Putative mitochondrial phosphate transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial phosphate transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B6X2_LEIMU

TriTrypDb:

LmxM.34.4430

Length:

317

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0020023	kinetoplast	2	2
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2

Previous1 2Next

Expansion

Sequence features

E9B6X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6X2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0006811	monoatomic ion transport	4	16
GO:0006817	phosphate ion transport	7	16
GO:0006820	monoatomic anion transport	5	16
GO:0009987	cellular process	1	16
GO:0015698	inorganic anion transport	6	16
GO:0034220	monoatomic ion transmembrane transport	3	16
GO:0035435	phosphate ion transmembrane transport	6	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	16
GO:0005315	inorganic phosphate transmembrane transporter activity	4	16
GO:0015291	secondary active transmembrane transporter activity	4	16
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	16
GO:0022804	active transmembrane transporter activity	3	16
GO:0022857	transmembrane transporter activity	2	16

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	197	201	PF00082	0.377
CLV_PCSK_SKI1_1	210	214	PF00082	0.488
CLV_PCSK_SKI1_1	303	307	PF00082	0.474
DOC_AGCK_PIF_2	99	104	PF00069	0.439
DOC_MAPK_gen_1	119	127	PF00069	0.520
DOC_MAPK_MEF2A_6	222	230	PF00069	0.393
DOC_PP4_FxxP_1	213	216	PF00568	0.433
DOC_USP7_MATH_1	172	176	PF00917	0.368
DOC_USP7_MATH_1	179	183	PF00917	0.168
DOC_USP7_MATH_1	241	245	PF00917	0.373

Previous1 2 3 4 5…9Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I993	Leptomonas seymouri	83%	100%
A0A0S4JBC4	Bodo saltans	38%	82%
A0A0S4JNX4	Bodo saltans	72%	94%
A0A0S4KJX8	Bodo saltans	26%	91%
A0A1D6N272	Zea mays	23%	94%
A0A1X0P0K9	Trypanosomatidae	39%	100%
A0A1X0P561	Trypanosomatidae	76%	99%
A0A3S5IRV4	Trypanosoma rangeli	77%	100%
A0A3S7X9V4	Leishmania donovani	96%	100%
A0A3S7X9Y0	Leishmania donovani	95%	100%

Previous1 2 3 4 5Next