4E-interacting_protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4E-interacting protein, putative

Species:

Leishmania mexicana

UniProt:

E9B6S6_LEIMU

TriTrypDb:

LmxM.34.3980

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B6S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6S6

PDB structure(s): 5wb5_B

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0045182	translation regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.693
CLV_NRD_NRD_1	119	121	PF00675	0.738
CLV_NRD_NRD_1	188	190	PF00675	0.620
CLV_NRD_NRD_1	30	32	PF00675	0.730
CLV_NRD_NRD_1	47	49	PF00675	0.582
CLV_NRD_NRD_1	739	741	PF00675	0.709
CLV_PCSK_KEX2_1	119	121	PF00082	0.738
CLV_PCSK_KEX2_1	178	180	PF00082	0.598
CLV_PCSK_KEX2_1	46	48	PF00082	0.733
CLV_PCSK_KEX2_1	739	741	PF00082	0.709
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.598
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.733
CLV_PCSK_SKI1_1	15	19	PF00082	0.641
CLV_PCSK_SKI1_1	195	199	PF00082	0.572
CLV_PCSK_SKI1_1	495	499	PF00082	0.776
CLV_Separin_Metazoa	12	16	PF03568	0.695
CLV_Separin_Metazoa	28	32	PF03568	0.465
DEG_APCC_DBOX_1	9	17	PF00400	0.598
DEG_COP1_1	473	483	PF00400	0.825
DEG_SCF_FBW7_1	293	300	PF00400	0.679
DEG_SCF_FBW7_1	444	450	PF00400	0.741
DEG_SIAH_1	288	296	PF03145	0.750
DEG_SPOP_SBC_1	365	369	PF00917	0.760
DOC_CKS1_1	294	299	PF01111	0.724
DOC_CKS1_1	444	449	PF01111	0.811
DOC_CYCLIN_yClb3_PxF_3	551	557	PF00134	0.829
DOC_CYCLIN_yClb5_NLxxxL_5	190	198	PF00134	0.631
DOC_CYCLIN_yCln2_LP_2	707	713	PF00134	0.714
DOC_MAPK_gen_1	31	38	PF00069	0.774
DOC_PP2B_LxvP_1	621	624	PF13499	0.810
DOC_PP2B_LxvP_1	707	710	PF13499	0.717
DOC_PP4_FxxP_1	145	148	PF00568	0.671
DOC_PP4_FxxP_1	274	277	PF00568	0.749
DOC_PP4_FxxP_1	362	365	PF00568	0.539
DOC_PP4_FxxP_1	557	560	PF00568	0.735
DOC_PP4_FxxP_1	570	573	PF00568	0.747
DOC_PP4_FxxP_1	720	723	PF00568	0.623
DOC_PP4_FxxP_1	738	741	PF00568	0.468
DOC_USP7_MATH_1	253	257	PF00917	0.782
DOC_USP7_MATH_1	266	270	PF00917	0.764
DOC_USP7_MATH_1	277	281	PF00917	0.675
DOC_USP7_MATH_1	289	293	PF00917	0.711
DOC_USP7_MATH_1	297	301	PF00917	0.622
DOC_USP7_MATH_1	309	313	PF00917	0.472
DOC_USP7_MATH_1	343	347	PF00917	0.773
DOC_USP7_MATH_1	366	370	PF00917	0.789
DOC_USP7_MATH_1	378	382	PF00917	0.660
DOC_USP7_MATH_1	385	389	PF00917	0.797
