LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6W8_LEIMU

TriTrypDb:

LmxM.34.4380

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.727
CLV_NRD_NRD_1	130	132	PF00675	0.642
CLV_NRD_NRD_1	185	187	PF00675	0.728
CLV_NRD_NRD_1	215	217	PF00675	0.711
CLV_NRD_NRD_1	270	272	PF00675	0.743
CLV_NRD_NRD_1	300	302	PF00675	0.700
CLV_NRD_NRD_1	355	357	PF00675	0.643
CLV_NRD_NRD_1	41	43	PF00675	0.666
CLV_NRD_NRD_1	70	72	PF00675	0.676
CLV_PCSK_KEX2_1	157	159	PF00082	0.758
CLV_PCSK_KEX2_1	242	244	PF00082	0.763
CLV_PCSK_KEX2_1	327	329	PF00082	0.704
CLV_PCSK_KEX2_1	389	391	PF00082	0.738
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.758
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.763
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.704
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.738
CLV_PCSK_SKI1_1	102	106	PF00082	0.617
CLV_PCSK_SKI1_1	357	361	PF00082	0.636
CLV_PCSK_SKI1_1	36	40	PF00082	0.571
CLV_PCSK_SKI1_1	72	76	PF00082	0.564
CLV_Separin_Metazoa	183	187	PF03568	0.686
CLV_Separin_Metazoa	268	272	PF03568	0.725
CLV_Separin_Metazoa	353	357	PF03568	0.627
CLV_Separin_Metazoa	68	72	PF03568	0.712
CLV_Separin_Metazoa	98	102	PF03568	0.688
DEG_SPOP_SBC_1	141	145	PF00917	0.751
DEG_SPOP_SBC_1	226	230	PF00917	0.746
DEG_SPOP_SBC_1	311	315	PF00917	0.703
DOC_CKS1_1	534	539	PF01111	0.817
DOC_MAPK_MEF2A_6	526	534	PF00069	0.741
DOC_PP2B_LxvP_1	3	6	PF13499	0.591
DOC_USP7_MATH_1	141	145	PF00917	0.751
DOC_USP7_MATH_1	226	230	PF00917	0.746
DOC_USP7_MATH_1	311	315	PF00917	0.703
DOC_USP7_MATH_1	411	415	PF00917	0.752
DOC_USP7_UBL2_3	102	106	PF12436	0.732
DOC_USP7_UBL2_3	107	111	PF12436	0.695
DOC_USP7_UBL2_3	153	157	PF12436	0.778
DOC_USP7_UBL2_3	162	166	PF12436	0.689
DOC_USP7_UBL2_3	187	191	PF12436	0.732
DOC_USP7_UBL2_3	192	196	PF12436	0.709
DOC_USP7_UBL2_3	238	242	PF12436	0.845
DOC_USP7_UBL2_3	247	251	PF12436	0.723
DOC_USP7_UBL2_3	272	276	PF12436	0.748
DOC_USP7_UBL2_3	277	281	PF12436	0.719
DOC_USP7_UBL2_3	323	327	PF12436	0.761
DOC_USP7_UBL2_3	332	336	PF12436	0.694
DOC_USP7_UBL2_3	357	361	PF12436	0.674
DOC_USP7_UBL2_3	362	366	PF12436	0.641
DOC_USP7_UBL2_3	385	389	PF12436	0.557
DOC_USP7_UBL2_3	72	76	PF12436	0.704
DOC_USP7_UBL2_3	77	81	PF12436	0.662
DOC_WW_Pin1_4	106	111	PF00397	0.677
DOC_WW_Pin1_4	157	162	PF00397	0.750
DOC_WW_Pin1_4	169	174	PF00397	0.705
DOC_WW_Pin1_4	191	196	PF00397	0.683
DOC_WW_Pin1_4	242	247	PF00397	0.756
DOC_WW_Pin1_4	254	259	PF00397	0.607
DOC_WW_Pin1_4	276	281	PF00397	0.710
DOC_WW_Pin1_4	327	332	PF00397	0.704
DOC_WW_Pin1_4	339	344	PF00397	0.718
DOC_WW_Pin1_4	361	366	PF00397	0.669
DOC_WW_Pin1_4	533	538	PF00397	0.723
DOC_WW_Pin1_4	76	81	PF00397	0.742
LIG_14-3-3_CanoR_1	22	30	PF00244	0.558
LIG_14-3-3_CanoR_1	542	547	PF00244	0.661
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_FHA_1	44	50	PF00498	0.575
LIG_FHA_1	534	540	PF00498	0.814
LIG_SH2_NCK_1	23	27	PF00017	0.629
LIG_SH2_STAP1	23	27	PF00017	0.629
LIG_SH2_STAT5	15	18	PF00017	0.495
LIG_SH2_STAT5	23	26	PF00017	0.529
LIG_SH3_1	366	372	PF00018	0.586
LIG_SH3_3	127	133	PF00018	0.810
LIG_SH3_3	148	154	PF00018	0.803
