LeishMANIAdb
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Hypoxia up-regulated 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypoxia up-regulated 1
Gene product:
Hsp70 protein, putative
Species:
Leishmania mexicana
UniProt:
E9B700_LEIMU
TriTrypDb:
LmxM.34.4710
Length:
723

Annotations

LeishMANIAdb annotations

Appears to be a secreted chaperone, related to mammalian HYOU1 proteins. Probably ER-localized as in other eukaryotes

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 3
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0043226 organelle 2 14
GO:0110165 cellular anatomical entity 1 14
GO:0032991 protein-containing complex 1 1
GO:0034663 endoplasmic reticulum chaperone complex 3 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B700
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B700

Function

Biological processes
Term Name Level Count
GO:0001666 response to hypoxia 3 1
GO:0006950 response to stress 2 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0009987 cellular process 1 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0010941 regulation of cell death 4 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0033554 cellular response to stress 3 1
GO:0036293 response to decreased oxygen levels 4 1
GO:0036294 cellular response to decreased oxygen levels 5 1
GO:0042221 response to chemical 2 1
GO:0042981 regulation of apoptotic process 6 1
GO:0043066 negative regulation of apoptotic process 7 1
GO:0043067 regulation of programmed cell death 5 1
GO:0043069 negative regulation of programmed cell death 6 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0060548 negative regulation of cell death 5 1
GO:0065007 biological regulation 1 1
GO:0070482 response to oxygen levels 3 1
GO:0070887 cellular response to chemical stimulus 3 1
GO:0071453 cellular response to oxygen levels 4 1
GO:0071456 cellular response to hypoxia 4 1
GO:0080134 regulation of response to stress 4 1
GO:0080135 regulation of cellular response to stress 4 1
GO:1900037 regulation of cellular response to hypoxia 5 1
GO:1900038 negative regulation of cellular response to hypoxia 5 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
GO:1903297 regulation of hypoxia-induced intrinsic apoptotic signaling pathway 7 1
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway 6 1
GO:2001233 regulation of apoptotic signaling pathway 5 1
GO:2001234 negative regulation of apoptotic signaling pathway 6 1
GO:2001242 regulation of intrinsic apoptotic signaling pathway 6 1
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 7 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 15
GO:0005488 binding 1 15
GO:0005524 ATP binding 5 15
GO:0017076 purine nucleotide binding 4 15
GO:0030554 adenyl nucleotide binding 5 15
GO:0032553 ribonucleotide binding 3 15
GO:0032555 purine ribonucleotide binding 4 15
GO:0032559 adenyl ribonucleotide binding 5 15
GO:0035639 purine ribonucleoside triphosphate binding 4 15
GO:0036094 small molecule binding 2 15
GO:0043167 ion binding 2 15
GO:0043168 anion binding 3 15
GO:0044183 protein folding chaperone 1 15
GO:0097159 organic cyclic compound binding 2 15
GO:0097367 carbohydrate derivative binding 2 15
GO:0140657 ATP-dependent activity 1 15
GO:0140662 ATP-dependent protein folding chaperone 2 15
GO:1901265 nucleoside phosphate binding 3 15
GO:1901363 heterocyclic compound binding 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 177 179 PF00675 0.430
CLV_NRD_NRD_1 455 457 PF00675 0.390
CLV_NRD_NRD_1 57 59 PF00675 0.342
CLV_NRD_NRD_1 67 69 PF00675 0.342
CLV_NRD_NRD_1 98 100 PF00675 0.479
CLV_PCSK_KEX2_1 177 179 PF00082 0.395
CLV_PCSK_KEX2_1 455 457 PF00082 0.392
CLV_PCSK_KEX2_1 57 59 PF00082 0.479
CLV_PCSK_KEX2_1 67 69 PF00082 0.479
CLV_PCSK_SKI1_1 178 182 PF00082 0.452
CLV_PCSK_SKI1_1 340 344 PF00082 0.317
CLV_PCSK_SKI1_1 427 431 PF00082 0.446
CLV_PCSK_SKI1_1 456 460 PF00082 0.364
CLV_PCSK_SKI1_1 503 507 PF00082 0.391
CLV_PCSK_SKI1_1 572 576 PF00082 0.480
CLV_PCSK_SKI1_1 6 10 PF00082 0.480
DEG_Nend_UBRbox_1 1 4 PF02207 0.614
DOC_CYCLIN_RxL_1 424 434 PF00134 0.479
DOC_CYCLIN_RxL_1 451 462 PF00134 0.406
DOC_MAPK_gen_1 2 9 PF00069 0.593
DOC_MAPK_gen_1 310 317 PF00069 0.388
DOC_MAPK_gen_1 57 66 PF00069 0.346
DOC_MAPK_gen_1 67 73 PF00069 0.329
DOC_MAPK_gen_1 97 107 PF00069 0.485
DOC_MAPK_MEF2A_6 162 170 PF00069 0.410
DOC_MAPK_MEF2A_6 492 499 PF00069 0.396
DOC_PP1_RVXF_1 216 223 PF00149 0.479
DOC_USP7_MATH_1 125 129 PF00917 0.473
DOC_USP7_MATH_1 244 248 PF00917 0.493
DOC_USP7_MATH_1 518 522 PF00917 0.445
DOC_USP7_MATH_1 716 720 PF00917 0.691
DOC_USP7_MATH_1 76 80 PF00917 0.201
DOC_USP7_MATH_2 595 601 PF00917 0.279
DOC_USP7_UBL2_3 2 6 PF12436 0.485
DOC_USP7_UBL2_3 568 572 PF12436 0.456
DOC_USP7_UBL2_3 702 706 PF12436 0.568
DOC_WW_Pin1_4 170 175 PF00397 0.502
DOC_WW_Pin1_4 318 323 PF00397 0.391
DOC_WW_Pin1_4 381 386 PF00397 0.391
DOC_WW_Pin1_4 418 423 PF00397 0.408
DOC_WW_Pin1_4 510 515 PF00397 0.470
LIG_14-3-3_CanoR_1 425 430 PF00244 0.374
LIG_14-3-3_CanoR_1 496 500 PF00244 0.459
LIG_14-3-3_CanoR_1 57 66 PF00244 0.381
LIG_14-3-3_CanoR_1 623 630 PF00244 0.444
LIG_14-3-3_CanoR_1 67 73 PF00244 0.363
LIG_Actin_WH2_2 269 287 PF00022 0.201
LIG_AP2alpha_2 134 136 PF02296 0.493
LIG_BRCT_BRCA1_1 245 249 PF00533 0.493
LIG_BRCT_BRCA1_1 470 474 PF00533 0.467
LIG_BRCT_BRCA1_1 480 484 PF00533 0.383
LIG_Clathr_ClatBox_1 535 539 PF01394 0.391
LIG_eIF4E_1 12 18 PF01652 0.447
LIG_FHA_1 124 130 PF00498 0.420
LIG_FHA_1 149 155 PF00498 0.500
LIG_FHA_1 214 220 PF00498 0.354
LIG_FHA_1 252 258 PF00498 0.348
LIG_FHA_1 312 318 PF00498 0.468
LIG_FHA_1 337 343 PF00498 0.306
LIG_FHA_1 360 366 PF00498 0.441
