Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B6Z1_LEIMU

TriTrypDb:

LmxM.34.4620

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Z1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.759
CLV_NRD_NRD_1	23	25	PF00675	0.549
CLV_PCSK_KEX2_1	23	25	PF00082	0.560
CLV_PCSK_SKI1_1	237	241	PF00082	0.423
CLV_Separin_Metazoa	169	173	PF03568	0.366
DEG_APCC_DBOX_1	236	244	PF00400	0.423
DOC_CKS1_1	64	69	PF01111	0.464
DOC_CYCLIN_RxL_1	231	242	PF00134	0.339
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.332
DOC_MAPK_JIP1_4	237	243	PF00069	0.456
DOC_PP4_FxxP_1	225	228	PF00568	0.423
DOC_WW_Pin1_4	209	214	PF00397	0.311
DOC_WW_Pin1_4	5	10	PF00397	0.692
DOC_WW_Pin1_4	63	68	PF00397	0.392
LIG_14-3-3_CanoR_1	24	32	PF00244	0.536
LIG_FHA_1	1	7	PF00498	0.565
LIG_FHA_1	148	154	PF00498	0.411
LIG_FHA_1	20	26	PF00498	0.516
LIG_FHA_1	200	206	PF00498	0.295
LIG_FHA_1	59	65	PF00498	0.509
LIG_Integrin_RGD_1	172	174	PF01839	0.456
LIG_LIR_Apic_2	224	228	PF02991	0.389
LIG_LIR_Apic_2	90	95	PF02991	0.287
LIG_LIR_Gen_1	66	74	PF02991	0.400
LIG_LIR_Nem_3	66	72	PF02991	0.398
LIG_LIR_Nem_3	86	92	PF02991	0.319
LIG_NRBOX	184	190	PF00104	0.423
LIG_SH2_CRK	155	159	PF00017	0.475
LIG_SH2_CRK	92	96	PF00017	0.467
LIG_SH2_STAT5	69	72	PF00017	0.382
LIG_SH3_3	6	12	PF00018	0.761
LIG_SH3_3	61	67	PF00018	0.496
LIG_SUMO_SIM_par_1	237	242	PF11976	0.339
LIG_TYR_ITIM	153	158	PF00017	0.475
LIG_UBA3_1	189	198	PF00899	0.265
MOD_CK1_1	19	25	PF00069	0.446
MOD_CK1_1	196	202	PF00069	0.274
MOD_CK1_1	221	227	PF00069	0.315
MOD_CK1_1	266	272	PF00069	0.672
MOD_CK1_1	273	279	PF00069	0.755
MOD_CK2_1	200	206	PF00069	0.164
MOD_CK2_1	273	279	PF00069	0.712
MOD_CK2_1	30	36	PF00069	0.497
MOD_GlcNHglycan	18	21	PF01048	0.418
MOD_GlcNHglycan	195	198	PF01048	0.261
MOD_GlcNHglycan	220	223	PF01048	0.349
MOD_GlcNHglycan	250	253	PF01048	0.536
MOD_GlcNHglycan	92	95	PF01048	0.544
MOD_GSK3_1	1	8	PF00069	0.684
MOD_GSK3_1	196	203	PF00069	0.359
MOD_GSK3_1	205	212	PF00069	0.337
MOD_GSK3_1	214	221	PF00069	0.264
MOD_GSK3_1	263	270	PF00069	0.696
MOD_GSK3_1	281	288	PF00069	0.743
MOD_GSK3_1	31	38	PF00069	0.354
MOD_N-GLC_1	273	278	PF02516	0.731
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	193	198	PF00069	0.439
MOD_NEK2_1	214	219	PF00069	0.370
MOD_NEK2_1	248	253	PF00069	0.469
MOD_NEK2_1	35	40	PF00069	0.500
MOD_PKA_2	25	31	PF00069	0.518
MOD_Plk_1	74	80	PF00069	0.451
MOD_Plk_2-3	267	273	PF00069	0.659
MOD_Plk_4	221	227	PF00069	0.334
MOD_ProDKin_1	209	215	PF00069	0.311
MOD_ProDKin_1	5	11	PF00069	0.692
MOD_ProDKin_1	63	69	PF00069	0.390
TRG_DiLeu_BaEn_1	206	211	PF01217	0.330
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.400
TRG_ENDOCYTIC_2	155	158	PF00928	0.487
TRG_ENDOCYTIC_2	69	72	PF00928	0.386
TRG_ER_diArg_1	23	26	PF00400	0.556
TRG_ER_diArg_1	39	42	PF00400	0.314
TRG_ER_diArg_1	45	48	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAR1	Leptomonas seymouri	59%	98%
A0A1X0P5S2	Trypanosomatidae	34%	100%
A0A3Q8IFJ8	Leishmania donovani	90%	100%
A0A422P1C1	Trypanosoma rangeli	32%	100%
A4HNC9	Leishmania braziliensis	79%	100%
C9ZYK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AFT9	Leishmania major	91%	100%
E9AHW8	Leishmania infantum	90%	100%
O70150	Rattus norvegicus	29%	84%
Q6P2M8	Homo sapiens	29%	84%
Q8BW96	Mus musculus	24%	75%
Q8IU85	Homo sapiens	24%	75%
Q9QYK9	Mus musculus	29%	84%
V5C2I6	Trypanosoma cruzi	33%	100%