Putative katanin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative katanin

Gene product:

katanin, putative

Species:

Leishmania mexicana

UniProt:

E9B6Z6_LEIMU

TriTrypDb:

LmxM.34.4670

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005856	cytoskeleton	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	9
GO:0005875	microtubule associated complex	2	1
GO:0008352	katanin complex	3	1
GO:0032991	protein-containing complex	1	4
GO:0005840	ribosome	5	3
GO:1990904	ribonucleoprotein complex	2	3

Expansion

Sequence features

E9B6Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Z6

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007019	microtubule depolymerization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0051261	protein depolymerization	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008017	microtubule binding	5	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0003824	catalytic activity	1	4
GO:0004609	phosphatidylserine decarboxylase activity	5	4
GO:0016829	lyase activity	2	4
GO:0016830	carbon-carbon lyase activity	3	4
GO:0016831	carboxy-lyase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.444
CLV_NRD_NRD_1	126	128	PF00675	0.344
CLV_NRD_NRD_1	300	302	PF00675	0.636
CLV_NRD_NRD_1	342	344	PF00675	0.737
CLV_NRD_NRD_1	429	431	PF00675	0.292
CLV_NRD_NRD_1	453	455	PF00675	0.322
CLV_NRD_NRD_1	528	530	PF00675	0.293
CLV_PCSK_KEX2_1	300	302	PF00082	0.636
CLV_PCSK_KEX2_1	429	431	PF00082	0.317
CLV_PCSK_KEX2_1	453	455	PF00082	0.287
CLV_PCSK_KEX2_1	528	530	PF00082	0.293
CLV_PCSK_SKI1_1	136	140	PF00082	0.444
CLV_PCSK_SKI1_1	480	484	PF00082	0.402
CLV_PCSK_SKI1_1	576	580	PF00082	0.308
CLV_PCSK_SKI1_1	90	94	PF00082	0.548
CLV_Separin_Metazoa	87	91	PF03568	0.541
DEG_APCC_DBOX_1	575	583	PF00400	0.492
DEG_Kelch_Keap1_1	402	407	PF01344	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_ODPH_VHL_1	318	329	PF01847	0.589
DEG_ODPH_VHL_1	399	412	PF01847	0.482
DEG_SPOP_SBC_1	400	404	PF00917	0.581
DOC_CKS1_1	222	227	PF01111	0.431
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.507
DOC_MAPK_gen_1	22	29	PF00069	0.529
DOC_MAPK_HePTP_8	495	507	PF00069	0.591
DOC_MAPK_MEF2A_6	22	29	PF00069	0.529
DOC_MAPK_MEF2A_6	498	507	PF00069	0.591
DOC_MIT_MIM_1	424	435	PF04212	0.383
DOC_PP2B_LxvP_1	260	263	PF13499	0.546
DOC_PP4_MxPP_1	582	585	PF00568	0.608
DOC_USP7_MATH_1	113	117	PF00917	0.363
DOC_USP7_MATH_1	183	187	PF00917	0.344
DOC_USP7_MATH_1	20	24	PF00917	0.619
DOC_USP7_MATH_1	311	315	PF00917	0.617
DOC_USP7_MATH_1	321	325	PF00917	0.673
DOC_USP7_MATH_1	373	377	PF00917	0.809
DOC_USP7_MATH_1	387	391	PF00917	0.709
DOC_USP7_MATH_1	401	405	PF00917	0.481
DOC_USP7_MATH_1	530	534	PF00917	0.563
DOC_WW_Pin1_4	145	150	PF00397	0.344
DOC_WW_Pin1_4	221	226	PF00397	0.438
DOC_WW_Pin1_4	319	324	PF00397	0.702
DOC_WW_Pin1_4	350	355	PF00397	0.778
LIG_14-3-3_CanoR_1	127	135	PF00244	0.350
LIG_14-3-3_CanoR_1	17	25	PF00244	0.477
LIG_14-3-3_CanoR_1	216	226	PF00244	0.574
LIG_14-3-3_CanoR_1	235	244	PF00244	0.224
LIG_14-3-3_CanoR_1	255	261	PF00244	0.267
