Histidine phosphatase superfamily (Branch 1)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania mexicana

UniProt:

E9B710_LEIMU

TriTrypDb:

LmxM.34.4820

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B710

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B710

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.686
CLV_NRD_NRD_1	158	160	PF00675	0.328
CLV_NRD_NRD_1	285	287	PF00675	0.460
CLV_PCSK_KEX2_1	126	128	PF00082	0.398
CLV_PCSK_KEX2_1	158	160	PF00082	0.328
CLV_PCSK_KEX2_1	285	287	PF00082	0.409
CLV_PCSK_KEX2_1	66	68	PF00082	0.416
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.398
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.451
CLV_PCSK_PC7_1	281	287	PF00082	0.400
CLV_PCSK_SKI1_1	102	106	PF00082	0.367
CLV_PCSK_SKI1_1	137	141	PF00082	0.366
CLV_PCSK_SKI1_1	281	285	PF00082	0.366
CLV_PCSK_SKI1_1	70	74	PF00082	0.353
CLV_PCSK_SKI1_1	95	99	PF00082	0.419
DEG_Kelch_Keap1_1	314	319	PF01344	0.435
DEG_Nend_Nbox_1	1	3	PF02207	0.486
DOC_CKS1_1	16	21	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.554
DOC_MAPK_gen_1	137	145	PF00069	0.385
DOC_MAPK_gen_1	66	74	PF00069	0.393
DOC_MAPK_MEF2A_6	66	73	PF00069	0.412
DOC_PP1_RVXF_1	140	146	PF00149	0.385
DOC_PP1_RVXF_1	68	74	PF00149	0.362
DOC_PP2B_LxvP_1	90	93	PF13499	0.560
DOC_PP4_FxxP_1	108	111	PF00568	0.407
DOC_PP4_FxxP_1	287	290	PF00568	0.487
DOC_USP7_MATH_1	111	115	PF00917	0.383
DOC_USP7_MATH_1	120	124	PF00917	0.328
DOC_USP7_MATH_1	147	151	PF00917	0.385
DOC_USP7_MATH_1	261	265	PF00917	0.523
DOC_USP7_UBL2_3	328	332	PF12436	0.509
DOC_WW_Pin1_4	116	121	PF00397	0.328
DOC_WW_Pin1_4	15	20	PF00397	0.516
DOC_WW_Pin1_4	166	171	PF00397	0.501
LIG_14-3-3_CanoR_1	171	181	PF00244	0.420
LIG_14-3-3_CanoR_1	55	60	PF00244	0.577
LIG_14-3-3_CanoR_1	75	81	PF00244	0.352
LIG_Actin_WH2_2	145	160	PF00022	0.245
LIG_AP2alpha_1	104	108	PF02296	0.491
LIG_AP2alpha_2	110	112	PF02296	0.409
LIG_BRCT_BRCA1_1	276	280	PF00533	0.344
LIG_FHA_1	146	152	PF00498	0.336
LIG_FHA_1	161	167	PF00498	0.267
LIG_FHA_1	211	217	PF00498	0.491
LIG_FHA_1	324	330	PF00498	0.473
LIG_FHA_1	49	55	PF00498	0.565
LIG_FHA_2	209	215	PF00498	0.429
LIG_FHA_2	310	316	PF00498	0.508
LIG_FHA_2	56	62	PF00498	0.682
LIG_IBAR_NPY_1	223	225	PF08397	0.361
LIG_LIR_Apic_2	105	111	PF02991	0.507
LIG_LIR_Gen_1	103	112	PF02991	0.421
LIG_LIR_Gen_1	236	246	PF02991	0.482
LIG_LIR_Gen_1	51	59	PF02991	0.521
LIG_LIR_Gen_1	79	85	PF02991	0.379
LIG_LIR_Nem_3	103	107	PF02991	0.440
LIG_LIR_Nem_3	277	283	PF02991	0.352
LIG_LIR_Nem_3	79	84	PF02991	0.368
LIG_MLH1_MIPbox_1	276	280	PF16413	0.360
LIG_Pex14_1	81	85	PF04695	0.393
LIG_Pex14_2	104	108	PF04695	0.442
LIG_Pex14_2	280	284	PF04695	0.358
LIG_PTB_Apo_2	79	86	PF02174	0.394
LIG_REV1ctd_RIR_1	281	288	PF16727	0.388
LIG_SH2_GRB2like	225	228	PF00017	0.503
LIG_SH2_SRC	225	228	PF00017	0.503
LIG_SH2_SRC	31	34	PF00017	0.480
LIG_SH2_STAT5	225	228	PF00017	0.490
LIG_SH2_STAT5	279	282	PF00017	0.410
LIG_SH2_STAT5	53	56	PF00017	0.560
LIG_SH3_3	13	19	PF00018	0.556
LIG_Sin3_3	7	14	PF02671	0.404
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.352
LIG_TRAF2_1	184	187	PF00917	0.388
LIG_WRC_WIRS_1	132	137	PF05994	0.390
MOD_CDK_SPK_2	166	171	PF00069	0.501
MOD_CDK_SPxxK_3	15	22	PF00069	0.545
MOD_CK1_1	119	125	PF00069	0.328
MOD_CK1_1	196	202	PF00069	0.517
MOD_CK1_1	296	302	PF00069	0.452
MOD_CK2_1	181	187	PF00069	0.380
MOD_CK2_1	309	315	PF00069	0.430
MOD_Cter_Amidation	124	127	PF01082	0.449
MOD_Cter_Amidation	64	67	PF01082	0.529
MOD_GlcNHglycan	251	254	PF01048	0.507
MOD_GlcNHglycan	276	279	PF01048	0.380
MOD_GlcNHglycan	48	51	PF01048	0.477
MOD_GSK3_1	102	109	PF00069	0.503
MOD_GSK3_1	116	123	PF00069	0.276
MOD_GSK3_1	131	138	PF00069	0.403
MOD_GSK3_1	141	148	PF00069	0.428
MOD_GSK3_1	166	173	PF00069	0.549
MOD_GSK3_1	289	296	PF00069	0.510
MOD_GSK3_1	309	316	PF00069	0.215
MOD_GSK3_1	44	51	PF00069	0.343
MOD_GSK3_1	76	83	PF00069	0.362
MOD_N-GLC_2	86	88	PF02516	0.538
MOD_NEK2_1	135	140	PF00069	0.328
MOD_NEK2_1	181	186	PF00069	0.440
MOD_NEK2_1	84	89	PF00069	0.467
MOD_PIKK_1	172	178	PF00454	0.568
MOD_PIKK_1	186	192	PF00454	0.543
MOD_PKA_2	170	176	PF00069	0.421
MOD_Plk_1	181	187	PF00069	0.364
MOD_Plk_1	322	328	PF00069	0.407
MOD_Plk_4	131	137	PF00069	0.370
MOD_Plk_4	147	153	PF00069	0.278
MOD_Plk_4	76	82	PF00069	0.356
MOD_ProDKin_1	116	122	PF00069	0.328
MOD_ProDKin_1	15	21	PF00069	0.508
MOD_ProDKin_1	166	172	PF00069	0.501
MOD_SUMO_for_1	39	42	PF00179	0.498
TRG_ENDOCYTIC_2	238	241	PF00928	0.375
TRG_ENDOCYTIC_2	331	334	PF00928	0.410
TRG_ENDOCYTIC_2	53	56	PF00928	0.492
TRG_ER_diArg_1	157	159	PF00400	0.328
TRG_ER_diArg_1	284	286	PF00400	0.458
TRG_NLS_Bipartite_1	285	301	PF00514	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P956	Leptomonas seymouri	76%	100%
A0A0S4J7E1	Bodo saltans	57%	100%
A0A1X0P4X0	Trypanosomatidae	58%	100%
A0A3Q8IVL2	Leishmania donovani	95%	100%
A0A422P1A4	Trypanosoma rangeli	58%	99%
A4HNE6	Leishmania braziliensis	87%	100%
A4IC18	Leishmania infantum	95%	100%
C9ZYI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AFV7	Leishmania major	94%	100%
V5BG29	Trypanosoma cruzi	55%	100%