LeishMANIAdb
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C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2H2-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6Y9_LEIMU
TriTrypDb:
LmxM.34.4600
Length:
512

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Y9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 455 459 PF00656 0.538
CLV_C14_Caspase3-7 84 88 PF00656 0.497
CLV_NRD_NRD_1 21 23 PF00675 0.500
CLV_NRD_NRD_1 426 428 PF00675 0.670
CLV_NRD_NRD_1 462 464 PF00675 0.582
CLV_PCSK_FUR_1 324 328 PF00082 0.493
CLV_PCSK_KEX2_1 127 129 PF00082 0.606
CLV_PCSK_KEX2_1 23 25 PF00082 0.447
CLV_PCSK_KEX2_1 326 328 PF00082 0.570
CLV_PCSK_KEX2_1 461 463 PF00082 0.623
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.595
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.447
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.570
CLV_PCSK_PC7_1 457 463 PF00082 0.468
CLV_PCSK_SKI1_1 110 114 PF00082 0.708
CLV_PCSK_SKI1_1 127 131 PF00082 0.452
CLV_PCSK_SKI1_1 200 204 PF00082 0.595
CLV_PCSK_SKI1_1 264 268 PF00082 0.614
CLV_PCSK_SKI1_1 462 466 PF00082 0.619
CLV_PCSK_SKI1_1 75 79 PF00082 0.575
DEG_APCC_DBOX_1 74 82 PF00400 0.589
DEG_SPOP_SBC_1 506 510 PF00917 0.683
DOC_CKS1_1 413 418 PF01111 0.483
DOC_CYCLIN_RxL_1 197 207 PF00134 0.533
DOC_MAPK_gen_1 262 271 PF00069 0.563
DOC_MAPK_MEF2A_6 262 271 PF00069 0.388
DOC_USP7_MATH_1 105 109 PF00917 0.643
DOC_USP7_MATH_1 256 260 PF00917 0.644
DOC_USP7_MATH_1 282 286 PF00917 0.651
DOC_USP7_MATH_1 293 297 PF00917 0.678
DOC_USP7_MATH_1 346 350 PF00917 0.759
DOC_USP7_MATH_1 405 409 PF00917 0.638
DOC_USP7_MATH_1 506 510 PF00917 0.703
DOC_USP7_MATH_1 86 90 PF00917 0.671
DOC_USP7_UBL2_3 372 376 PF12436 0.547
DOC_USP7_UBL2_3 394 398 PF12436 0.648
DOC_WW_Pin1_4 152 157 PF00397 0.736
DOC_WW_Pin1_4 336 341 PF00397 0.652
DOC_WW_Pin1_4 412 417 PF00397 0.672
DOC_WW_Pin1_4 500 505 PF00397 0.453
DOC_WW_Pin1_4 95 100 PF00397 0.672
LIG_14-3-3_CanoR_1 128 138 PF00244 0.505
LIG_14-3-3_CanoR_1 142 150 PF00244 0.635
LIG_14-3-3_CanoR_1 327 335 PF00244 0.570
LIG_Actin_WH2_2 70 85 PF00022 0.627
LIG_APCC_ABBA_1 71 76 PF00400 0.557
LIG_BIR_II_1 1 5 PF00653 0.634
LIG_eIF4E_1 26 32 PF01652 0.546
LIG_FHA_1 124 130 PF00498 0.533
LIG_FHA_1 230 236 PF00498 0.565
LIG_FHA_1 90 96 PF00498 0.495
LIG_FHA_2 350 356 PF00498 0.681
LIG_FHA_2 55 61 PF00498 0.522
LIG_LIR_Apic_2 154 160 PF02991 0.578
LIG_LIR_Nem_3 404 409 PF02991 0.476
LIG_LIR_Nem_3 41 46 PF02991 0.569
LIG_NRBOX 112 118 PF00104 0.630
LIG_NRBOX 16 22 PF00104 0.549
LIG_NRBOX 187 193 PF00104 0.552
LIG_SH2_CRK 43 47 PF00017 0.592
LIG_SH2_STAT3 310 313 PF00017 0.579
LIG_SH2_STAT5 19 22 PF00017 0.505
LIG_SH2_STAT5 385 388 PF00017 0.348
LIG_SH3_3 117 123 PF00018 0.595
LIG_SH3_3 153 159 PF00018 0.504
LIG_SH3_3 287 293 PF00018 0.686
LIG_SH3_3 337 343 PF00018 0.663
LIG_SH3_3 410 416 PF00018 0.688
LIG_SH3_3 417 423 PF00018 0.681
LIG_SH3_3 74 80 PF00018 0.488
