SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6S5_LEIMU

TriTrypDb:

LmxM.34.3970

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B6S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6S5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	614	618	PF00656	0.592
CLV_C14_Caspase3-7	86	90	PF00656	0.424
CLV_MEL_PAP_1	14	20	PF00089	0.388
CLV_NRD_NRD_1	156	158	PF00675	0.637
CLV_NRD_NRD_1	309	311	PF00675	0.419
CLV_NRD_NRD_1	68	70	PF00675	0.410
CLV_NRD_NRD_1	682	684	PF00675	0.629
CLV_NRD_NRD_1	696	698	PF00675	0.616
CLV_NRD_NRD_1	7	9	PF00675	0.498
CLV_NRD_NRD_1	95	97	PF00675	0.586
CLV_PCSK_KEX2_1	156	158	PF00082	0.637
CLV_PCSK_KEX2_1	309	311	PF00082	0.401
CLV_PCSK_KEX2_1	373	375	PF00082	0.379
CLV_PCSK_KEX2_1	684	686	PF00082	0.636
CLV_PCSK_KEX2_1	696	698	PF00082	0.630
CLV_PCSK_KEX2_1	7	9	PF00082	0.405
CLV_PCSK_KEX2_1	95	97	PF00082	0.586
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.379
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.681
CLV_PCSK_SKI1_1	173	177	PF00082	0.510
CLV_PCSK_SKI1_1	449	453	PF00082	0.499
CLV_PCSK_SKI1_1	49	53	PF00082	0.360
DEG_SPOP_SBC_1	264	268	PF00917	0.600
DEG_SPOP_SBC_1	282	286	PF00917	0.424
DEG_SPOP_SBC_1	463	467	PF00917	0.470
DOC_CKS1_1	347	352	PF01111	0.457
DOC_CKS1_1	368	373	PF01111	0.378
DOC_CKS1_1	414	419	PF01111	0.382
DOC_CYCLIN_RxL_1	443	457	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	190	193	PF00134	0.496
DOC_MAPK_gen_1	156	164	PF00069	0.643
DOC_MAPK_gen_1	309	315	PF00069	0.343
DOC_MAPK_gen_1	335	344	PF00069	0.335
DOC_PP2B_LxvP_1	190	193	PF13499	0.556
DOC_PP2B_LxvP_1	276	279	PF13499	0.581
DOC_PP2B_LxvP_1	305	308	PF13499	0.380
DOC_PP2B_LxvP_1	513	516	PF13499	0.483
DOC_PP2B_LxvP_1	662	665	PF13499	0.630
DOC_PP4_FxxP_1	322	325	PF00568	0.332
DOC_SPAK_OSR1_1	321	325	PF12202	0.395
DOC_USP7_MATH_1	146	150	PF00917	0.640
DOC_USP7_MATH_1	155	159	PF00917	0.648
DOC_USP7_MATH_1	222	226	PF00917	0.692
DOC_USP7_MATH_1	245	249	PF00917	0.718
DOC_USP7_MATH_1	255	259	PF00917	0.574
DOC_USP7_MATH_1	265	269	PF00917	0.618
DOC_USP7_MATH_1	461	465	PF00917	0.533
DOC_USP7_MATH_1	627	631	PF00917	0.807
DOC_USP7_MATH_1	633	637	PF00917	0.785
DOC_USP7_MATH_1	663	667	PF00917	0.619
DOC_USP7_UBL2_3	39	43	PF12436	0.384
DOC_WW_Pin1_4	113	118	PF00397	0.778
DOC_WW_Pin1_4	151	156	PF00397	0.638
DOC_WW_Pin1_4	195	200	PF00397	0.755
DOC_WW_Pin1_4	346	351	PF00397	0.466
DOC_WW_Pin1_4	367	372	PF00397	0.370
DOC_WW_Pin1_4	413	418	PF00397	0.460
DOC_WW_Pin1_4	452	457	PF00397	0.365
