Parkin coregulated gene protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PACRGB

Species:

Leishmania mexicana

UniProt:

E9B6Z8_LEIMU

TriTrypDb:

LmxM.34.4690

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 21
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B6Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Z8

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060548	negative regulation of cell death	5	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2
GO:0051087	protein-folding chaperone binding	3	2
GO:0051879	Hsp90 protein binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.561
CLV_NRD_NRD_1	224	226	PF00675	0.392
CLV_PCSK_KEX2_1	150	152	PF00082	0.351
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.377
CLV_PCSK_SKI1_1	151	155	PF00082	0.289
CLV_PCSK_SKI1_1	19	23	PF00082	0.545
CLV_PCSK_SKI1_1	213	217	PF00082	0.259
CLV_PCSK_SKI1_1	225	229	PF00082	0.259
CLV_PCSK_SKI1_1	250	254	PF00082	0.280
DEG_APCC_DBOX_1	150	158	PF00400	0.289
DEG_APCC_DBOX_1	18	26	PF00400	0.552
DOC_CDC14_PxL_1	202	210	PF14671	0.259
DOC_CYCLIN_RxL_1	147	158	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.259
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.117
DOC_MAPK_DCC_7	200	210	PF00069	0.259
DOC_MAPK_MEF2A_6	138	145	PF00069	0.259
DOC_MAPK_NFAT4_5	138	146	PF00069	0.217
DOC_PP1_RVXF_1	149	156	PF00149	0.253
DOC_PP2B_LxvP_1	208	211	PF13499	0.259
DOC_PP4_FxxP_1	110	113	PF00568	0.499
DOC_USP7_MATH_1	101	105	PF00917	0.537
DOC_USP7_MATH_1	149	153	PF00917	0.294
DOC_USP7_MATH_1	215	219	PF00917	0.245
DOC_USP7_MATH_1	47	51	PF00917	0.677
DOC_USP7_UBL2_3	260	264	PF12436	0.294
LIG_14-3-3_CanoR_1	275	283	PF00244	0.375
LIG_Actin_WH2_2	209	227	PF00022	0.392
LIG_APCC_ABBA_1	168	173	PF00400	0.259
LIG_EH1_1	228	236	PF00400	0.245
LIG_EVH1_2	128	132	PF00568	0.255
LIG_FHA_1	85	91	PF00498	0.447
LIG_Integrin_isoDGR_2	107	109	PF01839	0.492
LIG_LIR_Apic_2	292	297	PF02991	0.392
LIG_LIR_Gen_1	179	187	PF02991	0.313
LIG_LIR_Gen_1	298	308	PF02991	0.261
LIG_LIR_Nem_3	163	167	PF02991	0.262
LIG_LIR_Nem_3	179	185	PF02991	0.275
LIG_LIR_Nem_3	27	33	PF02991	0.464
LIG_LIR_Nem_3	298	303	PF02991	0.261
LIG_Pex14_2	33	37	PF04695	0.648
LIG_PTB_Apo_2	104	111	PF02174	0.654
LIG_PTB_Apo_2	299	306	PF02174	0.259
LIG_PTB_Phospho_1	299	305	PF10480	0.259
LIG_SH2_CRK	249	253	PF00017	0.266
LIG_SH2_CRK	305	309	PF00017	0.266
LIG_SH2_GRB2like	300	303	PF00017	0.275
LIG_SH2_PTP2	300	303	PF00017	0.275
LIG_SH2_SRC	167	170	PF00017	0.294
LIG_SH2_SRC	300	303	PF00017	0.275
LIG_SH2_STAP1	310	314	PF00017	0.284
LIG_SH2_STAT3	122	125	PF00017	0.570
LIG_SH2_STAT3	248	251	PF00017	0.265
LIG_SH2_STAT5	167	170	PF00017	0.284
LIG_SH2_STAT5	300	303	PF00017	0.251
LIG_SH3_1	200	206	PF00018	0.259
LIG_SH3_2	113	118	PF14604	0.499
LIG_SH3_3	110	116	PF00018	0.475
LIG_SH3_3	18	24	PF00018	0.555
LIG_SH3_3	200	206	PF00018	0.259
LIG_SH3_3	26	32	PF00018	0.465
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.696
LIG_UBA3_1	208	213	PF00899	0.259
LIG_WRC_WIRS_1	92	97	PF05994	0.520
MOD_CK1_1	45	51	PF00069	0.685
MOD_CK2_1	5	11	PF00069	0.493
MOD_GlcNHglycan	236	239	PF01048	0.174
MOD_GSK3_1	116	123	PF00069	0.457
MOD_GSK3_1	211	218	PF00069	0.275
MOD_GSK3_1	274	281	PF00069	0.392
MOD_GSK3_1	3	10	PF00069	0.476
MOD_GSK3_1	41	48	PF00069	0.573
MOD_GSK3_1	84	91	PF00069	0.513
MOD_N-GLC_1	101	106	PF02516	0.444
MOD_N-GLC_1	260	265	PF02516	0.392
MOD_N-GLC_1	284	289	PF02516	0.321
MOD_NEK2_1	3	8	PF00069	0.485
MOD_NEK2_1	95	100	PF00069	0.499
MOD_PIKK_1	5	11	PF00454	0.610
MOD_PKA_2	274	280	PF00069	0.399
MOD_PKA_2	41	47	PF00069	0.399
MOD_PKB_1	40	48	PF00069	0.400
MOD_Plk_1	101	107	PF00069	0.572
MOD_Plk_1	278	284	PF00069	0.281
MOD_Plk_4	279	285	PF00069	0.355
MOD_Plk_4	51	57	PF00069	0.633
TRG_DiLeu_BaEn_3	179	185	PF01217	0.266
TRG_ENDOCYTIC_2	167	170	PF00928	0.263
TRG_ENDOCYTIC_2	249	252	PF00928	0.266
TRG_ENDOCYTIC_2	300	303	PF00928	0.275
TRG_ER_diArg_1	39	42	PF00400	0.475
TRG_NES_CRM1_1	279	292	PF08389	0.250
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N4	Leptomonas seymouri	55%	100%
A0A0N0P9H6	Leptomonas seymouri	78%	99%
A0A0S4IYX0	Bodo saltans	52%	100%
A0A0S4J0U8	Bodo saltans	57%	100%
A0A1X0NY39	Trypanosomatidae	51%	100%
A0A1X0P4X2	Trypanosomatidae	60%	100%
A0A3S7WZF1	Leishmania donovani	57%	100%
A0A3S7XA05	Leishmania donovani	95%	100%
A0A422P182	Trypanosoma rangeli	58%	100%
A0A422P4M1	Trypanosoma rangeli	50%	100%
A4HEC4	Leishmania braziliensis	56%	77%
A4HND5	Leishmania braziliensis	88%	100%
A4I1R9	Leishmania infantum	57%	100%
A4IC08	Leishmania infantum	95%	100%
C9ZKC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZYJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AFU6	Leishmania major	96%	100%
E9AXV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4Q9L7	Leishmania major	57%	100%
Q96M98	Homo sapiens	45%	100%
V5B824	Trypanosoma cruzi	51%	100%
V5BXN2	Trypanosoma cruzi	58%	98%