FPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised conserved protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6Y3_LEIMU

TriTrypDb:

LmxM.34.4540

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005765	lysosomal membrane	7	1
GO:0005774	vacuolar membrane	5	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0036020	endolysosome membrane	6	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098852	lytic vacuole membrane	6	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0007041	lysosomal transport	5	1
GO:0008333	endosome to lysosome transport	5	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010506	regulation of autophagy	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016241	regulation of macroautophagy	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0033043	regulation of organelle organization	5	1
GO:0043244	regulation of protein-containing complex disassembly	5	1
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0065007	biological regulation	1	1
GO:1901096	regulation of autophagosome maturation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.593
CLV_C14_Caspase3-7	587	591	PF00656	0.624
CLV_NRD_NRD_1	41	43	PF00675	0.528
CLV_NRD_NRD_1	736	738	PF00675	0.678
CLV_NRD_NRD_1	844	846	PF00675	0.641
CLV_PCSK_KEX2_1	736	738	PF00082	0.678
CLV_PCSK_KEX2_1	843	845	PF00082	0.652
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.652
CLV_PCSK_SKI1_1	222	226	PF00082	0.519
CLV_PCSK_SKI1_1	287	291	PF00082	0.542
CLV_PCSK_SKI1_1	324	328	PF00082	0.449
CLV_PCSK_SKI1_1	434	438	PF00082	0.632
CLV_PCSK_SKI1_1	5	9	PF00082	0.722
CLV_PCSK_SKI1_1	55	59	PF00082	0.429
CLV_PCSK_SKI1_1	568	572	PF00082	0.625
CLV_PCSK_SKI1_1	736	740	PF00082	0.572
CLV_PCSK_SKI1_1	817	821	PF00082	0.624
CLV_PCSK_SKI1_1	844	848	PF00082	0.630
CLV_PCSK_SKI1_1	86	90	PF00082	0.429
CLV_PCSK_SKI1_1	866	870	PF00082	0.665
CLV_PCSK_SKI1_1	919	923	PF00082	0.587
DEG_APCC_DBOX_1	221	229	PF00400	0.511
DEG_APCC_DBOX_1	843	851	PF00400	0.643
DEG_MDM2_SWIB_1	377	384	PF02201	0.518
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_ODPH_VHL_1	796	807	PF01847	0.742
DOC_CKS1_1	466	471	PF01111	0.416
DOC_CKS1_1	799	804	PF01111	0.672
DOC_CYCLIN_RxL_1	148	158	PF00134	0.375
DOC_CYCLIN_RxL_1	564	572	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	659	665	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	822	828	PF00134	0.709
DOC_MAPK_gen_1	654	661	PF00069	0.732
DOC_MAPK_gen_1	814	824	PF00069	0.507
DOC_MAPK_gen_1	843	852	PF00069	0.633
DOC_MAPK_MEF2A_6	253	262	PF00069	0.584
DOC_MAPK_MEF2A_6	55	64	PF00069	0.375