LIG_SH3_3	182	188	PF00018	0.811
LIG_SH3_3	212	218	PF00018	0.802
LIG_SH3_3	233	239	PF00018	0.825
LIG_SH3_3	267	273	PF00018	0.817
LIG_SH3_3	297	303	PF00018	0.795
LIG_SH3_3	318	324	PF00018	0.787
LIG_SH3_3	352	358	PF00018	0.814
LIG_SH3_3	366	372	PF00018	0.685
LIG_SH3_3	67	73	PF00018	0.660
LIG_SH3_3	97	103	PF00018	0.812
LIG_SH3_4	102	109	PF00018	0.777
LIG_SH3_4	153	160	PF00018	0.815
LIG_SH3_4	162	169	PF00018	0.696
LIG_SH3_4	187	194	PF00018	0.777
LIG_SH3_4	238	245	PF00018	0.754
LIG_SH3_4	247	254	PF00018	0.644
LIG_SH3_4	272	279	PF00018	0.833
LIG_SH3_4	323	330	PF00018	0.700
LIG_SH3_4	332	339	PF00018	0.617
LIG_SH3_4	357	364	PF00018	0.613
LIG_SH3_4	385	392	PF00018	0.560
LIG_SH3_4	72	79	PF00018	0.830
LIG_TRAF2_1	29	32	PF00917	0.564
MOD_CDK_SPK_2	106	111	PF00069	0.677
MOD_CDK_SPK_2	157	162	PF00069	0.750
MOD_CDK_SPK_2	191	196	PF00069	0.683
MOD_CDK_SPK_2	242	247	PF00069	0.756
MOD_CDK_SPK_2	276	281	PF00069	0.710
MOD_CDK_SPK_2	327	332	PF00069	0.704
MOD_CDK_SPK_2	361	366	PF00069	0.669
MOD_CDK_SPK_2	76	81	PF00069	0.742
MOD_CK1_1	21	27	PF00069	0.528
MOD_CK1_1	414	420	PF00069	0.749
MOD_CK1_1	47	53	PF00069	0.632
MOD_CK1_1	535	541	PF00069	0.731
MOD_CK2_1	140	146	PF00069	0.744
MOD_CK2_1	225	231	PF00069	0.741
MOD_CK2_1	310	316	PF00069	0.699
MOD_CK2_1	376	382	PF00069	0.669
MOD_CK2_1	404	410	PF00069	0.767
MOD_GlcNHglycan	24	27	PF01048	0.547
MOD_GlcNHglycan	46	49	PF01048	0.564
MOD_GSK3_1	102	109	PF00069	0.573
MOD_GSK3_1	157	164	PF00069	0.734
MOD_GSK3_1	18	25	PF00069	0.584
MOD_GSK3_1	242	249	PF00069	0.732
MOD_GSK3_1	327	334	PF00069	0.691
MOD_GSK3_1	357	364	PF00069	0.579
MOD_GSK3_1	406	413	PF00069	0.843
MOD_GSK3_1	43	50	PF00069	0.640
MOD_GSK3_1	538	545	PF00069	0.809
MOD_GSK3_1	72	79	PF00069	0.627
MOD_N-GLC_1	414	419	PF02516	0.797
MOD_N-GLC_1	542	547	PF02516	0.715
MOD_NEK2_1	18	23	PF00069	0.502
MOD_PK_1	542	548	PF00069	0.646
MOD_PKA_2	21	27	PF00069	0.523
MOD_Plk_1	542	548	PF00069	0.716
MOD_Plk_2-3	121	127	PF00069	0.677
MOD_Plk_2-3	142	148	PF00069	0.713
MOD_Plk_2-3	176	182	PF00069	0.738
MOD_Plk_2-3	206	212	PF00069	0.709
MOD_Plk_2-3	227	233	PF00069	0.746
MOD_Plk_2-3	261	267	PF00069	0.722
MOD_Plk_2-3	291	297	PF00069	0.684
MOD_Plk_2-3	312	318	PF00069	0.697
MOD_Plk_2-3	346	352	PF00069	0.739
MOD_Plk_2-3	61	67	PF00069	0.617
MOD_Plk_2-3	91	97	PF00069	0.741
MOD_ProDKin_1	106	112	PF00069	0.678
MOD_ProDKin_1	157	163	PF00069	0.750
MOD_ProDKin_1	169	175	PF00069	0.705
MOD_ProDKin_1	191	197	PF00069	0.684
MOD_ProDKin_1	242	248	PF00069	0.754
MOD_ProDKin_1	254	260	PF00069	0.607
MOD_ProDKin_1	276	282	PF00069	0.710
MOD_ProDKin_1	327	333	PF00069	0.703
MOD_ProDKin_1	339	345	PF00069	0.716
MOD_ProDKin_1	361	367	PF00069	0.670
MOD_ProDKin_1	533	539	PF00069	0.722
MOD_ProDKin_1	76	82	PF00069	0.742
MOD_SUMO_for_1	6	9	PF00179	0.531
MOD_SUMO_rev_2	377	387	PF00179	0.563
TRG_ENDOCYTIC_2	15	18	PF00928	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X9Y7	Leishmania donovani	78%	86%
A4HNA7	Leishmania braziliensis	62%	100%
A4IBX8	Leishmania infantum	73%	98%
C9ZYM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AFR5	Leishmania major	64%	100%