Splicing factor 3B subunit 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Splicing factor 3B subunit 10 (SF3b10), putative

Species:

Leishmania mexicana

UniProt:

E9B6T8_LEIMU

TriTrypDb:

LmxM.34.4090

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B6T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6T8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.257
DEG_APCC_DBOX_1	41	49	PF00400	0.315
DEG_APCC_DBOX_1	51	59	PF00400	0.255
DEG_APCC_DBOX_1	70	78	PF00400	0.290
DOC_CYCLIN_RxL_1	68	75	PF00134	0.288
DOC_PP4_FxxP_1	5	8	PF00568	0.500
LIG_AP2alpha_2	3	5	PF02296	0.487
LIG_FHA_1	24	30	PF00498	0.290
LIG_FHA_2	29	35	PF00498	0.258
LIG_LIR_Apic_2	3	8	PF02991	0.494
LIG_LIR_Gen_1	56	65	PF02991	0.258
LIG_LIR_Nem_3	34	39	PF02991	0.290
LIG_LIR_Nem_3	56	60	PF02991	0.258
LIG_NRP_CendR_1	83	84	PF00754	0.549
LIG_SH2_SRC	12	15	PF00017	0.446
LIG_SH2_STAT5	57	60	PF00017	0.290
LIG_TYR_ITIM	55	60	PF00017	0.255
MOD_GSK3_1	25	32	PF00069	0.297
MOD_PKA_2	41	47	PF00069	0.255
MOD_SUMO_for_1	21	24	PF00179	0.255
MOD_SUMO_for_1	67	70	PF00179	0.349
TRG_ENDOCYTIC_2	57	60	PF00928	0.255
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K0	Leptomonas seymouri	92%	100%
A0A0S4IXB6	Bodo saltans	57%	83%
A0A3S5H805	Leishmania donovani	96%	100%
A4HN80	Leishmania braziliensis	99%	100%
A4IBU8	Leishmania infantum	96%	100%
C9ZYR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	94%
E9AFN5	Leishmania major	96%	100%
Q56K13	Bos taurus	37%	98%
Q923D4	Mus musculus	38%	98%
Q9BWJ5	Homo sapiens	37%	98%
Q9P7R6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	99%
Q9VHI4	Drosophila melanogaster	42%	99%