Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6W4_LEIMU

TriTrypDb:

LmxM.34.4340

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9B6W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.363
CLV_NRD_NRD_1	136	138	PF00675	0.542
CLV_NRD_NRD_1	142	144	PF00675	0.559
CLV_NRD_NRD_1	171	173	PF00675	0.532
CLV_NRD_NRD_1	185	187	PF00675	0.512
CLV_NRD_NRD_1	3	5	PF00675	0.658
CLV_NRD_NRD_1	42	44	PF00675	0.625
CLV_NRD_NRD_1	87	89	PF00675	0.664
CLV_NRD_NRD_1	96	98	PF00675	0.626
CLV_PCSK_KEX2_1	136	138	PF00082	0.533
CLV_PCSK_KEX2_1	171	173	PF00082	0.537
CLV_PCSK_KEX2_1	185	187	PF00082	0.512
CLV_PCSK_KEX2_1	3	5	PF00082	0.658
CLV_PCSK_KEX2_1	95	97	PF00082	0.653
CLV_PCSK_SKI1_1	164	168	PF00082	0.544
CLV_PCSK_SKI1_1	171	175	PF00082	0.487
CLV_PCSK_SKI1_1	230	234	PF00082	0.615
CLV_PCSK_SKI1_1	37	41	PF00082	0.588
DEG_APCC_DBOX_1	3	11	PF00400	0.434
DEG_MDM2_SWIB_1	311	319	PF02201	0.462
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DOC_CDC14_PxL_1	46	54	PF14671	0.415
DOC_CKS1_1	268	273	PF01111	0.448
DOC_CYCLIN_RxL_1	93	102	PF00134	0.434
DOC_PP2B_LxvP_1	190	193	PF13499	0.342
DOC_USP7_UBL2_3	326	330	PF12436	0.650
DOC_WW_Pin1_4	153	158	PF00397	0.439
DOC_WW_Pin1_4	267	272	PF00397	0.474
LIG_14-3-3_CanoR_1	112	117	PF00244	0.385
LIG_14-3-3_CanoR_1	3	10	PF00244	0.474
LIG_14-3-3_CanoR_1	43	47	PF00244	0.382
LIG_Actin_WH2_2	52	69	PF00022	0.377
LIG_BIR_III_4	57	61	PF00653	0.366
LIG_Clathr_ClatBox_1	166	170	PF01394	0.305
LIG_FHA_1	140	146	PF00498	0.351
LIG_FHA_1	229	235	PF00498	0.413
LIG_FHA_1	255	261	PF00498	0.394
LIG_FHA_1	315	321	PF00498	0.603
LIG_FHA_1	33	39	PF00498	0.420
LIG_FHA_1	70	76	PF00498	0.380
LIG_FHA_2	115	121	PF00498	0.452
LIG_FHA_2	146	152	PF00498	0.389
LIG_FHA_2	153	159	PF00498	0.427
LIG_FHA_2	197	203	PF00498	0.345
LIG_FHA_2	217	223	PF00498	0.433
LIG_FHA_2	241	247	PF00498	0.424
LIG_FHA_2	257	263	PF00498	0.408
LIG_FHA_2	268	274	PF00498	0.478
LIG_LIR_Gen_1	273	283	PF02991	0.374
LIG_LIR_Nem_3	226	232	PF02991	0.386
LIG_LIR_Nem_3	273	278	PF02991	0.378
LIG_LIR_Nem_3	295	299	PF02991	0.350
LIG_LIR_Nem_3	45	49	PF02991	0.408
LIG_LYPXL_yS_3	49	52	PF13949	0.433
LIG_NRBOX	162	168	PF00104	0.343
LIG_Pex14_1	286	290	PF04695	0.334
LIG_Pex14_1	293	297	PF04695	0.321
LIG_Pex14_2	311	315	PF04695	0.615
LIG_SH2_STAP1	110	114	PF00017	0.383
LIG_SH2_STAT5	126	129	PF00017	0.374
LIG_SH2_STAT5	332	335	PF00017	0.641
LIG_SH3_3	19	25	PF00018	0.379
LIG_SH3_3	262	268	PF00018	0.386
LIG_SUMO_SIM_anti_2	165	170	PF11976	0.332
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.383
LIG_SUMO_SIM_anti_2	300	308	PF11976	0.395
LIG_SUMO_SIM_par_1	111	117	PF11976	0.426
LIG_SUMO_SIM_par_1	165	170	PF11976	0.345
LIG_SUMO_SIM_par_1	205	210	PF11976	0.382
LIG_TRAF2_1	236	239	PF00917	0.424
LIG_TRAF2_1	39	42	PF00917	0.435
LIG_TYR_ITIM	283	288	PF00017	0.287
LIG_UBA3_1	12	21	PF00899	0.400
LIG_UBA3_1	206	214	PF00899	0.374
LIG_UBA3_1	309	313	PF00899	0.469
MOD_CK1_1	69	75	PF00069	0.377
MOD_CK2_1	114	120	PF00069	0.466
MOD_CK2_1	145	151	PF00069	0.370
MOD_CK2_1	152	158	PF00069	0.445
MOD_CK2_1	196	202	PF00069	0.415
MOD_CK2_1	216	222	PF00069	0.431
MOD_CK2_1	240	246	PF00069	0.371
MOD_CK2_1	256	262	PF00069	0.391
MOD_CMANNOS	286	289	PF00535	0.344
MOD_Cter_Amidation	183	186	PF01082	0.614
MOD_GlcNHglycan	13	16	PF01048	0.603
MOD_GlcNHglycan	28	31	PF01048	0.596
MOD_GlcNHglycan	334	337	PF01048	0.495
MOD_GlcNHglycan	63	66	PF01048	0.642
MOD_GSK3_1	152	159	PF00069	0.418
MOD_GSK3_1	192	199	PF00069	0.402
MOD_GSK3_1	69	76	PF00069	0.284
MOD_N-GLC_1	216	221	PF02516	0.616
MOD_NEK2_1	2	7	PF00069	0.466
MOD_NEK2_1	207	212	PF00069	0.432
MOD_NEK2_1	228	233	PF00069	0.433
MOD_NEK2_1	278	283	PF00069	0.412
MOD_NEK2_2	292	297	PF00069	0.475
MOD_PIKK_1	114	120	PF00454	0.447
MOD_PIKK_1	177	183	PF00454	0.426
MOD_PK_1	112	118	PF00069	0.396
MOD_PKA_1	136	142	PF00069	0.351
MOD_PKA_1	171	177	PF00069	0.425
MOD_PKA_1	73	79	PF00069	0.409
MOD_PKA_1	88	94	PF00069	0.414
MOD_PKA_2	136	142	PF00069	0.368
MOD_PKA_2	171	177	PF00069	0.385
MOD_PKA_2	2	8	PF00069	0.486
MOD_PKA_2	254	260	PF00069	0.375
MOD_PKA_2	278	284	PF00069	0.438
MOD_PKA_2	42	48	PF00069	0.389
MOD_Plk_1	207	213	PF00069	0.441
MOD_Plk_1	216	222	PF00069	0.421
MOD_Plk_2-3	196	202	PF00069	0.359
MOD_Plk_2-3	256	262	PF00069	0.415
MOD_Plk_2-3	42	48	PF00069	0.389
MOD_Plk_4	136	142	PF00069	0.364
MOD_Plk_4	256	262	PF00069	0.384
MOD_Plk_4	278	284	PF00069	0.369
MOD_Plk_4	292	298	PF00069	0.341
MOD_Plk_4	42	48	PF00069	0.389
MOD_ProDKin_1	153	159	PF00069	0.429
MOD_ProDKin_1	267	273	PF00069	0.473
MOD_SUMO_for_1	197	200	PF00179	0.369
MOD_SUMO_rev_2	147	155	PF00179	0.421
MOD_SUMO_rev_2	195	199	PF00179	0.377
MOD_SUMO_rev_2	41	45	PF00179	0.435
TRG_DiLeu_BaEn_1	158	163	PF01217	0.379
TRG_DiLeu_BaEn_1	202	207	PF01217	0.386
TRG_DiLeu_BaEn_1	302	307	PF01217	0.475
TRG_DiLeu_LyEn_5	202	207	PF01217	0.412
TRG_ENDOCYTIC_2	110	113	PF00928	0.375
TRG_ENDOCYTIC_2	285	288	PF00928	0.344
TRG_ENDOCYTIC_2	49	52	PF00928	0.418
TRG_ER_diArg_1	135	137	PF00400	0.339
TRG_ER_diArg_1	171	173	PF00400	0.337
TRG_ER_diArg_1	185	187	PF00400	0.312
TRG_ER_diArg_1	2	4	PF00400	0.458
TRG_ER_diArg_1	94	97	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P542	Leptomonas seymouri	25%	88%
A0A0N1I4W7	Leptomonas seymouri	74%	100%
A0A0S4JN93	Bodo saltans	46%	100%
A0A1X0P510	Trypanosomatidae	53%	99%
A0A3Q8IVJ8	Leishmania donovani	96%	100%
A4HNA3	Leishmania braziliensis	89%	100%
A4IBX4	Leishmania infantum	96%	100%
C9ZYN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	84%
E9AFR1	Leishmania major	96%	100%
V5BXU8	Trypanosoma cruzi	53%	99%