LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6Y2_LEIMU
TriTrypDb:
LmxM.34.4530
Length:
716

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6Y2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6Y2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 3 7 PF00656 0.594
CLV_MEL_PAP_1 402 408 PF00089 0.440
CLV_NRD_NRD_1 307 309 PF00675 0.616
CLV_NRD_NRD_1 542 544 PF00675 0.587
CLV_NRD_NRD_1 556 558 PF00675 0.678
CLV_NRD_NRD_1 76 78 PF00675 0.516
CLV_PCSK_KEX2_1 306 308 PF00082 0.515
CLV_PCSK_KEX2_1 419 421 PF00082 0.612
CLV_PCSK_KEX2_1 542 544 PF00082 0.573
CLV_PCSK_KEX2_1 76 78 PF00082 0.465
CLV_PCSK_PC1ET2_1 419 421 PF00082 0.520
CLV_PCSK_SKI1_1 183 187 PF00082 0.402
CLV_PCSK_SKI1_1 401 405 PF00082 0.454
CLV_PCSK_SKI1_1 604 608 PF00082 0.461
CLV_PCSK_SKI1_1 676 680 PF00082 0.541
CLV_PCSK_SKI1_1 82 86 PF00082 0.426
DEG_APCC_DBOX_1 307 315 PF00400 0.455
DEG_APCC_DBOX_1 390 398 PF00400 0.430
DEG_SPOP_SBC_1 374 378 PF00917 0.430
DOC_CYCLIN_RxL_1 600 610 PF00134 0.469
DOC_CYCLIN_yCln2_LP_2 88 94 PF00134 0.484
DOC_MAPK_gen_1 306 314 PF00069 0.474
DOC_MAPK_gen_1 689 698 PF00069 0.515
DOC_MAPK_MEF2A_6 156 164 PF00069 0.266
DOC_MAPK_MEF2A_6 307 316 PF00069 0.415
DOC_MAPK_MEF2A_6 689 698 PF00069 0.483
DOC_MAPK_NFAT4_5 691 699 PF00069 0.475
DOC_MAPK_RevD_3 404 420 PF00069 0.433
DOC_PP1_RVXF_1 84 90 PF00149 0.424
DOC_PP4_FxxP_1 226 229 PF00568 0.361
DOC_USP7_MATH_1 112 116 PF00917 0.729
DOC_USP7_MATH_1 218 222 PF00917 0.448
DOC_USP7_MATH_1 251 255 PF00917 0.454
DOC_USP7_MATH_1 301 305 PF00917 0.740
DOC_USP7_MATH_1 331 335 PF00917 0.660
DOC_USP7_MATH_1 348 352 PF00917 0.472
DOC_USP7_MATH_1 373 377 PF00917 0.467
DOC_USP7_MATH_1 482 486 PF00917 0.516
DOC_USP7_MATH_1 516 520 PF00917 0.605
DOC_USP7_MATH_1 524 528 PF00917 0.578
DOC_USP7_MATH_1 570 574 PF00917 0.753
DOC_WW_Pin1_4 247 252 PF00397 0.428
DOC_WW_Pin1_4 271 276 PF00397 0.521
DOC_WW_Pin1_4 329 334 PF00397 0.740
DOC_WW_Pin1_4 512 517 PF00397 0.554
DOC_WW_Pin1_4 562 567 PF00397 0.711
DOC_WW_Pin1_4 576 581 PF00397 0.596
DOC_WW_Pin1_4 633 638 PF00397 0.447
DOC_WW_Pin1_4 647 652 PF00397 0.440
LIG_14-3-3_CanoR_1 683 692 PF00244 0.489
LIG_Actin_WH2_2 168 185 PF00022 0.458
LIG_Actin_WH2_2 390 407 PF00022 0.411
LIG_Actin_WH2_2 433 448 PF00022 0.434
LIG_AP2alpha_1 659 663 PF02296 0.437
LIG_BIR_III_2 212 216 PF00653 0.473
LIG_BRCT_BRCA1_1 526 530 PF00533 0.601
LIG_BRCT_BRCA1_1 631 635 PF00533 0.413
LIG_Clathr_ClatBox_1 468 472 PF01394 0.336
LIG_CtBP_PxDLS_1 70 76 PF00389 0.466
LIG_EH1_1 172 180 PF00400 0.412
LIG_eIF4E_1 78 84 PF01652 0.519
LIG_FAT_LD_1 692 700 PF03623 0.355
LIG_FHA_1 117 123 PF00498 0.643
LIG_FHA_1 12 18 PF00498 0.476
LIG_FHA_1 134 140 PF00498 0.242
LIG_FHA_1 157 163 PF00498 0.450
LIG_FHA_1 351 357 PF00498 0.280
LIG_FHA_1 376 382 PF00498 0.468