LIG_14-3-3_CanoR_1	429	435	PF00244	0.492
LIG_14-3-3_CanoR_1	529	538	PF00244	0.533
LIG_14-3-3_CanoR_1	94	103	PF00244	0.566
LIG_Actin_WH2_2	420	437	PF00022	0.514
LIG_Actin_WH2_2	500	515	PF00022	0.561
LIG_BRCT_BRCA1_1	107	111	PF00533	0.524
LIG_BRCT_BRCA1_1	185	189	PF00533	0.344
LIG_BRCT_BRCA1_1	335	339	PF00533	0.700
LIG_BRCT_BRCA1_1	515	519	PF00533	0.487
LIG_eIF4E_1	501	507	PF01652	0.561
LIG_FHA_1	115	121	PF00498	0.409
LIG_FHA_1	137	143	PF00498	0.444
LIG_FHA_1	174	180	PF00498	0.438
LIG_FHA_1	202	208	PF00498	0.511
LIG_FHA_1	232	238	PF00498	0.548
LIG_FHA_1	247	253	PF00498	0.478
LIG_FHA_1	45	51	PF00498	0.471
LIG_FHA_1	481	487	PF00498	0.591
LIG_FHA_1	549	555	PF00498	0.580
LIG_FHA_1	65	71	PF00498	0.401
LIG_FHA_2	222	228	PF00498	0.426
LIG_FHA_2	360	366	PF00498	0.820
LIG_FHA_2	486	492	PF00498	0.537
LIG_FHA_2	497	503	PF00498	0.546
LIG_FHA_2	97	103	PF00498	0.407
LIG_Integrin_isoDGR_2	150	152	PF01839	0.401
LIG_LIR_Apic_2	535	541	PF02991	0.571
LIG_LIR_Gen_1	12	20	PF02991	0.518
LIG_LIR_Gen_1	192	202	PF02991	0.413
LIG_LIR_Gen_1	261	272	PF02991	0.429
LIG_LIR_Gen_1	422	431	PF02991	0.383
LIG_LIR_Gen_1	467	475	PF02991	0.383
LIG_LIR_Gen_1	488	497	PF02991	0.583
LIG_LIR_Nem_3	12	18	PF02991	0.514
LIG_LIR_Nem_3	192	198	PF02991	0.412
LIG_LIR_Nem_3	422	427	PF02991	0.383
LIG_LIR_Nem_3	461	465	PF02991	0.561
LIG_LIR_Nem_3	467	471	PF02991	0.555
LIG_LIR_Nem_3	488	492	PF02991	0.559
LIG_LIR_Nem_3	499	504	PF02991	0.563
LIG_LYPXL_S_1	38	42	PF13949	0.541
LIG_LYPXL_yS_3	39	42	PF13949	0.550
LIG_MYND_1	397	401	PF01753	0.517
LIG_Pex14_2	213	217	PF04695	0.438
LIG_Pex14_2	462	466	PF04695	0.561
LIG_Rb_pABgroove_1	160	168	PF01858	0.346
LIG_Rb_pABgroove_1	450	458	PF01858	0.466
LIG_SH2_CRK	15	19	PF00017	0.496
LIG_SH2_CRK	166	170	PF00017	0.401
LIG_SH2_NCK_1	15	19	PF00017	0.496
LIG_SH2_NCK_1	166	170	PF00017	0.369
LIG_SH2_SRC	456	459	PF00017	0.527
LIG_SH2_STAP1	166	170	PF00017	0.444
LIG_SH2_STAP1	44	48	PF00017	0.432
LIG_SH2_STAT5	195	198	PF00017	0.422
LIG_SH2_STAT5	230	233	PF00017	0.352
LIG_SH2_STAT5	44	47	PF00017	0.494
LIG_SH3_3	314	320	PF00018	0.694
LIG_SH3_3	390	396	PF00018	0.764
LIG_SH3_3	577	583	PF00018	0.567
LIG_Sin3_3	575	582	PF02671	0.591
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.591
LIG_SUMO_SIM_anti_2	488	494	PF11976	0.507
LIG_SUMO_SIM_anti_2	502	508	PF11976	0.561
LIG_SUMO_SIM_par_1	202	209	PF11976	0.514
LIG_TRAF2_1	302	305	PF00917	0.719
LIG_TYR_ITIM	193	198	PF00017	0.487
LIG_UBA3_1	120	128	PF00899	0.408
LIG_WRC_WIRS_1	174	179	PF05994	0.194
LIG_WRC_WIRS_1	210	215	PF05994	0.539
LIG_WRC_WIRS_1	486	491	PF05994	0.536
LIG_WW_3	584	588	PF00397	0.768
MOD_CDC14_SPxK_1	357	360	PF00782	0.813
MOD_CDK_SPxK_1	354	360	PF00069	0.774
MOD_CDK_SPxxK_3	145	152	PF00069	0.344
MOD_CDK_SPxxK_3	319	326	PF00069	0.707
MOD_CK1_1	16	22	PF00069	0.425
MOD_CK1_1	221	227	PF00069	0.504
MOD_CK1_1	250	256	PF00069	0.500
MOD_CK1_1	334	340	PF00069	0.764
MOD_CK1_1	350	356	PF00069	0.722
MOD_CK1_1	376	382	PF00069	0.814
MOD_CK1_1	402	408	PF00069	0.566
MOD_CK1_1	485	491	PF00069	0.548
MOD_CK1_1	514	520	PF00069	0.490
