Membrane-trafficking protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B707_LEIMU

TriTrypDb:

LmxM.34.4790

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0032588	trans-Golgi network membrane	4	1
GO:0055038	recycling endosome membrane	6	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9B707

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B707

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.363
CLV_PCSK_KEX2_1	19	21	PF00082	0.364
CLV_PCSK_KEX2_1	25	27	PF00082	0.414
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.493
CLV_PCSK_SKI1_1	20	24	PF00082	0.487
CLV_PCSK_SKI1_1	205	209	PF00082	0.321
DOC_CYCLIN_RxL_1	199	211	PF00134	0.449
DOC_MAPK_gen_1	131	138	PF00069	0.461
DOC_MAPK_gen_1	199	208	PF00069	0.460
DOC_MAPK_MEF2A_6	171	179	PF00069	0.318
DOC_PP2B_LxvP_1	109	112	PF13499	0.308
LIG_FHA_1	150	156	PF00498	0.373
LIG_FHA_1	168	174	PF00498	0.222
LIG_FHA_1	209	215	PF00498	0.538
LIG_FHA_1	74	80	PF00498	0.382
LIG_LIR_Gen_1	104	112	PF02991	0.264
LIG_LIR_Gen_1	148	158	PF02991	0.286
LIG_LIR_Nem_3	104	108	PF02991	0.264
LIG_LIR_Nem_3	117	123	PF02991	0.264
LIG_LIR_Nem_3	148	153	PF02991	0.312
LIG_NRBOX	134	140	PF00104	0.376
LIG_PCNA_PIPBox_1	67	76	PF02747	0.482
LIG_PDZ_Class_1	215	220	PF00595	0.595
LIG_Pex14_1	115	119	PF04695	0.388
LIG_Pex14_2	101	105	PF04695	0.264
LIG_SH2_CRK	123	127	PF00017	0.457
LIG_SH2_CRK	52	56	PF00017	0.449
LIG_SH2_CRK	83	87	PF00017	0.292
LIG_SH2_GRB2like	119	122	PF00017	0.439
LIG_SH2_GRB2like	52	55	PF00017	0.439
LIG_SH2_NCK_1	83	87	PF00017	0.453
LIG_SH2_PTP2	74	77	PF00017	0.343
LIG_SH2_STAP1	128	132	PF00017	0.411
LIG_SH2_STAP1	165	169	PF00017	0.286
LIG_SH2_STAT5	107	110	PF00017	0.263
LIG_SH2_STAT5	123	126	PF00017	0.472
LIG_SH2_STAT5	68	71	PF00017	0.429
LIG_SH2_STAT5	74	77	PF00017	0.257
LIG_SH3_3	35	41	PF00018	0.435
LIG_Sin3_3	176	183	PF02671	0.297
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.330
LIG_SUMO_SIM_par_1	176	182	PF11976	0.344
LIG_TYR_ITIM	198	203	PF00017	0.486
LIG_TYR_ITIM	50	55	PF00017	0.526
LIG_TYR_ITIM	81	86	PF00017	0.278
MOD_CMANNOS	115	118	PF00535	0.394
MOD_GlcNHglycan	181	184	PF01048	0.370
MOD_GlcNHglycan	96	99	PF01048	0.444
MOD_GSK3_1	149	156	PF00069	0.424
MOD_GSK3_1	24	31	PF00069	0.624
MOD_GSK3_1	90	97	PF00069	0.287
MOD_N-GLC_1	28	33	PF02516	0.396
MOD_NEK2_1	101	106	PF00069	0.273
MOD_NEK2_1	167	172	PF00069	0.287
MOD_NEK2_1	207	212	PF00069	0.555
MOD_NEK2_1	73	78	PF00069	0.321
MOD_NEK2_1	94	99	PF00069	0.223
MOD_PIKK_1	24	30	PF00454	0.645
MOD_PIKK_1	59	65	PF00454	0.508
MOD_PKA_2	201	207	PF00069	0.542
MOD_Plk_1	28	34	PF00069	0.596
MOD_Plk_4	101	107	PF00069	0.271
MOD_Plk_4	73	79	PF00069	0.287
TRG_ENDOCYTIC_2	119	122	PF00928	0.451
TRG_ENDOCYTIC_2	123	126	PF00928	0.441
TRG_ENDOCYTIC_2	200	203	PF00928	0.489
TRG_ENDOCYTIC_2	52	55	PF00928	0.449
TRG_ENDOCYTIC_2	74	77	PF00928	0.272
TRG_ENDOCYTIC_2	83	86	PF00928	0.252
TRG_NES_CRM1_1	134	148	PF08389	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P960	Leptomonas seymouri	64%	99%
A0A0S4J7Y6	Bodo saltans	36%	88%
A0A1X0P4W4	Trypanosomatidae	56%	97%
A0A3Q8IN09	Leishmania donovani	96%	100%
A0A3R7KQ76	Trypanosoma rangeli	58%	97%
A4HE02	Leishmania braziliensis	29%	100%
A4HNE3	Leishmania braziliensis	76%	100%
A4IC16	Leishmania infantum	96%	100%
C9ZYI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9AFV4	Leishmania major	95%	100%
O15127	Homo sapiens	28%	67%
Q17QF8	Bos taurus	27%	94%
Q28F21	Xenopus tropicalis	25%	95%
Q58DF6	Bos taurus	25%	96%
Q5R5Z8	Pongo abelii	27%	94%
Q5RCY9	Pongo abelii	28%	96%
Q6GM42	Xenopus laevis	27%	94%
Q6GPA8	Xenopus laevis	28%	94%
Q6P0C7	Danio rerio	27%	96%
Q8TAC9	Homo sapiens	27%	94%
Q969E2	Homo sapiens	28%	96%
Q9ERN0	Mus musculus	27%	67%
Q9ET20	Rattus norvegicus	26%	96%
Q9JKD3	Mus musculus	27%	94%
Q9JKE3	Rattus norvegicus	27%	94%
Q9JKV5	Mus musculus	25%	96%
Q9LR68	Arabidopsis thaliana	25%	78%