Protein-serine/threonine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B6Z4_LEIMU

TriTrypDb:

LmxM.34.4650

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Z4

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016311	dephosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.728
CLV_C14_Caspase3-7	189	193	PF00656	0.492
CLV_NRD_NRD_1	81	83	PF00675	0.755
CLV_NRD_NRD_1	88	90	PF00675	0.729
CLV_PCSK_KEX2_1	81	83	PF00082	0.755
CLV_PCSK_KEX2_1	88	90	PF00082	0.729
CLV_PCSK_SKI1_1	106	110	PF00082	0.603
CLV_PCSK_SKI1_1	88	92	PF00082	0.721
DEG_Nend_UBRbox_2	1	3	PF02207	0.697
DEG_SCF_FBW7_1	174	181	PF00400	0.604
DEG_SPOP_SBC_1	129	133	PF00917	0.803
DOC_CKS1_1	153	158	PF01111	0.709
DOC_CKS1_1	175	180	PF01111	0.513
DOC_MAPK_DCC_7	88	98	PF00069	0.586
DOC_MAPK_gen_1	327	337	PF00069	0.410
DOC_MAPK_gen_1	88	96	PF00069	0.696
DOC_MAPK_MEF2A_6	89	98	PF00069	0.757
DOC_USP7_MATH_1	130	134	PF00917	0.615
DOC_USP7_MATH_1	141	145	PF00917	0.710
DOC_USP7_MATH_1	146	150	PF00917	0.595
DOC_USP7_MATH_1	49	53	PF00917	0.721
DOC_WW_Pin1_4	122	127	PF00397	0.723
DOC_WW_Pin1_4	152	157	PF00397	0.712
DOC_WW_Pin1_4	164	169	PF00397	0.605
DOC_WW_Pin1_4	174	179	PF00397	0.518
DOC_WW_Pin1_4	4	9	PF00397	0.715
DOC_WW_Pin1_4	76	81	PF00397	0.704
DOC_WW_Pin1_4	83	88	PF00397	0.686
LIG_14-3-3_CanoR_1	188	192	PF00244	0.504
LIG_APCC_ABBA_1	272	277	PF00400	0.430
LIG_BRCT_BRCA1_1	49	53	PF00533	0.721
LIG_FHA_1	153	159	PF00498	0.740
LIG_FHA_1	175	181	PF00498	0.658
LIG_FHA_1	209	215	PF00498	0.483
LIG_FHA_2	115	121	PF00498	0.724
LIG_FHA_2	187	193	PF00498	0.510
LIG_FHA_2	210	216	PF00498	0.370
LIG_FHA_2	248	254	PF00498	0.397
LIG_FHA_2	285	291	PF00498	0.501
LIG_FHA_2	37	43	PF00498	0.736
LIG_FHA_2	71	77	PF00498	0.809
LIG_Integrin_isoDGR_2	332	334	PF01839	0.430
LIG_LIR_Apic_2	124	130	PF02991	0.729
LIG_LIR_Gen_1	268	278	PF02991	0.382
LIG_LIR_Nem_3	268	274	PF02991	0.378
LIG_LIR_Nem_3	277	281	PF02991	0.372
LIG_LIR_Nem_3	50	56	PF02991	0.807
LIG_PTB_Apo_2	337	344	PF02174	0.376
LIG_RPA_C_Fungi	300	312	PF08784	0.501
LIG_SH2_NCK_1	163	167	PF00017	0.670
LIG_SH2_SRC	351	354	PF00017	0.279
LIG_SH2_STAP1	278	282	PF00017	0.376
LIG_SH2_STAT3	176	179	PF00017	0.624
LIG_SH2_STAT5	176	179	PF00017	0.597
LIG_SH2_STAT5	219	222	PF00017	0.436
LIG_SH2_STAT5	271	274	PF00017	0.397
LIG_SH2_STAT5	351	354	PF00017	0.483
LIG_SH3_1	81	87	PF00018	0.521
LIG_SH3_2	84	89	PF14604	0.759
LIG_SH3_3	123	129	PF00018	0.672
LIG_SH3_3	162	168	PF00018	0.699
LIG_SH3_3	64	70	PF00018	0.766
LIG_SH3_3	72	78	PF00018	0.745
LIG_SH3_3	81	87	PF00018	0.710
LIG_TRAF2_1	61	64	PF00917	0.826
MOD_CDC14_SPxK_1	79	82	PF00782	0.774
MOD_CDC14_SPxK_1	86	89	PF00782	0.701
MOD_CDK_SPK_2	76	81	PF00069	0.726
MOD_CDK_SPK_2	83	88	PF00069	0.757
MOD_CDK_SPxK_1	122	128	PF00069	0.743
MOD_CDK_SPxK_1	76	82	PF00069	0.752
MOD_CDK_SPxK_1	83	89	PF00069	0.736
MOD_CK1_1	137	143	PF00069	0.672
MOD_CK1_1	209	215	PF00069	0.560
MOD_CK1_1	265	271	PF00069	0.501
MOD_CK1_1	59	65	PF00069	0.763
MOD_CK2_1	247	253	PF00069	0.430
MOD_CK2_1	284	290	PF00069	0.501
MOD_CK2_1	36	42	PF00069	0.734
MOD_CK2_1	70	76	PF00069	0.796
MOD_GlcNHglycan	132	135	PF01048	0.716
MOD_GlcNHglycan	136	139	PF01048	0.692
MOD_GlcNHglycan	143	146	PF01048	0.648
MOD_GSK3_1	130	137	PF00069	0.597
MOD_GSK3_1	174	181	PF00069	0.630
MOD_GSK3_1	36	43	PF00069	0.752
MOD_N-GLC_1	146	151	PF02516	0.523
MOD_N-GLC_1	303	308	PF02516	0.376
MOD_N-GLC_2	242	244	PF02516	0.430
MOD_NEK2_1	104	109	PF00069	0.774
MOD_NEK2_1	18	23	PF00069	0.684
MOD_NEK2_1	284	289	PF00069	0.501
MOD_NEK2_1	41	46	PF00069	0.738
MOD_NEK2_1	56	61	PF00069	0.744
MOD_PIKK_1	223	229	PF00454	0.509
MOD_PIKK_1	54	60	PF00454	0.752
MOD_PKA_2	187	193	PF00069	0.510
MOD_PKA_2	47	53	PF00069	0.726
MOD_PKA_2	54	60	PF00069	0.741
MOD_PKA_2	65	71	PF00069	0.749
MOD_Plk_1	146	152	PF00069	0.522
MOD_Plk_1	303	309	PF00069	0.376
MOD_Plk_1	358	364	PF00069	0.352
MOD_Plk_1	36	42	PF00069	0.758
MOD_Plk_4	209	215	PF00069	0.464
MOD_Plk_4	284	290	PF00069	0.501
MOD_ProDKin_1	122	128	PF00069	0.724
MOD_ProDKin_1	152	158	PF00069	0.710
MOD_ProDKin_1	164	170	PF00069	0.602
MOD_ProDKin_1	174	180	PF00069	0.507
MOD_ProDKin_1	4	10	PF00069	0.711
MOD_ProDKin_1	76	82	PF00069	0.704
MOD_ProDKin_1	83	89	PF00069	0.687
TRG_DiLeu_BaEn_4	269	275	PF01217	0.501
TRG_ENDOCYTIC_2	271	274	PF00928	0.376
TRG_ENDOCYTIC_2	278	281	PF00928	0.376
TRG_ER_diArg_1	334	337	PF00400	0.430
TRG_ER_diArg_1	80	82	PF00400	0.759
TRG_ER_diArg_1	87	89	PF00400	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PES2	Leptomonas seymouri	56%	100%
A0A0S4JQR8	Bodo saltans	31%	100%
A0A3Q8IJV8	Leishmania donovani	93%	100%
A4HND2	Leishmania braziliensis	76%	100%
A4IC04	Leishmania infantum	93%	100%
E9AFU2	Leishmania major	88%	100%