BBS1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 1 protein

Species:

Leishmania mexicana

UniProt:

E9B6U8_LEIMU

TriTrypDb:

LmxM.34.4180

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6U8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006897	endocytosis	5	1
GO:0006907	pinocytosis	6	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0030001	metal ion transport	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033572	transferrin transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0001664	G protein-coupled receptor binding	4	1
GO:0005102	signaling receptor binding	3	1
GO:0005113	patched binding	4	1
GO:0005119	smoothened binding	5	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.430
CLV_C14_Caspase3-7	83	87	PF00656	0.367
CLV_NRD_NRD_1	431	433	PF00675	0.464
CLV_PCSK_KEX2_1	54	56	PF00082	0.338
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.371
CLV_PCSK_SKI1_1	205	209	PF00082	0.393
CLV_PCSK_SKI1_1	230	234	PF00082	0.410
CLV_PCSK_SKI1_1	516	520	PF00082	0.451
CLV_PCSK_SKI1_1	54	58	PF00082	0.275
DEG_APCC_DBOX_1	20	28	PF00400	0.291
DEG_SCF_TRCP1_1	150	156	PF00400	0.393
DEG_SPOP_SBC_1	153	157	PF00917	0.329
DOC_CDC14_PxL_1	533	541	PF14671	0.369
DOC_CKS1_1	116	121	PF01111	0.154
DOC_CKS1_1	234	239	PF01111	0.393
DOC_MAPK_DCC_7	177	186	PF00069	0.393
DOC_MAPK_gen_1	305	314	PF00069	0.379
DOC_MAPK_gen_1	369	379	PF00069	0.329
DOC_MAPK_MEF2A_6	177	186	PF00069	0.410
DOC_MAPK_MEF2A_6	372	381	PF00069	0.325
DOC_MAPK_MEF2A_6	559	566	PF00069	0.286
DOC_PP1_RVXF_1	514	520	PF00149	0.469
DOC_PP2B_PxIxI_1	90	96	PF00149	0.246
DOC_PP4_FxxP_1	113	116	PF00568	0.335
DOC_PP4_FxxP_1	534	537	PF00568	0.431
DOC_PP4_FxxP_1	71	74	PF00568	0.367
DOC_PP4_FxxP_1	88	91	PF00568	0.367
DOC_PP4_MxPP_1	114	117	PF00568	0.410
DOC_SPAK_OSR1_1	112	116	PF12202	0.335
DOC_USP7_MATH_1	196	200	PF00917	0.410
DOC_USP7_MATH_1	425	429	PF00917	0.459
DOC_USP7_MATH_1	462	466	PF00917	0.553
DOC_USP7_MATH_1	575	579	PF00917	0.386
DOC_USP7_MATH_1	60	64	PF00917	0.316
DOC_USP7_MATH_1	76	80	PF00917	0.194
DOC_WW_Pin1_4	115	120	PF00397	0.255
DOC_WW_Pin1_4	164	169	PF00397	0.414
DOC_WW_Pin1_4	233	238	PF00397	0.378
DOC_WW_Pin1_4	571	576	PF00397	0.549
LIG_14-3-3_CanoR_1	177	182	PF00244	0.396
LIG_14-3-3_CanoR_1	369	379	PF00244	0.476
LIG_14-3-3_CanoR_1	450	458	PF00244	0.421
LIG_Actin_WH2_2	434	452	PF00022	0.458
LIG_BIR_III_2	277	281	PF00653	0.437
LIG_BRCT_BRCA1_1	11	15	PF00533	0.327
LIG_BRCT_BRCA1_1	420	424	PF00533	0.547
LIG_Clathr_ClatBox_1	183	187	PF01394	0.410
LIG_deltaCOP1_diTrp_1	13	20	PF00928	0.336
LIG_FHA_1	131	137	PF00498	0.350
LIG_FHA_1	157	163	PF00498	0.314
LIG_FHA_1	34	40	PF00498	0.356
LIG_FHA_2	1	7	PF00498	0.569
LIG_FHA_2	116	122	PF00498	0.270
LIG_FHA_2	165	171	PF00498	0.402
LIG_FHA_2	550	556	PF00498	0.529
LIG_FHA_2	577	583	PF00498	0.517
LIG_LIR_Apic_2	524	530	PF02991	0.524
LIG_LIR_Apic_2	86	91	PF02991	0.398
LIG_LIR_Gen_1	213	224	PF02991	0.268
LIG_LIR_Gen_1	437	446	PF02991	0.470
LIG_LIR_Gen_1	44	50	PF02991	0.410
LIG_LIR_Gen_1	97	104	PF02991	0.410
LIG_LIR_LC3C_4	385	388	PF02991	0.330
LIG_LIR_Nem_3	12	18	PF02991	0.433
LIG_LIR_Nem_3	213	219	PF02991	0.259
LIG_LIR_Nem_3	247	253	PF02991	0.280
LIG_LIR_Nem_3	298	304	PF02991	0.338
LIG_LIR_Nem_3	356	362	PF02991	0.361
LIG_LIR_Nem_3	437	442	PF02991	0.482
LIG_LIR_Nem_3	44	48	PF02991	0.296
LIG_LIR_Nem_3	67	73	PF02991	0.443
LIG_MYND_1	537	541	PF01753	0.369
LIG_NRBOX	144	150	PF00104	0.410
LIG_NRBOX	159	165	PF00104	0.410
LIG_PCNA_yPIPBox_3	105	114	PF02747	0.393
LIG_Pex14_1	16	20	PF04695	0.275
LIG_SH2_CRK	250	254	PF00017	0.275
LIG_SH2_CRK	359	363	PF00017	0.350
LIG_SH2_CRK	45	49	PF00017	0.291
LIG_SH2_CRK	527	531	PF00017	0.485
LIG_SH2_GRB2like	301	304	PF00017	0.406
LIG_SH2_STAT5	100	103	PF00017	0.367
LIG_SH2_STAT5	218	221	PF00017	0.296
LIG_SH2_STAT5	347	350	PF00017	0.367
LIG_SH2_STAT5	457	460	PF00017	0.401
LIG_SH2_STAT5	527	530	PF00017	0.485
LIG_SH3_3	113	119	PF00018	0.350
LIG_SH3_3	228	234	PF00018	0.299
LIG_SH3_3	270	276	PF00018	0.454
LIG_SH3_3	309	315	PF00018	0.385
LIG_SH3_3	410	416	PF00018	0.509
LIG_SH3_3	538	544	PF00018	0.474
LIG_SH3_3	578	584	PF00018	0.437
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.367
LIG_SUMO_SIM_par_1	335	340	PF11976	0.395
LIG_SUMO_SIM_par_1	562	568	PF11976	0.535
LIG_SUMO_SIM_par_1	578	585	PF11976	0.322
LIG_SUMO_SIM_par_1	91	97	PF11976	0.367
LIG_TRAF2_1	167	170	PF00917	0.396
LIG_TYR_ITIM	248	253	PF00017	0.310
LIG_TYR_ITIM	299	304	PF00017	0.340
LIG_TYR_ITIM	357	362	PF00017	0.484
LIG_UBA3_1	563	571	PF00899	0.274
LIG_WRC_WIRS_1	77	82	PF05994	0.335
MOD_CDK_SPxxK_3	164	171	PF00069	0.385
MOD_CK1_1	156	162	PF00069	0.292
MOD_CK1_1	319	325	PF00069	0.413
MOD_CK1_1	465	471	PF00069	0.513
MOD_CK1_1	75	81	PF00069	0.322
MOD_CK2_1	164	170	PF00069	0.385
MOD_CK2_1	196	202	PF00069	0.412
MOD_CK2_1	337	343	PF00069	0.405
MOD_CK2_1	425	431	PF00069	0.485
MOD_CK2_1	549	555	PF00069	0.487
MOD_Cter_Amidation	305	308	PF01082	0.395
MOD_Cter_Amidation	52	55	PF01082	0.201
MOD_GlcNHglycan	150	153	PF01048	0.432
MOD_GlcNHglycan	205	208	PF01048	0.437
MOD_GlcNHglycan	270	273	PF01048	0.340
MOD_GlcNHglycan	318	321	PF01048	0.384
MOD_GlcNHglycan	74	77	PF01048	0.294
MOD_GSK3_1	144	151	PF00069	0.343
MOD_GSK3_1	152	159	PF00069	0.316
MOD_GSK3_1	173	180	PF00069	0.324
MOD_GSK3_1	291	298	PF00069	0.338
MOD_GSK3_1	316	323	PF00069	0.320
MOD_GSK3_1	419	426	PF00069	0.553
MOD_GSK3_1	535	542	PF00069	0.412
MOD_GSK3_1	565	572	PF00069	0.407
MOD_GSK3_1	72	79	PF00069	0.300
MOD_N-GLC_1	382	387	PF02516	0.336
MOD_N-GLC_1	395	400	PF02516	0.423
MOD_N-GLC_1	462	467	PF02516	0.565
MOD_N-GLC_1	471	476	PF02516	0.581
MOD_NEK2_1	103	108	PF00069	0.329
MOD_NEK2_1	148	153	PF00069	0.426
MOD_NEK2_1	397	402	PF00069	0.604
MOD_NEK2_1	449	454	PF00069	0.405
MOD_NEK2_1	576	581	PF00069	0.480
MOD_NEK2_2	76	81	PF00069	0.335
MOD_PIKK_1	347	353	PF00454	0.419
MOD_PIKK_1	423	429	PF00454	0.514
MOD_PIKK_1	444	450	PF00454	0.491
MOD_PIKK_1	471	477	PF00454	0.520
MOD_PK_1	177	183	PF00069	0.329
MOD_PK_1	260	266	PF00069	0.367
MOD_PK_1	308	314	PF00069	0.443
MOD_PKA_2	449	455	PF00069	0.453
MOD_Plk_1	444	450	PF00069	0.442
MOD_Plk_1	481	487	PF00069	0.437
MOD_Plk_4	144	150	PF00069	0.439
MOD_Plk_4	297	303	PF00069	0.303
MOD_Plk_4	308	314	PF00069	0.378
MOD_Plk_4	382	388	PF00069	0.343
MOD_Plk_4	419	425	PF00069	0.451
MOD_Plk_4	535	541	PF00069	0.380
MOD_Plk_4	576	582	PF00069	0.439
MOD_Plk_4	76	82	PF00069	0.375
MOD_ProDKin_1	115	121	PF00069	0.255
MOD_ProDKin_1	164	170	PF00069	0.414
MOD_ProDKin_1	233	239	PF00069	0.378
MOD_ProDKin_1	571	577	PF00069	0.539
TRG_DiLeu_BaEn_1	331	336	PF01217	0.481
TRG_DiLeu_BaEn_3	169	175	PF01217	0.346
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.410
TRG_ENDOCYTIC_2	100	103	PF00928	0.287
TRG_ENDOCYTIC_2	111	114	PF00928	0.253
TRG_ENDOCYTIC_2	250	253	PF00928	0.275
TRG_ENDOCYTIC_2	286	289	PF00928	0.389
TRG_ENDOCYTIC_2	301	304	PF00928	0.359
TRG_ENDOCYTIC_2	359	362	PF00928	0.354
TRG_ENDOCYTIC_2	439	442	PF00928	0.501
TRG_ENDOCYTIC_2	45	48	PF00928	0.291
TRG_ENDOCYTIC_2	457	460	PF00928	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK5	Leptomonas seymouri	74%	100%
A0A0S4KEX6	Bodo saltans	40%	97%
A0A1X0P534	Trypanosomatidae	47%	97%
A0A3Q8IVI7	Leishmania donovani	93%	100%
A0A3R7KG84	Trypanosoma rangeli	47%	100%
A4HN90	Leishmania braziliensis	84%	100%
A4IBV8	Leishmania infantum	93%	100%
C9ZYQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9AFP5	Leishmania major	92%	100%
Q3V3N7	Mus musculus	33%	100%
Q8NFJ9	Homo sapiens	33%	100%
Q9NEZ7	Caenorhabditis elegans	22%	100%
V5DUI8	Trypanosoma cruzi	47%	100%