LIG_FHA_1 382 388 PF00498 0.391
LIG_FHA_1 531 537 PF00498 0.459
LIG_FHA_1 550 556 PF00498 0.192
LIG_FHA_1 585 591 PF00498 0.418
LIG_FHA_1 706 712 PF00498 0.779
LIG_FHA_2 135 141 PF00498 0.374
LIG_FHA_2 225 231 PF00498 0.363
LIG_FHA_2 561 567 PF00498 0.224
LIG_FHA_2 597 603 PF00498 0.459
LIG_GBD_Chelix_1 24 32 PF00786 0.493
LIG_LIR_Apic_2 589 595 PF02991 0.393
LIG_LIR_Gen_1 139 148 PF02991 0.391
LIG_LIR_Gen_1 300 308 PF02991 0.408
LIG_LIR_Gen_1 34 42 PF02991 0.370
LIG_LIR_Gen_1 349 358 PF02991 0.404
LIG_LIR_Gen_1 374 381 PF02991 0.389
LIG_LIR_Nem_3 139 145 PF02991 0.451
LIG_LIR_Nem_3 246 252 PF02991 0.395
LIG_LIR_Nem_3 300 305 PF02991 0.408
LIG_LIR_Nem_3 34 39 PF02991 0.370
LIG_LIR_Nem_3 349 354 PF02991 0.404
LIG_LIR_Nem_3 368 372 PF02991 0.445
LIG_LIR_Nem_3 60 66 PF02991 0.352
LIG_NRBOX 525 531 PF00104 0.201
LIG_PCNA_TLS_4 627 634 PF02747 0.408
LIG_Pex14_2 480 484 PF04695 0.493
LIG_PTB_Apo_2 363 370 PF02174 0.493
LIG_REV1ctd_RIR_1 105 113 PF16727 0.318
LIG_SH2_CRK 142 146 PF00017 0.459
LIG_SH2_PTP2 36 39 PF00017 0.391
LIG_SH2_SRC 113 116 PF00017 0.493
LIG_SH2_STAP1 113 117 PF00017 0.493
LIG_SH2_STAP1 142 146 PF00017 0.396
LIG_SH2_STAP1 416 420 PF00017 0.408
LIG_SH2_STAP1 547 551 PF00017 0.390
LIG_SH2_STAP1 686 690 PF00017 0.428
LIG_SH2_STAT5 12 15 PF00017 0.580
LIG_SH2_STAT5 148 151 PF00017 0.378
LIG_SH2_STAT5 323 326 PF00017 0.479
LIG_SH2_STAT5 36 39 PF00017 0.406
LIG_SH2_STAT5 633 636 PF00017 0.379
LIG_SH2_STAT5 72 75 PF00017 0.408
LIG_SH3_3 155 161 PF00018 0.408
LIG_SH3_3 163 169 PF00018 0.408
LIG_SH3_3 36 42 PF00018 0.376
LIG_SH3_3 451 457 PF00018 0.311
LIG_SH3_5 330 334 PF00018 0.415
LIG_SUMO_SIM_anti_2 187 193 PF11976 0.490
LIG_SUMO_SIM_par_1 124 132 PF11976 0.493
LIG_SUMO_SIM_par_1 313 319 PF11976 0.361
LIG_TRAF2_1 137 140 PF00917 0.363
LIG_TRAF2_1 599 602 PF00917 0.479
LIG_TRAF2_1 666 669 PF00917 0.468
LIG_UBA3_1 377 386 PF00899 0.454
LIG_UBA3_1 95 100 PF00899 0.279
LIG_WRC_WIRS_1 372 377 PF05994 0.476
MOD_CDC14_SPxK_1 513 516 PF00782 0.201
MOD_CDK_SPK_2 381 386 PF00069 0.391
MOD_CDK_SPxK_1 510 516 PF00069 0.201
MOD_CDK_SPxxK_3 170 177 PF00069 0.479
MOD_CDK_SPxxK_3 418 425 PF00069 0.410
MOD_CK1_1 187 193 PF00069 0.415
MOD_CK1_1 226 232 PF00069 0.362
MOD_CK1_1 300 306 PF00069 0.397
MOD_CK1_1 316 322 PF00069 0.337
MOD_CK1_1 336 342 PF00069 0.456
MOD_CK1_1 360 366 PF00069 0.296
MOD_CK1_1 564 570 PF00069 0.369
MOD_CK1_1 709 715 PF00069 0.751
MOD_CK2_1 134 140 PF00069 0.355
MOD_CK2_1 170 176 PF00069 0.425
MOD_CK2_1 224 230 PF00069 0.363
MOD_CK2_1 560 566 PF00069 0.230
MOD_CK2_1 596 602 PF00069 0.427
MOD_CK2_1 681 687 PF00069 0.396
MOD_GlcNHglycan 123 126 PF01048 0.451
MOD_GlcNHglycan 186 189 PF01048 0.482
MOD_GlcNHglycan 246 249 PF01048 0.464
MOD_GlcNHglycan 294 297 PF01048 0.500
MOD_GlcNHglycan 485 488 PF01048 0.263
MOD_GlcNHglycan 714 717 PF01048 0.762
