FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6V6_LEIMU

TriTrypDb:

LmxM.34.4260

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.697
CLV_C14_Caspase3-7	319	323	PF00656	0.202
CLV_NRD_NRD_1	136	138	PF00675	0.508
CLV_NRD_NRD_1	142	144	PF00675	0.512
CLV_NRD_NRD_1	183	185	PF00675	0.522
CLV_NRD_NRD_1	189	191	PF00675	0.486
CLV_NRD_NRD_1	192	194	PF00675	0.479
CLV_NRD_NRD_1	306	308	PF00675	0.510
CLV_NRD_NRD_1	85	87	PF00675	0.466
CLV_NRD_NRD_1	92	94	PF00675	0.439
CLV_PCSK_FUR_1	140	144	PF00082	0.503
CLV_PCSK_FUR_1	190	194	PF00082	0.523
CLV_PCSK_KEX2_1	136	138	PF00082	0.517
CLV_PCSK_KEX2_1	140	142	PF00082	0.500
CLV_PCSK_KEX2_1	189	191	PF00082	0.513
CLV_PCSK_KEX2_1	192	194	PF00082	0.513
CLV_PCSK_KEX2_1	305	307	PF00082	0.444
CLV_PCSK_KEX2_1	353	355	PF00082	0.383
CLV_PCSK_KEX2_1	92	94	PF00082	0.476
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.518
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.387
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.383
CLV_PCSK_PC7_1	136	142	PF00082	0.503
CLV_PCSK_SKI1_1	126	130	PF00082	0.377
CLV_PCSK_SKI1_1	260	264	PF00082	0.603
CLV_PCSK_SKI1_1	310	314	PF00082	0.440
CLV_PCSK_SKI1_1	37	41	PF00082	0.502
CLV_PCSK_SKI1_1	80	84	PF00082	0.455
DOC_CKS1_1	362	367	PF01111	0.360
DOC_MAPK_gen_1	305	314	PF00069	0.443
DOC_PP2B_LxvP_1	266	269	PF13499	0.621
DOC_PP4_FxxP_1	292	295	PF00568	0.463
DOC_USP7_MATH_1	270	274	PF00917	0.597
DOC_USP7_MATH_1	287	291	PF00917	0.415
DOC_USP7_MATH_1	348	352	PF00917	0.383
DOC_USP7_UBL2_3	185	189	PF12436	0.548
DOC_USP7_UBL2_3	217	221	PF12436	0.537
DOC_USP7_UBL2_3	305	309	PF12436	0.499
DOC_USP7_UBL2_3	57	61	PF12436	0.412
DOC_WW_Pin1_4	1	6	PF00397	0.680
DOC_WW_Pin1_4	279	284	PF00397	0.479
DOC_WW_Pin1_4	361	366	PF00397	0.360
LIG_14-3-3_CanoR_1	34	40	PF00244	0.523
LIG_14-3-3_CterR_2	374	377	PF00244	0.509
LIG_Actin_WH2_2	250	265	PF00022	0.638
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_deltaCOP1_diTrp_1	228	232	PF00928	0.607
LIG_LIR_Apic_2	290	295	PF02991	0.460
LIG_LIR_Apic_2	298	302	PF02991	0.429
LIG_LIR_Apic_2	359	365	PF02991	0.383
LIG_LIR_Gen_1	22	32	PF02991	0.478
LIG_LIR_Gen_1	228	237	PF02991	0.627
LIG_LIR_Gen_1	52	60	PF02991	0.426
LIG_LIR_Gen_1	73	83	PF02991	0.437
LIG_LIR_Nem_3	22	28	PF02991	0.502
LIG_LIR_Nem_3	228	232	PF02991	0.489
LIG_LIR_Nem_3	52	56	PF02991	0.425
LIG_LIR_Nem_3	73	79	PF02991	0.450
LIG_SH2_CRK	308	312	PF00017	0.506
LIG_SH2_CRK	362	366	PF00017	0.383
LIG_SH2_PTP2	53	56	PF00017	0.474
LIG_SH2_STAP1	63	67	PF00017	0.533
LIG_SH2_STAT5	281	284	PF00017	0.423
LIG_SH2_STAT5	53	56	PF00017	0.474
LIG_SH3_3	13	19	PF00018	0.600
LIG_SH3_3	2	8	PF00018	0.637
LIG_SH3_3	311	317	PF00018	0.323
LIG_TRAF2_1	109	112	PF00917	0.502
LIG_TRAF2_1	128	131	PF00917	0.585
LIG_TRAF2_1	153	156	PF00917	0.595
LIG_TRAF2_1	165	168	PF00917	0.536
LIG_TRAF2_1	176	179	PF00917	0.515
LIG_TYR_ITIM	51	56	PF00017	0.482
LIG_UBA3_1	35	40	PF00899	0.460
MOD_CDK_SPxK_1	361	367	PF00069	0.360
MOD_CK1_1	3	9	PF00069	0.738
MOD_GlcNHglycan	80	83	PF01048	0.487
MOD_GSK3_1	275	282	PF00069	0.558
MOD_GSK3_1	61	68	PF00069	0.528
MOD_N-GLC_1	348	353	PF02516	0.383
MOD_NEK2_1	232	237	PF00069	0.646
MOD_NEK2_1	262	267	PF00069	0.699
MOD_NEK2_1	277	282	PF00069	0.476
MOD_NEK2_1	35	40	PF00069	0.460
MOD_NEK2_2	19	24	PF00069	0.681
MOD_PKA_2	19	25	PF00069	0.607
MOD_PKA_2	332	338	PF00069	0.383
MOD_PKB_1	124	132	PF00069	0.439
MOD_Plk_2-3	52	58	PF00069	0.430
MOD_ProDKin_1	1	7	PF00069	0.676
MOD_ProDKin_1	279	285	PF00069	0.466
MOD_ProDKin_1	361	367	PF00069	0.360
MOD_SUMO_rev_2	258	265	PF00179	0.604
TRG_DiLeu_BaEn_1	46	51	PF01217	0.427
TRG_DiLeu_BaEn_4	202	208	PF01217	0.466
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.423
TRG_ENDOCYTIC_2	308	311	PF00928	0.528
TRG_ENDOCYTIC_2	370	373	PF00928	0.429
TRG_ENDOCYTIC_2	53	56	PF00928	0.439
TRG_ENDOCYTIC_2	63	66	PF00928	0.430
TRG_ER_diArg_1	140	143	PF00400	0.523
TRG_ER_diArg_1	190	193	PF00400	0.498
TRG_ER_diArg_1	306	308	PF00400	0.510
TRG_ER_diArg_1	373	376	PF00400	0.483
TRG_NES_CRM1_1	46	58	PF08389	0.429
TRG_NLS_MonoCore_2	188	193	PF00514	0.489
TRG_NLS_MonoExtC_3	188	193	PF00514	0.489
TRG_NLS_MonoExtC_3	304	309	PF00514	0.476
TRG_NLS_MonoExtN_4	188	193	PF00514	0.494
TRG_NLS_MonoExtN_4	302	309	PF00514	0.407
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3I7	Leptomonas seymouri	80%	95%
A0A0S4JE94	Bodo saltans	55%	100%
A0A3S5H806	Leishmania donovani	96%	100%
A4IBW6	Leishmania infantum	96%	100%
E9AFQ3	Leishmania major	95%	100%
E9AIX0	Leishmania braziliensis	88%	100%