C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6Y9_LEIMU

TriTrypDb:

LmxM.34.4600

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	455	459	PF00656	0.538
CLV_C14_Caspase3-7	84	88	PF00656	0.497
CLV_NRD_NRD_1	21	23	PF00675	0.500
CLV_NRD_NRD_1	426	428	PF00675	0.670
CLV_NRD_NRD_1	462	464	PF00675	0.582
CLV_PCSK_FUR_1	324	328	PF00082	0.493
CLV_PCSK_KEX2_1	127	129	PF00082	0.606
CLV_PCSK_KEX2_1	23	25	PF00082	0.447
CLV_PCSK_KEX2_1	326	328	PF00082	0.570
CLV_PCSK_KEX2_1	461	463	PF00082	0.623
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.595
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.447
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.570
CLV_PCSK_PC7_1	457	463	PF00082	0.468
CLV_PCSK_SKI1_1	110	114	PF00082	0.708
CLV_PCSK_SKI1_1	127	131	PF00082	0.452
CLV_PCSK_SKI1_1	200	204	PF00082	0.595
CLV_PCSK_SKI1_1	264	268	PF00082	0.614
CLV_PCSK_SKI1_1	462	466	PF00082	0.619
CLV_PCSK_SKI1_1	75	79	PF00082	0.575
DEG_APCC_DBOX_1	74	82	PF00400	0.589
DEG_SPOP_SBC_1	506	510	PF00917	0.683
DOC_CKS1_1	413	418	PF01111	0.483
DOC_CYCLIN_RxL_1	197	207	PF00134	0.533
DOC_MAPK_gen_1	262	271	PF00069	0.563
DOC_MAPK_MEF2A_6	262	271	PF00069	0.388
DOC_USP7_MATH_1	105	109	PF00917	0.643
DOC_USP7_MATH_1	256	260	PF00917	0.644
DOC_USP7_MATH_1	282	286	PF00917	0.651
DOC_USP7_MATH_1	293	297	PF00917	0.678
DOC_USP7_MATH_1	346	350	PF00917	0.759
DOC_USP7_MATH_1	405	409	PF00917	0.638
DOC_USP7_MATH_1	506	510	PF00917	0.703
DOC_USP7_MATH_1	86	90	PF00917	0.671
DOC_USP7_UBL2_3	372	376	PF12436	0.547
DOC_USP7_UBL2_3	394	398	PF12436	0.648
DOC_WW_Pin1_4	152	157	PF00397	0.736
DOC_WW_Pin1_4	336	341	PF00397	0.652
DOC_WW_Pin1_4	412	417	PF00397	0.672
DOC_WW_Pin1_4	500	505	PF00397	0.453
DOC_WW_Pin1_4	95	100	PF00397	0.672
LIG_14-3-3_CanoR_1	128	138	PF00244	0.505
LIG_14-3-3_CanoR_1	142	150	PF00244	0.635
LIG_14-3-3_CanoR_1	327	335	PF00244	0.570
LIG_Actin_WH2_2	70	85	PF00022	0.627
LIG_APCC_ABBA_1	71	76	PF00400	0.557
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_eIF4E_1	26	32	PF01652	0.546
LIG_FHA_1	124	130	PF00498	0.533
LIG_FHA_1	230	236	PF00498	0.565
LIG_FHA_1	90	96	PF00498	0.495
LIG_FHA_2	350	356	PF00498	0.681
LIG_FHA_2	55	61	PF00498	0.522
LIG_LIR_Apic_2	154	160	PF02991	0.578
LIG_LIR_Nem_3	404	409	PF02991	0.476
LIG_LIR_Nem_3	41	46	PF02991	0.569
LIG_NRBOX	112	118	PF00104	0.630
LIG_NRBOX	16	22	PF00104	0.549
LIG_NRBOX	187	193	PF00104	0.552
LIG_SH2_CRK	43	47	PF00017	0.592
LIG_SH2_STAT3	310	313	PF00017	0.579
LIG_SH2_STAT5	19	22	PF00017	0.505
LIG_SH2_STAT5	385	388	PF00017	0.348
LIG_SH3_3	117	123	PF00018	0.595
LIG_SH3_3	153	159	PF00018	0.504
LIG_SH3_3	287	293	PF00018	0.686
LIG_SH3_3	337	343	PF00018	0.663
LIG_SH3_3	410	416	PF00018	0.688
