Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B6U4_LEIMU

TriTrypDb:

LmxM.34.4140

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B6U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.702
CLV_MEL_PAP_1	115	121	PF00089	0.314
CLV_NRD_NRD_1	142	144	PF00675	0.408
CLV_NRD_NRD_1	213	215	PF00675	0.521
CLV_NRD_NRD_1	218	220	PF00675	0.487
CLV_NRD_NRD_1	292	294	PF00675	0.496
CLV_NRD_NRD_1	298	300	PF00675	0.423
CLV_PCSK_FUR_1	290	294	PF00082	0.411
CLV_PCSK_FUR_1	296	300	PF00082	0.375
CLV_PCSK_KEX2_1	142	144	PF00082	0.362
CLV_PCSK_KEX2_1	213	215	PF00082	0.436
CLV_PCSK_KEX2_1	292	294	PF00082	0.492
CLV_PCSK_KEX2_1	298	300	PF00082	0.425
CLV_PCSK_SKI1_1	166	170	PF00082	0.380
CLV_PCSK_SKI1_1	213	217	PF00082	0.441
CLV_PCSK_SKI1_1	89	93	PF00082	0.344
DEG_APCC_DBOX_1	165	173	PF00400	0.558
DEG_APCC_DBOX_1	227	235	PF00400	0.719
DEG_APCC_DBOX_1	297	305	PF00400	0.612
DEG_Nend_Nbox_1	1	3	PF02207	0.427
DOC_MAPK_DCC_7	54	64	PF00069	0.628
DOC_MAPK_gen_1	142	149	PF00069	0.591
DOC_MAPK_gen_1	199	207	PF00069	0.664
DOC_MAPK_gen_1	27	36	PF00069	0.588
DOC_MAPK_MEF2A_6	142	149	PF00069	0.565
DOC_MAPK_MEF2A_6	50	59	PF00069	0.645
DOC_PP1_RVXF_1	87	93	PF00149	0.335
DOC_PP2B_LxvP_1	97	100	PF13499	0.653
DOC_USP7_MATH_1	242	246	PF00917	0.751
DOC_USP7_MATH_1	249	253	PF00917	0.659
DOC_USP7_MATH_1	255	259	PF00917	0.634
DOC_WW_Pin1_4	122	127	PF00397	0.704
DOC_WW_Pin1_4	39	44	PF00397	0.655
LIG_14-3-3_CanoR_1	134	139	PF00244	0.666
LIG_14-3-3_CanoR_1	201	206	PF00244	0.608
LIG_14-3-3_CanoR_1	29	38	PF00244	0.643
LIG_APCC_ABBA_1	82	87	PF00400	0.335
LIG_BRCT_BRCA1_1	170	174	PF00533	0.615
LIG_BRCT_BRCA1_1	256	260	PF00533	0.585
LIG_BRCT_BRCA1_1	301	305	PF00533	0.628
LIG_deltaCOP1_diTrp_1	80	85	PF00928	0.376
LIG_FHA_1	126	132	PF00498	0.626
LIG_FHA_1	133	139	PF00498	0.634
LIG_FHA_1	207	213	PF00498	0.665
LIG_FHA_1	248	254	PF00498	0.727
LIG_FHA_1	29	35	PF00498	0.745
LIG_FHA_1	68	74	PF00498	0.448
LIG_FHA_2	260	266	PF00498	0.701
LIG_GBD_Chelix_1	8	16	PF00786	0.294
LIG_Integrin_RGD_1	293	295	PF01839	0.406
LIG_LIR_Apic_2	95	101	PF02991	0.458
LIG_LIR_Gen_1	106	116	PF02991	0.581
LIG_LIR_Gen_1	19	26	PF02991	0.276
LIG_LIR_Gen_1	193	198	PF02991	0.594
LIG_LIR_Nem_3	109	115	PF02991	0.584
LIG_LIR_Nem_3	19	23	PF02991	0.308
LIG_LIR_Nem_3	193	197	PF02991	0.597
LIG_LIR_Nem_3	80	85	PF02991	0.292
LIG_MLH1_MIPbox_1	256	260	PF16413	0.585
LIG_Pex14_1	81	85	PF04695	0.453
LIG_SH2_CRK	194	198	PF00017	0.618
LIG_SH2_CRK	94	98	PF00017	0.335
LIG_SH2_NCK_1	194	198	PF00017	0.600
LIG_SH2_NCK_1	98	102	PF00017	0.508
LIG_SH2_SRC	98	101	PF00017	0.628
LIG_SH2_STAP1	108	112	PF00017	0.577
LIG_SH2_STAP1	194	198	PF00017	0.588
LIG_SH2_STAP1	94	98	PF00017	0.335
LIG_SH2_STAT5	15	18	PF00017	0.335
LIG_SH2_STAT5	154	157	PF00017	0.638
LIG_SH2_STAT5	94	97	PF00017	0.335
LIG_SUMO_SIM_anti_2	30	39	PF11976	0.559
LIG_SUMO_SIM_par_1	6	11	PF11976	0.453
LIG_SUMO_SIM_par_1	64	70	PF11976	0.335
LIG_TRAF2_1	103	106	PF00917	0.578
LIG_WRC_WIRS_1	256	261	PF05994	0.583
MOD_CDK_SPxxK_3	122	129	PF00069	0.703
MOD_CK1_1	125	131	PF00069	0.608
MOD_CK1_1	254	260	PF00069	0.635
MOD_CK1_1	39	45	PF00069	0.745
MOD_CK2_1	275	281	PF00069	0.715
MOD_GlcNHglycan	222	228	PF01048	0.469
MOD_GlcNHglycan	253	256	PF01048	0.395
MOD_GlcNHglycan	277	280	PF01048	0.608
MOD_GlcNHglycan	300	304	PF01048	0.423
MOD_GlcNHglycan	38	41	PF01048	0.439
MOD_GSK3_1	155	162	PF00069	0.530
MOD_GSK3_1	186	193	PF00069	0.648
MOD_GSK3_1	247	254	PF00069	0.657
MOD_GSK3_1	255	262	PF00069	0.712
MOD_GSK3_1	28	35	PF00069	0.644
MOD_LATS_1	297	303	PF00433	0.579
MOD_N-GLC_1	152	157	PF02516	0.428
MOD_N-GLC_1	201	206	PF02516	0.340
MOD_NEK2_1	1	6	PF00069	0.445
MOD_NEK2_1	16	21	PF00069	0.268
MOD_NEK2_1	259	264	PF00069	0.692
MOD_NEK2_1	267	272	PF00069	0.779
MOD_NEK2_1	67	72	PF00069	0.453
MOD_NEK2_1	8	13	PF00069	0.300
MOD_NEK2_1	92	97	PF00069	0.354
MOD_NEK2_2	255	260	PF00069	0.584
MOD_PK_1	201	207	PF00069	0.552
MOD_PKA_2	186	192	PF00069	0.684
MOD_PKA_2	28	34	PF00069	0.625
MOD_PKB_1	199	207	PF00069	0.542
MOD_Plk_1	155	161	PF00069	0.599
MOD_Plk_1	201	207	PF00069	0.538
MOD_Plk_1	242	248	PF00069	0.670
MOD_Plk_4	134	140	PF00069	0.678
MOD_Plk_4	255	261	PF00069	0.617
MOD_Plk_4	32	38	PF00069	0.698
MOD_Plk_4	72	78	PF00069	0.469
MOD_Plk_4	8	14	PF00069	0.340
MOD_Plk_4	92	98	PF00069	0.225
MOD_ProDKin_1	122	128	PF00069	0.702
MOD_ProDKin_1	39	45	PF00069	0.656
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.581
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.437
TRG_ENDOCYTIC_2	108	111	PF00928	0.583
TRG_ENDOCYTIC_2	15	18	PF00928	0.335
TRG_ENDOCYTIC_2	194	197	PF00928	0.597
TRG_ENDOCYTIC_2	20	23	PF00928	0.335
TRG_ENDOCYTIC_2	94	97	PF00928	0.335
TRG_ER_diArg_1	141	143	PF00400	0.561
TRG_ER_diArg_1	212	214	PF00400	0.717
TRG_ER_diArg_1	290	293	PF00400	0.697
TRG_ER_diArg_1	296	299	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X0	Leptomonas seymouri	54%	99%
A0A3Q8IIP6	Leishmania donovani	86%	100%
A4HN86	Leishmania braziliensis	63%	100%
A4IBV4	Leishmania infantum	87%	100%
E9AFP1	Leishmania major	84%	100%