LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6W1_LEIMU
TriTrypDb:
LmxM.34.4310
Length:
141

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9B6W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W1

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_Nend_Nbox_1 1 3 PF02207 0.616
DOC_WW_Pin1_4 109 114 PF00397 0.636
DOC_WW_Pin1_4 41 46 PF00397 0.398
LIG_14-3-3_CanoR_1 133 138 PF00244 0.682
LIG_APCC_ABBA_1 89 94 PF00400 0.325
LIG_BRCT_BRCA1_1 3 7 PF00533 0.619
LIG_Clathr_ClatBox_1 90 94 PF01394 0.284
LIG_DLG_GKlike_1 133 141 PF00625 0.636
LIG_FHA_1 12 18 PF00498 0.458
LIG_FHA_1 32 38 PF00498 0.368
LIG_FHA_1 63 69 PF00498 0.394
LIG_FHA_2 34 40 PF00498 0.404
LIG_LIR_LC3C_4 14 18 PF02991 0.369
LIG_LIR_LC3C_4 85 88 PF02991 0.325
LIG_NRBOX 51 57 PF00104 0.453
LIG_NRBOX 85 91 PF00104 0.304
LIG_SH2_GRB2like 118 121 PF00017 0.632
LIG_SH2_STAP1 124 128 PF00017 0.638
LIG_SH2_STAT3 118 121 PF00017 0.601
LIG_SH2_STAT5 25 28 PF00017 0.304
LIG_SH3_1 42 48 PF00018 0.398
LIG_SH3_3 42 48 PF00018 0.426
LIG_SUMO_SIM_anti_2 14 20 PF11976 0.455
LIG_SUMO_SIM_anti_2 85 91 PF11976 0.369
LIG_SUMO_SIM_par_1 14 20 PF11976 0.455
LIG_TYR_ITIM 23 28 PF00017 0.272
MOD_CK2_1 33 39 PF00069 0.397
MOD_GlcNHglycan 130 133 PF01048 0.332
MOD_GlcNHglycan 7 10 PF01048 0.316
MOD_GlcNHglycan 74 77 PF01048 0.430
MOD_GSK3_1 1 8 PF00069 0.644
MOD_N-GLC_1 72 77 PF02516 0.576
MOD_NEK2_1 1 6 PF00069 0.630
MOD_NEK2_1 128 133 PF00069 0.556
MOD_NEK2_1 33 38 PF00069 0.454
MOD_NEK2_1 7 12 PF00069 0.617
MOD_NEK2_1 72 77 PF00069 0.364
MOD_Plk_1 72 78 PF00069 0.269
MOD_Plk_4 1 7 PF00069 0.604
MOD_ProDKin_1 109 115 PF00069 0.634
MOD_ProDKin_1 41 47 PF00069 0.398
TRG_ENDOCYTIC_2 25 28 PF00928 0.318
TRG_ER_diLys_1 138 141 PF00400 0.668
TRG_NES_CRM1_1 53 67 PF08389 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBU8 Leptomonas seymouri 53% 99%
A0A3S7X9Y2 Leishmania donovani 92% 100%
A4HNA0 Leishmania braziliensis 71% 100%
A4IBX1 Leishmania infantum 92% 100%
E9AFQ8 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS