PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6Y5_LEIMU

TriTrypDb:

LmxM.34.4560

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	44	50	PF00089	0.615
CLV_NRD_NRD_1	160	162	PF00675	0.598
CLV_NRD_NRD_1	271	273	PF00675	0.502
CLV_PCSK_KEX2_1	160	162	PF00082	0.598
CLV_PCSK_KEX2_1	271	273	PF00082	0.530
CLV_PCSK_KEX2_1	447	449	PF00082	0.606
CLV_PCSK_KEX2_1	9	11	PF00082	0.420
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.606
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.420
CLV_PCSK_PC7_1	156	162	PF00082	0.596
CLV_PCSK_PC7_1	267	273	PF00082	0.495
CLV_PCSK_SKI1_1	156	160	PF00082	0.647
CLV_PCSK_SKI1_1	3	7	PF00082	0.554
CLV_PCSK_SKI1_1	375	379	PF00082	0.295
CLV_PCSK_SKI1_1	425	429	PF00082	0.521
CLV_PCSK_SKI1_1	50	54	PF00082	0.669
CLV_PCSK_SKI1_1	9	13	PF00082	0.414
DEG_SCF_FBW7_1	129	136	PF00400	0.607
DEG_SPOP_SBC_1	211	215	PF00917	0.670
DOC_ANK_TNKS_1	167	174	PF00023	0.514
DOC_CDC14_PxL_1	38	46	PF14671	0.566
DOC_CKS1_1	149	154	PF01111	0.654
DOC_CKS1_1	203	208	PF01111	0.597
DOC_CKS1_1	240	245	PF01111	0.606
DOC_MAPK_gen_1	3	13	PF00069	0.471
DOC_MAPK_gen_1	407	414	PF00069	0.491
DOC_MAPK_gen_1	47	56	PF00069	0.622
DOC_PP1_RVXF_1	7	14	PF00149	0.428
DOC_PP2B_LxvP_1	303	306	PF13499	0.600
DOC_PP4_FxxP_1	19	22	PF00568	0.558
DOC_PP4_FxxP_1	400	403	PF00568	0.500
DOC_USP7_MATH_1	152	156	PF00917	0.647
DOC_USP7_MATH_1	211	215	PF00917	0.670
DOC_USP7_MATH_1	219	223	PF00917	0.598
DOC_USP7_MATH_1	230	234	PF00917	0.562
DOC_USP7_MATH_1	285	289	PF00917	0.616
DOC_USP7_MATH_1	313	317	PF00917	0.435
DOC_USP7_MATH_1	408	412	PF00917	0.537
DOC_USP7_MATH_1	423	427	PF00917	0.491
DOC_USP7_MATH_1	46	50	PF00917	0.514
DOC_USP7_MATH_1	99	103	PF00917	0.623
DOC_WW_Pin1_4	121	126	PF00397	0.688
DOC_WW_Pin1_4	129	134	PF00397	0.590
DOC_WW_Pin1_4	148	153	PF00397	0.653
DOC_WW_Pin1_4	182	187	PF00397	0.658
DOC_WW_Pin1_4	202	207	PF00397	0.486
DOC_WW_Pin1_4	239	244	PF00397	0.608
DOC_WW_Pin1_4	59	64	PF00397	0.565
LIG_14-3-3_CanoR_1	10	14	PF00244	0.403
LIG_14-3-3_CanoR_1	123	129	PF00244	0.625
LIG_14-3-3_CanoR_1	235	240	PF00244	0.665
LIG_14-3-3_CanoR_1	409	415	PF00244	0.414
LIG_14-3-3_CanoR_1	425	430	PF00244	0.491
LIG_14-3-3_CanoR_1	50	55	PF00244	0.630
LIG_Actin_WH2_2	352	367	PF00022	0.491
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_CtBP_PxDLS_1	243	247	PF00389	0.573
LIG_eIF4E_1	18	24	PF01652	0.518
LIG_EVH1_1	239	243	PF00568	0.551
LIG_FHA_1	133	139	PF00498	0.738
LIG_FHA_1	298	304	PF00498	0.682
LIG_FHA_1	393	399	PF00498	0.467
LIG_FHA_1	51	57	PF00498	0.641
LIG_FHA_1	60	66	PF00498	0.561
LIG_FHA_1	84	90	PF00498	0.609
LIG_FHA_2	137	143	PF00498	0.582
LIG_FHA_2	149	155	PF00498	0.797
LIG_FHA_2	255	261	PF00498	0.495
LIG_FHA_2	430	436	PF00498	0.514
LIG_LIR_Apic_2	146	152	PF02991	0.602
LIG_LIR_Apic_2	17	22	PF02991	0.540
LIG_LIR_Apic_2	399	403	PF02991	0.456
LIG_LIR_Gen_1	316	325	PF02991	0.482
LIG_LIR_Gen_1	94	103	PF02991	0.489
LIG_LIR_Nem_3	12	16	PF02991	0.465
LIG_LIR_Nem_3	316	320	PF02991	0.477
LIG_LIR_Nem_3	354	359	PF02991	0.491
LIG_LIR_Nem_3	94	100	PF02991	0.490
LIG_MYND_1	42	46	PF01753	0.556
LIG_Rb_LxCxE_1	346	363	PF01857	0.491
LIG_SH2_CRK	149	153	PF00017	0.821
LIG_SH2_CRK	97	101	PF00017	0.502
LIG_SH2_STAP1	224	228	PF00017	0.617
LIG_SH2_STAP1	357	361	PF00017	0.491
LIG_SH2_STAT3	81	84	PF00017	0.641
