SAS-6_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal protein 6 homolog

Species:

Leishmania mexicana

UniProt:

E9B6V8_LEIMU

TriTrypDb:

LmxM.34.4280

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

E9B6V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V8

PDB structure(s): 4ckm_A , 4ckm_B , 4ckm_C , 4ckn_A , 4ckn_B , 4ckn_C , 4ckn_D , 4ckp_A , 4ckp_B , 4ckp_C , 4ckp_D , 4ckp_E , 4ckp_F

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.550
CLV_C14_Caspase3-7	700	704	PF00656	0.733
CLV_C14_Caspase3-7	74	78	PF00656	0.501
CLV_NRD_NRD_1	32	34	PF00675	0.819
CLV_NRD_NRD_1	322	324	PF00675	0.534
CLV_NRD_NRD_1	553	555	PF00675	0.645
CLV_NRD_NRD_1	570	572	PF00675	0.621
CLV_NRD_NRD_1	75	77	PF00675	0.781
CLV_NRD_NRD_1	751	753	PF00675	0.738
CLV_PCSK_KEX2_1	276	278	PF00082	0.476

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL2	Leptomonas seymouri	58%	97%
A0A1X0NEU3	Trypanosomatidae	40%	100%
A0A3S7X9W8	Leishmania donovani	92%	100%
A4HN97	Leishmania braziliensis	79%	99%
A4IBW8	Leishmania infantum	92%	100%
E9AFQ5	Leishmania major	90%	100%
V5C2P0	Trypanosoma cruzi	46%	100%

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