LIG_SH3_3	417	423	PF00018	0.681
LIG_SH3_3	74	80	PF00018	0.488
LIG_TRAF2_1	252	255	PF00917	0.640
LIG_TRAF2_1	38	41	PF00917	0.560
LIG_TRAF2_1	45	48	PF00917	0.572
LIG_UBA3_1	191	200	PF00899	0.640
LIG_UBA3_1	78	83	PF00899	0.517
MOD_CDC14_SPxK_1	155	158	PF00782	0.581
MOD_CDK_SPxK_1	152	158	PF00069	0.737
MOD_CDK_SPxK_1	412	418	PF00069	0.660
MOD_CK1_1	194	200	PF00069	0.535
MOD_CK1_1	349	355	PF00069	0.636
MOD_CK1_1	401	407	PF00069	0.667
MOD_CK1_1	497	503	PF00069	0.664
MOD_CK1_1	89	95	PF00069	0.566
MOD_CK2_1	217	223	PF00069	0.542
MOD_CK2_1	293	299	PF00069	0.654
MOD_CK2_1	327	333	PF00069	0.633
MOD_CK2_1	349	355	PF00069	0.600
MOD_CK2_1	54	60	PF00069	0.605
MOD_CK2_1	95	101	PF00069	0.671
MOD_GlcNHglycan	144	147	PF01048	0.784
MOD_GlcNHglycan	177	180	PF01048	0.589
MOD_GlcNHglycan	284	287	PF01048	0.604
MOD_GlcNHglycan	336	339	PF01048	0.522
MOD_GlcNHglycan	343	346	PF01048	0.713
MOD_GlcNHglycan	403	406	PF01048	0.682
MOD_GlcNHglycan	84	87	PF01048	0.680
MOD_GlcNHglycan	88	91	PF01048	0.699
MOD_GSK3_1	101	108	PF00069	0.714
MOD_GSK3_1	397	404	PF00069	0.645
MOD_GSK3_1	418	425	PF00069	0.752
MOD_GSK3_1	494	501	PF00069	0.598
MOD_GSK3_1	82	89	PF00069	0.648
MOD_GSK3_1	91	98	PF00069	0.659
MOD_N-GLC_1	101	106	PF02516	0.752
MOD_N-GLC_1	152	157	PF02516	0.799
MOD_NEK2_1	129	134	PF00069	0.654
MOD_NEK2_1	177	182	PF00069	0.594
MOD_NEK2_1	191	196	PF00069	0.559
MOD_NEK2_1	209	214	PF00069	0.441
MOD_NEK2_1	499	504	PF00069	0.592
MOD_NEK2_2	385	390	PF00069	0.459
MOD_NEK2_2	69	74	PF00069	0.498
MOD_PIKK_1	194	200	PF00454	0.513
MOD_PIKK_1	327	333	PF00454	0.631
MOD_PIKK_1	494	500	PF00454	0.454
MOD_PKA_2	141	147	PF00069	0.749
MOD_Plk_1	101	107	PF00069	0.770
MOD_Plk_1	163	169	PF00069	0.504
MOD_Plk_1	398	404	PF00069	0.689
MOD_Plk_1	494	500	PF00069	0.412
MOD_Plk_4	177	183	PF00069	0.590
MOD_Plk_4	293	299	PF00069	0.601
MOD_ProDKin_1	152	158	PF00069	0.737
MOD_ProDKin_1	336	342	PF00069	0.655
MOD_ProDKin_1	412	418	PF00069	0.673
MOD_ProDKin_1	500	506	PF00069	0.457
MOD_ProDKin_1	95	101	PF00069	0.671
MOD_SUMO_rev_2	119	129	PF00179	0.591
MOD_SUMO_rev_2	421	429	PF00179	0.676
TRG_DiLeu_BaEn_1	125	130	PF01217	0.624
TRG_DiLeu_BaEn_4	299	305	PF01217	0.594
TRG_DiLeu_LyEn_5	125	130	PF01217	0.562
TRG_ENDOCYTIC_2	43	46	PF00928	0.588
TRG_ER_diArg_1	21	24	PF00400	0.504
TRG_ER_diArg_1	461	463	PF00400	0.575
TRG_NES_CRM1_1	380	395	PF08389	0.530
TRG_NES_CRM1_1	442	456	PF08389	0.579
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P962	Leptomonas seymouri	48%	91%
A0A1X0P582	Trypanosomatidae	26%	100%
A0A3S7X9X8	Leishmania donovani	89%	100%
A4HNC7	Leishmania braziliensis	69%	100%
A4IC00	Leishmania infantum	89%	100%
E9AFT7	Leishmania major	88%	100%
V5C2K9	Trypanosoma cruzi	24%	100%