TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TAX-1

Species:

Leishmania mexicana

UniProt:

E9B6W9_LEIMU

TriTrypDb:

LmxM.34.4390

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004427	inorganic diphosphate phosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.736
CLV_NRD_NRD_1	24	26	PF00675	0.652
CLV_NRD_NRD_1	262	264	PF00675	0.478
CLV_PCSK_KEX2_1	147	149	PF00082	0.517
CLV_PCSK_KEX2_1	262	264	PF00082	0.442
CLV_PCSK_KEX2_1	313	315	PF00082	0.564
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.517
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.564
CLV_PCSK_PC7_1	309	315	PF00082	0.544
CLV_PCSK_SKI1_1	143	147	PF00082	0.472
CLV_PCSK_SKI1_1	213	217	PF00082	0.499
CLV_PCSK_SKI1_1	344	348	PF00082	0.522
CLV_PCSK_SKI1_1	99	103	PF00082	0.406
DOC_CKS1_1	63	68	PF01111	0.554
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.324
DOC_MAPK_gen_1	123	132	PF00069	0.495
DOC_MAPK_gen_1	80	89	PF00069	0.263
DOC_MAPK_HePTP_8	162	174	PF00069	0.507
DOC_MAPK_MEF2A_6	112	120	PF00069	0.482
DOC_MAPK_MEF2A_6	165	174	PF00069	0.472
DOC_MAPK_MEF2A_6	324	333	PF00069	0.341
DOC_MAPK_MEF2A_6	82	91	PF00069	0.340
DOC_PP4_FxxP_1	124	127	PF00568	0.486
DOC_PP4_FxxP_1	356	359	PF00568	0.543
DOC_USP7_MATH_1	187	191	PF00917	0.501
DOC_USP7_MATH_1	230	234	PF00917	0.441
DOC_USP7_MATH_1	28	32	PF00917	0.640
DOC_USP7_MATH_1	298	302	PF00917	0.407
DOC_USP7_MATH_1	318	322	PF00917	0.339
DOC_USP7_MATH_1	51	55	PF00917	0.247
DOC_USP7_UBL2_3	143	147	PF12436	0.514
DOC_USP7_UBL2_3	22	26	PF12436	0.537
DOC_WW_Pin1_4	12	17	PF00397	0.599
DOC_WW_Pin1_4	273	278	PF00397	0.533
DOC_WW_Pin1_4	3	8	PF00397	0.661
DOC_WW_Pin1_4	62	67	PF00397	0.538
LIG_14-3-3_CanoR_1	201	205	PF00244	0.435
LIG_14-3-3_CanoR_1	213	222	PF00244	0.331
LIG_14-3-3_CanoR_1	271	277	PF00244	0.444
LIG_14-3-3_CanoR_1	314	323	PF00244	0.445
LIG_14-3-3_CanoR_1	350	359	PF00244	0.449
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BRCT_BRCA1_1	352	356	PF00533	0.447
LIG_deltaCOP1_diTrp_1	368	374	PF00928	0.384
LIG_FHA_1	201	207	PF00498	0.321
LIG_FHA_2	237	243	PF00498	0.222
LIG_FHA_2	334	340	PF00498	0.489
LIG_FHA_2	379	385	PF00498	0.670
LIG_FHA_2	397	403	PF00498	0.668
LIG_FHA_2	6	12	PF00498	0.584
LIG_LIR_Apic_2	122	127	PF02991	0.488
LIG_LIR_Apic_2	353	359	PF02991	0.545
LIG_LIR_Gen_1	203	212	PF02991	0.340
LIG_LIR_Gen_1	217	227	PF02991	0.364
LIG_LIR_Gen_1	239	249	PF02991	0.398
LIG_LIR_Gen_1	53	63	PF02991	0.379
LIG_LIR_Nem_3	203	208	PF02991	0.334
LIG_LIR_Nem_3	217	222	PF02991	0.360
LIG_LIR_Nem_3	239	244	PF02991	0.406
LIG_LIR_Nem_3	246	252	PF02991	0.453
LIG_LIR_Nem_3	48	52	PF02991	0.421
LIG_LIR_Nem_3	53	59	PF02991	0.351
LIG_Pex14_1	370	374	PF04695	0.383
LIG_SH2_CRK	241	245	PF00017	0.330
LIG_SH2_GRB2like	378	381	PF00017	0.544
LIG_SH2_PTP2	161	164	PF00017	0.490
LIG_SH2_STAP1	249	253	PF00017	0.520
LIG_SH2_STAP1	378	382	PF00017	0.375
LIG_SH2_STAT5	136	139	PF00017	0.339
LIG_SH2_STAT5	161	164	PF00017	0.481
LIG_SH2_STAT5	205	208	PF00017	0.347
LIG_SH2_STAT5	221	224	PF00017	0.331
LIG_SH2_STAT5	272	275	PF00017	0.445
LIG_SH3_3	356	362	PF00018	0.569
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.514
LIG_SUMO_SIM_anti_2	85	92	PF11976	0.248
LIG_TRAF2_1	277	280	PF00917	0.624
LIG_TRAF2_1	94	97	PF00917	0.484
LIG_TYR_ITIM	247	252	PF00017	0.423
LIG_TYR_ITSM	237	244	PF00017	0.217
LIG_WRC_WIRS_1	216	221	PF05994	0.339
MOD_CK1_1	2	8	PF00069	0.766
MOD_CK1_1	200	206	PF00069	0.467
MOD_CK1_1	31	37	PF00069	0.589
MOD_CK2_1	187	193	PF00069	0.490
MOD_CK2_1	333	339	PF00069	0.467
MOD_CK2_1	378	384	PF00069	0.619
MOD_Cter_Amidation	23	26	PF01082	0.469
MOD_GlcNHglycan	316	319	PF01048	0.501
MOD_GlcNHglycan	84	87	PF01048	0.483
MOD_GSK3_1	1	8	PF00069	0.763
MOD_GSK3_1	14	21	PF00069	0.685
MOD_GSK3_1	200	207	PF00069	0.340
MOD_GSK3_1	27	34	PF00069	0.621
MOD_GSK3_1	314	321	PF00069	0.444
MOD_GSK3_1	374	381	PF00069	0.497
MOD_GSK3_1	71	78	PF00069	0.594
MOD_N-GLC_1	45	50	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.745
MOD_NEK2_1	137	142	PF00069	0.335
MOD_NEK2_1	297	302	PF00069	0.488
MOD_PIKK_1	350	356	PF00454	0.424
MOD_PIKK_1	37	43	PF00454	0.568
MOD_PKA_2	200	206	PF00069	0.408
MOD_PKA_2	270	276	PF00069	0.444
MOD_PKA_2	75	81	PF00069	0.560
MOD_PKB_1	80	88	PF00069	0.511
MOD_Plk_1	168	174	PF00069	0.447
MOD_Plk_1	37	43	PF00069	0.586
MOD_Plk_1	374	380	PF00069	0.555
MOD_Plk_1	389	395	PF00069	0.678
MOD_Plk_1	45	51	PF00069	0.434
MOD_Plk_4	200	206	PF00069	0.325
MOD_Plk_4	236	242	PF00069	0.271
MOD_Plk_4	389	395	PF00069	0.494
MOD_ProDKin_1	12	18	PF00069	0.598
MOD_ProDKin_1	273	279	PF00069	0.530
MOD_ProDKin_1	3	9	PF00069	0.662
MOD_ProDKin_1	62	68	PF00069	0.547
TRG_DiLeu_BaEn_1	58	63	PF01217	0.378
TRG_DiLeu_BaEn_1	97	102	PF01217	0.424
TRG_ENDOCYTIC_2	136	139	PF00928	0.339
TRG_ENDOCYTIC_2	161	164	PF00928	0.490
TRG_ENDOCYTIC_2	205	208	PF00928	0.347
TRG_ENDOCYTIC_2	221	224	PF00928	0.331
TRG_ENDOCYTIC_2	241	244	PF00928	0.228
TRG_ENDOCYTIC_2	249	252	PF00928	0.356
TRG_ER_diArg_1	118	121	PF00400	0.466
TRG_ER_diArg_1	80	83	PF00400	0.521
TRG_NLS_MonoExtN_4	22	29	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P968	Leptomonas seymouri	74%	100%
A0A0S4JSR6	Bodo saltans	45%	71%
A0A1X0P6F9	Trypanosomatidae	58%	100%
A0A3R7KSW5	Trypanosoma rangeli	53%	100%
A0A3S7X9V3	Leishmania donovani	91%	100%
A4HNA8	Leishmania braziliensis	80%	100%
A4IBX9	Leishmania infantum	91%	100%
C9ZYM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AFR6	Leishmania major	89%	100%
V5BXU3	Trypanosoma cruzi	54%	100%