LIG_FHA_1 488 494 PF00498 0.532
LIG_FHA_1 576 582 PF00498 0.664
LIG_FHA_1 83 89 PF00498 0.440
LIG_FHA_2 1 7 PF00498 0.642
LIG_FHA_2 103 109 PF00498 0.679
LIG_FHA_2 24 30 PF00498 0.521
LIG_FHA_2 588 594 PF00498 0.635
LIG_FHA_2 685 691 PF00498 0.571
LIG_LIR_Gen_1 310 321 PF02991 0.393
LIG_LIR_Gen_1 508 518 PF02991 0.619
LIG_LIR_Gen_1 527 536 PF02991 0.626
LIG_LIR_LC3C_4 620 623 PF02991 0.471
LIG_LIR_Nem_3 247 252 PF02991 0.462
LIG_LIR_Nem_3 310 316 PF02991 0.374
LIG_LIR_Nem_3 508 513 PF02991 0.688
LIG_LIR_Nem_3 527 533 PF02991 0.597
LIG_NRBOX 694 700 PF00104 0.465
LIG_NRBOX 83 89 PF00104 0.423
LIG_PCNA_PIPBox_1 219 228 PF02747 0.436
LIG_PCNA_yPIPBox_3 424 436 PF02747 0.598
LIG_Pex14_1 359 363 PF04695 0.460
LIG_Pex14_2 655 659 PF04695 0.448
LIG_PTB_Apo_2 444 451 PF02174 0.537
LIG_REV1ctd_RIR_1 537 545 PF16727 0.526
LIG_SH2_CRK 249 253 PF00017 0.474
LIG_SH2_STAT5 393 396 PF00017 0.427
LIG_SH2_STAT5 656 659 PF00017 0.507
LIG_SH3_3 117 123 PF00018 0.533
LIG_SH3_3 212 218 PF00018 0.483
LIG_SH3_3 245 251 PF00018 0.384
LIG_SH3_3 31 37 PF00018 0.611
LIG_SH3_3 403 409 PF00018 0.437
LIG_SH3_3 510 516 PF00018 0.743
LIG_SH3_3 563 569 PF00018 0.643
LIG_SH3_3 628 634 PF00018 0.433
LIG_SH3_3 88 94 PF00018 0.389
LIG_Sin3_3 619 626 PF02671 0.481
LIG_SUMO_SIM_anti_2 157 164 PF11976 0.434
LIG_SUMO_SIM_anti_2 64 70 PF11976 0.451
LIG_SUMO_SIM_anti_2 690 696 PF11976 0.371
LIG_SUMO_SIM_par_1 131 136 PF11976 0.444
LIG_SUMO_SIM_par_1 467 473 PF11976 0.345
LIG_TRAF2_1 150 153 PF00917 0.588
LIG_TRAF2_1 439 442 PF00917 0.459
LIG_UBA3_1 694 702 PF00899 0.496
MOD_CK1_1 102 108 PF00069 0.728
MOD_CK1_1 128 134 PF00069 0.576
MOD_CK1_1 167 173 PF00069 0.531
MOD_CK1_1 190 196 PF00069 0.528
MOD_CK1_1 247 253 PF00069 0.554
MOD_CK1_1 283 289 PF00069 0.557
MOD_CK1_1 334 340 PF00069 0.535
MOD_CK1_1 376 382 PF00069 0.445
MOD_CK1_1 449 455 PF00069 0.527
MOD_CK1_1 508 514 PF00069 0.675
MOD_CK1_1 562 568 PF00069 0.784
MOD_CK1_1 575 581 PF00069 0.619
MOD_CK1_1 7 13 PF00069 0.658
MOD_CK2_1 102 108 PF00069 0.745
MOD_CK2_1 23 29 PF00069 0.517
MOD_CK2_1 587 593 PF00069 0.625
MOD_GlcNHglycan 110 113 PF01048 0.691
MOD_GlcNHglycan 116 119 PF01048 0.711
MOD_GlcNHglycan 189 192 PF01048 0.600
MOD_GlcNHglycan 195 198 PF01048 0.683
MOD_GlcNHglycan 257 260 PF01048 0.688
MOD_GlcNHglycan 288 291 PF01048 0.715
MOD_GlcNHglycan 299 302 PF01048 0.591
MOD_GlcNHglycan 303 306 PF01048 0.506
MOD_GlcNHglycan 316 319 PF01048 0.293
MOD_GlcNHglycan 336 339 PF01048 0.705
MOD_GlcNHglycan 349 353 PF01048 0.388
MOD_GlcNHglycan 406 409 PF01048 0.478
MOD_GlcNHglycan 472 475 PF01048 0.432
MOD_GlcNHglycan 484 487 PF01048 0.519
MOD_GlcNHglycan 55 58 PF01048 0.370
MOD_GlcNHglycan 9 12 PF01048 0.725
MOD_GSK3_1 108 115 PF00069 0.626
MOD_GSK3_1 152 159 PF00069 0.449
MOD_GSK3_1 18 25 PF00069 0.567