LIG_SH2_STAT5	18	21	PF00017	0.487
LIG_SH2_STAT5	420	423	PF00017	0.560
LIG_SH3_3	123	129	PF00018	0.813
LIG_SH3_3	203	209	PF00018	0.598
LIG_SH3_3	237	243	PF00018	0.609
LIG_SH3_3	36	42	PF00018	0.686
LIG_SH3_3	45	51	PF00018	0.716
LIG_SH3_3	90	96	PF00018	0.638
LIG_SUMO_SIM_par_1	176	183	PF11976	0.567
LIG_SUMO_SIM_par_1	298	304	PF11976	0.473
LIG_SUMO_SIM_par_1	85	91	PF11976	0.505
LIG_WRC_WIRS_1	109	114	PF05994	0.505
MOD_CDK_SPK_2	202	207	PF00069	0.590
MOD_CDK_SPxxK_3	133	140	PF00069	0.576
MOD_CK1_1	136	142	PF00069	0.583
MOD_CK1_1	202	208	PF00069	0.638
MOD_CK1_1	222	228	PF00069	0.638
MOD_CK1_1	233	239	PF00069	0.591
MOD_CK1_1	261	267	PF00069	0.525
MOD_CK1_1	286	292	PF00069	0.542
MOD_CK1_1	88	94	PF00069	0.535
MOD_CK2_1	136	142	PF00069	0.648
MOD_CK2_1	148	154	PF00069	0.660
MOD_CK2_1	177	183	PF00069	0.643
MOD_CK2_1	446	452	PF00069	0.672
MOD_GlcNHglycan	19	22	PF01048	0.645
MOD_GlcNHglycan	192	195	PF01048	0.631
MOD_GlcNHglycan	214	217	PF01048	0.632
MOD_GlcNHglycan	259	263	PF01048	0.496
MOD_GlcNHglycan	285	288	PF01048	0.620
MOD_GlcNHglycan	425	428	PF01048	0.464
MOD_GlcNHglycan	438	442	PF01048	0.496
MOD_GlcNHglycan	90	93	PF01048	0.576
MOD_GSK3_1	117	124	PF00069	0.660
MOD_GSK3_1	129	136	PF00069	0.565
MOD_GSK3_1	141	148	PF00069	0.598
MOD_GSK3_1	152	159	PF00069	0.628
MOD_GSK3_1	182	189	PF00069	0.742
MOD_GSK3_1	219	226	PF00069	0.662
MOD_GSK3_1	235	242	PF00069	0.516
MOD_GSK3_1	254	261	PF00069	0.474
MOD_GSK3_1	281	288	PF00069	0.607
MOD_GSK3_1	29	36	PF00069	0.610
MOD_GSK3_1	297	304	PF00069	0.516
MOD_GSK3_1	392	399	PF00069	0.456
MOD_GSK3_1	423	430	PF00069	0.588
MOD_GSK3_1	46	53	PF00069	0.593
MOD_N-GLC_1	307	312	PF02516	0.567
MOD_NEK2_1	199	204	PF00069	0.536
MOD_NEK2_1	210	215	PF00069	0.672
MOD_NEK2_1	296	301	PF00069	0.469
MOD_NEK2_1	446	451	PF00069	0.772
MOD_NEK2_2	219	224	PF00069	0.563
MOD_NEK2_2	230	235	PF00069	0.511
MOD_NEK2_2	396	401	PF00069	0.479
MOD_OFUCOSY	391	396	PF10250	0.256
MOD_PIKK_1	117	123	PF00454	0.582
MOD_PIKK_1	186	192	PF00454	0.461
MOD_PIKK_1	199	205	PF00454	0.553
MOD_PIKK_1	24	30	PF00454	0.580
MOD_PIKK_1	290	296	PF00454	0.523
MOD_PKA_1	9	15	PF00069	0.413
MOD_PKA_2	219	225	PF00069	0.612
MOD_PKA_2	408	414	PF00069	0.498
MOD_PKA_2	46	52	PF00069	0.608
MOD_PKA_2	9	15	PF00069	0.413
MOD_Plk_1	145	151	PF00069	0.578
MOD_Plk_1	297	303	PF00069	0.469
MOD_Plk_1	33	39	PF00069	0.652
MOD_Plk_2-3	145	151	PF00069	0.578
MOD_Plk_4	14	20	PF00069	0.429
MOD_Plk_4	177	183	PF00069	0.689
MOD_Plk_4	242	248	PF00069	0.659
MOD_ProDKin_1	121	127	PF00069	0.689
MOD_ProDKin_1	129	135	PF00069	0.590
MOD_ProDKin_1	148	154	PF00069	0.654
MOD_ProDKin_1	182	188	PF00069	0.647
MOD_ProDKin_1	202	208	PF00069	0.488
MOD_ProDKin_1	239	245	PF00069	0.610
MOD_ProDKin_1	59	65	PF00069	0.563
TRG_DiLeu_BaEn_1	34	39	PF01217	0.603
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.578
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.491
TRG_ENDOCYTIC_2	97	100	PF00928	0.503
TRG_ER_diArg_1	271	273	PF00400	0.619
TRG_ER_diArg_1	373	376	PF00400	0.491
TRG_ER_diArg_1	44	47	PF00400	0.622
TRG_NLS_MonoExtC_3	446	452	PF00514	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I986	Leptomonas seymouri	31%	93%
A0A3S7X9X5	Leishmania donovani	83%	100%
A4IBZ6	Leishmania infantum	83%	100%
E9AFT3	Leishmania major	79%	100%