5'-deoxynucleotidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6U0_LEIMU

TriTrypDb:

LmxM.34.4110

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6U0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002953	5'-deoxynucleotidase activity	6	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.348
CLV_PCSK_KEX2_1	28	30	PF00082	0.348
CLV_PCSK_SKI1_1	68	72	PF00082	0.230
CLV_PCSK_SKI1_1	91	95	PF00082	0.373
DEG_APCC_DBOX_1	47	55	PF00400	0.301
DOC_MAPK_gen_1	63	71	PF00069	0.242
DOC_USP7_MATH_1	57	61	PF00917	0.320
DOC_USP7_UBL2_3	91	95	PF12436	0.373
DOC_WW_Pin1_4	109	114	PF00397	0.323
DOC_WW_Pin1_4	35	40	PF00397	0.378
DOC_WW_Pin1_4	81	86	PF00397	0.242
LIG_14-3-3_CanoR_1	48	52	PF00244	0.320
LIG_Actin_WH2_2	10	26	PF00022	0.344
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_FHA_2	182	188	PF00498	0.472
LIG_HCF-1_HBM_1	44	47	PF13415	0.242
LIG_LIR_Gen_1	153	159	PF02991	0.379
LIG_LIR_Nem_3	123	128	PF02991	0.279
LIG_LIR_Nem_3	153	157	PF02991	0.350
LIG_REV1ctd_RIR_1	164	172	PF16727	0.401
LIG_SH2_NCK_1	154	158	PF00017	0.354
LIG_SH2_STAP1	182	186	PF00017	0.372
LIG_SH2_STAT3	128	131	PF00017	0.242
LIG_SH2_STAT5	191	194	PF00017	0.472
LIG_UBA3_1	79	88	PF00899	0.285
LIG_WRC_WIRS_1	13	18	PF05994	0.533
LIG_WRC_WIRS_1	163	168	PF05994	0.362
MOD_CDK_SPxxK_3	81	88	PF00069	0.320
MOD_CK1_1	112	118	PF00069	0.315
MOD_CK1_1	153	159	PF00069	0.318
MOD_CK1_1	38	44	PF00069	0.269
MOD_CK2_1	181	187	PF00069	0.469
MOD_GlcNHglycan	168	171	PF01048	0.328
MOD_GSK3_1	108	115	PF00069	0.372
MOD_GSK3_1	12	19	PF00069	0.522
MOD_GSK3_1	162	169	PF00069	0.366
MOD_GSK3_1	181	188	PF00069	0.221
MOD_N-GLC_1	113	118	PF02516	0.245
MOD_NEK2_1	1	6	PF00069	0.527
MOD_NEK2_1	108	113	PF00069	0.373
MOD_NEK2_1	16	21	PF00069	0.400
MOD_NEK2_1	166	171	PF00069	0.442
MOD_NEK2_1	185	190	PF00069	0.207
MOD_NEK2_1	23	28	PF00069	0.315
MOD_PKA_2	47	53	PF00069	0.320
MOD_Plk_1	113	119	PF00069	0.341
MOD_Plk_1	57	63	PF00069	0.260
MOD_Plk_4	162	168	PF00069	0.366
MOD_Plk_4	181	187	PF00069	0.236
MOD_Plk_4	47	53	PF00069	0.320
MOD_Plk_4	75	81	PF00069	0.242
MOD_ProDKin_1	109	115	PF00069	0.323
MOD_ProDKin_1	35	41	PF00069	0.378
MOD_ProDKin_1	81	87	PF00069	0.242
TRG_ENDOCYTIC_2	154	157	PF00928	0.348
TRG_ENDOCYTIC_2	182	185	PF00928	0.370
TRG_NES_CRM1_1	44	58	PF08389	0.320
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.341
TRG_PTS2	1	36	PF00400	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX92	Leptomonas seymouri	77%	100%
A0A0S4J0X2	Bodo saltans	61%	100%
A0A1X0P6J6	Trypanosomatidae	59%	100%
A0A3Q8IQ15	Leishmania donovani	95%	100%
A0A3R7MHB3	Trypanosoma rangeli	61%	100%
A4HN82	Leishmania braziliensis	87%	100%
A4IBV0	Leishmania infantum	95%	100%
C9ZYR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AFN7	Leishmania major	93%	100%
P38331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	87%
P53144	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	96%
P87242	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q0P565	Bos taurus	45%	100%
Q1LUI2	Danio rerio	41%	100%
Q3SXD3	Mus musculus	45%	100%
Q54FK1	Dictyostelium discoideum	37%	100%
Q66L17	Xenopus laevis	44%	100%
Q7Z4H3	Homo sapiens	44%	100%