MOD_CK1_1	533	539	PF00069	0.401
MOD_CK1_1	98	104	PF00069	0.387
MOD_CK2_1	401	407	PF00069	0.699
MOD_CK2_1	496	502	PF00069	0.546
MOD_GlcNHglycan	107	110	PF01048	0.532
MOD_GlcNHglycan	129	132	PF01048	0.418
MOD_GlcNHglycan	18	21	PF01048	0.497
MOD_GlcNHglycan	199	202	PF01048	0.456
MOD_GlcNHglycan	231	234	PF01048	0.485
MOD_GlcNHglycan	313	316	PF01048	0.752
MOD_GlcNHglycan	389	392	PF01048	0.693
MOD_GSK3_1	127	134	PF00069	0.387
MOD_GSK3_1	16	23	PF00069	0.530
MOD_GSK3_1	178	185	PF00069	0.397
MOD_GSK3_1	197	204	PF00069	0.215
MOD_GSK3_1	217	224	PF00069	0.246
MOD_GSK3_1	246	253	PF00069	0.502
MOD_GSK3_1	281	288	PF00069	0.480
MOD_GSK3_1	350	357	PF00069	0.799
MOD_GSK3_1	372	379	PF00069	0.817
MOD_GSK3_1	387	394	PF00069	0.557
MOD_GSK3_1	395	402	PF00069	0.781
MOD_GSK3_1	419	426	PF00069	0.501
MOD_GSK3_1	51	58	PF00069	0.492
MOD_N-GLC_1	250	255	PF02516	0.578
MOD_N-GLC_1	334	339	PF02516	0.765
MOD_N-GLC_1	347	352	PF02516	0.721
MOD_N-GLC_2	555	557	PF02516	0.328
MOD_NEK2_1	111	116	PF00069	0.394
MOD_NEK2_1	217	222	PF00069	0.567
MOD_NEK2_1	231	236	PF00069	0.327
MOD_NEK2_1	247	252	PF00069	0.357
MOD_NEK2_1	281	286	PF00069	0.464
MOD_NEK2_1	42	47	PF00069	0.585
MOD_NEK2_1	482	487	PF00069	0.585
MOD_NEK2_1	542	547	PF00069	0.569
MOD_NEK2_2	183	188	PF00069	0.369
MOD_NEK2_2	508	513	PF00069	0.561
MOD_PIKK_1	218	224	PF00454	0.540
MOD_PIKK_1	321	327	PF00454	0.701
MOD_PIKK_1	530	536	PF00454	0.561
MOD_PIKK_1	542	548	PF00454	0.561
MOD_PK_1	32	38	PF00069	0.491
MOD_PKA_1	127	133	PF00069	0.344
MOD_PKA_2	126	132	PF00069	0.432
MOD_PKA_2	16	22	PF00069	0.459
MOD_PKA_2	530	536	PF00069	0.560
MOD_Plk_1	253	259	PF00069	0.509
MOD_Plk_1	32	38	PF00069	0.468
MOD_Plk_1	334	340	PF00069	0.696
MOD_Plk_1	64	70	PF00069	0.533
MOD_Plk_2-3	209	215	PF00069	0.533
MOD_Plk_2-3	82	88	PF00069	0.529
MOD_Plk_4	203	209	PF00069	0.371
MOD_Plk_4	313	319	PF00069	0.611
MOD_Plk_4	334	340	PF00069	0.733
MOD_Plk_4	419	425	PF00069	0.396
MOD_Plk_4	467	473	PF00069	0.595
MOD_Plk_4	485	491	PF00069	0.409
MOD_Plk_4	65	71	PF00069	0.499
MOD_ProDKin_1	145	151	PF00069	0.344
MOD_ProDKin_1	221	227	PF00069	0.434
MOD_ProDKin_1	319	325	PF00069	0.705
MOD_ProDKin_1	350	356	PF00069	0.779
TRG_DiLeu_BaEn_1	502	507	PF01217	0.533
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.554
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.591
TRG_ENDOCYTIC_2	15	18	PF00928	0.499
TRG_ENDOCYTIC_2	166	169	PF00928	0.401
TRG_ENDOCYTIC_2	194	197	PF00928	0.386
TRG_ENDOCYTIC_2	39	42	PF00928	0.485
TRG_ENDOCYTIC_2	501	504	PF00928	0.561
TRG_ER_diArg_1	299	301	PF00400	0.600
TRG_ER_diArg_1	429	431	PF00400	0.519
TRG_ER_diArg_1	452	454	PF00400	0.522
TRG_ER_diArg_1	519	522	PF00400	0.526
TRG_ER_diArg_1	528	531	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P963	Leptomonas seymouri	67%	100%
A0A1X0P573	Trypanosomatidae	39%	100%
A0A3R7M9G2	Trypanosoma rangeli	38%	100%
A0A3S7XA71	Leishmania donovani	95%	100%
A4HND4	Leishmania braziliensis	84%	100%
A4IC06	Leishmania infantum	95%	100%
C9ZYJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AFU4	Leishmania major	93%	100%