Sm protein F

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sm protein F

Gene product:

sm-f snRNP core complex protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6X5_LEIMU

TriTrypDb:

LmxM.34.4460

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0120114	Sm-like protein family complex	2	9
GO:0140513	nuclear protein-containing complex	2	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9B6X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6X5

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0022618	ribonucleoprotein complex assembly	6	9
GO:0043933	protein-containing complex organization	4	9
GO:0065003	protein-containing complex assembly	5	9
GO:0071826	ribonucleoprotein complex subunit organization	5	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	16	20	PF00082	0.290
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DOC_USP7_UBL2_3	17	21	PF12436	0.426
LIG_LIR_Gen_1	36	46	PF02991	0.445
LIG_LIR_Nem_3	22	27	PF02991	0.423
LIG_LIR_Nem_3	36	41	PF02991	0.445
LIG_Pex14_1	24	28	PF04695	0.423
LIG_SH2_STAT5	68	71	PF00017	0.434
MOD_CK1_1	34	40	PF00069	0.492
MOD_Cter_Amidation	14	17	PF01082	0.226
MOD_GlcNHglycan	71	76	PF01048	0.508
MOD_LATS_1	49	55	PF00433	0.490
MOD_NEK2_1	19	24	PF00069	0.448
MOD_NEK2_1	9	14	PF00069	0.424
MOD_Plk_4	34	40	PF00069	0.490
MOD_Plk_4	9	15	PF00069	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAR9	Leptomonas seymouri	92%	100%
A0A0S4JPM0	Bodo saltans	55%	97%
A0A3Q8IGN2	Leishmania donovani	96%	100%
A1CE19	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	40%	97%
A1DM27	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	40%	95%
A4HNB4	Leishmania braziliensis	92%	100%
A4IBY6	Leishmania infantum	96%	100%
A5DRQ6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	40%	95%
A6R363	Ajellomyces capsulatus (strain NAm1 / WU24)	40%	95%
A6S5C9	Botryotinia fuckeliana (strain B05.10)	38%	89%
A7F5M4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	37%	89%
C9ZYL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AFS3	Leishmania major	95%	100%
O59734	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	97%
P34659	Caenorhabditis elegans	50%	89%
P54999	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	88%
P62306	Homo sapiens	52%	88%
P62307	Mus musculus	52%	88%
P62321	Xenopus laevis	52%	88%
Q1DRN0	Coccidioides immitis (strain RS)	38%	95%
Q24297	Drosophila melanogaster	52%	86%
Q2HAN0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	36%	93%
Q3T0Z8	Bos taurus	52%	88%
Q4WNI0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	40%	95%
Q54XP2	Dictyostelium discoideum	44%	84%
Q6CPS7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	95%
Q9P5Z8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	84%
Q9SUM2	Arabidopsis thaliana	51%	86%
Q9UUI1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%