LIG_14-3-3_CanoR_1	111	117	PF00244	0.554
LIG_14-3-3_CanoR_1	156	164	PF00244	0.643
LIG_14-3-3_CanoR_1	17	21	PF00244	0.617
LIG_14-3-3_CanoR_1	173	179	PF00244	0.668
LIG_14-3-3_CanoR_1	246	252	PF00244	0.668
LIG_14-3-3_CanoR_1	303	308	PF00244	0.384
LIG_14-3-3_CanoR_1	314	320	PF00244	0.314
LIG_14-3-3_CanoR_1	521	528	PF00244	0.486
LIG_14-3-3_CanoR_1	75	84	PF00244	0.417
LIG_Actin_WH2_2	298	316	PF00022	0.337
LIG_Actin_WH2_2	44	61	PF00022	0.398
LIG_BIR_III_2	574	578	PF00653	0.313
LIG_BRCT_BRCA1_1	229	233	PF00533	0.582
LIG_FHA_1	103	109	PF00498	0.603
LIG_FHA_1	148	154	PF00498	0.608
LIG_FHA_1	163	169	PF00498	0.543
LIG_FHA_1	186	192	PF00498	0.511
LIG_FHA_1	23	29	PF00498	0.353
LIG_FHA_1	278	284	PF00498	0.627
LIG_FHA_1	391	397	PF00498	0.347
LIG_FHA_1	414	420	PF00498	0.537
LIG_FHA_1	467	473	PF00498	0.279
LIG_FHA_2	29	35	PF00498	0.510
LIG_FHA_2	353	359	PF00498	0.365
LIG_FHA_2	601	607	PF00498	0.503
LIG_FHA_2	697	703	PF00498	0.623
LIG_GBD_Chelix_1	37	45	PF00786	0.391
LIG_Integrin_isoDGR_2	67	69	PF01839	0.379
LIG_LIR_Apic_2	413	417	PF02991	0.476
LIG_LIR_Gen_1	257	265	PF02991	0.749
LIG_LIR_Gen_1	481	487	PF02991	0.363
LIG_LIR_Gen_1	561	571	PF02991	0.363
LIG_LIR_Nem_3	22	26	PF02991	0.322
LIG_LIR_Nem_3	257	262	PF02991	0.728
LIG_LIR_Nem_3	3	9	PF02991	0.383
LIG_LIR_Nem_3	385	390	PF02991	0.366
LIG_LIR_Nem_3	481	485	PF02991	0.414
LIG_LIR_Nem_3	561	567	PF02991	0.352
LIG_LIR_Nem_3	574	579	PF02991	0.429
LIG_NRBOX	47	53	PF00104	0.408
LIG_PDZ_Class_2	701	706	PF00595	0.601
LIG_Pex14_2	233	237	PF04695	0.538
LIG_Pex14_2	311	315	PF04695	0.338
LIG_PTB_Apo_2	408	415	PF02174	0.434
LIG_PTB_Phospho_1	408	414	PF10480	0.431
LIG_REV1ctd_RIR_1	299	307	PF16727	0.387
LIG_SH2_CRK	259	263	PF00017	0.770
LIG_SH2_CRK	340	344	PF00017	0.370
LIG_SH2_CRK	414	418	PF00017	0.388
LIG_SH2_CRK	482	486	PF00017	0.359
LIG_SH2_GRB2like	362	365	PF00017	0.342
LIG_SH2_GRB2like	542	545	PF00017	0.443
LIG_SH2_NCK_1	259	263	PF00017	0.594
LIG_SH2_SRC	328	331	PF00017	0.396
LIG_SH2_SRC	53	56	PF00017	0.456
LIG_SH2_STAP1	482	486	PF00017	0.478
LIG_SH2_STAT5	328	331	PF00017	0.473
LIG_SH2_STAT5	36	39	PF00017	0.458
LIG_SH2_STAT5	362	365	PF00017	0.402
LIG_SH2_STAT5	387	390	PF00017	0.449
LIG_SH2_STAT5	394	397	PF00017	0.448
LIG_SH2_STAT5	566	569	PF00017	0.392
LIG_SH2_STAT5	579	582	PF00017	0.298
LIG_SH3_2	152	157	PF14604	0.482
LIG_SH3_2	347	352	PF14604	0.363
LIG_SH3_3	149	155	PF00018	0.525
LIG_SH3_3	15	21	PF00018	0.379
LIG_SH3_3	181	187	PF00018	0.585
