Roadblock/LC7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6Y6_LEIMU

TriTrypDb:

LmxM.34.4570

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071986	Ragulator complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

E9B6Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y6

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	12
GO:0009967	positive regulation of signal transduction	5	12
GO:0010646	regulation of cell communication	4	12
GO:0010647	positive regulation of cell communication	5	12
GO:0023051	regulation of signaling	3	12
GO:0023056	positive regulation of signaling	4	12
GO:0032006	regulation of TOR signaling	6	12
GO:0032008	positive regulation of TOR signaling	7	12
GO:0048518	positive regulation of biological process	3	12
GO:0048522	positive regulation of cellular process	4	12
GO:0048583	regulation of response to stimulus	3	12
GO:0048584	positive regulation of response to stimulus	4	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:1902531	regulation of intracellular signal transduction	5	12
GO:1902533	positive regulation of intracellular signal transduction	6	12
GO:0001101	response to acid chemical	3	1
GO:0009719	response to endogenous stimulus	2	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0042221	response to chemical	2	1
GO:0043200	response to amino acid	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071229	cellular response to acid chemical	4	1
GO:0071230	cellular response to amino acid stimulus	5	1
GO:0071310	cellular response to organic substance	4	1
GO:0071417	cellular response to organonitrogen compound	4	1
GO:0071495	cellular response to endogenous stimulus	3	1
GO:1901698	response to nitrogen compound	3	1
GO:1901699	cellular response to nitrogen compound	4	1
GO:1901700	response to oxygen-containing compound	3	1
GO:1901701	cellular response to oxygen-containing compound	4	1

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	12
GO:0030234	enzyme regulator activity	2	12
GO:0030695	GTPase regulator activity	4	12
GO:0060090	molecular adaptor activity	1	12
GO:0060589	nucleoside-triphosphatase regulator activity	3	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12
GO:0140678	molecular function inhibitor activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.378
DEG_Nend_Nbox_1	1	3	PF02207	0.388
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.489
DOC_MAPK_gen_1	130	138	PF00069	0.482
DOC_MAPK_gen_1	90	97	PF00069	0.345
DOC_USP7_MATH_1	101	105	PF00917	0.449
DOC_USP7_MATH_1	9	13	PF00917	0.371
LIG_Actin_WH2_2	105	122	PF00022	0.363
LIG_APCC_ABBA_1	84	89	PF00400	0.482
LIG_BIR_III_4	26	30	PF00653	0.500
LIG_Clathr_ClatBox_1	105	109	PF01394	0.462
LIG_FHA_1	119	125	PF00498	0.346
LIG_FHA_1	75	81	PF00498	0.430
LIG_FHA_1	98	104	PF00498	0.465
LIG_LIR_Gen_1	113	124	PF02991	0.436
LIG_LIR_Nem_3	113	119	PF02991	0.452
LIG_LIR_Nem_3	44	50	PF02991	0.449
LIG_NRBOX	127	133	PF00104	0.490
LIG_NRBOX	19	25	PF00104	0.435
LIG_PCNA_yPIPBox_3	118	132	PF02747	0.435
LIG_SH2_CRK	47	51	PF00017	0.431
LIG_SH2_SRC	47	50	PF00017	0.411
LIG_SH3_3	82	88	PF00018	0.475
LIG_SUMO_SIM_par_1	20	26	PF11976	0.311
LIG_SUMO_SIM_par_1	99	107	PF11976	0.445
LIG_UBA3_1	83	91	PF00899	0.376
MOD_CK1_1	104	110	PF00069	0.468
MOD_CK2_1	108	114	PF00069	0.450
MOD_GlcNHglycan	26	30	PF01048	0.363
MOD_GlcNHglycan	38	41	PF01048	0.357
MOD_GSK3_1	104	111	PF00069	0.412
MOD_GSK3_1	93	100	PF00069	0.408
MOD_NEK2_1	25	30	PF00069	0.381
MOD_NEK2_1	36	41	PF00069	0.363
MOD_Plk_1	108	114	PF00069	0.445
MOD_Plk_2-3	76	82	PF00069	0.448
MOD_Plk_4	101	107	PF00069	0.439
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.469
TRG_ENDOCYTIC_2	47	50	PF00928	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P966	Leptomonas seymouri	78%	100%
A0A0S4JTI2	Bodo saltans	39%	100%
A0A1X0P543	Trypanosomatidae	45%	100%
A0A3Q8IIR8	Leishmania donovani	95%	100%
A0A422P194	Trypanosoma rangeli	43%	100%
A4HNC4	Leishmania braziliensis	91%	100%
A4IBZ7	Leishmania infantum	95%	100%
C9ZYK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AFT4	Leishmania major	95%	100%
V5BCJ6	Trypanosoma cruzi	46%	80%