SAS-6_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal protein 6 homolog

Species:

Leishmania mexicana

UniProt:

E9B6V8_LEIMU

TriTrypDb:

LmxM.34.4280

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0043226	organelle	2	9
GO:0043229	intracellular organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9B6V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V8

PDB structure(s): 4ckm_A , 4ckm_B , 4ckm_C , 4ckn_A , 4ckn_B , 4ckn_C , 4ckn_D , 4ckp_A , 4ckp_B , 4ckp_C , 4ckp_D , 4ckp_E , 4ckp_F

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007099	centriole replication	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0098534	centriole assembly	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.550
CLV_C14_Caspase3-7	700	704	PF00656	0.733
CLV_C14_Caspase3-7	74	78	PF00656	0.501
CLV_NRD_NRD_1	32	34	PF00675	0.819
CLV_NRD_NRD_1	322	324	PF00675	0.534
CLV_NRD_NRD_1	553	555	PF00675	0.645
CLV_NRD_NRD_1	570	572	PF00675	0.621
CLV_NRD_NRD_1	75	77	PF00675	0.781
CLV_NRD_NRD_1	751	753	PF00675	0.738
CLV_PCSK_KEX2_1	276	278	PF00082	0.476
CLV_PCSK_KEX2_1	31	33	PF00082	0.820
CLV_PCSK_KEX2_1	553	555	PF00082	0.645
CLV_PCSK_KEX2_1	75	77	PF00082	0.738
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.476
CLV_PCSK_PC7_1	27	33	PF00082	0.810
CLV_PCSK_SKI1_1	171	175	PF00082	0.507
CLV_PCSK_SKI1_1	525	529	PF00082	0.576
CLV_PCSK_SKI1_1	793	797	PF00082	0.626
CLV_Separin_Metazoa	568	572	PF03568	0.622
DEG_APCC_DBOX_1	170	178	PF00400	0.496
DEG_APCC_DBOX_1	245	253	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.728
DOC_ANK_TNKS_1	220	227	PF00023	0.597
DOC_ANK_TNKS_1	74	81	PF00023	0.794
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.410
DOC_MAPK_gen_1	323	331	PF00069	0.558
DOC_MAPK_gen_1	587	596	PF00069	0.625
DOC_MAPK_MEF2A_6	200	209	PF00069	0.501
DOC_MAPK_MEF2A_6	258	267	PF00069	0.501
DOC_MAPK_NFAT4_5	200	208	PF00069	0.501
DOC_PP4_FxxP_1	23	26	PF00568	0.778
DOC_USP7_MATH_1	100	104	PF00917	0.694
DOC_USP7_MATH_1	124	128	PF00917	0.800
DOC_USP7_MATH_1	358	362	PF00917	0.646
DOC_USP7_MATH_1	396	400	PF00917	0.584
DOC_USP7_MATH_1	467	471	PF00917	0.730
DOC_USP7_MATH_1	59	63	PF00917	0.516
DOC_USP7_MATH_1	621	625	PF00917	0.715
DOC_USP7_MATH_1	630	634	PF00917	0.735
DOC_USP7_MATH_1	687	691	PF00917	0.677
DOC_USP7_MATH_1	701	705	PF00917	0.765
DOC_USP7_MATH_1	719	723	PF00917	0.565
DOC_USP7_MATH_1	724	728	PF00917	0.751
DOC_USP7_MATH_1	746	750	PF00917	0.734
DOC_USP7_MATH_1	761	765	PF00917	0.720
DOC_USP7_MATH_1	769	773	PF00917	0.457
DOC_USP7_MATH_1	791	795	PF00917	0.673
DOC_USP7_MATH_1	812	816	PF00917	0.651
DOC_USP7_UBL2_3	508	512	PF12436	0.646
DOC_WD40_RPTOR_TOS_1	187	193	PF00400	0.525
DOC_WW_Pin1_4	120	125	PF00397	0.744
DOC_WW_Pin1_4	677	682	PF00397	0.721
DOC_WW_Pin1_4	717	722	PF00397	0.707
DOC_WW_Pin1_4	776	781	PF00397	0.700
LIG_14-3-3_CanoR_1	176	180	PF00244	0.501
LIG_14-3-3_CanoR_1	319	323	PF00244	0.633
LIG_14-3-3_CanoR_1	397	405	PF00244	0.651
LIG_14-3-3_CanoR_1	53	59	PF00244	0.793
LIG_14-3-3_CanoR_1	672	676	PF00244	0.752
LIG_14-3-3_CanoR_1	677	681	PF00244	0.755
LIG_14-3-3_CanoR_1	730	739	PF00244	0.749
LIG_14-3-3_CanoR_1	745	749	PF00244	0.744
LIG_14-3-3_CanoR_1	752	756	PF00244	0.720
LIG_14-3-3_CanoR_1	784	788	PF00244	0.785
LIG_14-3-3_CanoR_1	804	813	PF00244	0.664
LIG_Actin_WH2_2	253	271	PF00022	0.501
LIG_Actin_WH2_2	304	321	PF00022	0.546
LIG_Actin_WH2_2	366	383	PF00022	0.630
LIG_Actin_WH2_2	448	464	PF00022	0.615
LIG_AP2alpha_2	182	184	PF02296	0.501
LIG_BRCT_BRCA1_1	19	23	PF00533	0.777
LIG_BRCT_BRCA1_1	814	818	PF00533	0.617
LIG_CaM_IQ_9	563	579	PF13499	0.682
LIG_Clathr_ClatBox_1	186	190	PF01394	0.525
LIG_eIF4E_1	664	670	PF01652	0.447
LIG_FHA_1	136	142	PF00498	0.525
LIG_FHA_1	168	174	PF00498	0.531
LIG_FHA_1	246	252	PF00498	0.501
LIG_FHA_1	299	305	PF00498	0.495
LIG_FHA_1	368	374	PF00498	0.594
LIG_FHA_1	375	381	PF00498	0.605
LIG_FHA_1	396	402	PF00498	0.640
LIG_FHA_1	416	422	PF00498	0.667
LIG_FHA_1	456	462	PF00498	0.582
LIG_FHA_1	561	567	PF00498	0.674
LIG_FHA_1	605	611	PF00498	0.726
LIG_FHA_1	654	660	PF00498	0.659
LIG_FHA_1	734	740	PF00498	0.748
LIG_FHA_2	332	338	PF00498	0.534
LIG_FHA_2	381	387	PF00498	0.609
LIG_FHA_2	426	432	PF00498	0.630
LIG_FHA_2	454	460	PF00498	0.667
LIG_FHA_2	62	68	PF00498	0.644
LIG_FHA_2	698	704	PF00498	0.747
LIG_Integrin_isoDGR_2	611	613	PF01839	0.623
LIG_LIR_Apic_2	20	26	PF02991	0.738
LIG_LIR_Gen_1	193	203	PF02991	0.597
LIG_LIR_Gen_1	451	461	PF02991	0.620
LIG_LIR_Gen_1	486	493	PF02991	0.554
LIG_LIR_Nem_3	182	187	PF02991	0.499
LIG_LIR_Nem_3	193	199	PF02991	0.496
LIG_LIR_Nem_3	208	212	PF02991	0.501
LIG_LIR_Nem_3	254	260	PF02991	0.503
LIG_LIR_Nem_3	281	286	PF02991	0.447
LIG_LIR_Nem_3	451	457	PF02991	0.616
LIG_LIR_Nem_3	486	491	PF02991	0.553
LIG_LIR_Nem_3	785	790	PF02991	0.720
LIG_MLH1_MIPbox_1	814	818	PF16413	0.617
LIG_PCNA_PIPBox_1	475	484	PF02747	0.648
LIG_Pex14_2	648	652	PF04695	0.688
LIG_SH2_PTP2	454	457	PF00017	0.613
LIG_SH2_PTP2	488	491	PF00017	0.554
LIG_SH2_STAP1	230	234	PF00017	0.525
LIG_SH2_STAP1	286	290	PF00017	0.495
LIG_SH2_STAT3	482	485	PF00017	0.568
LIG_SH2_STAT5	215	218	PF00017	0.497
LIG_SH2_STAT5	278	281	PF00017	0.423
LIG_SH2_STAT5	454	457	PF00017	0.613
LIG_SH2_STAT5	488	491	PF00017	0.554
LIG_SH3_1	144	150	PF00018	0.638
LIG_SH3_3	102	108	PF00018	0.734
LIG_SH3_3	144	150	PF00018	0.574
LIG_SH3_3	177	183	PF00018	0.498
LIG_SH3_3	763	769	PF00018	0.622
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.493
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.400
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.501
LIG_SUMO_SIM_par_1	136	143	PF11976	0.538
LIG_SUMO_SIM_par_1	417	423	PF11976	0.511
LIG_TRAF2_1	127	130	PF00917	0.749
LIG_TRAF2_1	325	328	PF00917	0.550
LIG_TRAF2_1	372	375	PF00917	0.587
LIG_TRAF2_1	470	473	PF00917	0.639
LIG_TRAF2_1	726	729	PF00917	0.746
LIG_TYR_ITIM	452	457	PF00017	0.613
LIG_WRC_WIRS_1	436	441	PF05994	0.423
LIG_WRC_WIRS_1	792	797	PF05994	0.710
MOD_CDC14_SPxK_1	680	683	PF00782	0.614
MOD_CDK_SPK_2	120	125	PF00069	0.802
MOD_CDK_SPxK_1	677	683	PF00069	0.616
MOD_CK1_1	10	16	PF00069	0.739
MOD_CK1_1	18	24	PF00069	0.747
MOD_CK1_1	245	251	PF00069	0.420
MOD_CK1_1	293	299	PF00069	0.512
MOD_CK1_1	407	413	PF00069	0.608
MOD_CK1_1	420	426	PF00069	0.632
MOD_CK1_1	61	67	PF00069	0.585
MOD_CK1_1	671	677	PF00069	0.719
MOD_CK1_1	733	739	PF00069	0.788
MOD_CK1_1	747	753	PF00069	0.637
MOD_CK1_1	779	785	PF00069	0.721
MOD_CK2_1	124	130	PF00069	0.663
MOD_CK2_1	225	231	PF00069	0.529
MOD_CK2_1	331	337	PF00069	0.530
MOD_CK2_1	380	386	PF00069	0.608
MOD_CK2_1	396	402	PF00069	0.609
MOD_CK2_1	425	431	PF00069	0.554
MOD_CK2_1	445	451	PF00069	0.600
MOD_CK2_1	453	459	PF00069	0.581
MOD_CK2_1	467	473	PF00069	0.527
MOD_CK2_1	723	729	PF00069	0.696
MOD_DYRK1A_RPxSP_1	677	681	PF00069	0.613
MOD_GlcNHglycan	102	105	PF01048	0.665
MOD_GlcNHglycan	126	129	PF01048	0.756
MOD_GlcNHglycan	193	199	PF01048	0.372
MOD_GlcNHglycan	227	230	PF01048	0.405
MOD_GlcNHglycan	237	240	PF01048	0.279
MOD_GlcNHglycan	413	416	PF01048	0.610
MOD_GlcNHglycan	619	622	PF01048	0.660
MOD_GlcNHglycan	632	635	PF01048	0.606
MOD_GlcNHglycan	687	690	PF01048	0.706
MOD_GlcNHglycan	703	706	PF01048	0.604
MOD_GlcNHglycan	732	735	PF01048	0.815
MOD_GlcNHglycan	757	760	PF01048	0.718
MOD_GlcNHglycan	763	766	PF01048	0.692
MOD_GlcNHglycan	814	817	PF01048	0.614
MOD_GSK3_1	120	127	PF00069	0.777
MOD_GSK3_1	135	142	PF00069	0.456
MOD_GSK3_1	241	248	PF00069	0.498
MOD_GSK3_1	252	259	PF00069	0.464
MOD_GSK3_1	286	293	PF00069	0.587
MOD_GSK3_1	391	398	PF00069	0.635
MOD_GSK3_1	407	414	PF00069	0.442
MOD_GSK3_1	420	427	PF00069	0.595
MOD_GSK3_1	441	448	PF00069	0.571
MOD_GSK3_1	463	470	PF00069	0.677
MOD_GSK3_1	54	61	PF00069	0.815
MOD_GSK3_1	6	13	PF00069	0.738
MOD_GSK3_1	617	624	PF00069	0.704
MOD_GSK3_1	653	660	PF00069	0.685
MOD_GSK3_1	67	74	PF00069	0.576
MOD_GSK3_1	671	678	PF00069	0.712
MOD_GSK3_1	681	688	PF00069	0.661
MOD_GSK3_1	693	700	PF00069	0.691
MOD_GSK3_1	719	726	PF00069	0.650
MOD_GSK3_1	729	736	PF00069	0.632
MOD_GSK3_1	747	754	PF00069	0.574
MOD_GSK3_1	779	786	PF00069	0.594
MOD_GSK3_1	799	806	PF00069	0.596
MOD_N-GLC_1	7	12	PF02516	0.731
MOD_NEK2_1	1	6	PF00069	0.728
MOD_NEK2_1	134	139	PF00069	0.618
MOD_NEK2_1	140	145	PF00069	0.543
MOD_NEK2_1	158	163	PF00069	0.289
MOD_NEK2_1	318	323	PF00069	0.533
MOD_NEK2_1	380	385	PF00069	0.607
MOD_NEK2_1	391	396	PF00069	0.527
MOD_NEK2_1	461	466	PF00069	0.625
MOD_NEK2_1	54	59	PF00069	0.806
MOD_NEK2_1	580	585	PF00069	0.625
MOD_NEK2_1	604	609	PF00069	0.608
MOD_NEK2_1	723	728	PF00069	0.751
MOD_NEK2_2	286	291	PF00069	0.545
MOD_NEK2_2	791	796	PF00069	0.696
MOD_PIKK_1	407	413	PF00454	0.464
MOD_PIKK_1	52	58	PF00454	0.523
MOD_PIKK_1	594	600	PF00454	0.587
MOD_PIKK_1	653	659	PF00454	0.679
MOD_PIKK_1	724	730	PF00454	0.744
MOD_PIKK_1	799	805	PF00454	0.771
MOD_PIKK_1	90	96	PF00454	0.695
MOD_PKA_2	175	181	PF00069	0.491
MOD_PKA_2	245	251	PF00069	0.510
MOD_PKA_2	290	296	PF00069	0.562
MOD_PKA_2	318	324	PF00069	0.524
MOD_PKA_2	358	364	PF00069	0.527
MOD_PKA_2	380	386	PF00069	0.652
MOD_PKA_2	396	402	PF00069	0.398
MOD_PKA_2	461	467	PF00069	0.667
MOD_PKA_2	52	58	PF00069	0.792
MOD_PKA_2	671	677	PF00069	0.750
MOD_PKA_2	709	715	PF00069	0.748
MOD_PKA_2	729	735	PF00069	0.808
MOD_PKA_2	744	750	PF00069	0.688
MOD_PKA_2	751	757	PF00069	0.734
MOD_PKA_2	783	789	PF00069	0.551
MOD_PKA_2	803	809	PF00069	0.673
MOD_PKB_1	460	468	PF00069	0.622
MOD_Plk_1	135	141	PF00069	0.522
MOD_Plk_1	194	200	PF00069	0.524
MOD_Plk_1	230	236	PF00069	0.546
MOD_Plk_1	286	292	PF00069	0.547
MOD_Plk_1	424	430	PF00069	0.407
MOD_Plk_1	7	13	PF00069	0.730
MOD_Plk_2-3	256	262	PF00069	0.501
MOD_Plk_2-3	425	431	PF00069	0.629
MOD_Plk_4	135	141	PF00069	0.518
MOD_Plk_4	18	24	PF00069	0.791
MOD_Plk_4	230	236	PF00069	0.544
MOD_Plk_4	671	677	PF00069	0.740
MOD_Plk_4	7	13	PF00069	0.761
MOD_Plk_4	703	709	PF00069	0.693
MOD_Plk_4	791	797	PF00069	0.627
MOD_ProDKin_1	120	126	PF00069	0.743
MOD_ProDKin_1	677	683	PF00069	0.723
MOD_ProDKin_1	717	723	PF00069	0.711
MOD_ProDKin_1	776	782	PF00069	0.699
MOD_SUMO_for_1	439	442	PF00179	0.666
MOD_SUMO_rev_2	253	260	PF00179	0.560
MOD_SUMO_rev_2	360	366	PF00179	0.591
MOD_SUMO_rev_2	399	406	PF00179	0.604
MOD_SUMO_rev_2	470	476	PF00179	0.723
MOD_SUMO_rev_2	588	597	PF00179	0.585
TRG_DiLeu_BaEn_1	130	135	PF01217	0.540
TRG_DiLeu_BaEn_1	261	266	PF01217	0.501
TRG_DiLeu_BaEn_1	337	342	PF01217	0.622
TRG_DiLeu_BaEn_3	326	332	PF01217	0.575
TRG_ENDOCYTIC_2	196	199	PF00928	0.501
TRG_ENDOCYTIC_2	454	457	PF00928	0.613
TRG_ENDOCYTIC_2	488	491	PF00928	0.554
TRG_ENDOCYTIC_2	664	667	PF00928	0.615
TRG_ER_diArg_1	31	33	PF00400	0.820
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL2	Leptomonas seymouri	58%	97%
A0A1X0NEU3	Trypanosomatidae	40%	100%
A0A3S7X9W8	Leishmania donovani	92%	100%
A4HN97	Leishmania braziliensis	79%	99%
A4IBW8	Leishmania infantum	92%	100%
E9AFQ5	Leishmania major	90%	100%
V5C2P0	Trypanosoma cruzi	46%	100%