LeishMANIAdb
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SAC domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SAC domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B6V3_LEIMU
TriTrypDb:
LmxM.34.4230
Length:
1000

Annotations

LeishMANIAdb annotations

Carries a conserved SAC1-type phosphatidylinositol phosphatase domain. Other eukaryotic homologs have no TM domains

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9B6V3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V3

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006644 phospholipid metabolic process 4 1
GO:0006650 glycerophospholipid metabolic process 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016311 dephosphorylation 5 1
GO:0019637 organophosphate metabolic process 3 1
GO:0030258 lipid modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0046486 glycerolipid metabolic process 4 1
GO:0046488 phosphatidylinositol metabolic process 6 1
GO:0046839 phospholipid dephosphorylation 5 1
GO:0046856 phosphatidylinositol dephosphorylation 6 1
GO:0071704 organic substance metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016791 phosphatase activity 5 7
GO:0042578 phosphoric ester hydrolase activity 4 7
GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 7 1
GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity 8 1
GO:0052744 phosphatidylinositol monophosphate phosphatase activity 7 1
GO:0052866 phosphatidylinositol phosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.489
CLV_C14_Caspase3-7 173 177 PF00656 0.524
CLV_C14_Caspase3-7 530 534 PF00656 0.433
CLV_C14_Caspase3-7 649 653 PF00656 0.694
CLV_C14_Caspase3-7 751 755 PF00656 0.716
CLV_C14_Caspase3-7 756 760 PF00656 0.668
CLV_C14_Caspase3-7 822 826 PF00656 0.614
CLV_NRD_NRD_1 147 149 PF00675 0.280
CLV_NRD_NRD_1 369 371 PF00675 0.317
CLV_NRD_NRD_1 496 498 PF00675 0.277
CLV_NRD_NRD_1 539 541 PF00675 0.340
CLV_NRD_NRD_1 553 555 PF00675 0.238
CLV_NRD_NRD_1 620 622 PF00675 0.335
CLV_NRD_NRD_1 880 882 PF00675 0.320
CLV_PCSK_KEX2_1 147 149 PF00082 0.280
CLV_PCSK_KEX2_1 355 357 PF00082 0.375
CLV_PCSK_KEX2_1 369 371 PF00082 0.281
CLV_PCSK_KEX2_1 496 498 PF00082 0.277
CLV_PCSK_KEX2_1 539 541 PF00082 0.340
CLV_PCSK_KEX2_1 553 555 PF00082 0.238
CLV_PCSK_KEX2_1 620 622 PF00082 0.277
CLV_PCSK_KEX2_1 687 689 PF00082 0.355
CLV_PCSK_KEX2_1 880 882 PF00082 0.320
CLV_PCSK_PC1ET2_1 355 357 PF00082 0.366
CLV_PCSK_PC1ET2_1 687 689 PF00082 0.327
CLV_PCSK_SKI1_1 11 15 PF00082 0.379
CLV_PCSK_SKI1_1 355 359 PF00082 0.326
CLV_PCSK_SKI1_1 584 588 PF00082 0.279
CLV_PCSK_SKI1_1 687 691 PF00082 0.341
CLV_PCSK_SKI1_1 836 840 PF00082 0.371
CLV_PCSK_SKI1_1 988 992 PF00082 0.351
CLV_Separin_Metazoa 421 425 PF03568 0.535
DEG_APCC_DBOX_1 53 61 PF00400 0.628
DEG_APCC_DBOX_1 762 770 PF00400 0.639
DEG_SCF_FBW7_1 448 455 PF00400 0.401
DOC_CDC14_PxL_1 933 941 PF14671 0.208
DOC_CKS1_1 449 454 PF01111 0.401
DOC_CKS1_1 516 521 PF01111 0.477
DOC_CYCLIN_RxL_1 982 994 PF00134 0.558
DOC_MAPK_MEF2A_6 758 766 PF00069 0.689
DOC_PP1_RVXF_1 128 135 PF00149 0.477
DOC_PP1_RVXF_1 9 15 PF00149 0.625
DOC_PP1_SILK_1 544 549 PF00149 0.401
DOC_PP2B_LxvP_1 135 138 PF13499 0.478
DOC_PP2B_LxvP_1 458 461 PF13499 0.477
DOC_PP2B_PxIxI_1 564 570 PF00149 0.477
DOC_PP4_FxxP_1 390 393 PF00568 0.535
DOC_SPAK_OSR1_1 540 544 PF12202 0.499
DOC_USP7_MATH_1 100 104 PF00917 0.499
DOC_USP7_MATH_1 357 361 PF00917 0.493
DOC_USP7_MATH_1 407 411 PF00917 0.499
DOC_USP7_MATH_1 452 456 PF00917 0.561
DOC_USP7_MATH_1 473 477 PF00917 0.570
DOC_USP7_MATH_1 501 505 PF00917 0.503
DOC_USP7_MATH_1 511 515 PF00917 0.503
DOC_USP7_MATH_1 525 529 PF00917 0.541
DOC_USP7_MATH_1 629 633 PF00917 0.675
DOC_USP7_MATH_1 667 671 PF00917 0.716
DOC_USP7_MATH_1 78 82 PF00917 0.707
DOC_USP7_UBL2_3 564 568 PF12436 0.535
DOC_USP7_UBL2_3 683 687 PF12436 0.509
DOC_WW_Pin1_4 285 290 PF00397 0.477
DOC_WW_Pin1_4 448 453 PF00397 0.401
DOC_WW_Pin1_4 471 476 PF00397 0.458
DOC_WW_Pin1_4 515 520 PF00397 0.477
DOC_WW_Pin1_4 523 528 PF00397 0.477
DOC_WW_Pin1_4 567 572 PF00397 0.399
DOC_WW_Pin1_4 625 630 PF00397 0.650
DOC_WW_Pin1_4 911 916 PF00397 0.606
LIG_14-3-3_CanoR_1 192 196 PF00244 0.435
LIG_14-3-3_CanoR_1 281 285 PF00244 0.447
LIG_14-3-3_CanoR_1 3 13 PF00244 0.628
LIG_14-3-3_CanoR_1 356 366 PF00244 0.569
LIG_14-3-3_CanoR_1 478 482 PF00244 0.555
LIG_14-3-3_CanoR_1 54 58 PF00244 0.592
LIG_14-3-3_CanoR_1 688 694 PF00244 0.618
LIG_14-3-3_CanoR_1 763 767 PF00244 0.729
LIG_14-3-3_CanoR_1 820 828 PF00244 0.586
LIG_14-3-3_CanoR_1 949 959 PF00244 0.346
LIG_14-3-3_CanoR_1 980 986 PF00244 0.554
LIG_Actin_WH2_2 40 56 PF00022 0.609
LIG_BIR_II_1 1 5 PF00653 0.805
LIG_BIR_III_2 759 763 PF00653 0.670
LIG_BRCT_BRCA1_1 611 615 PF00533 0.535
LIG_BRCT_BRCA1_1 953 957 PF00533 0.274
LIG_CtBP_PxDLS_1 895 901 PF00389 0.592
LIG_eIF4E_1 985 991 PF01652 0.543
LIG_EVH1_2 626 630 PF00568 0.688
LIG_FHA_1 114 120 PF00498 0.535
LIG_FHA_1 139 145 PF00498 0.535
LIG_FHA_1 220 226 PF00498 0.561
LIG_FHA_1 288 294 PF00498 0.477
LIG_FHA_1 373 379 PF00498 0.477
LIG_FHA_1 564 570 PF00498 0.487
LIG_FHA_1 602 608 PF00498 0.503
LIG_FHA_1 639 645 PF00498 0.664
LIG_FHA_1 783 789 PF00498 0.499
LIG_FHA_2 107 113 PF00498 0.477
LIG_FHA_2 201 207 PF00498 0.483
LIG_FHA_2 222 228 PF00498 0.477
LIG_FHA_2 259 265 PF00498 0.463
LIG_FHA_2 334 340 PF00498 0.497
LIG_FHA_2 341 347 PF00498 0.446
LIG_FHA_2 645 651 PF00498 0.752
LIG_FHA_2 712 718 PF00498 0.587
LIG_FHA_2 749 755 PF00498 0.720
LIG_LIR_Apic_2 17 23 PF02991 0.592
LIG_LIR_Apic_2 283 289 PF02991 0.477
LIG_LIR_Apic_2 388 393 PF02991 0.535
LIG_LIR_Apic_2 513 519 PF02991 0.477
LIG_LIR_Gen_1 227 235 PF02991 0.475
LIG_LIR_Gen_1 280 289 PF02991 0.401
LIG_LIR_Gen_1 451 461 PF02991 0.535
LIG_LIR_Gen_1 714 723 PF02991 0.570
LIG_LIR_Gen_1 972 983 PF02991 0.493
LIG_LIR_Nem_3 227 231 PF02991 0.475
LIG_LIR_Nem_3 280 285 PF02991 0.478
LIG_LIR_Nem_3 412 417 PF02991 0.535
LIG_LIR_Nem_3 451 456 PF02991 0.535
LIG_LIR_Nem_3 714 718 PF02991 0.575
LIG_LIR_Nem_3 89 95 PF02991 0.477
LIG_LIR_Nem_3 972 978 PF02991 0.483
LIG_MYND_1 26 30 PF01753 0.603
LIG_NRBOX 834 840 PF00104 0.538
LIG_NRBOX 938 944 PF00104 0.283
LIG_PDZ_Class_3 995 1000 PF00595 0.689
LIG_PDZ_Wminus1_1 998 1000 PF00595 0.693
LIG_Pex14_2 828 832 PF04695 0.459
LIG_Pex14_2 957 961 PF04695 0.315
LIG_SH2_CRK 544 548 PF00017 0.615
LIG_SH2_CRK 92 96 PF00017 0.477
LIG_SH2_CRK 940 944 PF00017 0.372
LIG_SH2_CRK 975 979 PF00017 0.600
LIG_SH2_GRB2like 985 988 PF00017 0.542
LIG_SH2_SRC 459 462 PF00017 0.453
LIG_SH2_SRC 803 806 PF00017 0.606
LIG_SH2_STAP1 940 944 PF00017 0.315
LIG_SH2_STAP1 993 997 PF00017 0.607
LIG_SH2_STAT3 68 71 PF00017 0.690
LIG_SH2_STAT3 993 996 PF00017 0.617
LIG_SH2_STAT5 107 110 PF00017 0.477
LIG_SH2_STAT5 113 116 PF00017 0.477
LIG_SH2_STAT5 21 24 PF00017 0.580
LIG_SH2_STAT5 228 231 PF00017 0.468
LIG_SH2_STAT5 284 287 PF00017 0.477
LIG_SH2_STAT5 42 45 PF00017 0.591
LIG_SH2_STAT5 459 462 PF00017 0.473
LIG_SH2_STAT5 463 466 PF00017 0.482
LIG_SH2_STAT5 597 600 PF00017 0.535
LIG_SH2_STAT5 638 641 PF00017 0.769
LIG_SH2_STAT5 695 698 PF00017 0.448
LIG_SH2_STAT5 803 806 PF00017 0.549
LIG_SH2_STAT5 85 88 PF00017 0.578
LIG_SH2_STAT5 970 973 PF00017 0.315
LIG_SH2_STAT5 985 988 PF00017 0.542
LIG_SH2_STAT5 993 996 PF00017 0.617
LIG_SH3_1 20 26 PF00018 0.566
LIG_SH3_3 20 26 PF00018 0.566
LIG_SH3_3 438 444 PF00018 0.579
LIG_SH3_3 446 452 PF00018 0.501
LIG_SH3_3 469 475 PF00018 0.499
LIG_SH3_3 623 629 PF00018 0.508
LIG_SH3_4 564 571 PF00018 0.535
LIG_SUMO_SIM_anti_2 227 233 PF11976 0.477
LIG_SUMO_SIM_anti_2 894 900 PF11976 0.539
LIG_SUMO_SIM_par_1 288 296 PF11976 0.477
LIG_SUMO_SIM_par_1 299 305 PF11976 0.477
LIG_SUMO_SIM_par_1 988 994 PF11976 0.567
LIG_TRAF2_1 575 578 PF00917 0.462
LIG_TRAF2_1 647 650 PF00917 0.747
LIG_TRFH_1 68 72 PF08558 0.618
LIG_TYR_ITIM 973 978 PF00017 0.405
LIG_WRC_WIRS_1 788 793 PF05994 0.366
LIG_WRC_WIRS_1 952 957 PF05994 0.483
MOD_CDK_SPxxK_3 471 478 PF00069 0.283
MOD_CDK_SPxxK_3 911 918 PF00069 0.486
MOD_CK1_1 142 148 PF00069 0.348
MOD_CK1_1 160 166 PF00069 0.370
MOD_CK1_1 2 8 PF00069 0.640
MOD_CK1_1 280 286 PF00069 0.264
MOD_CK1_1 325 331 PF00069 0.424
MOD_CK1_1 333 339 PF00069 0.411
MOD_CK1_1 340 346 PF00069 0.298
MOD_CK1_1 521 527 PF00069 0.389
MOD_CK1_1 628 634 PF00069 0.676
MOD_CK1_1 640 646 PF00069 0.550
MOD_CK1_1 897 903 PF00069 0.456
MOD_CK1_1 914 920 PF00069 0.465
MOD_CK2_1 106 112 PF00069 0.315
MOD_CK2_1 167 173 PF00069 0.208
MOD_CK2_1 196 202 PF00069 0.385
MOD_CK2_1 258 264 PF00069 0.296
MOD_CK2_1 333 339 PF00069 0.319
MOD_CK2_1 340 346 PF00069 0.332
MOD_CK2_1 53 59 PF00069 0.520
MOD_CK2_1 600 606 PF00069 0.323
MOD_CK2_1 644 650 PF00069 0.712
MOD_CK2_1 716 722 PF00069 0.458
MOD_Cter_Amidation 145 148 PF01082 0.395
MOD_GlcNHglycan 102 105 PF01048 0.311
MOD_GlcNHglycan 141 144 PF01048 0.319
MOD_GlcNHglycan 149 152 PF01048 0.312
MOD_GlcNHglycan 162 165 PF01048 0.417
MOD_GlcNHglycan 248 251 PF01048 0.307
MOD_GlcNHglycan 267 270 PF01048 0.237
MOD_GlcNHglycan 306 309 PF01048 0.399
MOD_GlcNHglycan 339 343 PF01048 0.333
MOD_GlcNHglycan 359 362 PF01048 0.472
MOD_GlcNHglycan 503 506 PF01048 0.347
MOD_GlcNHglycan 520 523 PF01048 0.377
MOD_GlcNHglycan 535 538 PF01048 0.303
MOD_GlcNHglycan 631 634 PF01048 0.653
MOD_GlcNHglycan 664 668 PF01048 0.574
MOD_GlcNHglycan 709 712 PF01048 0.454
MOD_GlcNHglycan 816 819 PF01048 0.546
MOD_GlcNHglycan 862 865 PF01048 0.390
MOD_GlcNHglycan 919 923 PF01048 0.469
MOD_GSK3_1 138 145 PF00069 0.357
MOD_GSK3_1 196 203 PF00069 0.422
MOD_GSK3_1 287 294 PF00069 0.336
MOD_GSK3_1 324 331 PF00069 0.392
MOD_GSK3_1 333 340 PF00069 0.317
MOD_GSK3_1 341 348 PF00069 0.326
MOD_GSK3_1 439 446 PF00069 0.329
MOD_GSK3_1 448 455 PF00069 0.379
MOD_GSK3_1 473 480 PF00069 0.340
MOD_GSK3_1 49 56 PF00069 0.500
MOD_GSK3_1 511 518 PF00069 0.325
MOD_GSK3_1 521 528 PF00069 0.365
MOD_GSK3_1 559 566 PF00069 0.341
MOD_GSK3_1 598 605 PF00069 0.329
MOD_GSK3_1 625 632 PF00069 0.590
MOD_GSK3_1 640 647 PF00069 0.750
MOD_GSK3_1 663 670 PF00069 0.594
MOD_GSK3_1 707 714 PF00069 0.442
MOD_GSK3_1 744 751 PF00069 0.622
MOD_GSK3_1 914 921 PF00069 0.464
MOD_N-GLC_1 14 19 PF02516 0.489
MOD_N-GLC_1 211 216 PF02516 0.375
MOD_N-GLC_1 328 333 PF02516 0.445
MOD_N-GLC_1 559 564 PF02516 0.315
MOD_N-GLC_1 743 748 PF02516 0.626
MOD_NEK2_1 14 19 PF00069 0.489
MOD_NEK2_1 191 196 PF00069 0.208
MOD_NEK2_1 235 240 PF00069 0.315
MOD_NEK2_1 510 515 PF00069 0.315
MOD_NEK2_1 53 58 PF00069 0.445
MOD_NEK2_1 547 552 PF00069 0.395
MOD_NEK2_1 637 642 PF00069 0.724
MOD_NEK2_1 716 721 PF00069 0.411
MOD_NEK2_1 782 787 PF00069 0.331
MOD_NEK2_1 938 943 PF00069 0.288
MOD_NEK2_1 991 996 PF00069 0.476
MOD_NEK2_2 559 564 PF00069 0.395
MOD_PIKK_1 267 273 PF00454 0.315
MOD_PIKK_1 62 68 PF00454 0.518
MOD_PIKK_1 805 811 PF00454 0.560
MOD_PKA_1 147 153 PF00069 0.345
MOD_PKA_2 147 153 PF00069 0.383
MOD_PKA_2 157 163 PF00069 0.276
MOD_PKA_2 191 197 PF00069 0.208
MOD_PKA_2 2 8 PF00069 0.590
MOD_PKA_2 246 252 PF00069 0.288
MOD_PKA_2 280 286 PF00069 0.273
MOD_PKA_2 337 343 PF00069 0.355
MOD_PKA_2 351 357 PF00069 0.298
MOD_PKA_2 477 483 PF00069 0.416
MOD_PKA_2 53 59 PF00069 0.450
MOD_PKA_2 547 553 PF00069 0.351
MOD_PKA_2 707 713 PF00069 0.511
MOD_PKA_2 762 768 PF00069 0.474
MOD_PKA_2 819 825 PF00069 0.568
MOD_PKA_2 981 987 PF00069 0.415
MOD_Plk_1 14 20 PF00069 0.478
MOD_Plk_1 49 55 PF00069 0.535
MOD_Plk_1 559 565 PF00069 0.321
MOD_Plk_1 738 744 PF00069 0.641
MOD_Plk_2-3 198 204 PF00069 0.456
MOD_Plk_4 212 218 PF00069 0.318
MOD_Plk_4 459 465 PF00069 0.315
MOD_Plk_4 477 483 PF00069 0.315
MOD_Plk_4 511 517 PF00069 0.315
MOD_Plk_4 542 548 PF00069 0.351
MOD_Plk_4 677 683 PF00069 0.411
MOD_Plk_4 691 697 PF00069 0.418
MOD_Plk_4 711 717 PF00069 0.441
MOD_Plk_4 744 750 PF00069 0.509
MOD_Plk_4 787 793 PF00069 0.336
MOD_Plk_4 894 900 PF00069 0.509
MOD_Plk_4 938 944 PF00069 0.404
MOD_Plk_4 951 957 PF00069 0.356
MOD_Plk_4 969 975 PF00069 0.284
MOD_ProDKin_1 285 291 PF00069 0.315
MOD_ProDKin_1 448 454 PF00069 0.208
MOD_ProDKin_1 471 477 PF00069 0.288
MOD_ProDKin_1 515 521 PF00069 0.315
MOD_ProDKin_1 523 529 PF00069 0.315
MOD_ProDKin_1 567 573 PF00069 0.206
MOD_ProDKin_1 625 631 PF00069 0.562
MOD_ProDKin_1 911 917 PF00069 0.492
TRG_DiLeu_BaEn_4 48 54 PF01217 0.493
TRG_DiLeu_BaLyEn_6 381 386 PF01217 0.294
TRG_DiLeu_BaLyEn_6 581 586 PF01217 0.315
TRG_DiLeu_BaLyEn_6 833 838 PF01217 0.464
TRG_DiLeu_BaLyEn_6 986 991 PF01217 0.407
TRG_ENDOCYTIC_2 228 231 PF00928 0.313
TRG_ENDOCYTIC_2 544 547 PF00928 0.351
TRG_ENDOCYTIC_2 695 698 PF00928 0.382
TRG_ENDOCYTIC_2 92 95 PF00928 0.315
TRG_ENDOCYTIC_2 940 943 PF00928 0.372
TRG_ENDOCYTIC_2 970 973 PF00928 0.315
TRG_ENDOCYTIC_2 975 978 PF00928 0.410
TRG_ER_diArg_1 37 40 PF00400 0.515
TRG_ER_diArg_1 403 406 PF00400 0.327
TRG_ER_diArg_1 539 541 PF00400 0.391
TRG_ER_diArg_1 552 554 PF00400 0.264
TRG_ER_diArg_1 619 621 PF00400 0.395
TRG_ER_diArg_1 834 837 PF00400 0.377
TRG_ER_diArg_1 879 881 PF00400 0.395
TRG_Pf-PMV_PEXEL_1 376 380 PF00026 0.315
TRG_Pf-PMV_PEXEL_1 465 470 PF00026 0.315
TRG_Pf-PMV_PEXEL_1 584 588 PF00026 0.315

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5I0 Leptomonas seymouri 55% 99%
A0A3S7X9T5 Leishmania donovani 87% 99%
A4HN93 Leishmania braziliensis 76% 100%
A4IBW3 Leishmania infantum 87% 99%
E9AFQ0 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS