Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B6V9_LEIMU

TriTrypDb:

LmxM.34.4290

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B6V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.599
CLV_NRD_NRD_1	60	62	PF00675	0.371
CLV_NRD_NRD_1	73	75	PF00675	0.362
CLV_PCSK_FUR_1	57	61	PF00082	0.371
CLV_PCSK_FUR_1	71	75	PF00082	0.303
CLV_PCSK_KEX2_1	272	274	PF00082	0.404
CLV_PCSK_KEX2_1	284	286	PF00082	0.434
CLV_PCSK_KEX2_1	59	61	PF00082	0.368
CLV_PCSK_KEX2_1	71	73	PF00082	0.360
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.387
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.374
CLV_PCSK_PC7_1	68	74	PF00082	0.400
CLV_PCSK_SKI1_1	12	16	PF00082	0.634
CLV_PCSK_SKI1_1	284	288	PF00082	0.380
CLV_PCSK_SKI1_1	298	302	PF00082	0.451
CLV_PCSK_SKI1_1	80	84	PF00082	0.410
DEG_Nend_UBRbox_2	1	3	PF02207	0.519
DEG_SPOP_SBC_1	105	109	PF00917	0.695
DEG_SPOP_SBC_1	206	210	PF00917	0.619
DEG_SPOP_SBC_1	96	100	PF00917	0.697
DOC_CYCLIN_RxL_1	282	292	PF00134	0.641
DOC_CYCLIN_yClb1_LxF_4	221	226	PF00134	0.680
DOC_MAPK_DCC_7	182	191	PF00069	0.625
DOC_MAPK_gen_1	133	141	PF00069	0.621
DOC_MAPK_gen_1	182	191	PF00069	0.625
DOC_MAPK_HePTP_8	179	191	PF00069	0.626
DOC_MAPK_MEF2A_6	182	191	PF00069	0.731
DOC_MAPK_MEF2A_6	80	88	PF00069	0.533
DOC_PP1_RVXF_1	221	227	PF00149	0.682
DOC_PP2B_LxvP_1	139	142	PF13499	0.666
DOC_PP2B_LxvP_1	189	192	PF13499	0.714
DOC_PP4_FxxP_1	226	229	PF00568	0.686
DOC_USP7_MATH_1	10	14	PF00917	0.459
DOC_USP7_MATH_1	105	109	PF00917	0.662
DOC_USP7_MATH_1	142	146	PF00917	0.671
DOC_USP7_MATH_1	192	196	PF00917	0.679
DOC_USP7_MATH_1	212	216	PF00917	0.725
DOC_USP7_MATH_1	294	298	PF00917	0.684
DOC_USP7_MATH_1	302	306	PF00917	0.728
DOC_USP7_MATH_1	46	50	PF00917	0.591
DOC_WW_Pin1_4	149	154	PF00397	0.715
DOC_WW_Pin1_4	201	206	PF00397	0.680
DOC_WW_Pin1_4	225	230	PF00397	0.656
DOC_WW_Pin1_4	6	11	PF00397	0.408
LIG_14-3-3_CanoR_1	155	161	PF00244	0.607
LIG_14-3-3_CanoR_1	260	268	PF00244	0.612
LIG_Actin_WH2_2	120	135	PF00022	0.579
LIG_BIR_III_2	150	154	PF00653	0.616
LIG_CSL_BTD_1	135	138	PF09270	0.671
LIG_FHA_1	127	133	PF00498	0.571
LIG_FHA_1	154	160	PF00498	0.708
LIG_FHA_1	174	180	PF00498	0.845
LIG_FHA_1	215	221	PF00498	0.692
LIG_FHA_1	288	294	PF00498	0.669
LIG_FHA_1	319	325	PF00498	0.711
LIG_FHA_1	81	87	PF00498	0.581
LIG_FHA_1	9	15	PF00498	0.396
LIG_FHA_2	176	182	PF00498	0.632
LIG_FHA_2	195	201	PF00498	0.794
LIG_FHA_2	232	238	PF00498	0.649
LIG_FHA_2	96	102	PF00498	0.614
LIG_LIR_Gen_1	13	20	PF02991	0.411
LIG_LIR_Nem_3	13	18	PF02991	0.414
LIG_LIR_Nem_3	135	140	PF02991	0.624
LIG_MYND_1	138	142	PF01753	0.681
LIG_NRBOX	23	29	PF00104	0.345
LIG_PALB2_WD40_1	132	140	PF16756	0.668
LIG_PCNA_yPIPBox_3	267	281	PF02747	0.631
LIG_Rb_LxCxE_1	49	63	PF01857	0.569
LIG_SH2_GRB2like	20	23	PF00017	0.346
LIG_SH2_GRB2like	244	247	PF00017	0.662
LIG_Sin3_3	137	144	PF02671	0.592
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.324
LIG_SUMO_SIM_par_1	81	87	PF11976	0.531
LIG_TYR_ITIM	29	34	PF00017	0.381
LIG_UBA3_1	42	47	PF00899	0.207
LIG_WW_3	152	156	PF00397	0.567
MOD_CDC14_SPxK_1	152	155	PF00782	0.640
MOD_CDK_SPxK_1	149	155	PF00069	0.639
MOD_CDK_SPxK_1	6	12	PF00069	0.499
MOD_CK1_1	107	113	PF00069	0.648
MOD_CK1_1	195	201	PF00069	0.625
MOD_CK1_1	215	221	PF00069	0.575
MOD_CK1_1	242	248	PF00069	0.743
MOD_CK1_1	252	258	PF00069	0.554
MOD_CK1_1	6	12	PF00069	0.610
MOD_CK1_1	87	93	PF00069	0.608
MOD_CK2_1	125	131	PF00069	0.632
MOD_CK2_1	175	181	PF00069	0.603
MOD_CK2_1	231	237	PF00069	0.552
MOD_CK2_1	259	265	PF00069	0.474
MOD_GlcNHglycan	194	197	PF01048	0.696
MOD_GlcNHglycan	214	217	PF01048	0.674
MOD_GlcNHglycan	304	307	PF01048	0.522
MOD_GlcNHglycan	80	83	PF01048	0.479
MOD_GSK3_1	107	114	PF00069	0.567
MOD_GSK3_1	149	156	PF00069	0.681
MOD_GSK3_1	181	188	PF00069	0.624
MOD_GSK3_1	192	199	PF00069	0.620
MOD_GSK3_1	201	208	PF00069	0.770
MOD_GSK3_1	210	217	PF00069	0.711
MOD_GSK3_1	238	245	PF00069	0.663
MOD_GSK3_1	248	255	PF00069	0.598
MOD_GSK3_1	318	325	PF00069	0.704
MOD_GSK3_1	4	11	PF00069	0.625
MOD_GSK3_1	80	87	PF00069	0.611
MOD_GSK3_1	97	104	PF00069	0.640
MOD_N-GLC_1	167	172	PF02516	0.628
MOD_N-GLC_1	231	236	PF02516	0.490
MOD_N-GLC_1	245	250	PF02516	0.644
MOD_N-GLC_1	3	8	PF02516	0.595
MOD_N-GLC_1	96	101	PF02516	0.568
MOD_N-GLC_2	256	258	PF02516	0.614
MOD_NEK2_1	132	137	PF00069	0.452
MOD_NEK2_1	239	244	PF00069	0.590
MOD_NEK2_1	289	294	PF00069	0.576
MOD_NEK2_1	86	91	PF00069	0.481
MOD_NEK2_2	10	15	PF00069	0.479
MOD_NEK2_2	175	180	PF00069	0.586
MOD_PIKK_1	207	213	PF00454	0.516
MOD_PKA_2	154	160	PF00069	0.501
MOD_PKA_2	242	248	PF00069	0.769
MOD_PKA_2	252	258	PF00069	0.546
MOD_PKA_2	259	265	PF00069	0.484
MOD_Plk_1	239	245	PF00069	0.743
MOD_Plk_1	84	90	PF00069	0.407
MOD_Plk_4	132	138	PF00069	0.506
MOD_Plk_4	46	52	PF00069	0.401
MOD_ProDKin_1	149	155	PF00069	0.649
MOD_ProDKin_1	201	207	PF00069	0.598
MOD_ProDKin_1	225	231	PF00069	0.567
MOD_ProDKin_1	6	12	PF00069	0.499
MOD_SUMO_rev_2	125	135	PF00179	0.521
TRG_DiLeu_BaEn_1	25	30	PF01217	0.381
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.594
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.550
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.532
TRG_ENDOCYTIC_2	31	34	PF00928	0.391
TRG_ER_diArg_1	59	61	PF00400	0.441
TRG_ER_diArg_1	71	74	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK89	Leptomonas seymouri	34%	100%
A0A3S7X9U4	Leishmania donovani	82%	100%
A4HN98	Leishmania braziliensis	58%	100%
A4IBW9	Leishmania infantum	82%	100%
E9AFQ6	Leishmania major	77%	100%