Mitochondrial inner membrane protein OXA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6Y7_LEIMU

TriTrypDb:

LmxM.34.4580

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

E9B6Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1

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Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	10
GO:0140104	molecular carrier activity	1	10
GO:0140597	protein carrier chaperone	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.361
CLV_NRD_NRD_1	336	338	PF00675	0.547
CLV_PCSK_KEX2_1	183	185	PF00082	0.376
CLV_PCSK_KEX2_1	336	338	PF00082	0.547
CLV_PCSK_KEX2_1	511	513	PF00082	0.624
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.624
CLV_PCSK_SKI1_1	145	149	PF00082	0.391
CLV_PCSK_SKI1_1	184	188	PF00082	0.363
CLV_PCSK_SKI1_1	263	267	PF00082	0.420
CLV_PCSK_SKI1_1	337	341	PF00082	0.525

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFR8	Leptomonas seymouri	55%	100%
A0A0S4JMC8	Bodo saltans	34%	100%
A0A3S7XA08	Leishmania donovani	88%	100%
A0A422P166	Trypanosoma rangeli	38%	100%
A4HNC5	Leishmania braziliensis	75%	100%
A4IBZ8	Leishmania infantum	89%	100%
E9AFT5	Leishmania major	87%	100%
V5BT14	Trypanosoma cruzi	38%	100%

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