RNA polymerase III RPC4 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III RPC4, putative

Species:

Leishmania mexicana

UniProt:

E9B6U7_LEIMU

TriTrypDb:

LmxM.34.4170

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	6
GO:0005666	RNA polymerase III complex	4	6
GO:0030880	RNA polymerase complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	6
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	6
GO:0140513	nuclear protein-containing complex	2	6
GO:0140535	intracellular protein-containing complex	2	6
GO:1902494	catalytic complex	2	6
GO:1990234	transferase complex	3	6

Expansion

Sequence features

E9B6U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6U7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006351	DNA-templated transcription	7	6
GO:0006383	transcription by RNA polymerase III	8	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009059	macromolecule biosynthetic process	4	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0032774	RNA biosynthetic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0097659	nucleic acid-templated transcription	6	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003677	DNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.685
CLV_PCSK_KEX2_1	139	141	PF00082	0.653
CLV_PCSK_SKI1_1	13	17	PF00082	0.713
CLV_PCSK_SKI1_1	197	201	PF00082	0.600
CLV_PCSK_SKI1_1	300	304	PF00082	0.451
DEG_SPOP_SBC_1	51	55	PF00917	0.690
DEG_SPOP_SBC_1	67	71	PF00917	0.717
DOC_CKS1_1	358	363	PF01111	0.376
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.696
DOC_MAPK_FxFP_2	145	148	PF00069	0.482
DOC_MAPK_gen_1	294	303	PF00069	0.390
DOC_MAPK_gen_1	9	16	PF00069	0.695
DOC_MAPK_MEF2A_6	297	305	PF00069	0.501
DOC_MAPK_MEF2A_6	9	16	PF00069	0.695
DOC_PP2B_LxvP_1	178	181	PF13499	0.701
DOC_PP2B_LxvP_1	200	203	PF13499	0.513
DOC_PP4_FxxP_1	118	121	PF00568	0.491
DOC_PP4_FxxP_1	145	148	PF00568	0.482
DOC_PP4_FxxP_1	283	286	PF00568	0.515
DOC_USP7_MATH_1	114	118	PF00917	0.723
DOC_USP7_MATH_1	155	159	PF00917	0.709
DOC_USP7_MATH_1	173	177	PF00917	0.547
DOC_USP7_MATH_1	336	340	PF00917	0.432
DOC_USP7_MATH_1	51	55	PF00917	0.694
DOC_USP7_MATH_1	67	71	PF00917	0.689
DOC_USP7_MATH_1	84	88	PF00917	0.745
DOC_USP7_UBL2_3	9	13	PF12436	0.684
DOC_WW_Pin1_4	207	212	PF00397	0.777
DOC_WW_Pin1_4	257	262	PF00397	0.511
DOC_WW_Pin1_4	357	362	PF00397	0.376
LIG_14-3-3_CanoR_1	197	203	PF00244	0.602
LIG_BRCT_BRCA1_1	68	72	PF00533	0.518
LIG_FHA_1	222	228	PF00498	0.595
LIG_FHA_1	261	267	PF00498	0.393
LIG_FHA_1	29	35	PF00498	0.680
LIG_FHA_1	358	364	PF00498	0.376
LIG_LIR_Apic_2	116	121	PF02991	0.495
LIG_LIR_Apic_2	143	148	PF02991	0.476
LIG_LIR_Apic_2	281	286	PF02991	0.501
LIG_LIR_Nem_3	176	182	PF02991	0.702
LIG_LIR_Nem_3	281	285	PF02991	0.440
LIG_SH2_CRK	179	183	PF00017	0.689
LIG_SH2_NCK_1	317	321	PF00017	0.376
LIG_SH2_SRC	245	248	PF00017	0.563
LIG_SH2_SRC	317	320	PF00017	0.430
LIG_SH2_STAP1	238	242	PF00017	0.536
LIG_SH2_STAP1	245	249	PF00017	0.531
LIG_SH2_STAP1	310	314	PF00017	0.376
LIG_SH2_STAT5	46	49	PF00017	0.664
LIG_SH3_3	149	155	PF00018	0.690
LIG_SH3_3	335	341	PF00018	0.460
LIG_SH3_3	358	364	PF00018	0.423
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.642
LIG_TRAF2_1	133	136	PF00917	0.659
LIG_TRAF2_1	193	196	PF00917	0.705
LIG_TRFH_1	283	287	PF08558	0.501
LIG_WW_2	152	155	PF00397	0.692
MOD_CK1_1	158	164	PF00069	0.664
MOD_CK1_1	187	193	PF00069	0.622
MOD_CK1_1	255	261	PF00069	0.678
MOD_CK1_1	339	345	PF00069	0.385
MOD_CK2_1	343	349	PF00069	0.430
MOD_CK2_1	50	56	PF00069	0.692
MOD_GlcNHglycan	128	131	PF01048	0.750
MOD_GlcNHglycan	165	168	PF01048	0.784
MOD_GlcNHglycan	175	178	PF01048	0.728
MOD_GlcNHglycan	200	203	PF01048	0.698
MOD_GlcNHglycan	207	210	PF01048	0.667
MOD_GlcNHglycan	257	260	PF01048	0.705
MOD_GlcNHglycan	297	300	PF01048	0.341
MOD_GlcNHglycan	334	337	PF01048	0.392
MOD_GlcNHglycan	60	63	PF01048	0.689
MOD_GlcNHglycan	88	91	PF01048	0.516
MOD_GSK3_1	122	129	PF00069	0.650
MOD_GSK3_1	28	35	PF00069	0.636
MOD_GSK3_1	332	339	PF00069	0.420
MOD_N-GLC_1	101	106	PF02516	0.731
MOD_NEK2_1	184	189	PF00069	0.716
MOD_NEK2_1	252	257	PF00069	0.752
MOD_NEK2_2	245	250	PF00069	0.572
MOD_PIKK_1	25	31	PF00454	0.795
MOD_PIKK_1	329	335	PF00454	0.430
MOD_Plk_1	184	190	PF00069	0.658
MOD_Plk_1	245	251	PF00069	0.644
MOD_Plk_1	32	38	PF00069	0.590
MOD_Plk_4	114	120	PF00069	0.790
MOD_Plk_4	158	164	PF00069	0.658
MOD_Plk_4	32	38	PF00069	0.590
MOD_ProDKin_1	207	213	PF00069	0.777
MOD_ProDKin_1	257	263	PF00069	0.510
MOD_ProDKin_1	357	363	PF00069	0.376
TRG_DiLeu_BaEn_4	195	201	PF01217	0.675
TRG_ENDOCYTIC_2	179	182	PF00928	0.698
TRG_ENDOCYTIC_2	309	312	PF00928	0.357
TRG_NES_CRM1_1	304	318	PF08389	0.338
TRG_NES_CRM1_1	38	49	PF08389	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD4	Leptomonas seymouri	58%	93%
A0A3S7XA21	Leishmania donovani	90%	100%
A4HN89	Leishmania braziliensis	75%	100%
A4IBV7	Leishmania infantum	90%	100%
C9ZYQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AFP4	Leishmania major	91%	100%