PIH1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania mexicana

UniProt:

E9B6W3_LEIMU

TriTrypDb:

LmxM.34.4330

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.651
CLV_C14_Caspase3-7	358	362	PF00656	0.500
CLV_NRD_NRD_1	181	183	PF00675	0.341
CLV_NRD_NRD_1	349	351	PF00675	0.342
CLV_NRD_NRD_1	399	401	PF00675	0.261
CLV_NRD_NRD_1	456	458	PF00675	0.546
CLV_NRD_NRD_1	468	470	PF00675	0.420
CLV_NRD_NRD_1	508	510	PF00675	0.502
CLV_NRD_NRD_1	545	547	PF00675	0.659
CLV_PCSK_KEX2_1	181	183	PF00082	0.360
CLV_PCSK_KEX2_1	311	313	PF00082	0.576
CLV_PCSK_KEX2_1	349	351	PF00082	0.314
CLV_PCSK_KEX2_1	456	458	PF00082	0.583
CLV_PCSK_KEX2_1	468	470	PF00082	0.602
CLV_PCSK_KEX2_1	50	52	PF00082	0.541
CLV_PCSK_KEX2_1	508	510	PF00082	0.543
CLV_PCSK_KEX2_1	587	589	PF00082	0.718
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.585
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.610
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.718
CLV_PCSK_PC7_1	345	351	PF00082	0.341
CLV_PCSK_SKI1_1	281	285	PF00082	0.526
CLV_PCSK_SKI1_1	297	301	PF00082	0.517
CLV_PCSK_SKI1_1	426	430	PF00082	0.606
CLV_PCSK_SKI1_1	617	621	PF00082	0.554
CLV_PCSK_SKI1_1	68	72	PF00082	0.313
DEG_APCC_DBOX_1	495	503	PF00400	0.496
DEG_APCC_KENBOX_2	319	323	PF00400	0.459
DEG_Nend_UBRbox_3	1	3	PF02207	0.590
DEG_SPOP_SBC_1	557	561	PF00917	0.590
DOC_CYCLIN_RxL_1	614	623	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	265	268	PF00134	0.456
DOC_MAPK_gen_1	157	166	PF00069	0.444
DOC_MAPK_gen_1	397	407	PF00069	0.490
DOC_MAPK_MEF2A_6	400	409	PF00069	0.473
DOC_MAPK_RevD_3	334	350	PF00069	0.541
DOC_PP1_RVXF_1	204	211	PF00149	0.541
DOC_PP2B_LxvP_1	265	268	PF13499	0.456
DOC_PP2B_LxvP_1	331	334	PF13499	0.513
DOC_PP2B_LxvP_1	87	90	PF13499	0.478
DOC_USP7_MATH_1	23	27	PF00917	0.445
DOC_USP7_MATH_1	242	246	PF00917	0.722
DOC_USP7_MATH_1	273	277	PF00917	0.705
DOC_USP7_MATH_1	283	287	PF00917	0.630
DOC_USP7_MATH_1	477	481	PF00917	0.526
DOC_USP7_MATH_1	582	586	PF00917	0.742
DOC_USP7_MATH_1	590	594	PF00917	0.665
DOC_USP7_UBL2_3	211	215	PF12436	0.509
DOC_USP7_UBL2_3	397	401	PF12436	0.461
DOC_WW_Pin1_4	275	280	PF00397	0.727
DOC_WW_Pin1_4	375	380	PF00397	0.541
DOC_WW_Pin1_4	558	563	PF00397	0.747
DOC_WW_Pin1_4	570	575	PF00397	0.748
LIG_14-3-3_CanoR_1	140	150	PF00244	0.541
LIG_14-3-3_CanoR_1	222	227	PF00244	0.489
LIG_14-3-3_CanoR_1	400	405	PF00244	0.475
LIG_14-3-3_CanoR_1	468	472	PF00244	0.462
LIG_BIR_III_2	272	276	PF00653	0.493
LIG_BRCT_BRCA1_1	12	16	PF00533	0.299
LIG_Clathr_ClatBox_1	619	623	PF01394	0.567
LIG_DLG_GKlike_1	400	407	PF00625	0.564
LIG_FHA_1	285	291	PF00498	0.681
LIG_FHA_1	328	334	PF00498	0.533
LIG_FHA_1	400	406	PF00498	0.541
LIG_FHA_1	567	573	PF00498	0.698
LIG_FHA_2	267	273	PF00498	0.683
LIG_FHA_2	336	342	PF00498	0.492
LIG_FHA_2	358	364	PF00498	0.439
LIG_FHA_2	420	426	PF00498	0.603
LIG_FHA_2	427	433	PF00498	0.551
LIG_FHA_2	516	522	PF00498	0.326
LIG_IBAR_NPY_1	316	318	PF08397	0.454
LIG_KLC1_Yacidic_2	352	357	PF13176	0.492
LIG_LIR_Apic_2	136	142	PF02991	0.461
LIG_LIR_Gen_1	13	24	PF02991	0.566
LIG_LIR_Gen_1	378	388	PF02991	0.542
LIG_LIR_Nem_3	13	19	PF02991	0.565
LIG_LIR_Nem_3	177	183	PF02991	0.461
LIG_LIR_Nem_3	203	208	PF02991	0.523
LIG_LIR_Nem_3	378	383	PF02991	0.542
LIG_Pex14_2	16	20	PF04695	0.427
LIG_PTB_Apo_2	204	211	PF02174	0.475
LIG_PTB_Apo_2	313	320	PF02174	0.481
LIG_SH2_CRK	139	143	PF00017	0.541
LIG_SH2_CRK	162	166	PF00017	0.461
LIG_SH2_SRC	332	335	PF00017	0.509
LIG_SH2_STAP1	162	166	PF00017	0.461
LIG_SH2_STAT5	305	308	PF00017	0.446
LIG_SH2_STAT5	318	321	PF00017	0.471
LIG_SH2_STAT5	332	335	PF00017	0.450
LIG_SH2_STAT5	355	358	PF00017	0.461
LIG_SH2_STAT5	398	401	PF00017	0.541
LIG_SH2_STAT5	471	474	PF00017	0.453
LIG_SH2_STAT5	534	537	PF00017	0.437
LIG_SH2_STAT5	618	621	PF00017	0.557
LIG_SH3_3	118	124	PF00018	0.517
LIG_SH3_3	408	414	PF00018	0.461
LIG_SUMO_SIM_par_1	85	91	PF11976	0.356
LIG_TRAF2_1	551	554	PF00917	0.595
LIG_UBA3_1	404	408	PF00899	0.357
LIG_UBA3_1	531	538	PF00899	0.503
MOD_CDC14_SPxK_1	278	281	PF00782	0.488
MOD_CDK_SPxK_1	275	281	PF00069	0.490
MOD_CK1_1	196	202	PF00069	0.387
MOD_CK1_1	250	256	PF00069	0.706
MOD_CK1_1	515	521	PF00069	0.328
MOD_CK1_1	560	566	PF00069	0.739
MOD_CK1_1	570	576	PF00069	0.644
MOD_CK2_1	335	341	PF00069	0.314
MOD_CK2_1	357	363	PF00069	0.284
MOD_CK2_1	39	45	PF00069	0.677
MOD_CK2_1	426	432	PF00069	0.585
MOD_CK2_1	467	473	PF00069	0.479
MOD_CK2_1	515	521	PF00069	0.387
MOD_GlcNHglycan	127	130	PF01048	0.323
MOD_GlcNHglycan	244	247	PF01048	0.686
MOD_GlcNHglycan	25	28	PF01048	0.636
MOD_GlcNHglycan	275	278	PF01048	0.701
MOD_GlcNHglycan	475	478	PF01048	0.558