MOD_GlcNHglycan 89 92 PF01048 0.467
MOD_GSK3_1 117 124 PF00069 0.397
MOD_GSK3_1 125 132 PF00069 0.437
MOD_GSK3_1 140 147 PF00069 0.473
MOD_GSK3_1 244 251 PF00069 0.470
MOD_GSK3_1 342 349 PF00069 0.262
MOD_GSK3_1 356 363 PF00069 0.247
MOD_GSK3_1 466 473 PF00069 0.374
MOD_GSK3_1 474 481 PF00069 0.315
MOD_GSK3_1 53 60 PF00069 0.358
MOD_GSK3_1 557 564 PF00069 0.375
MOD_GSK3_1 593 600 PF00069 0.389
MOD_GSK3_1 681 688 PF00069 0.483
MOD_GSK3_1 705 712 PF00069 0.730
MOD_N-GLC_1 213 218 PF02516 0.376
MOD_N-GLC_1 365 370 PF02516 0.444
MOD_N-GLC_1 474 479 PF02516 0.342
MOD_N-GLC_1 518 523 PF02516 0.385
MOD_N-GLC_1 530 535 PF02516 0.342
MOD_N-GLC_1 557 562 PF02516 0.378
MOD_NEK2_1 144 149 PF00069 0.479
MOD_NEK2_1 17 22 PF00069 0.524
MOD_NEK2_1 194 199 PF00069 0.376
MOD_NEK2_1 224 229 PF00069 0.428
MOD_NEK2_1 290 295 PF00069 0.374
MOD_NEK2_1 357 362 PF00069 0.447
MOD_NEK2_1 431 436 PF00069 0.440
MOD_NEK2_1 466 471 PF00069 0.455
MOD_NEK2_1 530 535 PF00069 0.412
MOD_NEK2_1 603 608 PF00069 0.392
MOD_NEK2_1 622 627 PF00069 0.163
MOD_NEK2_2 213 218 PF00069 0.451
MOD_NEK2_2 248 253 PF00069 0.439
MOD_PIKK_1 17 23 PF00454 0.449
MOD_PIKK_1 297 303 PF00454 0.390
MOD_PIKK_1 549 555 PF00454 0.500
MOD_PIKK_1 603 609 PF00454 0.500
MOD_PIKK_1 681 687 PF00454 0.505
MOD_PKA_1 57 63 PF00069 0.479
MOD_PKA_1 99 105 PF00069 0.479
MOD_PKA_2 184 190 PF00069 0.434
MOD_PKA_2 311 317 PF00069 0.414
MOD_PKA_2 495 501 PF00069 0.438
MOD_PKA_2 57 63 PF00069 0.363
MOD_PKA_2 622 628 PF00069 0.423
MOD_PKA_2 66 72 PF00069 0.363
MOD_PKB_1 97 105 PF00069 0.415
MOD_Plk_1 100 106 PF00069 0.415
MOD_Plk_1 213 219 PF00069 0.376
MOD_Plk_1 259 265 PF00069 0.353
MOD_Plk_1 365 371 PF00069 0.404
MOD_Plk_1 399 405 PF00069 0.395
MOD_Plk_1 431 437 PF00069 0.473
MOD_Plk_1 478 484 PF00069 0.367
MOD_Plk_1 518 524 PF00069 0.370
MOD_Plk_2-3 371 377 PF00069 0.479
MOD_Plk_2-3 561 567 PF00069 0.499
MOD_Plk_2-3 597 603 PF00069 0.435
MOD_Plk_4 100 106 PF00069 0.450
MOD_Plk_4 140 146 PF00069 0.483
MOD_Plk_4 187 193 PF00069 0.398
MOD_Plk_4 346 352 PF00069 0.405
MOD_Plk_4 360 366 PF00069 0.469
MOD_Plk_4 609 615 PF00069 0.443
MOD_ProDKin_1 170 176 PF00069 0.502
MOD_ProDKin_1 318 324 PF00069 0.391
MOD_ProDKin_1 381 387 PF00069 0.391
MOD_ProDKin_1 418 424 PF00069 0.408
MOD_ProDKin_1 510 516 PF00069 0.470
MOD_SUMO_for_1 608 611 PF00179 0.298
MOD_SUMO_rev_2 128 135 PF00179 0.496
MOD_SUMO_rev_2 156 164 PF00179 0.439
MOD_SUMO_rev_2 561 570 PF00179 0.479
MOD_SUMO_rev_2 597 606 PF00179 0.306
TRG_DiLeu_BaEn_3 139 145 PF01217 0.408
TRG_ENDOCYTIC_2 142 145 PF00928 0.396
TRG_ENDOCYTIC_2 204 207 PF00928 0.391
TRG_ENDOCYTIC_2 234 237 PF00928 0.498
TRG_ENDOCYTIC_2 36 39 PF00928 0.400
TRG_ER_diArg_1 207 210 PF00400 0.391
TRG_ER_diArg_1 454 456 PF00400 0.418
TRG_ER_diArg_1 579 582 PF00400 0.441
TRG_ER_diArg_1 66 68 PF00400 0.415
TRG_ER_diArg_1 96 99 PF00400 0.415
TRG_NES_CRM1_1 356 371 PF08389 0.470
TRG_NES_CRM1_1 393 407 PF08389 0.415
TRG_Pf-PMV_PEXEL_1 109 114 PF00026 0.318
TRG_Pf-PMV_PEXEL_1 178 182 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD3 Leptomonas seymouri 24% 86%
A0A0N1PEF0 Leptomonas seymouri 69% 97%
A0A0S4IUZ2 Bodo saltans 33% 82%
A0A0S4JJU2 Bodo saltans 40% 94%
A0A0S4JRV7 Bodo saltans 25% 87%
A0A1X0P2S1 Trypanosomatidae 31% 83%
A0A1X0P4V9 Trypanosomatidae 46% 100%
A0A1X0P8H2 Trypanosomatidae 26% 88%
A0A3R7L0X2 Trypanosoma rangeli 26% 87%
A0A3S5H744 Leishmania donovani 24% 88%
A0A3S5H808 Leishmania donovani 94% 100%
A0A3S7WZX1 Leishmania donovani 24% 100%
A0A422NGS3 Trypanosoma rangeli 33% 77%
A0A422P1B1 Trypanosoma rangeli 47% 100%
A4H9P0 Leishmania braziliensis 25% 100%
A4HND7 Leishmania braziliensis 82% 100%
A4I253 Leishmania infantum 23% 100%
A4IC10 Leishmania infantum 94% 100%
C9ZXL9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 87%
C9ZYJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A590 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 89%
D0A8Z2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AFU8 Leishmania major 92% 100%
E9AGQ5 Leishmania infantum 24% 88%
E9ARS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 88%
F4HQD4 Arabidopsis thaliana 27% 87%
F4JMJ1 Arabidopsis thaliana 25% 83%
O59838 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
O74225 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
O88600 Rattus norvegicus 26% 86%
O95757 Homo sapiens 28% 86%
P17066 Homo sapiens 25% 100%
P20030 Trypanosoma brucei brucei 26% 100%
P32589 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P32590 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P34932 Homo sapiens 26% 86%
P48722 Mus musculus 28% 86%
P78695 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 24% 100%
P87047 Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) 24% 100%
Q00043 Ajellomyces capsulatus 25% 100%
Q01877 Puccinia graminis 24% 100%
Q04967 Sus scrofa 25% 100%
Q05036 Caenorhabditis elegans 25% 93%
Q0VA61 Xenopus tropicalis 29% 100%
Q2TFN9 Canis lupus familiaris 27% 86%
Q4Q970 Leishmania major 24% 96%
Q4QDQ2 Leishmania major 24% 100%
Q566I3 Xenopus laevis 30% 100%
Q5RDM4 Pongo abelii 26% 86%
Q5ZLK7 Gallus gallus 26% 72%
Q61316 Mus musculus 26% 86%
Q6FJI3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 24% 100%
Q6TMK3 Dictyostelium discoideum 23% 94%
Q74ZJ0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 25% 100%
Q7ZUW2 Danio rerio 29% 74%
Q875V0 Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) 26% 100%
Q9S7C0 Arabidopsis thaliana 27% 87%
Q9SAB1 Arabidopsis thaliana 23% 95%
Q9Y4L1 Homo sapiens 31% 72%
V5ARL4 Trypanosoma cruzi 46% 100%
V5DD81 Trypanosoma cruzi 32% 89%
V5DFF3 Trypanosoma cruzi 25% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS