Ufd2P_core domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B6R9_LEIMU

TriTrypDb:

LmxM.34.3920

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B6R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B6R9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.453
CLV_NRD_NRD_1	179	181	PF00675	0.714
CLV_NRD_NRD_1	222	224	PF00675	0.637
CLV_NRD_NRD_1	377	379	PF00675	0.642
CLV_PCSK_KEX2_1	210	212	PF00082	0.547
CLV_PCSK_KEX2_1	277	279	PF00082	0.621
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.594
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.621
CLV_PCSK_SKI1_1	203	207	PF00082	0.535
CLV_PCSK_SKI1_1	305	309	PF00082	0.709
CLV_PCSK_SKI1_1	35	39	PF00082	0.576
CLV_PCSK_SKI1_1	466	470	PF00082	0.379
CLV_PCSK_SKI1_1	597	601	PF00082	0.455
CLV_PCSK_SKI1_1	726	730	PF00082	0.448
DEG_APCC_DBOX_1	202	210	PF00400	0.415
DEG_APCC_DBOX_1	304	312	PF00400	0.490
DEG_APCC_DBOX_1	389	397	PF00400	0.311
DEG_SPOP_SBC_1	125	129	PF00917	0.556
DEG_SPOP_SBC_1	364	368	PF00917	0.467
DOC_CDC14_PxL_1	189	197	PF14671	0.495
DOC_CDC14_PxL_1	295	303	PF14671	0.388
DOC_CYCLIN_RxL_1	302	312	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.529
DOC_MAPK_gen_1	161	170	PF00069	0.367
DOC_MAPK_gen_1	466	475	PF00069	0.563
DOC_MAPK_MEF2A_6	161	170	PF00069	0.392
DOC_MAPK_MEF2A_6	390	398	PF00069	0.402
DOC_MAPK_MEF2A_6	785	793	PF00069	0.440
DOC_MAPK_RevD_3	166	181	PF00069	0.491
DOC_PP1_RVXF_1	201	208	PF00149	0.391
DOC_PP1_RVXF_1	602	608	PF00149	0.651
DOC_PP2B_LxvP_1	104	107	PF13499	0.337
DOC_PP2B_LxvP_1	133	136	PF13499	0.537
DOC_PP2B_LxvP_1	168	171	PF13499	0.459
DOC_PP2B_LxvP_1	622	625	PF13499	0.743
DOC_PP4_FxxP_1	172	175	PF00568	0.426
DOC_PP4_FxxP_1	330	333	PF00568	0.405
DOC_USP7_MATH_1	124	128	PF00917	0.527
DOC_USP7_MATH_1	151	155	PF00917	0.533
DOC_USP7_MATH_1	290	294	PF00917	0.422
DOC_USP7_MATH_1	356	360	PF00917	0.440
DOC_USP7_MATH_1	533	537	PF00917	0.557
DOC_USP7_MATH_1	582	586	PF00917	0.730
DOC_USP7_MATH_1	79	83	PF00917	0.448
DOC_USP7_UBL2_3	116	120	PF12436	0.441
DOC_USP7_UBL2_3	379	383	PF12436	0.220
DOC_USP7_UBL2_3	466	470	PF12436	0.587
DOC_USP7_UBL2_3	579	583	PF12436	0.724
DOC_USP7_UBL2_3	612	616	PF12436	0.770
DOC_WW_Pin1_4	346	351	PF00397	0.505
DOC_WW_Pin1_4	771	776	PF00397	0.651
LIG_14-3-3_CanoR_1	126	131	PF00244	0.545
LIG_14-3-3_CanoR_1	214	222	PF00244	0.456
LIG_14-3-3_CanoR_1	272	280	PF00244	0.441
LIG_14-3-3_CanoR_1	316	322	PF00244	0.396
LIG_14-3-3_CanoR_1	378	382	PF00244	0.336
LIG_14-3-3_CanoR_1	532	538	PF00244	0.616
LIG_14-3-3_CanoR_1	539	548	PF00244	0.598
LIG_14-3-3_CanoR_1	597	605	PF00244	0.684
LIG_14-3-3_CanoR_1	779	785	PF00244	0.480
LIG_APCC_ABBA_1	169	174	PF00400	0.475
LIG_BRCT_BRCA1_1	107	111	PF00533	0.394
LIG_BRCT_BRCA1_1	126	130	PF00533	0.422
LIG_BRCT_BRCA1_1	215	219	PF00533	0.437
LIG_BRCT_BRCA1_1	347	351	PF00533	0.483
LIG_BRCT_BRCA1_1	438	442	PF00533	0.398
LIG_BRCT_BRCA1_1	750	754	PF00533	0.656
LIG_BRCT_BRCA1_1	769	773	PF00533	0.599
LIG_BRCT_BRCA1_1	93	97	PF00533	0.375
LIG_Clathr_ClatBox_1	393	397	PF01394	0.299
LIG_CtBP_PxDLS_1	775	779	PF00389	0.649
LIG_deltaCOP1_diTrp_1	412	421	PF00928	0.404
LIG_DLG_GKlike_1	126	133	PF00625	0.502
LIG_EH_1	418	422	PF12763	0.424
LIG_EH1_1	494	502	PF00400	0.610
LIG_eIF4E_1	199	205	PF01652	0.370
LIG_FHA_1	244	250	PF00498	0.361
LIG_FHA_1	289	295	PF00498	0.352
LIG_FHA_1	334	340	PF00498	0.317
LIG_FHA_1	406	412	PF00498	0.359
LIG_FHA_1	524	530	PF00498	0.575
LIG_FHA_1	543	549	PF00498	0.649
LIG_FHA_1	554	560	PF00498	0.577
LIG_FHA_1	566	572	PF00498	0.639
LIG_FHA_1	590	596	PF00498	0.732
LIG_FHA_1	78	84	PF00498	0.409
LIG_FHA_1	784	790	PF00498	0.333
LIG_FHA_2	177	183	PF00498	0.445
LIG_FHA_2	284	290	PF00498	0.442
LIG_FHA_2	356	362	PF00498	0.543
LIG_FHA_2	47	53	PF00498	0.394
LIG_FHA_2	494	500	PF00498	0.668
LIG_FHA_2	556	562	PF00498	0.417
LIG_FHA_2	598	604	PF00498	0.670
LIG_LIR_Apic_2	154	160	PF02991	0.507
LIG_LIR_Apic_2	760	766	PF02991	0.651
LIG_LIR_Gen_1	18	27	PF02991	0.420
LIG_LIR_Gen_1	237	248	PF02991	0.464
LIG_LIR_Gen_1	260	268	PF02991	0.383
LIG_LIR_Gen_1	412	421	PF02991	0.318
LIG_LIR_Gen_1	439	450	PF02991	0.279
LIG_LIR_Gen_1	49	58	PF02991	0.422
LIG_LIR_Gen_1	666	674	PF02991	0.672
LIG_LIR_Gen_1	786	795	PF02991	0.324
LIG_LIR_Gen_1	797	804	PF02991	0.348
LIG_LIR_Nem_3	127	133	PF02991	0.482
LIG_LIR_Nem_3	18	23	PF02991	0.293
LIG_LIR_Nem_3	237	243	PF02991	0.442
LIG_LIR_Nem_3	260	264	PF02991	0.343
LIG_LIR_Nem_3	3	7	PF02991	0.445
LIG_LIR_Nem_3	412	417	PF02991	0.315
LIG_LIR_Nem_3	438	443	PF02991	0.286
LIG_LIR_Nem_3	49	53	PF02991	0.359
LIG_LIR_Nem_3	561	567	PF02991	0.576
LIG_LIR_Nem_3	666	672	PF02991	0.725
LIG_LIR_Nem_3	770	776	PF02991	0.642
LIG_LIR_Nem_3	786	790	PF02991	0.225
LIG_LIR_Nem_3	797	802	PF02991	0.370
LIG_NRBOX	200	206	PF00104	0.369
LIG_PCNA_yPIPBox_3	223	232	PF02747	0.337
LIG_PCNA_yPIPBox_3	470	484	PF02747	0.598
LIG_PDZ_Class_2	799	804	PF00595	0.367
LIG_Pex14_1	780	784	PF04695	0.542
LIG_Pex14_2	16	20	PF04695	0.407
LIG_Pex14_2	37	41	PF04695	0.445
LIG_Pex14_2	505	509	PF04695	0.522
LIG_Pex14_2	570	574	PF04695	0.642
LIG_Pex14_2	795	799	PF04695	0.445
LIG_REV1ctd_RIR_1	142	150	PF16727	0.469
LIG_REV1ctd_RIR_1	35	44	PF16727	0.478
LIG_REV1ctd_RIR_1	605	613	PF16727	0.717
LIG_SH2_CRK	157	161	PF00017	0.465
LIG_SH2_CRK	244	248	PF00017	0.402
LIG_SH2_CRK	254	258	PF00017	0.286
LIG_SH2_CRK	669	673	PF00017	0.671
LIG_SH2_PTP2	261	264	PF00017	0.403
LIG_SH2_PTP2	534	537	PF00017	0.590
LIG_SH2_STAP1	240	244	PF00017	0.459
LIG_SH2_STAP1	254	258	PF00017	0.365
LIG_SH2_STAP1	669	673	PF00017	0.636
LIG_SH2_STAP1	686	690	PF00017	0.629
LIG_SH2_STAT3	25	28	PF00017	0.430
LIG_SH2_STAT3	432	435	PF00017	0.419
LIG_SH2_STAT5	131	134	PF00017	0.459
LIG_SH2_STAT5	19	22	PF00017	0.424
LIG_SH2_STAT5	199	202	PF00017	0.314
LIG_SH2_STAT5	261	264	PF00017	0.349
LIG_SH2_STAT5	265	268	PF00017	0.316
LIG_SH2_STAT5	335	338	PF00017	0.379
LIG_SH2_STAT5	401	404	PF00017	0.407
LIG_SH2_STAT5	409	412	PF00017	0.281
LIG_SH2_STAT5	432	435	PF00017	0.321
LIG_SH2_STAT5	534	537	PF00017	0.545
LIG_SH2_STAT5	58	61	PF00017	0.446
LIG_SH2_STAT5	62	65	PF00017	0.448
LIG_SH2_STAT5	763	766	PF00017	0.588
LIG_SH3_3	190	196	PF00018	0.448
LIG_SH3_3	20	26	PF00018	0.368
LIG_SH3_3	246	252	PF00018	0.367
LIG_SH3_3	592	598	PF00018	0.753
LIG_SH3_3	769	775	PF00018	0.699
LIG_Sin3_3	202	209	PF02671	0.409
LIG_SUMO_SIM_anti_2	293	298	PF11976	0.420
LIG_SUMO_SIM_anti_2	555	561	PF11976	0.623
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.369
LIG_SUMO_SIM_par_1	391	397	PF11976	0.381
LIG_SUMO_SIM_par_1	555	561	PF11976	0.579
LIG_TRAF2_1	664	667	PF00917	0.592
LIG_TRAF2_1	8	11	PF00917	0.439
LIG_TRFH_1	25	29	PF08558	0.417
LIG_UBA3_1	201	210	PF00899	0.356
LIG_WRC_WIRS_1	437	442	PF05994	0.340
LIG_WRC_WIRS_1	47	52	PF05994	0.389
LIG_WRC_WIRS_1	799	804	PF05994	0.438
MOD_CK1_1	105	111	PF00069	0.439
MOD_CK1_1	276	282	PF00069	0.473
MOD_CK1_1	31	37	PF00069	0.428
MOD_CK1_1	343	349	PF00069	0.455
MOD_CK1_1	363	369	PF00069	0.412
MOD_CK1_1	405	411	PF00069	0.365
MOD_CK1_1	490	496	PF00069	0.603
MOD_CK1_1	542	548	PF00069	0.654
MOD_CK1_1	589	595	PF00069	0.703
MOD_CK1_1	731	737	PF00069	0.586
MOD_CK1_1	774	780	PF00069	0.686
MOD_CK1_1	783	789	PF00069	0.391
MOD_CK2_1	176	182	PF00069	0.446
MOD_CK2_1	456	462	PF00069	0.481
MOD_CK2_1	493	499	PF00069	0.645
MOD_CK2_1	54	60	PF00069	0.435
MOD_CK2_1	555	561	PF00069	0.618
MOD_CK2_1	597	603	PF00069	0.684
MOD_CK2_1	661	667	PF00069	0.656
MOD_CK2_1	702	708	PF00069	0.670
MOD_CK2_1	96	102	PF00069	0.375
MOD_DYRK1A_RPxSP_1	771	775	PF00069	0.649
MOD_GlcNHglycan	107	110	PF01048	0.681
MOD_GlcNHglycan	215	218	PF01048	0.609
MOD_GlcNHglycan	240	243	PF01048	0.701
MOD_GlcNHglycan	266	269	PF01048	0.636
MOD_GlcNHglycan	730	733	PF01048	0.436
MOD_GSK3_1	120	127	PF00069	0.434
MOD_GSK3_1	264	271	PF00069	0.426
MOD_GSK3_1	272	279	PF00069	0.408
MOD_GSK3_1	284	291	PF00069	0.385
MOD_GSK3_1	340	347	PF00069	0.422
MOD_GSK3_1	356	363	PF00069	0.488
MOD_GSK3_1	452	459	PF00069	0.376
MOD_GSK3_1	570	577	PF00069	0.610
MOD_GSK3_1	578	585	PF00069	0.644
MOD_GSK3_1	726	733	PF00069	0.641
MOD_GSK3_1	767	774	PF00069	0.645
MOD_GSK3_1	79	86	PF00069	0.441
MOD_GSK3_1	794	801	PF00069	0.433
MOD_GSK3_1	92	99	PF00069	0.315
MOD_N-GLC_1	120	125	PF02516	0.705
MOD_N-GLC_1	283	288	PF02516	0.642
MOD_N-GLC_1	487	492	PF02516	0.431
MOD_N-GLC_1	523	528	PF02516	0.439
MOD_N-GLC_2	628	630	PF02516	0.339
MOD_NEK2_1	243	248	PF00069	0.405
MOD_NEK2_1	257	262	PF00069	0.364
MOD_NEK2_1	456	461	PF00069	0.465
MOD_NEK2_1	54	59	PF00069	0.425
MOD_NEK2_1	553	558	PF00069	0.621
MOD_NEK2_1	570	575	PF00069	0.521
MOD_NEK2_1	651	656	PF00069	0.594
MOD_NEK2_1	682	687	PF00069	0.637
MOD_NEK2_1	748	753	PF00069	0.575
MOD_NEK2_1	794	799	PF00069	0.440
MOD_NEK2_1	83	88	PF00069	0.421
MOD_OFUCOSY	707	714	PF10250	0.464
MOD_PIKK_1	181	187	PF00454	0.542
MOD_PIKK_1	356	362	PF00454	0.437
MOD_PIKK_1	427	433	PF00454	0.387
MOD_PIKK_1	473	479	PF00454	0.601
MOD_PIKK_1	487	493	PF00454	0.655
MOD_PIKK_1	565	571	PF00454	0.588
MOD_PK_1	586	592	PF00069	0.732
MOD_PKA_2	125	131	PF00069	0.545
MOD_PKA_2	213	219	PF00069	0.413
MOD_PKA_2	315	321	PF00069	0.422
MOD_PKA_2	377	383	PF00069	0.338
MOD_PKA_2	574	580	PF00069	0.622
MOD_PKA_2	757	763	PF00069	0.600
MOD_Plk_1	360	366	PF00069	0.543
MOD_Plk_1	542	548	PF00069	0.551
MOD_Plk_1	702	708	PF00069	0.649
MOD_Plk_1	748	754	PF00069	0.683
MOD_Plk_2-3	555	561	PF00069	0.620
MOD_Plk_4	126	132	PF00069	0.496
MOD_Plk_4	257	263	PF00069	0.398
MOD_Plk_4	290	296	PF00069	0.364
MOD_Plk_4	377	383	PF00069	0.327
MOD_Plk_4	384	390	PF00069	0.274
MOD_Plk_4	452	458	PF00069	0.441
MOD_Plk_4	479	485	PF00069	0.587
MOD_Plk_4	555	561	PF00069	0.550
MOD_Plk_4	591	597	PF00069	0.705
MOD_Plk_4	668	674	PF00069	0.633
MOD_Plk_4	794	800	PF00069	0.397
MOD_Plk_4	83	89	PF00069	0.374
MOD_Plk_4	93	99	PF00069	0.339
MOD_ProDKin_1	346	352	PF00069	0.505
MOD_ProDKin_1	771	777	PF00069	0.650
MOD_SUMO_rev_2	31	37	PF00179	0.401
MOD_SUMO_rev_2	547	556	PF00179	0.659
TRG_DiLeu_BaEn_1	555	560	PF01217	0.620
TRG_DiLeu_BaEn_1	646	651	PF01217	0.627
TRG_DiLeu_BaEn_2	437	443	PF01217	0.334
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.391
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.585
TRG_ENDOCYTIC_2	199	202	PF00928	0.314
TRG_ENDOCYTIC_2	240	243	PF00928	0.451
TRG_ENDOCYTIC_2	244	247	PF00928	0.401
TRG_ENDOCYTIC_2	254	257	PF00928	0.267
TRG_ENDOCYTIC_2	261	264	PF00928	0.252
TRG_ENDOCYTIC_2	335	338	PF00928	0.401
TRG_ENDOCYTIC_2	534	537	PF00928	0.565
TRG_ENDOCYTIC_2	669	672	PF00928	0.698
TRG_ER_diArg_1	160	163	PF00400	0.428
TRG_NES_CRM1_1	547	561	PF08389	0.626
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	663	667	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IID0	Leptomonas seymouri	58%	100%
A0A0S4IXF5	Bodo saltans	23%	83%
A0A1X0P5G3	Trypanosomatidae	32%	99%
A0A3R7K1M8	Trypanosoma rangeli	33%	89%
A0A3S7X9Q6	Leishmania donovani	94%	100%
A4HN62	Leishmania braziliensis	82%	100%
A4IBS9	Leishmania infantum	94%	100%
C9ZYT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	91%
E9AFL6	Leishmania major	92%	100%
V5BTB4	Trypanosoma cruzi	34%	100%