LIG_SH3_3	259	265	PF00018	0.645
LIG_SH3_3	276	282	PF00018	0.532
LIG_SH3_3	344	350	PF00018	0.397
LIG_SH3_3	365	371	PF00018	0.378
LIG_SH3_3	626	632	PF00018	0.619
LIG_SH3_3	651	657	PF00018	0.610
LIG_SUMO_SIM_par_1	174	180	PF11976	0.495
LIG_SUMO_SIM_par_1	24	29	PF11976	0.280
LIG_SUMO_SIM_par_1	274	280	PF11976	0.467
LIG_SUMO_SIM_par_1	388	393	PF11976	0.330
LIG_SUMO_SIM_par_1	464	473	PF11976	0.300
LIG_TRAF2_1	208	211	PF00917	0.570
LIG_TRAF2_1	427	430	PF00917	0.413
LIG_TRAF2_1	692	695	PF00917	0.655
LIG_TRAF2_2	325	330	PF00917	0.420
LIG_TYR_ITSM	255	262	PF00017	0.568
LIG_WRC_WIRS_1	567	572	PF05994	0.384
MOD_CDC14_SPxK_1	154	157	PF00782	0.629
MOD_CDK_SPK_2	151	156	PF00069	0.627
MOD_CDK_SPxK_1	151	157	PF00069	0.629
MOD_CDK_SPxK_1	346	352	PF00069	0.468
MOD_CDK_SPxK_1	367	373	PF00069	0.372
MOD_CDK_SPxxK_3	367	374	PF00069	0.371
MOD_CK1_1	177	183	PF00069	0.595
MOD_CK1_1	198	204	PF00069	0.650
MOD_CK1_1	225	231	PF00069	0.723
MOD_CK1_1	266	272	PF00069	0.575
MOD_CK1_1	277	283	PF00069	0.753
MOD_CK1_1	284	290	PF00069	0.492
MOD_CK1_1	454	460	PF00069	0.461
MOD_CK1_1	464	470	PF00069	0.435
MOD_CK1_1	520	526	PF00069	0.321
MOD_CK1_1	600	606	PF00069	0.527
MOD_CK1_1	638	644	PF00069	0.613
MOD_CK1_1	649	655	PF00069	0.634
MOD_CK1_1	98	104	PF00069	0.622
MOD_CK2_1	16	22	PF00069	0.589
MOD_CK2_1	284	290	PF00069	0.508
MOD_CK2_1	352	358	PF00069	0.432
MOD_CK2_1	424	430	PF00069	0.351
MOD_CK2_1	613	619	PF00069	0.632
MOD_CK2_1	637	643	PF00069	0.630
MOD_CK2_1	688	694	PF00069	0.734
MOD_Cter_Amidation	67	70	PF01082	0.458
MOD_GlcNHglycan	101	104	PF01048	0.550
MOD_GlcNHglycan	120	123	PF01048	0.657
MOD_GlcNHglycan	133	136	PF01048	0.653
MOD_GlcNHglycan	224	227	PF01048	0.667
MOD_GlcNHglycan	230	233	PF01048	0.690
MOD_GlcNHglycan	268	271	PF01048	0.603
MOD_GlcNHglycan	296	299	PF01048	0.409
MOD_GlcNHglycan	466	469	PF01048	0.360
MOD_GlcNHglycan	582	585	PF01048	0.425
MOD_GlcNHglycan	629	632	PF01048	0.681
MOD_GlcNHglycan	637	640	PF01048	0.621
MOD_GlcNHglycan	654	657	PF01048	0.619
MOD_GlcNHglycan	665	668	PF01048	0.573
MOD_GlcNHglycan	688	693	PF01048	0.601
MOD_GlcNHglycan	85	88	PF01048	0.660
MOD_GSK3_1	111	118	PF00069	0.496
MOD_GSK3_1	147	154	PF00069	0.641
MOD_GSK3_1	191	198	PF00069	0.713
MOD_GSK3_1	199	206	PF00069	0.691
MOD_GSK3_1	221	228	PF00069	0.681
MOD_GSK3_1	264	271	PF00069	0.758
MOD_GSK3_1	277	284	PF00069	0.486
MOD_GSK3_1	390	397	PF00069	0.386
MOD_GSK3_1	451	458	PF00069	0.457
MOD_GSK3_1	462	469	PF00069	0.451
MOD_GSK3_1	534	541	PF00069	0.293
MOD_GSK3_1	558	565	PF00069	0.425
MOD_GSK3_1	633	640	PF00069	0.667
MOD_GSK3_1	646	653	PF00069	0.542
MOD_GSK3_1	95	102	PF00069	0.622
MOD_N-GLC_1	294	299	PF02516	0.480
MOD_NEK2_1	144	149	PF00069	0.710
MOD_NEK2_1	28	33	PF00069	0.276
MOD_NEK2_1	283	288	PF00069	0.584
MOD_NEK2_1	294	299	PF00069	0.352
MOD_NEK2_1	315	320	PF00069	0.464
MOD_NEK2_1	390	395	PF00069	0.322
MOD_NEK2_1	435	440	PF00069	0.381
MOD_NEK2_1	451	456	PF00069	0.482
MOD_NEK2_1	462	467	PF00069	0.452
MOD_NEK2_1	470	475	PF00069	0.248
MOD_NEK2_1	533	538	PF00069	0.273
MOD_NEK2_1	580	585	PF00069	0.420
MOD_NEK2_1	83	88	PF00069	0.388
MOD_PIKK_1	506	512	PF00454	0.330
MOD_PK_1	303	309	PF00069	0.465
MOD_PK_1	59	65	PF00069	0.464
MOD_PKA_1	156	162	PF00069	0.632
MOD_PKA_1	696	702	PF00069	0.525
MOD_PKA_1	95	101	PF00069	0.599
MOD_PKA_2	125	131	PF00069	0.646
MOD_PKA_2	155	161	PF00069	0.651
MOD_PKA_2	16	22	PF00069	0.430
MOD_PKA_2	245	251	PF00069	0.602
MOD_PKA_2	517	523	PF00069	0.361
MOD_PKA_2	696	702	PF00069	0.648
MOD_PKA_2	95	101	PF00069	0.622
MOD_Plk_1	390	396	PF00069	0.323
MOD_Plk_1	59	65	PF00069	0.464
MOD_Plk_1	649	655	PF00069	0.637
MOD_Plk_2-3	613	619	PF00069	0.667
MOD_Plk_2-3	690	696	PF00069	0.646
MOD_Plk_4	185	191	PF00069	0.638
MOD_Plk_4	22	28	PF00069	0.409
MOD_Plk_4	315	321	PF00069	0.377
MOD_Plk_4	383	389	PF00069	0.329
MOD_Plk_4	466	472	PF00069	0.414
MOD_Plk_4	538	544	PF00069	0.316
MOD_Plk_4	558	564	PF00069	0.191
MOD_Plk_4	59	65	PF00069	0.464
MOD_ProDKin_1	113	119	PF00069	0.645
MOD_ProDKin_1	151	157	PF00069	0.639
MOD_ProDKin_1	195	201	PF00069	0.757
MOD_ProDKin_1	346	352	PF00069	0.468
MOD_ProDKin_1	367	373	PF00069	0.372
MOD_ProDKin_1	413	419	PF00069	0.454
MOD_ProDKin_1	452	458	PF00069	0.368
MOD_SUMO_rev_2	19	26	PF00179	0.545
TRG_DiLeu_BaEn_1	171	176	PF01217	0.556
TRG_DiLeu_BaEn_1	47	52	PF01217	0.399
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.418
TRG_ENDOCYTIC_2	259	262	PF00928	0.770
TRG_ENDOCYTIC_2	387	390	PF00928	0.400
TRG_ENDOCYTIC_2	482	485	PF00928	0.386
TRG_ENDOCYTIC_2	579	582	PF00928	0.397
TRG_ER_diArg_1	155	157	PF00400	0.630
TRG_ER_diArg_1	308	310	PF00400	0.462
TRG_ER_diArg_1	6	8	PF00400	0.430
TRG_ER_diArg_1	682	685	PF00400	0.603
TRG_ER_diArg_1	94	96	PF00400	0.619
TRG_NLS_MonoExtC_3	682	687	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M6	Leptomonas seymouri	52%	97%
A0A3Q8IPZ9	Leishmania donovani	91%	100%
A0A422MY81	Trypanosoma rangeli	40%	100%
A4IBT5	Leishmania infantum	92%	100%
E9AFM2	Leishmania major	91%	100%