354
LIG_LIR_Apic_2	310	315	PF02991	0.587
LIG_LIR_Apic_2	6	10	PF02991	0.485
LIG_LIR_Gen_1	255	265	PF02991	0.452
LIG_LIR_Gen_1	273	284	PF02991	0.397
LIG_LIR_Gen_1	306	315	PF02991	0.584
LIG_LIR_Gen_1	377	388	PF02991	0.550
LIG_LIR_Gen_1	95	105	PF02991	0.387
LIG_LIR_Nem_3	255	260	PF02991	0.440
LIG_LIR_Nem_3	273	279	PF02991	0.307
LIG_LIR_Nem_3	306	312	PF02991	0.628
LIG_LIR_Nem_3	377	383	PF02991	0.540
LIG_LIR_Nem_3	6	11	PF02991	0.488
LIG_LIR_Nem_3	78	84	PF02991	0.420
LIG_LIR_Nem_3	95	100	PF02991	0.321
LIG_Pex14_2	142	146	PF04695	0.466
LIG_Rb_LxCxE_1	83	101	PF01857	0.528
LIG_SH2_CRK	102	106	PF00017	0.490
LIG_SH2_CRK	276	280	PF00017	0.400
LIG_SH2_CRK	284	288	PF00017	0.416
LIG_SH2_CRK	289	293	PF00017	0.457
LIG_SH2_CRK	8	12	PF00017	0.527
LIG_SH2_CRK	84	88	PF00017	0.462
LIG_SH2_NCK_1	102	106	PF00017	0.523
LIG_SH2_STAP1	161	165	PF00017	0.373
LIG_SH2_STAP1	276	280	PF00017	0.376
LIG_SH2_STAP1	305	309	PF00017	0.573
LIG_SH2_STAT3	176	179	PF00017	0.433
LIG_SH3_3	180	186	PF00018	0.425
LIG_SH3_5	172	176	PF00018	0.488
LIG_TRAF2_1	253	256	PF00917	0.411
LIG_TYR_ITAM	273	292	PF00017	0.446
LIG_WRC_WIRS_1	104	109	PF05994	0.427
MOD_CDK_SPK_2	130	135	PF00069	0.563
MOD_CDK_SPxxK_3	130	137	PF00069	0.580
MOD_CK1_1	268	274	PF00069	0.484
MOD_CK1_1	333	339	PF00069	0.584
MOD_CK1_1	352	358	PF00069	0.739
MOD_CK2_1	122	128	PF00069	0.410
MOD_CK2_1	220	226	PF00069	0.380
MOD_CK2_1	250	256	PF00069	0.410
MOD_CK2_1	267	273	PF00069	0.431
MOD_CK2_1	352	358	PF00069	0.681
MOD_GlcNHglycan	124	127	PF01048	0.394
MOD_GlcNHglycan	16	19	PF01048	0.578
MOD_GlcNHglycan	267	270	PF01048	0.463
MOD_GlcNHglycan	332	335	PF01048	0.637
MOD_GlcNHglycan	59	63	PF01048	0.530
MOD_GSK3_1	103	110	PF00069	0.389
MOD_GSK3_1	352	359	PF00069	0.651
MOD_GSK3_1	364	371	PF00069	0.608
MOD_NEK2_1	107	112	PF00069	0.484
MOD_NEK2_1	122	127	PF00069	0.275
MOD_NEK2_1	260	265	PF00069	0.494
MOD_NEK2_1	279	284	PF00069	0.250
MOD_NEK2_1	364	369	PF00069	0.641
MOD_PIKK_1	107	113	PF00454	0.522
MOD_PIKK_1	279	285	PF00454	0.229
MOD_PKA_2	3	9	PF00069	0.551
MOD_PKA_2	364	370	PF00069	0.693
MOD_Plk_1	120	126	PF00069	0.395
MOD_Plk_1	161	167	PF00069	0.464
MOD_Plk_1	250	256	PF00069	0.415
MOD_Plk_4	260	266	PF00069	0.467
MOD_Plk_4	3	9	PF00069	0.551
MOD_ProDKin_1	130	136	PF00069	0.505
MOD_ProDKin_1	188	194	PF00069	0.479
MOD_SUMO_for_1	187	190	PF00179	0.559
TRG_DiLeu_BaEn_1	95	100	PF01217	0.424
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.567
TRG_ENDOCYTIC_2	276	279	PF00928	0.441
TRG_ENDOCYTIC_2	289	292	PF00928	0.466
TRG_ENDOCYTIC_2	309	312	PF00928	0.364
TRG_ENDOCYTIC_2	8	11	PF00928	0.518
TRG_ENDOCYTIC_2	84	87	PF00928	0.462
TRG_ER_diArg_1	364	366	PF00400	0.670
TRG_ER_diArg_1	39	41	PF00400	0.459
TRG_NES_CRM1_1	114	128	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR1	Leptomonas seymouri	84%	82%
A0A0S4J7W9	Bodo saltans	50%	98%
A0A1X0P558	Trypanosomatidae	67%	84%
A0A3Q8IFL6	Leishmania donovani	96%	100%
A4HNE7	Leishmania braziliensis	92%	100%
A4IC19	Leishmania infantum	96%	100%
C9ZYI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	85%
E9AFV8	Leishmania major	95%	100%
V5BBH8	Trypanosoma cruzi	64%	84%