Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6U9_LEIMU

TriTrypDb:

LmxM.34.4190

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0031410	cytoplasmic vesicle	6	6
GO:0031982	vesicle	4	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0097708	intracellular vesicle	5	6
GO:0110165	cellular anatomical entity	1	10
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

E9B6U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6U9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0043933	protein-containing complex organization	4	6
GO:0065003	protein-containing complex assembly	5	6
GO:0070070	proton-transporting V-type ATPase complex assembly	7	6
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	6
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	8	6
GO:0071840	cellular component organization or biogenesis	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.699
CLV_PCSK_KEX2_1	118	120	PF00082	0.398
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.398
CLV_PCSK_SKI1_1	115	119	PF00082	0.392
CLV_PCSK_SKI1_1	72	76	PF00082	0.443
DEG_SCF_FBW7_1	18	24	PF00400	0.712
DEG_SPOP_SBC_1	34	38	PF00917	0.736
DEG_SPOP_SBC_1	39	43	PF00917	0.796
DOC_CKS1_1	18	23	PF01111	0.712
DOC_MAPK_MEF2A_6	175	183	PF00069	0.409
DOC_PP2B_LxvP_1	176	179	PF13499	0.412
DOC_PP2B_LxvP_1	9	12	PF13499	0.595
DOC_PP4_MxPP_1	8	11	PF00568	0.564
DOC_USP7_MATH_1	19	23	PF00917	0.764
DOC_USP7_MATH_1	39	43	PF00917	0.779
DOC_USP7_MATH_1	56	60	PF00917	0.705
DOC_WW_Pin1_4	17	22	PF00397	0.784
DOC_WW_Pin1_4	58	63	PF00397	0.695
LIG_EVH1_1	9	13	PF00568	0.597
LIG_FHA_1	124	130	PF00498	0.712
LIG_FHA_1	162	168	PF00498	0.300
LIG_FHA_1	172	178	PF00498	0.386
LIG_FHA_1	44	50	PF00498	0.636
LIG_FHA_1	59	65	PF00498	0.685
LIG_FHA_1	69	75	PF00498	0.649
LIG_FHA_2	104	110	PF00498	0.660
LIG_GBD_Chelix_1	168	176	PF00786	0.275
LIG_LIR_Nem_3	203	207	PF02991	0.294
LIG_LIR_Nem_3	87	93	PF02991	0.640
LIG_NRP_CendR_1	226	229	PF00754	0.493
LIG_PCNA_yPIPBox_3	141	155	PF02747	0.589
LIG_SH2_NCK_1	207	211	PF00017	0.348
LIG_SH2_STAP1	86	90	PF00017	0.602
LIG_SH2_STAT5	204	207	PF00017	0.296
LIG_SH2_STAT5	84	87	PF00017	0.569
LIG_SH3_3	7	13	PF00018	0.603
LIG_SUMO_SIM_par_1	168	174	PF11976	0.235
LIG_TRAF2_1	13	16	PF00917	0.611
LIG_TYR_ITIM	205	210	PF00017	0.373
LIG_WRC_WIRS_1	140	145	PF05994	0.601
MOD_CK1_1	42	48	PF00069	0.799
MOD_CK2_1	218	224	PF00069	0.679
MOD_CK2_1	47	53	PF00069	0.793
MOD_GlcNHglycan	136	139	PF01048	0.390
MOD_GlcNHglycan	21	24	PF01048	0.527
MOD_GlcNHglycan	53	57	PF01048	0.504
MOD_GlcNHglycan	58	61	PF01048	0.501
MOD_GSK3_1	103	110	PF00069	0.608
MOD_GSK3_1	123	130	PF00069	0.561
MOD_GSK3_1	17	24	PF00069	0.771
MOD_GSK3_1	196	203	PF00069	0.455
MOD_GSK3_1	218	225	PF00069	0.762
MOD_GSK3_1	34	41	PF00069	0.789
MOD_GSK3_1	43	50	PF00069	0.693
MOD_GSK3_1	52	59	PF00069	0.712
MOD_GSK3_1	85	92	PF00069	0.649
MOD_N-GLC_1	134	139	PF02516	0.481
MOD_N-GLC_1	218	223	PF02516	0.447
MOD_N-GLC_1	56	61	PF02516	0.451
MOD_NEK2_1	139	144	PF00069	0.675
MOD_NEK2_1	161	166	PF00069	0.288
MOD_NEK2_1	171	176	PF00069	0.429
MOD_NEK2_1	200	205	PF00069	0.374
MOD_NEK2_1	85	90	PF00069	0.603
MOD_PIKK_1	141	147	PF00454	0.715
MOD_PIKK_1	23	29	PF00454	0.679
MOD_PIKK_1	47	53	PF00454	0.675
MOD_PKA_2	43	49	PF00069	0.637
MOD_PKA_2	68	74	PF00069	0.663
MOD_Plk_1	103	109	PF00069	0.676
MOD_Plk_1	134	140	PF00069	0.684
MOD_Plk_2-3	103	109	PF00069	0.666
MOD_Plk_4	200	206	PF00069	0.336
MOD_Plk_4	85	91	PF00069	0.612
MOD_ProDKin_1	17	23	PF00069	0.785
MOD_ProDKin_1	58	64	PF00069	0.694
MOD_SUMO_for_1	117	120	PF00179	0.596
TRG_DiLeu_BaEn_4	80	86	PF01217	0.526
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.305
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.431
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.650
TRG_ENDOCYTIC_2	207	210	PF00928	0.416
TRG_ENDOCYTIC_2	86	89	PF00928	0.628
TRG_ENDOCYTIC_2	90	93	PF00928	0.649
TRG_ER_diLys_1	226	229	PF00400	0.666
TRG_ER_FFAT_2	116	126	PF00635	0.527
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVK4	Leptomonas seymouri	50%	100%
A0A0S4KKT5	Bodo saltans	29%	100%
A0A1X0P5D2	Trypanosomatidae	40%	100%
A0A3Q8IFH5	Leishmania donovani	81%	100%
A4HN91	Leishmania braziliensis	69%	100%
A4IBV9	Leishmania infantum	80%	100%
C9ZYQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AFP6	Leishmania major	81%	100%