Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6W0_LEIMU

TriTrypDb:

LmxM.34.4300

Length:

249

Annotations

LeishMANIAdb annotations

A very conserved protein restricted to Kinetoplastids, protentially involved in coiled-coil interactions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.368
CLV_NRD_NRD_1	181	183	PF00675	0.321
CLV_NRD_NRD_1	230	232	PF00675	0.345
CLV_NRD_NRD_1	25	27	PF00675	0.700
CLV_NRD_NRD_1	76	78	PF00675	0.599
CLV_PCSK_FUR_1	74	78	PF00082	0.538
CLV_PCSK_KEX2_1	180	182	PF00082	0.322
CLV_PCSK_KEX2_1	2	4	PF00082	0.649
CLV_PCSK_KEX2_1	230	232	PF00082	0.369
CLV_PCSK_KEX2_1	246	248	PF00082	0.343
CLV_PCSK_KEX2_1	25	27	PF00082	0.695
CLV_PCSK_KEX2_1	74	76	PF00082	0.601
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.345
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.726
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.335
CLV_PCSK_PC7_1	226	232	PF00082	0.355
CLV_PCSK_SKI1_1	133	137	PF00082	0.382
CLV_PCSK_SKI1_1	150	154	PF00082	0.320
CLV_PCSK_SKI1_1	181	185	PF00082	0.388
CLV_Separin_Metazoa	157	161	PF03568	0.552
DEG_APCC_DBOX_1	149	157	PF00400	0.521
DEG_APCC_KENBOX_2	60	64	PF00400	0.375
DEG_Nend_UBRbox_1	1	4	PF02207	0.472
DOC_MAPK_gen_1	160	167	PF00069	0.541
DOC_MAPK_gen_1	180	186	PF00069	0.546
DOC_MAPK_gen_1	74	82	PF00069	0.412
DOC_MAPK_MEF2A_6	109	116	PF00069	0.286
DOC_USP7_MATH_1	185	189	PF00917	0.536
DOC_USP7_MATH_1	64	68	PF00917	0.517
LIG_14-3-3_CanoR_1	230	236	PF00244	0.550
LIG_14-3-3_CanoR_1	3	9	PF00244	0.437
LIG_FHA_1	119	125	PF00498	0.401
LIG_FHA_1	147	153	PF00498	0.544
LIG_FHA_1	211	217	PF00498	0.616
LIG_FHA_1	84	90	PF00498	0.413
LIG_FHA_1	92	98	PF00498	0.361
LIG_LIR_Nem_3	99	104	PF02991	0.352
LIG_Pex14_2	103	107	PF04695	0.319
LIG_SH2_PTP2	90	93	PF00017	0.372
LIG_SH2_SRC	90	93	PF00017	0.372
LIG_SH2_STAP1	27	31	PF00017	0.491
LIG_SH2_STAT3	174	177	PF00017	0.531
LIG_SH2_STAT5	235	238	PF00017	0.513
LIG_SH2_STAT5	90	93	PF00017	0.393
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.546
LIG_SUMO_SIM_par_1	78	83	PF11976	0.449
LIG_TRAF2_1	69	72	PF00917	0.453
LIG_UBA3_1	152	161	PF00899	0.624
MOD_CK1_1	14	20	PF00069	0.436
MOD_CK1_1	83	89	PF00069	0.425
MOD_CK2_1	151	157	PF00069	0.538
MOD_CK2_1	186	192	PF00069	0.544
MOD_GlcNHglycan	16	19	PF01048	0.736
MOD_GlcNHglycan	5	8	PF01048	0.621
MOD_GSK3_1	127	134	PF00069	0.633
MOD_N-GLC_1	83	88	PF02516	0.605
MOD_NEK2_1	118	123	PF00069	0.274
MOD_NEK2_1	82	87	PF00069	0.406
MOD_PIKK_1	118	124	PF00454	0.274
MOD_PIKK_1	133	139	PF00454	0.578
MOD_PIKK_1	229	235	PF00454	0.547
MOD_PKA_1	2	8	PF00069	0.428
MOD_PKA_2	127	133	PF00069	0.624
MOD_PKA_2	2	8	PF00069	0.442
MOD_PKA_2	207	213	PF00069	0.602
MOD_PKA_2	229	235	PF00069	0.558
MOD_Plk_2-3	151	157	PF00069	0.532
MOD_Plk_2-3	192	198	PF00069	0.635
MOD_Plk_4	8	14	PF00069	0.497
MOD_Plk_4	96	102	PF00069	0.358
MOD_SUMO_rev_2	41	48	PF00179	0.415
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.538
TRG_ENDOCYTIC_2	101	104	PF00928	0.334
TRG_ER_diArg_1	25	27	PF00400	0.451
TRG_ER_diArg_1	73	76	PF00400	0.503
TRG_ER_diLys_1	244	249	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X4	Leptomonas seymouri	78%	98%
A0A0S4KGJ1	Bodo saltans	63%	100%
A0A1X0P6H7	Trypanosomatidae	82%	95%
A0A3Q8IIE6	Leishmania donovani	94%	100%
A0A422NU86	Trypanosoma rangeli	76%	98%
A4HN99	Leishmania braziliensis	83%	99%
A4IBX0	Leishmania infantum	95%	100%
C9ZYN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	98%
E9AFQ7	Leishmania major	94%	100%
V5DUI0	Trypanosoma cruzi	80%	100%