DOC_MAPK_MEF2A_6	654	661	PF00069	0.749
DOC_MAPK_MEF2A_6	817	826	PF00069	0.634
DOC_MAPK_MEF2A_6	845	854	PF00069	0.655
DOC_MAPK_NFAT4_5	654	662	PF00069	0.747
DOC_MAPK_NFAT4_5	817	825	PF00069	0.630
DOC_PIKK_1	298	306	PF02985	0.494
DOC_PP1_RVXF_1	322	328	PF00149	0.500
DOC_PP1_RVXF_1	597	603	PF00149	0.666
DOC_PP1_RVXF_1	815	822	PF00149	0.683
DOC_PP2B_LxvP_1	642	645	PF13499	0.485
DOC_PP2B_LxvP_1	795	798	PF13499	0.581
DOC_PP2B_LxvP_1	822	825	PF13499	0.713
DOC_PP4_FxxP_1	398	401	PF00568	0.625
DOC_SPAK_OSR1_1	410	414	PF12202	0.573
DOC_USP7_MATH_1	252	256	PF00917	0.552
DOC_USP7_MATH_1	344	348	PF00917	0.633
DOC_USP7_MATH_1	364	368	PF00917	0.588
DOC_USP7_MATH_1	401	405	PF00917	0.618
DOC_USP7_MATH_1	444	448	PF00917	0.700
DOC_USP7_MATH_1	507	511	PF00917	0.651
DOC_USP7_UBL2_3	491	495	PF12436	0.667
DOC_USP7_UBL2_3	650	654	PF12436	0.467
DOC_WW_Pin1_4	155	160	PF00397	0.429
DOC_WW_Pin1_4	306	311	PF00397	0.505
DOC_WW_Pin1_4	446	451	PF00397	0.660
DOC_WW_Pin1_4	465	470	PF00397	0.411
DOC_WW_Pin1_4	501	506	PF00397	0.643
DOC_WW_Pin1_4	714	719	PF00397	0.657
DOC_WW_Pin1_4	756	761	PF00397	0.671
DOC_WW_Pin1_4	798	803	PF00397	0.673
LIG_14-3-3_CanoR_1	114	119	PF00244	0.266
LIG_14-3-3_CanoR_1	21	29	PF00244	0.523
LIG_14-3-3_CanoR_1	253	258	PF00244	0.633
LIG_14-3-3_CanoR_1	287	292	PF00244	0.531
LIG_14-3-3_CanoR_1	410	414	PF00244	0.573
LIG_14-3-3_CanoR_1	455	461	PF00244	0.678
LIG_14-3-3_CanoR_1	530	538	PF00244	0.568
LIG_14-3-3_CanoR_1	599	603	PF00244	0.669
LIG_14-3-3_CanoR_1	716	726	PF00244	0.646
LIG_14-3-3_CanoR_1	831	838	PF00244	0.712
LIG_14-3-3_CanoR_1	845	851	PF00244	0.500
LIG_14-3-3_CanoR_1	907	912	PF00244	0.634
LIG_Actin_WH2_2	140	158	PF00022	0.413
LIG_APCC_ABBA_1	135	140	PF00400	0.406
LIG_APCC_ABBA_1	162	167	PF00400	0.411
LIG_APCC_ABBAyCdc20_2	817	823	PF00400	0.698
LIG_BRCT_BRCA1_1	764	768	PF00533	0.791
LIG_BRCT_BRCA1_1	869	873	PF00533	0.543
LIG_BRCT_BRCA1_1	909	913	PF00533	0.625
LIG_Clathr_ClatBox_1	61	65	PF01394	0.429
LIG_Clathr_ClatBox_1	819	823	PF01394	0.623
LIG_CSL_BTD_1	678	681	PF09270	0.682
LIG_DLG_GKlike_1	114	121	PF00625	0.411
LIG_DLG_GKlike_1	907	915	PF00625	0.622
LIG_EH1_1	410	418	PF00400	0.651
LIG_eIF4E_1	729	735	PF01652	0.679
LIG_EVH1_2	452	456	PF00568	0.713
LIG_FHA_1	104	110	PF00498	0.265
LIG_FHA_1	113	119	PF00498	0.375
LIG_FHA_1	159	165	PF00498	0.399
LIG_FHA_1	284	290	PF00498	0.580
LIG_FHA_1	320	326	PF00498	0.404
LIG_FHA_1	471	477	PF00498	0.634
LIG_FHA_1	504	510	PF00498	0.518
LIG_FHA_1	533	539	PF00498	0.559
LIG_FHA_1	56	62	PF00498	0.369
LIG_FHA_1	772	778	PF00498	0.670
LIG_FHA_1	87	93	PF00498	0.419
LIG_FHA_2	22	28	PF00498	0.578
LIG_FHA_2	331	337	PF00498	0.333
LIG_FHA_2	419	425	PF00498	0.684
LIG_FHA_2	893	899	PF00498	0.690
LIG_LIR_Apic_2	396	401	PF02991	0.508
LIG_LIR_Apic_2	684	690	PF02991	0.471
LIG_LIR_Apic_2	870	874	PF02991	0.654
LIG_LIR_Gen_1	139	150	PF02991	0.419
LIG_LIR_Gen_1	241	248	PF02991	0.711
LIG_LIR_Gen_1	408	418	PF02991	0.381
LIG_LIR_Gen_1	506	516	PF02991	0.444
LIG_LIR_Gen_1	554	563	PF02991	0.609
LIG_LIR_Gen_1	6	16	PF02991	0.575
LIG_LIR_Gen_1	656	666	PF02991	0.633
LIG_LIR_Gen_1	697	708	PF02991	0.633
LIG_LIR_Gen_1	70	80	PF02991	0.366
LIG_LIR_Gen_1	818	829	PF02991	0.688
LIG_LIR_Nem_3	139	145	PF02991	0.419
LIG_LIR_Nem_3	219	224	PF02991	0.451
LIG_LIR_Nem_3	241	245	PF02991	0.693
LIG_LIR_Nem_3	408	414	PF02991	0.395
LIG_LIR_Nem_3	506	511	PF02991	0.463
LIG_LIR_Nem_3	554	558	PF02991	0.623
LIG_LIR_Nem_3	6	11	PF02991	0.712
LIG_LIR_Nem_3	601	605	PF02991	0.653
LIG_LIR_Nem_3	656	661	PF02991	0.667
LIG_LIR_Nem_3	677	682	PF02991	0.553
LIG_LIR_Nem_3	697	703	PF02991	0.637
LIG_LIR_Nem_3	70	75	PF02991	0.368
LIG_LIR_Nem_3	818	824	PF02991	0.684
LIG_LIR_Nem_3	851	857	PF02991	0.637
LIG_LYPXL_yS_3	357	360	PF13949	0.481
LIG_MAD2	866	874	PF02301	0.637
LIG_NRBOX	537	543	PF00104	0.590
LIG_NRBOX	729	735	PF00104	0.587
LIG_Pex14_1	555	559	PF04695	0.605
LIG_Pex14_1	696	700	PF04695	0.735
LIG_Pex14_2	377	381	PF04695	0.506
LIG_Pex14_2	660	664	PF04695	0.744
LIG_REV1ctd_RIR_1	395	400	PF16727	0.413
LIG_SH2_CRK	520	524	PF00017	0.641
LIG_SH2_CRK	577	581	PF00017	0.513
LIG_SH2_CRK	687	691	PF00017	0.701
LIG_SH2_CRK	700	704	PF00017	0.612
LIG_SH2_CRK	871	875	PF00017	0.653
LIG_SH2_GRB2like	302	305	PF00017	0.433
LIG_SH2_SRC	368	371	PF00017	0.524
LIG_SH2_STAP1	577	581	PF00017	0.618
LIG_SH2_STAT3	380	383	PF00017	0.520
LIG_SH2_STAT5	120	123	PF00017	0.380
LIG_SH2_STAT5	146	149	PF00017	0.375
LIG_SH2_STAT5	302	305	PF00017	0.433
LIG_SH2_STAT5	465	468	PF00017	0.464
LIG_SH2_STAT5	520	523	PF00017	0.580
LIG_SH2_STAT5	525	528	PF00017	0.595
LIG_SH2_STAT5	559	562	PF00017	0.660
LIG_SH2_STAT5	658	661	PF00017	0.678
LIG_SH2_STAT5	729	732	PF00017	0.542
LIG_SH3_2	450	455	PF14604	0.676
LIG_SH3_2	861	866	PF14604	0.713
LIG_SH3_3	322	328	PF00018	0.587
LIG_SH3_3	447	453	PF00018	0.706
LIG_SH3_3	616	622	PF00018	0.672
LIG_SH3_3	659	665	PF00018	0.617
LIG_SH3_3	796	802	PF00018	0.665
LIG_SH3_3	858	864	PF00018	0.721
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.356
LIG_SUMO_SIM_anti_2	537	543	PF11976	0.543
LIG_SUMO_SIM_par_1	129	134	PF11976	0.406
LIG_SUMO_SIM_par_1	664	671	PF11976	0.663
LIG_SUMO_SIM_par_1	823	830	PF11976	0.657
LIG_SxIP_EBH_1	478	489	PF03271	0.595