DOC_USP7_MATH_1	407	411	PF00917	0.694
DOC_USP7_MATH_1	571	575	PF00917	0.792
DOC_USP7_MATH_1	580	584	PF00917	0.740
DOC_USP7_MATH_1	627	631	PF00917	0.800
DOC_USP7_MATH_1	633	637	PF00917	0.782
DOC_WW_Pin1_4	102	107	PF00397	0.749
DOC_WW_Pin1_4	259	264	PF00397	0.716
DOC_WW_Pin1_4	279	284	PF00397	0.486
DOC_WW_Pin1_4	293	298	PF00397	0.649
DOC_WW_Pin1_4	341	346	PF00397	0.678
DOC_WW_Pin1_4	399	404	PF00397	0.726
DOC_WW_Pin1_4	417	422	PF00397	0.522
DOC_WW_Pin1_4	440	445	PF00397	0.794
DOC_WW_Pin1_4	447	452	PF00397	0.751
DOC_WW_Pin1_4	509	514	PF00397	0.676
DOC_WW_Pin1_4	550	555	PF00397	0.831
DOC_WW_Pin1_4	573	578	PF00397	0.838
DOC_WW_Pin1_4	589	594	PF00397	0.756
DOC_WW_Pin1_4	678	683	PF00397	0.843
LIG_14-3-3_CanoR_1	15	20	PF00244	0.719
LIG_14-3-3_CanoR_1	241	248	PF00244	0.692
LIG_AP2alpha_1	59	63	PF02296	0.620
LIG_APCC_ABBAyCdc20_2	55	61	PF00400	0.622
LIG_BIR_III_2	342	346	PF00653	0.767
LIG_BRCT_BRCA1_1	239	243	PF00533	0.683
LIG_BRCT_BRCA1_1	358	362	PF00533	0.545
LIG_BRCT_BRCA1_1	566	570	PF00533	0.633
LIG_EH_1	768	772	PF12763	0.788
LIG_eIF4E_1	8	14	PF01652	0.595
LIG_EVH1_1	621	625	PF00568	0.809
LIG_FHA_1	215	221	PF00498	0.639
LIG_FHA_1	283	289	PF00498	0.758
LIG_FHA_1	518	524	PF00498	0.740
LIG_FHA_1	684	690	PF00498	0.846
LIG_FHA_2	159	165	PF00498	0.724
LIG_FHA_2	226	232	PF00498	0.772
LIG_FHA_2	249	255	PF00498	0.758
LIG_FHA_2	522	528	PF00498	0.740
LIG_FHA_2	7	13	PF00498	0.601
LIG_LIR_Apic_2	143	148	PF02991	0.678
LIG_LIR_Apic_2	271	277	PF02991	0.756
LIG_LIR_Apic_2	359	365	PF02991	0.539
LIG_LIR_Apic_2	567	573	PF02991	0.633
LIG_LIR_Gen_1	140	148	PF02991	0.788
LIG_LIR_Nem_3	140	145	PF02991	0.701
LIG_MLH1_MIPbox_1	239	243	PF16413	0.683
LIG_MYND_1	687	691	PF01753	0.844
LIG_NRBOX	488	494	PF00104	0.640
LIG_NRP_CendR_1	785	786	PF00754	0.795
LIG_Pex14_2	59	63	PF04695	0.620
LIG_SH2_STAP1	142	146	PF00017	0.685
LIG_SH2_STAT5	719	722	PF00017	0.686
LIG_SH2_STAT5	8	11	PF00017	0.599
LIG_SH3_3	258	264	PF00018	0.699
LIG_SH3_3	348	354	PF00018	0.744
LIG_SH3_3	35	41	PF00018	0.696
LIG_SH3_3	392	398	PF00018	0.805
LIG_SH3_3	400	406	PF00018	0.687
LIG_SH3_3	408	414	PF00018	0.581
LIG_SH3_3	441	447	PF00018	0.805
LIG_SH3_3	455	461	PF00018	0.767
LIG_SH3_3	501	507	PF00018	0.746
LIG_SH3_3	548	554	PF00018	0.825
LIG_SH3_3	557	563	PF00018	0.681
LIG_SH3_3	574	580	PF00018	0.739
LIG_SH3_3	617	623	PF00018	0.684
LIG_SH3_3	662	668	PF00018	0.807
LIG_SH3_3	685	691	PF00018	0.790
LIG_SH3_3	764	770	PF00018	0.785
LIG_SUMO_SIM_anti_2	488	493	PF11976	0.660
LIG_SUMO_SIM_par_1	34	40	PF11976	0.692
LIG_TRAF2_1	161	164	PF00917	0.637
LIG_TRAF2_1	9	12	PF00917	0.697
MOD_CK1_1	104	110	PF00069	0.728
MOD_CK1_1	252	258	PF00069	0.555
MOD_CK1_1	282	288	PF00069	0.678
MOD_CK1_1	312	318	PF00069	0.767
MOD_CK1_1	325	331	PF00069	0.575
MOD_CK1_1	356	362	PF00069	0.807
MOD_CK1_1	443	449	PF00069	0.788
MOD_CK1_1	456	462	PF00069	0.731
MOD_CK1_1	473	479	PF00069	0.684
MOD_CK1_1	509	515	PF00069	0.738
MOD_CK1_1	57	63	PF00069	0.767
MOD_CK1_1	583	589	PF00069	0.761
MOD_CK1_1	64	70	PF00069	0.708
MOD_CK1_1	97	103	PF00069	0.748
MOD_CK2_1	158	164	PF00069	0.734
MOD_CK2_1	248	254	PF00069	0.748
MOD_CK2_1	521	527	PF00069	0.774
MOD_CK2_1	6	12	PF00069	0.665
MOD_GlcNHglycan	139	142	PF01048	0.725
MOD_GlcNHglycan	172	175	PF01048	0.570
MOD_GlcNHglycan	20	23	PF01048	0.639
MOD_GlcNHglycan	243	246	PF01048	0.706
MOD_GlcNHglycan	251	254	PF01048	0.744
MOD_GlcNHglycan	255	258	PF01048	0.743
MOD_GlcNHglycan	299	302	PF01048	0.729
MOD_GlcNHglycan	327	330	PF01048	0.685
MOD_GlcNHglycan	385	388	PF01048	0.722
MOD_GlcNHglycan	395	398	PF01048	0.658
MOD_GlcNHglycan	42	45	PF01048	0.530
MOD_GlcNHglycan	472	475	PF01048	0.762
MOD_GlcNHglycan	484	487	PF01048	0.720
MOD_GlcNHglycan	501	504	PF01048	0.611
MOD_GlcNHglycan	586	589	PF01048	0.760
MOD_GlcNHglycan	71	74	PF01048	0.770
MOD_GlcNHglycan	87	90	PF01048	0.760
MOD_GSK3_1	133	140	PF00069	0.649
MOD_GSK3_1	233	240	PF00069	0.685
MOD_GSK3_1	248	255	PF00069	0.711
MOD_GSK3_1	266	273	PF00069	0.691
MOD_GSK3_1	289	296	PF00069	0.682
MOD_GSK3_1	308	315	PF00069	0.551
MOD_GSK3_1	318	325	PF00069	0.615
MOD_GSK3_1	330	337	PF00069	0.583
MOD_GSK3_1	356	363	PF00069	0.805
MOD_GSK3_1	379	386	PF00069	0.675
MOD_GSK3_1	389	396	PF00069	0.785
MOD_GSK3_1	428	435	PF00069	0.708
MOD_GSK3_1	443	450	PF00069	0.710
MOD_GSK3_1	470	477	PF00069	0.704
MOD_GSK3_1	478	485	PF00069	0.694
MOD_GSK3_1	495	502	PF00069	0.712
MOD_GSK3_1	509	516	PF00069	0.800
MOD_GSK3_1	517	524	PF00069	0.619
MOD_GSK3_1	542	549	PF00069	0.783
MOD_GSK3_1	57	64	PF00069	0.777
MOD_GSK3_1	579	586	PF00069	0.763
MOD_GSK3_1	633	640	PF00069	0.800
MOD_GSK3_1	65	72	PF00069	0.705
MOD_GSK3_1	93	100	PF00069	0.732
MOD_N-GLC_1	131	136	PF02516	0.531
MOD_N-GLC_1	379	384	PF02516	0.698
MOD_N-GLC_1	417	422	PF02516	0.535
MOD_N-GLC_1	678	683	PF02516	0.843
MOD_N-GLC_1	84	89	PF02516	0.737
MOD_N-GLC_1	97	102	PF02516	0.807
MOD_NEK2_1	137	142	PF00069	0.595
MOD_NEK2_1	170	175	PF00069	0.574
MOD_NEK2_1	319	324	PF00069	0.684
MOD_NEK2_1	330	335	PF00069	0.602
MOD_NEK2_1	393	398	PF00069	0.546
MOD_NEK2_1	499	504	PF00069	0.743
MOD_NEK2_1	54	59	PF00069	0.808
MOD_NEK2_1	63	68	PF00069	0.710
MOD_NEK2_1	729	734	PF00069	0.724
MOD_NEK2_2	3	8	PF00069	0.652
MOD_NEK2_2	309	314	PF00069	0.702
MOD_NEK2_2	741	746	PF00069	0.722
MOD_PIKK_1	299	305	PF00454	0.754
MOD_PIKK_1	353	359	PF00454	0.812
MOD_PIKK_1	366	372	PF00454	0.764
MOD_PIKK_1	451	457	PF00454	0.801
MOD_PIKK_1	517	523	PF00454	0.823
MOD_PIKK_1	627	633	PF00454	0.728
MOD_PIKK_1	637	643	PF00454	0.757
MOD_PKA_2	170	176	PF00069	0.601
MOD_PKB_1	239	247	PF00069	0.694
MOD_Plk_2-3	214	220	PF00069	0.748
MOD_Plk_4	233	239	PF00069	0.566
MOD_Plk_4	289	295	PF00069	0.826
MOD_Plk_4	407	413	PF00069	0.844
MOD_Plk_4	495	501	PF00069	0.732
MOD_Plk_4	527	533	PF00069	0.635
MOD_Plk_4	54	60	PF00069	0.819
MOD_Plk_4	564	570	PF00069	0.633
MOD_Plk_4	741	747	PF00069	0.630
MOD_ProDKin_1	102	108	PF00069	0.750
MOD_ProDKin_1	259	265	PF00069	0.806
MOD_ProDKin_1	279	285	PF00069	0.488
MOD_ProDKin_1	293	299	PF00069	0.650
MOD_ProDKin_1	341	347	PF00069	0.679
MOD_ProDKin_1	399	405	PF00069	0.726
MOD_ProDKin_1	417	423	PF00069	0.523
MOD_ProDKin_1	440	446	PF00069	0.794
MOD_ProDKin_1	447	453	PF00069	0.757
MOD_ProDKin_1	509	515	PF00069	0.676
MOD_ProDKin_1	550	556	PF00069	0.836
MOD_ProDKin_1	573	579	PF00069	0.839
MOD_ProDKin_1	589	595	PF00069	0.759
MOD_ProDKin_1	678	684	PF00069	0.845
MOD_SUMO_for_1	201	204	PF00179	0.744
TRG_DiLeu_BaEn_1	219	224	PF01217	0.724
TRG_DiLeu_LyEn_5	219	224	PF01217	0.724
TRG_ENDOCYTIC_2	142	145	PF00928	0.695
TRG_ER_diArg_1	238	241	PF00400	0.628
TRG_ER_diArg_1	738	740	PF00400	0.588
TRG_NES_CRM1_1	24	37	PF08389	0.747
TRG_NLS_MonoExtC_3	176	182	PF00514	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU08	Leptomonas seymouri	42%	100%
A0A3S7X9R7	Leishmania donovani	91%	99%
A4HN68	Leishmania braziliensis	74%	100%
A4IBT6	Leishmania infantum	90%	99%
E9AFM3	Leishmania major	89%	100%