MOD_GSK3_1 186 193 PF00069 0.565
MOD_GSK3_1 227 234 PF00069 0.429
MOD_GSK3_1 247 254 PF00069 0.569
MOD_GSK3_1 270 277 PF00069 0.646
MOD_GSK3_1 297 304 PF00069 0.638
MOD_GSK3_1 325 332 PF00069 0.609
MOD_GSK3_1 373 380 PF00069 0.481
MOD_GSK3_1 482 489 PF00069 0.339
MOD_GSK3_1 508 515 PF00069 0.601
MOD_GSK3_1 571 578 PF00069 0.735
MOD_GSK3_1 583 590 PF00069 0.685
MOD_GSK3_1 629 636 PF00069 0.437
MOD_GSK3_1 645 652 PF00069 0.518
MOD_GSK3_1 679 686 PF00069 0.508
MOD_GSK3_1 7 14 PF00069 0.579
MOD_N-GLC_1 102 107 PF02516 0.680
MOD_N-GLC_1 125 130 PF02516 0.380
MOD_N-GLC_1 235 240 PF02516 0.553
MOD_N-GLC_1 271 276 PF02516 0.765
MOD_N-GLC_1 446 451 PF02516 0.559
MOD_N-GLC_1 581 586 PF02516 0.709
MOD_N-GLC_2 341 343 PF02516 0.565
MOD_NEK2_1 231 236 PF00069 0.423
MOD_NEK2_1 252 257 PF00069 0.637
MOD_NEK2_1 296 301 PF00069 0.743
MOD_NEK2_1 312 317 PF00069 0.369
MOD_NEK2_1 395 400 PF00069 0.418
MOD_NEK2_1 4 9 PF00069 0.741
MOD_NEK2_1 404 409 PF00069 0.464
MOD_NEK2_1 415 420 PF00069 0.293
MOD_NEK2_1 607 612 PF00069 0.395
MOD_NEK2_1 621 626 PF00069 0.347
MOD_NEK2_1 679 684 PF00069 0.527
MOD_NEK2_2 684 689 PF00069 0.543
MOD_PIKK_1 396 402 PF00454 0.484
MOD_PIKK_1 422 428 PF00454 0.552
MOD_PIKK_1 487 493 PF00454 0.528
MOD_PIKK_1 545 551 PF00454 0.577
MOD_PIKK_1 71 77 PF00454 0.545
MOD_PK_1 5 11 PF00069 0.598
MOD_PKA_2 404 410 PF00069 0.428
MOD_Plk_1 156 162 PF00069 0.430
MOD_Plk_1 167 173 PF00069 0.479
MOD_Plk_1 441 447 PF00069 0.529
MOD_Plk_1 5 11 PF00069 0.544
MOD_Plk_1 531 537 PF00069 0.489
MOD_Plk_1 581 587 PF00069 0.711
MOD_Plk_1 592 598 PF00069 0.554
MOD_Plk_4 116 122 PF00069 0.527
MOD_Plk_4 128 134 PF00069 0.455
MOD_Plk_4 18 24 PF00069 0.647
MOD_Plk_4 218 224 PF00069 0.384
MOD_Plk_4 244 250 PF00069 0.453
MOD_Plk_4 275 281 PF00069 0.705
MOD_Plk_4 377 383 PF00069 0.481
MOD_Plk_4 446 452 PF00069 0.420
MOD_Plk_4 666 672 PF00069 0.586
MOD_ProDKin_1 247 253 PF00069 0.442
MOD_ProDKin_1 271 277 PF00069 0.522
MOD_ProDKin_1 329 335 PF00069 0.739
MOD_ProDKin_1 512 518 PF00069 0.553
MOD_ProDKin_1 562 568 PF00069 0.713
MOD_ProDKin_1 576 582 PF00069 0.597
MOD_ProDKin_1 633 639 PF00069 0.452
MOD_ProDKin_1 647 653 PF00069 0.441
TRG_DiLeu_BaLyEn_6 694 699 PF01217 0.506
TRG_DiLeu_BaLyEn_6 79 84 PF01217 0.443
TRG_ENDOCYTIC_2 249 252 PF00928 0.546
TRG_ENDOCYTIC_2 656 659 PF00928 0.507
TRG_ER_diArg_1 306 308 PF00400 0.554
TRG_ER_diArg_1 711 714 PF00400 0.434
TRG_ER_diArg_1 76 78 PF00400 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMN1 Leptomonas seymouri 52% 98%
A0A1X0P552 Trypanosomatidae 29% 100%
A0A3Q8IIF7 Leishmania donovani 90% 100%
A4HNC0 Leishmania braziliensis 71% 100%
A4IBZ3 Leishmania infantum 90% 100%
C9ZYL2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AFT0 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS