Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B6V2_LEIMU

TriTrypDb:

LmxM.34.4220

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.552
CLV_NRD_NRD_1	265	267	PF00675	0.697
CLV_NRD_NRD_1	36	38	PF00675	0.753
CLV_NRD_NRD_1	379	381	PF00675	0.534
CLV_NRD_NRD_1	572	574	PF00675	0.749
CLV_NRD_NRD_1	585	587	PF00675	0.578
CLV_PCSK_KEX2_1	123	125	PF00082	0.552
CLV_PCSK_KEX2_1	208	210	PF00082	0.766
CLV_PCSK_KEX2_1	36	38	PF00082	0.753
CLV_PCSK_KEX2_1	379	381	PF00082	0.534
CLV_PCSK_KEX2_1	584	586	PF00082	0.717
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.766
CLV_PCSK_SKI1_1	208	212	PF00082	0.779
CLV_PCSK_SKI1_1	236	240	PF00082	0.512
CLV_PCSK_SKI1_1	24	28	PF00082	0.688
CLV_PCSK_SKI1_1	380	384	PF00082	0.693
CLV_PCSK_SKI1_1	45	49	PF00082	0.521
DEG_SCF_FBW7_1	152	158	PF00400	0.582
DEG_SPOP_SBC_1	134	138	PF00917	0.579
DEG_SPOP_SBC_1	313	317	PF00917	0.626
DOC_CKS1_1	152	157	PF01111	0.548
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.725
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.679
DOC_MAPK_gen_1	379	385	PF00069	0.534
DOC_MAPK_gen_1	552	562	PF00069	0.530
DOC_MAPK_HePTP_8	72	84	PF00069	0.564
DOC_MAPK_MEF2A_6	75	84	PF00069	0.668
DOC_PP2B_LxvP_1	242	245	PF13499	0.720
DOC_PP2B_LxvP_1	298	301	PF13499	0.567
DOC_USP7_MATH_1	111	115	PF00917	0.802
DOC_USP7_MATH_1	118	122	PF00917	0.741
DOC_USP7_MATH_1	184	188	PF00917	0.664
DOC_USP7_MATH_1	198	202	PF00917	0.691
DOC_USP7_MATH_1	246	250	PF00917	0.746
DOC_USP7_MATH_1	252	256	PF00917	0.677
DOC_USP7_MATH_1	313	317	PF00917	0.729
DOC_USP7_MATH_1	322	326	PF00917	0.602
DOC_USP7_MATH_1	353	357	PF00917	0.849
DOC_USP7_MATH_1	366	370	PF00917	0.629
DOC_USP7_MATH_1	389	393	PF00917	0.739
DOC_USP7_MATH_1	491	495	PF00917	0.621
DOC_WW_Pin1_4	151	156	PF00397	0.574
DOC_WW_Pin1_4	49	54	PF00397	0.750
DOC_WW_Pin1_4	493	498	PF00397	0.627
DOC_WW_Pin1_4	92	97	PF00397	0.701
LIG_14-3-3_CanoR_1	212	220	PF00244	0.690
LIG_14-3-3_CanoR_1	266	274	PF00244	0.717
LIG_14-3-3_CanoR_1	304	313	PF00244	0.578
LIG_14-3-3_CanoR_1	355	361	PF00244	0.782
LIG_14-3-3_CanoR_1	365	372	PF00244	0.639
LIG_14-3-3_CanoR_1	374	379	PF00244	0.508
LIG_14-3-3_CanoR_1	504	512	PF00244	0.691
LIG_14-3-3_CanoR_1	515	520	PF00244	0.670
LIG_14-3-3_CanoR_1	573	577	PF00244	0.590
LIG_Actin_WH2_2	457	474	PF00022	0.601
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BRCT_BRCA1_1	215	219	PF00533	0.552
LIG_BRCT_BRCA1_1	562	566	PF00533	0.621
LIG_FHA_1	135	141	PF00498	0.645
LIG_FHA_1	188	194	PF00498	0.620
LIG_FHA_1	411	417	PF00498	0.664
LIG_FHA_1	473	479	PF00498	0.731
LIG_FHA_2	225	231	PF00498	0.736
LIG_FHA_2	548	554	PF00498	0.568
LIG_FHA_2	586	592	PF00498	0.735
LIG_IBAR_NPY_1	321	323	PF08397	0.496
LIG_LIR_Apic_2	19	23	PF02991	0.638
LIG_LIR_Gen_1	431	441	PF02991	0.726
LIG_LIR_Gen_1	588	593	PF02991	0.736
LIG_LIR_Nem_3	237	242	PF02991	0.502
LIG_LIR_Nem_3	395	401	PF02991	0.708
LIG_LIR_Nem_3	431	437	PF02991	0.724
LIG_LIR_Nem_3	588	593	PF02991	0.736
LIG_PDZ_Class_3	588	593	PF00595	0.736
LIG_Rb_pABgroove_1	435	443	PF01858	0.509
LIG_SH2_CRK	323	327	PF00017	0.503
LIG_SH2_CRK	434	438	PF00017	0.729
LIG_SH2_SRC	20	23	PF00017	0.693
LIG_SH2_SRC	396	399	PF00017	0.654
LIG_SH2_STAP1	334	338	PF00017	0.517
LIG_SH2_STAP1	441	445	PF00017	0.655
LIG_SH2_STAT5	20	23	PF00017	0.693
LIG_SH3_3	149	155	PF00018	0.561
LIG_SH3_3	158	164	PF00018	0.655
LIG_SH3_3	167	173	PF00018	0.724
LIG_SH3_3	291	297	PF00018	0.696
LIG_SH3_3	307	313	PF00018	0.518
LIG_SH3_3	316	322	PF00018	0.575
LIG_SH3_3	494	500	PF00018	0.580
LIG_SH3_3	522	528	PF00018	0.529
LIG_SH3_3	98	104	PF00018	0.732
LIG_TRAF2_2	164	169	PF00917	0.557
MOD_CDC14_SPxK_1	496	499	PF00782	0.552
MOD_CDK_SPK_2	49	54	PF00069	0.756
MOD_CDK_SPxK_1	493	499	PF00069	0.554
MOD_CK1_1	186	192	PF00069	0.748
MOD_CK1_1	201	207	PF00069	0.589
MOD_CK1_1	215	221	PF00069	0.632
MOD_CK1_1	225	231	PF00069	0.682
MOD_CK1_1	283	289	PF00069	0.658
MOD_CK1_1	356	362	PF00069	0.687
MOD_CK1_1	427	433	PF00069	0.687
MOD_CK1_1	482	488	PF00069	0.529
MOD_CK1_1	508	514	PF00069	0.726
MOD_CK1_1	537	543	PF00069	0.678
MOD_CK1_1	92	98	PF00069	0.731
MOD_CK2_1	107	113	PF00069	0.550
MOD_CK2_1	224	230	PF00069	0.736
MOD_CK2_1	231	237	PF00069	0.643
MOD_CK2_1	547	553	PF00069	0.679
MOD_GlcNHglycan	109	112	PF01048	0.787
MOD_GlcNHglycan	120	123	PF01048	0.654
MOD_GlcNHglycan	140	143	PF01048	0.617
MOD_GlcNHglycan	149	152	PF01048	0.751
MOD_GlcNHglycan	181	184	PF01048	0.704
MOD_GlcNHglycan	215	218	PF01048	0.737
MOD_GlcNHglycan	224	227	PF01048	0.699
MOD_GlcNHglycan	24	27	PF01048	0.474
MOD_GlcNHglycan	242	245	PF01048	0.709
MOD_GlcNHglycan	269	272	PF01048	0.750
MOD_GlcNHglycan	291	294	PF01048	0.820
MOD_GlcNHglycan	330	333	PF01048	0.668
MOD_GlcNHglycan	368	371	PF01048	0.639
MOD_GlcNHglycan	392	395	PF01048	0.702
MOD_GlcNHglycan	433	437	PF01048	0.614
MOD_GlcNHglycan	481	484	PF01048	0.585
MOD_GlcNHglycan	493	496	PF01048	0.658
MOD_GlcNHglycan	507	510	PF01048	0.615
MOD_GlcNHglycan	536	539	PF01048	0.620
MOD_GlcNHglycan	567	570	PF01048	0.528
MOD_GlcNHglycan	77	80	PF01048	0.514
MOD_GlcNHglycan	8	11	PF01048	0.775
MOD_GSK3_1	107	114	PF00069	0.710
MOD_GSK3_1	134	141	PF00069	0.593
MOD_GSK3_1	147	154	PF00069	0.714
MOD_GSK3_1	173	180	PF00069	0.803
MOD_GSK3_1	183	190	PF00069	0.692
MOD_GSK3_1	200	207	PF00069	0.604
MOD_GSK3_1	211	218	PF00069	0.735
MOD_GSK3_1	220	227	PF00069	0.626
MOD_GSK3_1	285	292	PF00069	0.798
MOD_GSK3_1	347	354	PF00069	0.751
MOD_GSK3_1	355	362	PF00069	0.740
MOD_GSK3_1	364	371	PF00069	0.635
MOD_GSK3_1	412	419	PF00069	0.780
MOD_GSK3_1	420	427	PF00069	0.657
MOD_GSK3_1	428	435	PF00069	0.575
MOD_GSK3_1	45	52	PF00069	0.722
MOD_GSK3_1	482	489	PF00069	0.594
MOD_GSK3_1	511	518	PF00069	0.673
MOD_GSK3_1	530	537	PF00069	0.543
MOD_GSK3_1	561	568	PF00069	0.539
MOD_N-GLC_1	155	160	PF02516	0.599
MOD_N-GLC_1	261	266	PF02516	0.534
MOD_NEK2_1	146	151	PF00069	0.607
MOD_NEK2_1	178	183	PF00069	0.595
MOD_NEK2_1	211	216	PF00069	0.733
MOD_NEK2_1	361	366	PF00069	0.607
MOD_NEK2_1	416	421	PF00069	0.747
MOD_NEK2_1	471	476	PF00069	0.604
MOD_NEK2_1	530	535	PF00069	0.719
MOD_NEK2_2	231	236	PF00069	0.670
MOD_NEK2_2	322	327	PF00069	0.656
MOD_PIKK_1	416	422	PF00454	0.746
MOD_PK_1	374	380	PF00069	0.638
MOD_PKA_1	585	591	PF00069	0.735
MOD_PKA_2	178	184	PF00069	0.565
MOD_PKA_2	211	217	PF00069	0.753
MOD_PKA_2	289	295	PF00069	0.744
MOD_PKA_2	336	342	PF00069	0.805
MOD_PKA_2	354	360	PF00069	0.782
MOD_PKA_2	364	370	PF00069	0.645
MOD_PKA_2	373	379	PF00069	0.537
MOD_PKA_2	471	477	PF00069	0.777
MOD_PKA_2	503	509	PF00069	0.663
MOD_PKA_2	572	578	PF00069	0.645
MOD_PKA_2	585	591	PF00069	0.678
MOD_PKB_1	259	267	PF00069	0.666
MOD_Plk_1	187	193	PF00069	0.551
MOD_Plk_1	231	237	PF00069	0.686
MOD_Plk_1	261	267	PF00069	0.549
MOD_Plk_1	404	410	PF00069	0.562
MOD_Plk_1	432	438	PF00069	0.725
MOD_Plk_1	45	51	PF00069	0.673
MOD_Plk_1	547	553	PF00069	0.532
MOD_Plk_2-3	547	553	PF00069	0.532
MOD_Plk_4	215	221	PF00069	0.523
MOD_Plk_4	463	469	PF00069	0.535
MOD_ProDKin_1	151	157	PF00069	0.576
MOD_ProDKin_1	49	55	PF00069	0.748
MOD_ProDKin_1	493	499	PF00069	0.629
MOD_ProDKin_1	92	98	PF00069	0.705
MOD_SUMO_for_1	551	554	PF00179	0.747
TRG_ENDOCYTIC_2	323	326	PF00928	0.502
TRG_ENDOCYTIC_2	398	401	PF00928	0.704
TRG_ENDOCYTIC_2	434	437	PF00928	0.729
TRG_ER_diArg_1	123	125	PF00400	0.593
TRG_ER_diArg_1	35	37	PF00400	0.755
TRG_ER_diArg_1	378	380	PF00400	0.547
TRG_ER_diArg_1	499	502	PF00400	0.548
TRG_ER_diArg_1	583	586	PF00400	0.744

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJF9	Leishmania donovani	78%	99%
A4HN92	Leishmania braziliensis	52%	100%
A4IBW2	Leishmania infantum	77%	99%
E9AFP9	Leishmania major	76%	100%