BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B709_LEIMU

TriTrypDb:

LmxM.34.4810

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B709

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B709

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016311	dephosphorylation	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.668
CLV_NRD_NRD_1	34	36	PF00675	0.542
CLV_PCSK_KEX2_1	298	300	PF00082	0.669
CLV_PCSK_KEX2_1	34	36	PF00082	0.542
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.669
CLV_PCSK_PC7_1	30	36	PF00082	0.550
CLV_PCSK_SKI1_1	264	268	PF00082	0.453
DOC_CKS1_1	362	367	PF01111	0.522
DOC_CYCLIN_RxL_1	261	268	PF00134	0.531
DOC_MAPK_gen_1	244	252	PF00069	0.613
DOC_MAPK_gen_1	320	326	PF00069	0.417
DOC_MAPK_MEF2A_6	244	252	PF00069	0.661
DOC_USP7_MATH_1	59	63	PF00917	0.465
DOC_USP7_MATH_1	82	86	PF00917	0.453
DOC_USP7_UBL2_3	177	181	PF12436	0.742
DOC_USP7_UBL2_3	294	298	PF12436	0.592
DOC_USP7_UBL2_3	375	379	PF12436	0.536
DOC_WW_Pin1_4	272	277	PF00397	0.417
DOC_WW_Pin1_4	361	366	PF00397	0.519
LIG_14-3-3_CanoR_1	212	216	PF00244	0.653
LIG_14-3-3_CanoR_1	307	315	PF00244	0.481
LIG_14-3-3_CanoR_1	70	79	PF00244	0.454
LIG_APCC_ABBA_1	202	207	PF00400	0.661
LIG_FHA_1	133	139	PF00498	0.602
LIG_FHA_1	229	235	PF00498	0.601
LIG_FHA_1	309	315	PF00498	0.421
LIG_FHA_1	364	370	PF00498	0.468
LIG_FHA_1	72	78	PF00498	0.277
LIG_FHA_2	99	105	PF00498	0.550
LIG_GBD_Chelix_1	114	122	PF00786	0.459
LIG_LIR_Apic_2	164	168	PF02991	0.609
LIG_LIR_Gen_1	19	29	PF02991	0.426
LIG_NBox_RRM_1	219	229	PF00076	0.427
LIG_NRBOX	117	123	PF00104	0.404
LIG_SH2_CRK	165	169	PF00017	0.602
LIG_SH2_CRK	28	32	PF00017	0.381
LIG_SH2_NCK_1	165	169	PF00017	0.568
LIG_SH2_STAT5	165	168	PF00017	0.430
LIG_SH2_STAT5	22	25	PF00017	0.447
LIG_SH2_STAT5	363	366	PF00017	0.449
LIG_SH2_STAT5	377	380	PF00017	0.475
LIG_SH3_3	107	113	PF00018	0.393
LIG_SH3_3	137	143	PF00018	0.521
LIG_SH3_3	85	91	PF00018	0.423
LIG_UBA3_1	252	261	PF00899	0.474
LIG_UBA3_1	369	376	PF00899	0.462
MOD_CDK_SPxxK_3	361	368	PF00069	0.561
MOD_CK1_1	10	16	PF00069	0.419
MOD_CK1_1	179	185	PF00069	0.745
MOD_CK1_1	214	220	PF00069	0.537
MOD_CK1_1	243	249	PF00069	0.524
MOD_CK1_1	255	261	PF00069	0.463
MOD_CK2_1	98	104	PF00069	0.478
MOD_GlcNHglycan	181	184	PF01048	0.750
MOD_GlcNHglycan	267	270	PF01048	0.437
MOD_GlcNHglycan	41	44	PF01048	0.544
MOD_GSK3_1	10	17	PF00069	0.337
MOD_GSK3_1	117	124	PF00069	0.493
MOD_GSK3_1	141	148	PF00069	0.681
MOD_GSK3_1	163	170	PF00069	0.626
MOD_GSK3_1	224	231	PF00069	0.626
MOD_GSK3_1	298	305	PF00069	0.537
MOD_GSK3_1	375	382	PF00069	0.541
MOD_N-GLC_1	10	15	PF02516	0.417
MOD_NEK2_1	117	122	PF00069	0.428
MOD_NEK2_1	205	210	PF00069	0.589
MOD_NEK2_1	211	216	PF00069	0.547
MOD_NEK2_1	252	257	PF00069	0.554
MOD_NEK2_1	302	307	PF00069	0.508
MOD_NEK2_1	331	336	PF00069	0.547
MOD_NEK2_1	341	346	PF00069	0.449
MOD_NEK2_1	369	374	PF00069	0.438
MOD_PIKK_1	205	211	PF00454	0.704
MOD_PKA_1	298	304	PF00069	0.549
MOD_PKA_1	375	381	PF00069	0.527
MOD_PKA_2	132	138	PF00069	0.552
MOD_PKA_2	211	217	PF00069	0.605
MOD_PKA_2	243	249	PF00069	0.652
MOD_PKA_2	298	304	PF00069	0.598
MOD_PKA_2	65	71	PF00069	0.257
MOD_Plk_1	10	16	PF00069	0.426
MOD_Plk_1	163	169	PF00069	0.621
MOD_Plk_1	18	24	PF00069	0.488
MOD_Plk_4	117	123	PF00069	0.450
MOD_Plk_4	127	133	PF00069	0.458
MOD_Plk_4	211	217	PF00069	0.684
MOD_Plk_4	82	88	PF00069	0.514
MOD_ProDKin_1	272	278	PF00069	0.415
MOD_ProDKin_1	361	367	PF00069	0.525
MOD_SUMO_for_1	229	232	PF00179	0.646
MOD_SUMO_rev_2	316	322	PF00179	0.329
TRG_DiLeu_BaEn_1	327	332	PF01217	0.338
TRG_ENDOCYTIC_2	157	160	PF00928	0.417
TRG_ENDOCYTIC_2	22	25	PF00928	0.431
TRG_NLS_MonoExtC_3	243	248	PF00514	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9H3	Leptomonas seymouri	68%	98%
A0A0S4J3S6	Bodo saltans	47%	98%
A0A1X0P4V1	Trypanosomatidae	50%	100%
A0A3R7RRN6	Trypanosoma rangeli	49%	99%
A0A3S7XA18	Leishmania donovani	88%	100%
A4HNE5	Leishmania braziliensis	66%	100%
C9ZYI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9AFV6	Leishmania major	85%	100%
E9AHW9	Leishmania infantum	88%	100%
V5B718	Trypanosoma cruzi	49%	99%