Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6V4_LEIMU

TriTrypDb:

LmxM.34.4240

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.686
CLV_NRD_NRD_1	267	269	PF00675	0.404
CLV_PCSK_KEX2_1	267	269	PF00082	0.404
CLV_PCSK_KEX2_1	286	288	PF00082	0.455
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.455
CLV_PCSK_SKI1_1	133	137	PF00082	0.387
CLV_PCSK_SKI1_1	177	181	PF00082	0.628
CLV_PCSK_SKI1_1	257	261	PF00082	0.492
CLV_PCSK_SKI1_1	279	283	PF00082	0.462
CLV_Separin_Metazoa	238	242	PF03568	0.460
DEG_APCC_DBOX_1	60	68	PF00400	0.453
DEG_SCF_FBW7_2	231	238	PF00400	0.425
DOC_CKS1_1	232	237	PF01111	0.420
DOC_CYCLIN_RxL_1	276	285	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.510
DOC_MAPK_MEF2A_6	206	214	PF00069	0.442
DOC_PP2B_LxvP_1	210	213	PF13499	0.386
DOC_PP4_FxxP_1	5	8	PF00568	0.621
DOC_USP7_MATH_1	175	179	PF00917	0.699
DOC_USP7_MATH_1	290	294	PF00917	0.493
DOC_WW_Pin1_4	138	143	PF00397	0.409
DOC_WW_Pin1_4	168	173	PF00397	0.718
DOC_WW_Pin1_4	231	236	PF00397	0.339
LIG_14-3-3_CanoR_1	160	164	PF00244	0.530
LIG_14-3-3_CanoR_1	226	232	PF00244	0.391
LIG_14-3-3_CanoR_1	279	289	PF00244	0.486
LIG_14-3-3_CanoR_1	29	35	PF00244	0.510
LIG_14-3-3_CanoR_1	36	40	PF00244	0.429
LIG_14-3-3_CanoR_1	7	13	PF00244	0.579
LIG_CSL_BTD_1	42	45	PF09270	0.319
LIG_deltaCOP1_diTrp_1	40	46	PF00928	0.443
LIG_FHA_1	192	198	PF00498	0.745
LIG_FHA_1	207	213	PF00498	0.395
LIG_FHA_1	73	79	PF00498	0.372
LIG_FHA_1	83	89	PF00498	0.378
LIG_FHA_2	214	220	PF00498	0.462
LIG_FHA_2	240	246	PF00498	0.449
LIG_LIR_Gen_1	89	99	PF02991	0.304
LIG_LIR_LC3C_4	208	212	PF02991	0.460
LIG_LIR_Nem_3	124	129	PF02991	0.471
LIG_LIR_Nem_3	40	46	PF02991	0.437
LIG_LIR_Nem_3	97	102	PF02991	0.320
LIG_SH2_SRC	217	220	PF00017	0.490
LIG_SH2_STAT5	123	126	PF00017	0.384
LIG_SH2_STAT5	127	130	PF00017	0.314
LIG_SH2_STAT5	217	220	PF00017	0.490
LIG_SH3_1	241	247	PF00018	0.417
LIG_SH3_3	241	247	PF00018	0.417
MOD_CK1_1	141	147	PF00069	0.484
MOD_CK1_1	225	231	PF00069	0.320
MOD_CK2_1	213	219	PF00069	0.446
MOD_CK2_1	239	245	PF00069	0.549
MOD_GlcNHglycan	12	15	PF01048	0.656
MOD_GlcNHglycan	177	180	PF01048	0.661
MOD_GlcNHglycan	282	285	PF01048	0.425
MOD_GlcNHglycan	292	295	PF01048	0.427
MOD_GlcNHglycan	96	99	PF01048	0.383
MOD_GSK3_1	102	109	PF00069	0.536
MOD_GSK3_1	140	147	PF00069	0.524
MOD_GSK3_1	154	161	PF00069	0.681
MOD_GSK3_1	171	178	PF00069	0.486
MOD_GSK3_1	24	31	PF00069	0.517
MOD_N-GLC_1	121	126	PF02516	0.480
MOD_NEK2_1	129	134	PF00069	0.361
MOD_NEK2_1	145	150	PF00069	0.535
MOD_NEK2_1	239	244	PF00069	0.505
MOD_NEK2_1	282	287	PF00069	0.484
MOD_NEK2_1	82	87	PF00069	0.458
MOD_NEK2_1	91	96	PF00069	0.326
MOD_NEK2_2	149	154	PF00069	0.504
MOD_NEK2_2	155	160	PF00069	0.512
MOD_NEK2_2	19	24	PF00069	0.574
MOD_OFUCOSY	69	76	PF10250	0.437
MOD_PIKK_1	44	50	PF00454	0.560
MOD_PKA_2	145	151	PF00069	0.702
MOD_PKA_2	159	165	PF00069	0.459
MOD_PKA_2	225	231	PF00069	0.439
MOD_PKA_2	28	34	PF00069	0.544
MOD_PKA_2	35	41	PF00069	0.480
MOD_Plk_1	155	161	PF00069	0.641
MOD_Plk_1	222	228	PF00069	0.530
MOD_Plk_4	206	212	PF00069	0.486
MOD_Plk_4	213	219	PF00069	0.437
MOD_Plk_4	91	97	PF00069	0.442
MOD_ProDKin_1	138	144	PF00069	0.406
MOD_ProDKin_1	168	174	PF00069	0.718
MOD_ProDKin_1	231	237	PF00069	0.341
MOD_SUMO_for_1	271	274	PF00179	0.504
TRG_ENDOCYTIC_2	126	129	PF00928	0.470
TRG_ENDOCYTIC_2	20	23	PF00928	0.561
TRG_ER_diArg_1	240	243	PF00400	0.412
TRG_ER_diArg_1	266	268	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY73	Leptomonas seymouri	51%	100%
A0A0S4JF57	Bodo saltans	37%	100%
A0A1X0P581	Trypanosomatidae	34%	100%
A0A3R7NNI3	Trypanosoma rangeli	38%	100%
A0A3S7X9V8	Leishmania donovani	91%	100%
A4HN94	Leishmania braziliensis	72%	100%
A4IBW4	Leishmania infantum	92%	100%
C9ZYP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFQ1	Leishmania major	90%	100%
V5BCR5	Trypanosoma cruzi	32%	100%