LIG_TRAF2_1	607	610	PF00917	0.629
LIG_TRFH_1	397	401	PF08558	0.527
LIG_TYR_ITIM	698	703	PF00017	0.636
LIG_UBA3_1	623	628	PF00899	0.703
LIG_WRC_WIRS_1	146	151	PF05994	0.375
LIG_WRC_WIRS_1	248	253	PF05994	0.474
LIG_WRC_WIRS_1	262	267	PF05994	0.451
MOD_CDK_SPxxK_3	448	455	PF00069	0.682
MOD_CDK_SPxxK_3	465	472	PF00069	0.410
MOD_CK1_1	101	107	PF00069	0.429
MOD_CK1_1	113	119	PF00069	0.278
MOD_CK1_1	241	247	PF00069	0.660
MOD_CK1_1	256	262	PF00069	0.603
MOD_CK1_1	264	270	PF00069	0.750
MOD_CK1_1	348	354	PF00069	0.661
MOD_CK1_1	405	411	PF00069	0.659
MOD_CK1_1	446	452	PF00069	0.693
MOD_CK1_1	499	505	PF00069	0.686
MOD_CK1_1	532	538	PF00069	0.564
MOD_CK1_1	598	604	PF00069	0.681
MOD_CK1_1	714	720	PF00069	0.648
MOD_CK1_1	771	777	PF00069	0.491
MOD_CK2_1	21	27	PF00069	0.576
MOD_CK2_1	717	723	PF00069	0.650
MOD_CK2_1	824	830	PF00069	0.708
MOD_CK2_1	892	898	PF00069	0.660
MOD_GlcNHglycan	209	212	PF01048	0.495
MOD_GlcNHglycan	339	342	PF01048	0.576
MOD_GlcNHglycan	36	39	PF01048	0.472
MOD_GlcNHglycan	364	367	PF01048	0.493
MOD_GlcNHglycan	405	408	PF01048	0.705
MOD_GlcNHglycan	446	449	PF01048	0.530
MOD_GlcNHglycan	546	549	PF01048	0.688
MOD_GlcNHglycan	676	679	PF01048	0.723
MOD_GlcNHglycan	919	922	PF01048	0.626
MOD_GSK3_1	110	117	PF00069	0.375
MOD_GSK3_1	141	148	PF00069	0.361
MOD_GSK3_1	252	259	PF00069	0.712
MOD_GSK3_1	283	290	PF00069	0.572
MOD_GSK3_1	29	36	PF00069	0.566
MOD_GSK3_1	309	316	PF00069	0.372
MOD_GSK3_1	344	351	PF00069	0.602
MOD_GSK3_1	358	365	PF00069	0.546
MOD_GSK3_1	379	386	PF00069	0.613
MOD_GSK3_1	401	408	PF00069	0.582
MOD_GSK3_1	442	449	PF00069	0.756
MOD_GSK3_1	499	506	PF00069	0.535
MOD_GSK3_1	532	539	PF00069	0.576
MOD_GSK3_1	666	673	PF00069	0.658
MOD_GSK3_1	756	763	PF00069	0.744
MOD_GSK3_1	768	775	PF00069	0.573
MOD_GSK3_1	782	789	PF00069	0.595
MOD_LATS_1	53	59	PF00433	0.411
MOD_N-GLC_1	110	115	PF02516	0.375
MOD_N-GLC_1	771	776	PF02516	0.665
MOD_N-GLC_2	902	904	PF02516	0.617
MOD_NEK2_1	112	117	PF00069	0.230
MOD_NEK2_1	145	150	PF00069	0.384
MOD_NEK2_1	189	194	PF00069	0.340
MOD_NEK2_1	204	209	PF00069	0.413
MOD_NEK2_1	33	38	PF00069	0.468
MOD_NEK2_1	345	350	PF00069	0.567
MOD_NEK2_1	379	384	PF00069	0.515
MOD_NEK2_1	402	407	PF00069	0.588
MOD_NEK2_1	418	423	PF00069	0.635
MOD_NEK2_1	437	442	PF00069	0.462
MOD_NEK2_1	526	531	PF00069	0.547
MOD_NEK2_1	674	679	PF00069	0.714
MOD_NEK2_1	683	688	PF00069	0.646
MOD_NEK2_1	703	708	PF00069	0.623
MOD_NEK2_1	711	716	PF00069	0.586
MOD_NEK2_1	750	755	PF00069	0.606
MOD_NEK2_1	766	771	PF00069	0.643
MOD_PIKK_1	313	319	PF00454	0.428
MOD_PIKK_1	379	385	PF00454	0.592
MOD_PIKK_1	518	524	PF00454	0.561
MOD_PIKK_1	740	746	PF00454	0.459
MOD_PIKK_1	760	766	PF00454	0.695
MOD_PIKK_1	788	794	PF00454	0.771
MOD_PIKK_1	831	837	PF00454	0.720
MOD_PKA_2	113	119	PF00069	0.356
MOD_PKA_2	252	258	PF00069	0.743
MOD_PKA_2	330	336	PF00069	0.398
MOD_PKA_2	409	415	PF00069	0.578
MOD_PKA_2	41	47	PF00069	0.385
MOD_PKA_2	529	535	PF00069	0.587
MOD_PKA_2	598	604	PF00069	0.733
MOD_PKB_1	905	913	PF00069	0.629
MOD_Plk_1	29	35	PF00069	0.506
MOD_Plk_1	345	351	PF00069	0.454
MOD_Plk_1	418	424	PF00069	0.660
MOD_Plk_1	47	53	PF00069	0.473
MOD_Plk_1	670	676	PF00069	0.660
MOD_Plk_1	775	781	PF00069	0.764
MOD_Plk_2-3	12	18	PF00069	0.529
MOD_Plk_4	103	109	PF00069	0.396
MOD_Plk_4	114	120	PF00069	0.283
MOD_Plk_4	141	147	PF00069	0.384
MOD_Plk_4	238	244	PF00069	0.598
MOD_Plk_4	29	35	PF00069	0.507
MOD_Plk_4	412	418	PF00069	0.639
MOD_Plk_4	507	513	PF00069	0.403
MOD_Plk_4	536	542	PF00069	0.508
MOD_Plk_4	576	582	PF00069	0.627
MOD_Plk_4	590	596	PF00069	0.594
MOD_Plk_4	670	676	PF00069	0.660
MOD_ProDKin_1	155	161	PF00069	0.429
MOD_ProDKin_1	306	312	PF00069	0.518
MOD_ProDKin_1	446	452	PF00069	0.659
MOD_ProDKin_1	465	471	PF00069	0.505
MOD_ProDKin_1	501	507	PF00069	0.637
MOD_ProDKin_1	714	720	PF00069	0.648
MOD_ProDKin_1	756	762	PF00069	0.675
MOD_ProDKin_1	798	804	PF00069	0.669
MOD_SUMO_rev_2	35	44	PF00179	0.520
TRG_DiLeu_BaEn_1	561	566	PF01217	0.569
TRG_DiLeu_BaEn_1	815	820	PF01217	0.694
TRG_DiLeu_BaEn_4	609	615	PF01217	0.487
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.429
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.637
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.739
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.492
TRG_DiLeu_BaLyEn_6	791	796	PF01217	0.572
TRG_ENDOCYTIC_2	146	149	PF00928	0.375
TRG_ENDOCYTIC_2	357	360	PF00928	0.481
TRG_ENDOCYTIC_2	520	523	PF00928	0.580
TRG_ENDOCYTIC_2	559	562	PF00928	0.660
TRG_ENDOCYTIC_2	577	580	PF00928	0.509
TRG_ENDOCYTIC_2	620	623	PF00928	0.641
TRG_ENDOCYTIC_2	658	661	PF00928	0.678
TRG_ENDOCYTIC_2	700	703	PF00928	0.569
TRG_ENDOCYTIC_2	729	732	PF00928	0.569
TRG_ER_diArg_1	439	442	PF00400	0.649
TRG_ER_diArg_1	735	737	PF00400	0.681
TRG_ER_diArg_1	844	846	PF00400	0.641
TRG_NES_CRM1_1	52	65	PF08389	0.399
TRG_NES_CRM1_1	561	572	PF08389	0.642
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	756	761	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F5	Leptomonas seymouri	53%	95%
A0A0S4JRP3	Bodo saltans	26%	100%
A0A3S7X9Y3	Leishmania donovani	89%	100%
A4HNC1	Leishmania braziliensis	74%	100%
A4IBZ4	Leishmania infantum	89%	86%
E9AFT1	Leishmania major	88%	100%