MOD_GlcNHglycan	479	482	PF01048	0.588
MOD_GlcNHglycan	548	551	PF01048	0.722
MOD_GlcNHglycan	569	572	PF01048	0.690
MOD_GSK3_1	127	134	PF00069	0.167
MOD_GSK3_1	273	280	PF00069	0.676
MOD_GSK3_1	375	382	PF00069	0.422
MOD_GSK3_1	473	480	PF00069	0.582
MOD_GSK3_1	556	563	PF00069	0.745
MOD_GSK3_1	566	573	PF00069	0.675
MOD_GSK3_1	599	606	PF00069	0.621
MOD_LATS_1	310	316	PF00433	0.606
MOD_N-GLC_1	125	130	PF02516	0.264
MOD_N-GLC_1	473	478	PF02516	0.558
MOD_N-GLC_2	109	111	PF02516	0.314
MOD_NEK2_1	327	332	PF00069	0.376
MOD_NEK2_1	39	44	PF00069	0.646
MOD_NEK2_1	600	605	PF00069	0.644
MOD_NEK2_2	335	340	PF00069	0.459
MOD_PIKK_1	127	133	PF00454	0.167
MOD_PIKK_1	222	228	PF00454	0.409
MOD_PIKK_1	247	253	PF00454	0.707
MOD_PIKK_1	414	420	PF00454	0.633
MOD_PIKK_1	590	596	PF00454	0.741
MOD_PK_1	512	518	PF00069	0.508
MOD_PKA_1	400	406	PF00069	0.459
MOD_PKA_1	546	552	PF00069	0.683
MOD_PKA_2	221	227	PF00069	0.314
MOD_PKA_2	399	405	PF00069	0.314
MOD_PKA_2	467	473	PF00069	0.464
MOD_PKB_1	220	228	PF00069	0.310
MOD_PKB_1	544	552	PF00069	0.669
MOD_Plk_1	327	333	PF00069	0.167
MOD_Plk_1	473	479	PF00069	0.565
MOD_Plk_2-3	357	363	PF00069	0.398
MOD_Plk_2-3	467	473	PF00069	0.483
MOD_Plk_2-3	537	543	PF00069	0.630
MOD_Plk_4	400	406	PF00069	0.459
MOD_Plk_4	515	521	PF00069	0.380
MOD_ProDKin_1	275	281	PF00069	0.728
MOD_ProDKin_1	375	381	PF00069	0.426
MOD_ProDKin_1	558	564	PF00069	0.746
MOD_ProDKin_1	570	576	PF00069	0.747
MOD_SUMO_for_1	290	293	PF00179	0.691
MOD_SUMO_for_1	49	52	PF00179	0.615
MOD_SUMO_for_1	551	554	PF00179	0.703
MOD_SUMO_rev_2	390	399	PF00179	0.387
TRG_DiLeu_BaEn_2	178	184	PF01217	0.357
TRG_ENDOCYTIC_2	162	165	PF00928	0.314
TRG_ER_diArg_1	180	182	PF00400	0.426
TRG_ER_diArg_1	220	223	PF00400	0.314
TRG_ER_diArg_1	349	351	PF00400	0.454
TRG_ER_diArg_1	508	511	PF00400	0.545
TRG_ER_diArg_1	543	546	PF00400	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6F3	Leptomonas seymouri	63%	100%
A0A1X0P509	Trypanosomatidae	48%	100%
A0A3Q8IIQ5	Leishmania donovani	90%	98%
A0A422NU93	Trypanosoma rangeli	48%	100%
A4HNA2	Leishmania braziliensis	78%	100%
A4IBX3	Leishmania infantum	89%	98%
B6F1W5	Oryzias latipes	21%	100%
C9ZYN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AFR0	Leishmania major	89%	100%
V5BT79	Trypanosoma cruzi	47%	100%