LIG_TRAF2_1 252 255 PF00917 0.640
LIG_TRAF2_1 38 41 PF00917 0.560
LIG_TRAF2_1 45 48 PF00917 0.572
LIG_UBA3_1 191 200 PF00899 0.640
LIG_UBA3_1 78 83 PF00899 0.517
MOD_CDC14_SPxK_1 155 158 PF00782 0.581
MOD_CDK_SPxK_1 152 158 PF00069 0.737
MOD_CDK_SPxK_1 412 418 PF00069 0.660
MOD_CK1_1 194 200 PF00069 0.535
MOD_CK1_1 349 355 PF00069 0.636
MOD_CK1_1 401 407 PF00069 0.667
MOD_CK1_1 497 503 PF00069 0.664
MOD_CK1_1 89 95 PF00069 0.566
MOD_CK2_1 217 223 PF00069 0.542
MOD_CK2_1 293 299 PF00069 0.654
MOD_CK2_1 327 333 PF00069 0.633
MOD_CK2_1 349 355 PF00069 0.600
MOD_CK2_1 54 60 PF00069 0.605
MOD_CK2_1 95 101 PF00069 0.671
MOD_GlcNHglycan 144 147 PF01048 0.784
MOD_GlcNHglycan 177 180 PF01048 0.589
MOD_GlcNHglycan 284 287 PF01048 0.604
MOD_GlcNHglycan 336 339 PF01048 0.522
MOD_GlcNHglycan 343 346 PF01048 0.713
MOD_GlcNHglycan 403 406 PF01048 0.682
MOD_GlcNHglycan 84 87 PF01048 0.680
MOD_GlcNHglycan 88 91 PF01048 0.699
MOD_GSK3_1 101 108 PF00069 0.714
MOD_GSK3_1 397 404 PF00069 0.645
MOD_GSK3_1 418 425 PF00069 0.752
MOD_GSK3_1 494 501 PF00069 0.598
MOD_GSK3_1 82 89 PF00069 0.648
MOD_GSK3_1 91 98 PF00069 0.659
MOD_N-GLC_1 101 106 PF02516 0.752
MOD_N-GLC_1 152 157 PF02516 0.799
MOD_NEK2_1 129 134 PF00069 0.654
MOD_NEK2_1 177 182 PF00069 0.594
MOD_NEK2_1 191 196 PF00069 0.559
MOD_NEK2_1 209 214 PF00069 0.441
MOD_NEK2_1 499 504 PF00069 0.592
MOD_NEK2_2 385 390 PF00069 0.459
MOD_NEK2_2 69 74 PF00069 0.498
MOD_PIKK_1 194 200 PF00454 0.513
MOD_PIKK_1 327 333 PF00454 0.631
MOD_PIKK_1 494 500 PF00454 0.454
MOD_PKA_2 141 147 PF00069 0.749
MOD_Plk_1 101 107 PF00069 0.770
MOD_Plk_1 163 169 PF00069 0.504
MOD_Plk_1 398 404 PF00069 0.689
MOD_Plk_1 494 500 PF00069 0.412
MOD_Plk_4 177 183 PF00069 0.590
MOD_Plk_4 293 299 PF00069 0.601
MOD_ProDKin_1 152 158 PF00069 0.737
MOD_ProDKin_1 336 342 PF00069 0.655
MOD_ProDKin_1 412 418 PF00069 0.673
MOD_ProDKin_1 500 506 PF00069 0.457
MOD_ProDKin_1 95 101 PF00069 0.671
MOD_SUMO_rev_2 119 129 PF00179 0.591
MOD_SUMO_rev_2 421 429 PF00179 0.676
TRG_DiLeu_BaEn_1 125 130 PF01217 0.624
TRG_DiLeu_BaEn_4 299 305 PF01217 0.594
TRG_DiLeu_LyEn_5 125 130 PF01217 0.562
TRG_ENDOCYTIC_2 43 46 PF00928 0.588
TRG_ER_diArg_1 21 24 PF00400 0.504
TRG_ER_diArg_1 461 463 PF00400 0.575
TRG_NES_CRM1_1 380 395 PF08389 0.530
TRG_NES_CRM1_1 442 456 PF08389 0.579
TRG_Pf-PMV_PEXEL_1 110 114 PF00026 0.599
TRG_Pf-PMV_PEXEL_1 251 255 PF00026 0.575
TRG_Pf-PMV_PEXEL_1 314 318 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.576
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.359

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P962 Leptomonas seymouri 48% 91%
A0A1X0P582 Trypanosomatidae 26% 100%
A0A3S7X9X8 Leishmania donovani 89% 100%
A4HNC7 Leishmania braziliensis 69% 100%
A4IC00 Leishmania infantum 89% 100%
E9AFT7 Leishmania major 88% 100%
V5C2K9 Trypanosoma cruzi 24% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS