HAD-like domain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

HAD-like domain

Gene product:

HAD hydrolase, TIGR01456 family/HAD hydrolase, family IIA, putative

Species:

Leishmania mexicana

UniProt:

E9B6W2_LEIMU

TriTrypDb:

LmxM.34.4320

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.540
CLV_NRD_NRD_1	20	22	PF00675	0.525
CLV_NRD_NRD_1	212	214	PF00675	0.222
CLV_NRD_NRD_1	290	292	PF00675	0.450
CLV_NRD_NRD_1	482	484	PF00675	0.443
CLV_NRD_NRD_1	51	53	PF00675	0.514
CLV_NRD_NRD_1	76	78	PF00675	0.542
CLV_PCSK_KEX2_1	13	15	PF00082	0.536
CLV_PCSK_KEX2_1	20	22	PF00082	0.512
CLV_PCSK_KEX2_1	290	292	PF00082	0.408
CLV_PCSK_KEX2_1	315	317	PF00082	0.467
CLV_PCSK_KEX2_1	426	428	PF00082	0.254
CLV_PCSK_KEX2_1	482	484	PF00082	0.443
CLV_PCSK_KEX2_1	51	53	PF00082	0.482
CLV_PCSK_KEX2_1	76	78	PF00082	0.660
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.509
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.270
CLV_PCSK_SKI1_1	118	122	PF00082	0.417
CLV_PCSK_SKI1_1	393	397	PF00082	0.337
CLV_PCSK_SKI1_1	426	430	PF00082	0.296
CLV_PCSK_SKI1_1	443	447	PF00082	0.237
CLV_PCSK_SKI1_1	515	519	PF00082	0.320
DEG_APCC_DBOX_1	392	400	PF00400	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.615
DEG_ODPH_VHL_1	263	275	PF01847	0.413
DEG_SPOP_SBC_1	171	175	PF00917	0.655
DOC_CKS1_1	365	370	PF01111	0.439
DOC_CYCLIN_RxL_1	512	522	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.405
DOC_MAPK_gen_1	213	220	PF00069	0.413
DOC_MAPK_MEF2A_6	213	222	PF00069	0.415
DOC_PP2B_LxvP_1	218	221	PF13499	0.405
DOC_PP2B_LxvP_1	262	265	PF13499	0.416
DOC_PP4_FxxP_1	22	25	PF00568	0.482
DOC_USP7_MATH_1	134	138	PF00917	0.620
DOC_USP7_MATH_1	169	173	PF00917	0.646
DOC_USP7_MATH_1	359	363	PF00917	0.408
DOC_WW_Pin1_4	12	17	PF00397	0.673
DOC_WW_Pin1_4	130	135	PF00397	0.565
DOC_WW_Pin1_4	167	172	PF00397	0.652
DOC_WW_Pin1_4	176	181	PF00397	0.645
DOC_WW_Pin1_4	255	260	PF00397	0.410
DOC_WW_Pin1_4	364	369	PF00397	0.410
DOC_WW_Pin1_4	499	504	PF00397	0.378
DOC_WW_Pin1_4	68	73	PF00397	0.483
DOC_WW_Pin1_4	98	103	PF00397	0.597
LIG_14-3-3_CanoR_1	2	8	PF00244	0.649
LIG_14-3-3_CanoR_1	213	219	PF00244	0.507
LIG_14-3-3_CanoR_1	290	296	PF00244	0.397
LIG_14-3-3_CanoR_1	482	486	PF00244	0.419
LIG_EH1_1	511	519	PF00400	0.399
LIG_eIF4E_1	199	205	PF01652	0.448
LIG_FHA_1	215	221	PF00498	0.507
LIG_FHA_1	482	488	PF00498	0.484
LIG_FHA_2	30	36	PF00498	0.565
LIG_FHA_2	343	349	PF00498	0.338
LIG_LIR_Apic_2	162	167	PF02991	0.514
LIG_LIR_Apic_2	502	508	PF02991	0.346
LIG_LIR_Gen_1	337	347	PF02991	0.345
LIG_LIR_Gen_1	398	408	PF02991	0.357
LIG_LIR_Gen_1	464	472	PF02991	0.219
LIG_LIR_LC3C_4	270	275	PF02991	0.459
LIG_LIR_Nem_3	321	327	PF02991	0.332
LIG_LIR_Nem_3	337	343	PF02991	0.279
LIG_LIR_Nem_3	34	40	PF02991	0.481
LIG_LIR_Nem_3	398	403	PF02991	0.358
LIG_LIR_Nem_3	464	469	PF02991	0.219
LIG_LIR_Nem_3	5	11	PF02991	0.604
LIG_LYPXL_SIV_4	368	376	PF13949	0.436
LIG_LYPXL_SIV_4	420	428	PF13949	0.336
LIG_NRBOX	239	245	PF00104	0.507
LIG_Pex14_2	22	26	PF04695	0.480
LIG_Pex14_2	442	446	PF04695	0.270
LIG_SH2_CRK	413	417	PF00017	0.257
LIG_SH2_CRK	8	12	PF00017	0.667
LIG_SH2_NCK_1	400	404	PF00017	0.476
LIG_SH2_PTP2	164	167	PF00017	0.539
LIG_SH2_PTP2	505	508	PF00017	0.331
LIG_SH2_SRC	164	167	PF00017	0.515
LIG_SH2_SRC	421	424	PF00017	0.215
LIG_SH2_STAP1	141	145	PF00017	0.477
LIG_SH2_STAP1	161	165	PF00017	0.485
LIG_SH2_STAT5	105	108	PF00017	0.428
LIG_SH2_STAT5	164	167	PF00017	0.539
LIG_SH2_STAT5	360	363	PF00017	0.391
LIG_SH2_STAT5	369	372	PF00017	0.254
LIG_SH2_STAT5	505	508	PF00017	0.331
LIG_SH3_3	177	183	PF00018	0.574
LIG_SH3_3	272	278	PF00018	0.430
LIG_SH3_3	319	325	PF00018	0.351
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.510
LIG_SUMO_SIM_anti_2	345	351	PF11976	0.339
LIG_SUMO_SIM_par_1	483	489	PF11976	0.441
LIG_TRAF2_1	32	35	PF00917	0.587
LIG_TRAF2_1	71	74	PF00917	0.508
MOD_CDC14_SPxK_1	258	261	PF00782	0.507
MOD_CDK_SPxK_1	255	261	PF00069	0.472
MOD_CDK_SPxK_1	98	104	PF00069	0.596
MOD_CK1_1	128	134	PF00069	0.668
MOD_CK1_1	137	143	PF00069	0.605
MOD_CK1_1	170	176	PF00069	0.662
MOD_CK1_1	497	503	PF00069	0.385
MOD_CK2_1	132	138	PF00069	0.687
MOD_CK2_1	29	35	PF00069	0.486
MOD_CK2_1	395	401	PF00069	0.461
MOD_CK2_1	68	74	PF00069	0.507
MOD_GlcNHglycan	127	130	PF01048	0.601
MOD_GlcNHglycan	174	177	PF01048	0.662
MOD_GlcNHglycan	227	230	PF01048	0.240
MOD_GlcNHglycan	238	243	PF01048	0.198
MOD_GlcNHglycan	247	251	PF01048	0.132
MOD_GlcNHglycan	327	330	PF01048	0.410
MOD_GlcNHglycan	361	364	PF01048	0.465
MOD_GlcNHglycan	430	434	PF01048	0.338
MOD_GlcNHglycan	472	475	PF01048	0.242
MOD_GlcNHglycan	8	11	PF01048	0.605
MOD_GSK3_1	128	135	PF00069	0.605
MOD_GSK3_1	137	144	PF00069	0.603
MOD_GSK3_1	167	174	PF00069	0.657
MOD_GSK3_1	2	9	PF00069	0.591
MOD_GSK3_1	225	232	PF00069	0.558
MOD_GSK3_1	359	366	PF00069	0.378
MOD_GSK3_1	395	402	PF00069	0.467
MOD_N-GLC_1	125	130	PF02516	0.664
MOD_NEK2_1	1	6	PF00069	0.603
MOD_NEK2_1	106	111	PF00069	0.483
MOD_NEK2_1	184	189	PF00069	0.320
MOD_NEK2_1	225	230	PF00069	0.396
MOD_NEK2_1	395	400	PF00069	0.416
MOD_NEK2_1	41	46	PF00069	0.538
MOD_NEK2_1	465	470	PF00069	0.336
MOD_PIKK_1	128	134	PF00454	0.529
MOD_PK_1	291	297	PF00069	0.361
MOD_PK_1	483	489	PF00069	0.567
MOD_PKA_1	213	219	PF00069	0.495
MOD_PKA_2	1	7	PF00069	0.569
MOD_PKA_2	481	487	PF00069	0.443
MOD_Plk_1	238	244	PF00069	0.448
MOD_Plk_2-3	342	348	PF00069	0.352
MOD_Plk_4	342	348	PF00069	0.345
MOD_Plk_4	395	401	PF00069	0.461
MOD_ProDKin_1	12	18	PF00069	0.673
MOD_ProDKin_1	130	136	PF00069	0.566
MOD_ProDKin_1	167	173	PF00069	0.653
MOD_ProDKin_1	176	182	PF00069	0.628
MOD_ProDKin_1	255	261	PF00069	0.410
MOD_ProDKin_1	364	370	PF00069	0.406
MOD_ProDKin_1	499	505	PF00069	0.371
MOD_ProDKin_1	68	74	PF00069	0.483
MOD_ProDKin_1	98	104	PF00069	0.596
MOD_SUMO_rev_2	151	158	PF00179	0.562
MOD_SUMO_rev_2	27	33	PF00179	0.460
TRG_DiLeu_BaEn_1	239	244	PF01217	0.430
TRG_DiLeu_BaEn_1	269	274	PF01217	0.459
TRG_DiLeu_BaEn_3	90	96	PF01217	0.548
TRG_DiLeu_BaEn_4	73	79	PF01217	0.586
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.537
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.507
TRG_ENDOCYTIC_2	400	403	PF00928	0.481
TRG_ENDOCYTIC_2	8	11	PF00928	0.669
TRG_ER_diArg_1	12	14	PF00400	0.540
TRG_ER_diArg_1	20	22	PF00400	0.502
TRG_ER_diArg_1	289	291	PF00400	0.455
TRG_ER_diArg_1	76	78	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I3	Leptomonas seymouri	74%	100%
A0A0S4JPF8	Bodo saltans	52%	100%
A0A1X0P5B2	Trypanosomatidae	58%	100%
A0A3Q8IMX2	Leishmania donovani	94%	100%
A0A3R7L7A5	Trypanosoma rangeli	59%	100%
A4HNA1	Leishmania braziliensis	84%	100%
A4IBX2	Leishmania infantum	94%	100%
C9ZYN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AFQ9	Leishmania major	94%	100%
O13899	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	96%
V5BCR1	Trypanosoma cruzi	60%	100%