Phosphatidylserine decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylserine decarboxylase, putative

Species:

Leishmania mexicana

UniProt:

E9B6Y8_LEIMU

TriTrypDb:

LmxM.34.4590

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9B6Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y8

Function

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Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	13
GO:0006644	phospholipid metabolic process	4	13
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006658	phosphatidylserine metabolic process	4	1
GO:0006660	phosphatidylserine catabolic process	5	1
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004609	phosphatidylserine decarboxylase activity	5	13
GO:0016829	lyase activity	2	13
GO:0016830	carbon-carbon lyase activity	3	13
GO:0016831	carboxy-lyase activity	4	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.488
CLV_NRD_NRD_1	26	28	PF00675	0.421
CLV_PCSK_KEX2_1	196	198	PF00082	0.479
CLV_PCSK_KEX2_1	26	28	PF00082	0.410
CLV_PCSK_KEX2_1	284	286	PF00082	0.557
CLV_PCSK_KEX2_1	337	339	PF00082	0.556
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.556
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.556
CLV_PCSK_SKI1_1	173	177	PF00082	0.460
CLV_PCSK_SKI1_1	180	184	PF00082	0.437

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9I0	Leptomonas seymouri	66%	100%
A0A0S4J8S6	Bodo saltans	32%	100%
A0A0S4JVQ1	Bodo saltans	32%	94%
A0A1X0P613	Trypanosomatidae	45%	93%
A0A3S7X9Y9	Leishmania donovani	93%	100%
A0A422P1A9	Trypanosoma rangeli	48%	93%
A0KSQ8	Shewanella sp. (strain ANA-3)	27%	100%
A0Q562	Francisella tularensis subsp. novicida (strain U112)	22%	100%
A0RIV4	Bacillus thuringiensis (strain Al Hakam)	25%	100%
A1JIQ6	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	27%	100%

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