ARL2_Bind_BART domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6X7_LEIMU

TriTrypDb:

LmxM.34.4480

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

E9B6X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.426
CLV_PCSK_SKI1_1	139	143	PF00082	0.269
DOC_PP2B_LxvP_1	19	22	PF13499	0.363
DOC_USP7_MATH_1	98	102	PF00917	0.502
DOC_WW_Pin1_4	116	121	PF00397	0.539
DOC_WW_Pin1_4	4	9	PF00397	0.661
LIG_14-3-3_CanoR_1	107	117	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_FHA_1	127	133	PF00498	0.417
LIG_FHA_1	25	31	PF00498	0.380
LIG_FHA_1	41	47	PF00498	0.440
LIG_FHA_1	54	60	PF00498	0.494
LIG_FHA_2	1	7	PF00498	0.503
LIG_FHA_2	66	72	PF00498	0.469
LIG_LIR_Apic_2	115	120	PF02991	0.525
LIG_LIR_Gen_1	54	61	PF02991	0.493
LIG_LIR_Nem_3	121	127	PF02991	0.447
LIG_LIR_Nem_3	135	141	PF02991	0.505
LIG_LIR_Nem_3	54	60	PF02991	0.493
LIG_SH2_CRK	124	128	PF00017	0.522
LIG_SH2_PTP2	83	86	PF00017	0.427
LIG_SH2_STAT5	131	134	PF00017	0.442
LIG_SH2_STAT5	83	86	PF00017	0.500
LIG_SH3_3	12	18	PF00018	0.457
LIG_TRAF2_1	112	115	PF00917	0.458
LIG_TRAF2_1	163	166	PF00917	0.607
LIG_TYR_ITSM	120	127	PF00017	0.427
MOD_CK1_1	101	107	PF00069	0.512
MOD_CK1_1	108	114	PF00069	0.522
MOD_CK1_1	119	125	PF00069	0.559
MOD_CK1_1	184	190	PF00069	0.582
MOD_CK2_1	160	166	PF00069	0.627
MOD_CK2_1	59	65	PF00069	0.459
MOD_GlcNHglycan	110	113	PF01048	0.391
MOD_GlcNHglycan	12	15	PF01048	0.616
MOD_GlcNHglycan	160	165	PF01048	0.588
MOD_GlcNHglycan	175	179	PF01048	0.513
MOD_GSK3_1	94	101	PF00069	0.521
MOD_NEK2_1	10	15	PF00069	0.472
MOD_NEK2_1	105	110	PF00069	0.418
MOD_PIKK_1	35	41	PF00454	0.469
MOD_Plk_1	101	107	PF00069	0.469
MOD_Plk_1	53	59	PF00069	0.534
MOD_Plk_4	101	107	PF00069	0.516
MOD_Plk_4	127	133	PF00069	0.491
MOD_ProDKin_1	116	122	PF00069	0.539
MOD_ProDKin_1	4	10	PF00069	0.659
MOD_SUMO_rev_2	111	120	PF00179	0.406
MOD_SUMO_rev_2	135	141	PF00179	0.469
TRG_ENDOCYTIC_2	124	127	PF00928	0.520
TRG_ENDOCYTIC_2	138	141	PF00928	0.562
TRG_ENDOCYTIC_2	77	80	PF00928	0.431
TRG_ENDOCYTIC_2	83	86	PF00928	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICH3	Leptomonas seymouri	53%	98%
A0A0S4JM98	Bodo saltans	33%	100%
A0A1X0P624	Trypanosomatidae	32%	100%
A0A3Q8IQ44	Leishmania donovani	85%	100%
A0A422P1B2	Trypanosoma rangeli	34%	100%
A4HNB6	Leishmania braziliensis	73%	100%
A4IBY8	Leishmania infantum	85%	100%
C9ZYL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%