C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6X4_LEIMU

TriTrypDb:

LmxM.34.4450

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6X4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.481
CLV_PCSK_KEX2_1	196	198	PF00082	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.673
DEG_SCF_FBW7_1	236	242	PF00400	0.678
DEG_SPOP_SBC_1	254	258	PF00917	0.426
DEG_SPOP_SBC_1	55	59	PF00917	0.503
DOC_CKS1_1	160	165	PF01111	0.514
DOC_CKS1_1	216	221	PF01111	0.520
DOC_CKS1_1	226	231	PF01111	0.518
DOC_CKS1_1	236	241	PF01111	0.673
DOC_MAPK_gen_1	11	20	PF00069	0.459
DOC_PP4_FxxP_1	201	204	PF00568	0.448
DOC_PP4_FxxP_1	251	254	PF00568	0.664
DOC_USP7_MATH_1	239	243	PF00917	0.566
DOC_USP7_MATH_1	255	259	PF00917	0.539
DOC_USP7_MATH_1	55	59	PF00917	0.501
DOC_USP7_MATH_2	90	96	PF00917	0.471
DOC_WW_Pin1_4	109	114	PF00397	0.637
DOC_WW_Pin1_4	140	145	PF00397	0.661
DOC_WW_Pin1_4	159	164	PF00397	0.534
DOC_WW_Pin1_4	205	210	PF00397	0.688
DOC_WW_Pin1_4	215	220	PF00397	0.551
DOC_WW_Pin1_4	225	230	PF00397	0.532
DOC_WW_Pin1_4	232	237	PF00397	0.554
DOC_WW_Pin1_4	4	9	PF00397	0.685
DOC_WW_Pin1_4	78	83	PF00397	0.710
LIG_BRCT_BRCA1_1	72	76	PF00533	0.489
LIG_FHA_1	141	147	PF00498	0.572
LIG_FHA_1	175	181	PF00498	0.446
LIG_FHA_1	243	249	PF00498	0.675
LIG_FHA_1	95	101	PF00498	0.723
LIG_FHA_2	216	222	PF00498	0.612
LIG_FHA_2	255	261	PF00498	0.643
LIG_Integrin_isoDGR_2	191	193	PF01839	0.447
LIG_LIR_Apic_2	250	254	PF02991	0.656
LIG_LIR_Gen_1	152	163	PF02991	0.630
LIG_LIR_Gen_1	228	239	PF02991	0.592
LIG_LIR_Gen_1	256	263	PF02991	0.495
LIG_LIR_Nem_3	152	158	PF02991	0.627
LIG_LIR_Nem_3	228	234	PF02991	0.633
LIG_LIR_Nem_3	238	243	PF02991	0.592
LIG_LIR_Nem_3	256	262	PF02991	0.418
LIG_LIR_Nem_3	81	86	PF02991	0.570
LIG_SH2_CRK	155	159	PF00017	0.626
LIG_SH2_CRK	240	244	PF00017	0.609
LIG_SH2_GRB2like	189	192	PF00017	0.441
LIG_SH2_SRC	189	192	PF00017	0.441
LIG_SH2_SRC	19	22	PF00017	0.598
LIG_SH2_SRC	86	89	PF00017	0.642
LIG_SH2_STAT3	84	87	PF00017	0.646
LIG_SH2_STAT5	189	192	PF00017	0.441
LIG_SH2_STAT5	19	22	PF00017	0.560
LIG_SH2_STAT5	217	220	PF00017	0.549
LIG_SH2_STAT5	31	34	PF00017	0.577
LIG_SH3_2	6	11	PF14604	0.456
LIG_SH3_3	110	116	PF00018	0.627
LIG_SH3_3	15	21	PF00018	0.675
LIG_SH3_3	203	209	PF00018	0.578
LIG_SH3_3	213	219	PF00018	0.524
LIG_SH3_3	233	239	PF00018	0.728
LIG_SH3_3	3	9	PF00018	0.679
LIG_SH3_3	33	39	PF00018	0.432
LIG_TYR_ITSM	151	158	PF00017	0.561
LIG_WRC_WIRS_1	248	253	PF05994	0.542
MOD_CDK_SPxxK_3	220	227	PF00069	0.459
MOD_CDK_SPxxK_3	4	11	PF00069	0.465
MOD_CK1_1	121	127	PF00069	0.628
MOD_CK1_1	128	134	PF00069	0.608
MOD_CK1_1	159	165	PF00069	0.483
MOD_CK1_1	235	241	PF00069	0.595
MOD_CK1_1	242	248	PF00069	0.629
MOD_CK1_1	258	264	PF00069	0.542
MOD_CK1_1	75	81	PF00069	0.620
MOD_CK1_1	94	100	PF00069	0.563
MOD_CK2_1	254	260	PF00069	0.643
MOD_GlcNHglycan	168	171	PF01048	0.696
MOD_GSK3_1	103	110	PF00069	0.686
MOD_GSK3_1	118	125	PF00069	0.545
MOD_GSK3_1	235	242	PF00069	0.678
MOD_GSK3_1	249	256	PF00069	0.516
MOD_GSK3_1	70	77	PF00069	0.539
MOD_GSK3_1	90	97	PF00069	0.519
MOD_N-GLC_1	180	185	PF02516	0.455
MOD_NEK2_1	118	123	PF00069	0.724
MOD_NEK2_1	166	171	PF00069	0.616
MOD_PIKK_1	134	140	PF00454	0.763
MOD_PIKK_1	164	170	PF00454	0.605
MOD_PIKK_1	20	26	PF00454	0.657
MOD_PIKK_1	56	62	PF00454	0.590
MOD_PK_1	13	19	PF00069	0.465
MOD_Plk_4	13	19	PF00069	0.615
MOD_Plk_4	258	264	PF00069	0.580
MOD_Plk_4	32	38	PF00069	0.503
MOD_Plk_4	96	102	PF00069	0.614
MOD_ProDKin_1	109	115	PF00069	0.640
MOD_ProDKin_1	140	146	PF00069	0.660
MOD_ProDKin_1	159	165	PF00069	0.530
MOD_ProDKin_1	205	211	PF00069	0.691
MOD_ProDKin_1	215	221	PF00069	0.553
MOD_ProDKin_1	225	231	PF00069	0.534
MOD_ProDKin_1	232	238	PF00069	0.551
MOD_ProDKin_1	4	10	PF00069	0.682
MOD_ProDKin_1	78	84	PF00069	0.713
TRG_ENDOCYTIC_2	155	158	PF00928	0.562
TRG_ENDOCYTIC_2	240	243	PF00928	0.677
TRG_NLS_MonoExtN_4	196	201	PF00514	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I468	Leptomonas seymouri	30%	100%
A0A3S7X9W1	Leishmania donovani	85%	100%
A4HNB3	Leishmania braziliensis	61%	100%
A4IBY5	Leishmania infantum	85%	100%
E9AFS2	Leishmania major	85%	100%